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BRCA1 and BRCA2 Common Mutations in Iranian Breast Cancer Patients: a Meta Analysis

  • Forat-Yazdi, Mohammad;Neamatzadeh, Hossein;Sheikhha, Mohammad Hasan;Zare-Shehneh, Masoud;Fattahi, Mortaza
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.3
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    • pp.1219-1224
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    • 2015
  • Background: To date several common mutations in BRCA1 and BRCA2 associated with breast cancer have been reported in different populations. However, the common BRCA1 and BRCA2 mutations among breast cancer patients in Iran have not been described in detail. Materials and Methods: To comprehensively assess the frequency and distribution of the most common BRCA1 and BRCA2 mutations in Iranian breast cancer patients, we conducted this meta-analysis on 13 relevant published studies indentified in a literature search on PubMed and SID. Results: A total of 11 BRCA1 and BRCA2 distinct common mutations were identified, reported twice or more in the articles, of which 10 (c.2311T>C, c.3113A>G, c.4308T>C, c.4837A>G, c.2612C>T, c.3119G>A, c.3548A>G, c.5213G>A c.IVS16-92A/G, and c.IVS16-68A/G) mutations were in BRCA1, and 1 (c.4770A>G) was in BRCA2. The mutations were in exon 11, exon 13, intron 16, and exon 20 of BRCA1 and exon 11 of BRCA2. All have been previously reported in different populations. Conclusions: These meta analysis results should be helpful in understanding the possibility of any first true founder mutation of BRCA1/BRCA2 in the Iranian population. In addition, they will be of significance for diagnostic testing, genetic counseling and for epidemiological studies.

Protective Measures From Solar Ultraviolet Radiation for Beach Lifeguards in Tuscany (Italy): Shade and Clothing Strategies

  • Daniele Grifoni;Giulio Betti;Andrea Bogi;Lucia Bramanti;Alessandra Chiarugi;Bernardo Gozzini;Marco Morabito;Francesco Picciolo;Francesco Sabatini;Lucia Miligi
    • Safety and Health at Work
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    • v.13 no.4
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    • pp.421-428
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    • 2022
  • Background: The exposure to solar ultraviolet radiation is a significant risk factor generally underestimated by outdoor workers and employers. Several studies have pointed out that occupational solar exposure increased eye and skin diseases with a considerable impact on the lives and productivity of affected workers. The main purpose of this study was to evaluate the effectiveness against ultraviolet radiation of some measures recently undertaken for the protection of lifeguards in a coastal area of Tuscany. Methods: Different shading structures (gazebos and beach umbrella) were tested during a sunny summer's day on a sandy beach by means of two radiometers; the UV protection offered by some T-shirts used by lifeguards was also tested in the laboratory with a spectrophotometer. Results: The analysed shading structures strongly reduced the ultraviolet radiation by up to 90%, however a not always negligible diffuse radiation is also present in the shade, requiring further protective measures (T-shirt, sunglasses, sunscreen, etc.); the tested T-shirts showed a very good-excellent protection according to the Australian/New Zealand standard. Conclusion: Results obtained in this study suggest how the adoption and dissemination of good practices, including those tested, could be particularly effective as a primary prevention for lifeguards who are subjected to very high levels of radiation for long periods.

Status of Water Quality in Nakdong River Districts (낙동강 수계의 수질 현황)

  • Lim, Young-Sung;Cho, Ju-Sik;Lee, Hong-Jae;Lee, Young-Han;Sohn, Bo-Kyoon;Heo, Jong-Soo
    • Korean Journal of Environmental Agriculture
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    • v.18 no.2
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    • pp.126-134
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    • 1999
  • To provide the basic information for the water improvement and control of water resource in Nakdong river districts, the physico-chemical characteristics of water in four main streams and three branch streams of the river were investigated through 36 times totally, one time per each month from January in 1995 to November in 1997. The pH values of each sites in main or branch stream of Nakdong river was pH $6.3{\sim}9.3$ range, pH range of Jukpo and Namji area at spring and fall was almost over pH 8.5, which was exceeded the water quality standard for agriculture. DO values of Nakdong river was almost $8.0{\sim}13mg/l$, except for Kangchang area in downstream of Kumho river. BOD values in Dasa area where was prior to mixing of Kumho river was $1.5{\sim}4.8mg/l$, which was under the water quality standard for agriculture(8mg/l), but BOD values followed mixing of Kumho river was over the permit standard of agricultural water as $3.8{\sim}8.9mg/l$ in Koryung, $3.4{\sim}8.4mg/l$ in Jukpo and $3.3{\sim}7.8mg/l$ in Namji according to time or season. Especially, BOD values at Gangchang area in Kumho river were $7.6{\sim}18.5mg/l$, which was over the water quality standard for agriculture and so Kumho river was a main pollutant: source of Nakdong river. COD values of main stream of Nakdong river was over the permit standard of agriculture(8mg/l) as $5.2{\sim}13.5mg/l$ in Koryvng, $5.0{\sim}12.7mg/l$ in Jukpo and $5.0{\sim}12.2mg/l$ in Namji according to time or season. And COD values was much high rather than BOD values and its gap of concentration was increased along with downstream. $NH_4-N$ of main stream of Nakdong river followed mixing of Kumho river($0.5{\sim}13.1mg/l$) was the highest affected in Koryung($0.18{\sim}5.0mg/l$) and detected much more in winter than in summer. T-N in Koryung($4.96{\sim}12.06mg/l$) followed mixing of Kumho river was significantly high rather than $2.86{\sim}4.86mg/l$ in Dasa, $4.20{\sim}8.20mg/l$ in Jukpo and $3.18{\sim}8.64mg/l$ in Namji, which was almost over the permit standard of agricultural water(1.0mg/l). T-P in Koryung($0.10{\sim}0.58mg/l$) also was significantly high rather than those $0.07{\sim}0.36mg/l$ in Jukpo and $0.08{\sim}0.4mg/l$ in Namji as over the standard of agricultural water(0.1mg/l). The concentration of T-N or T-P in Nakdong districts was trended of increasing in every year.

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Analysis of the Correlation between atrophy of exocervical epithelial cell and osteoporosis (자궁경부 상피세포위축과 골다공증의 상관관계 분석)

  • Lee, Dae-Il;Nam, Ha-Gyeong;Lee, Mi-Hwa;Gwak, Min-Jeong;Lee, Hyeon-Jeong;Lee, Su-Bae;Hong, Gwang-Seon
    • Journal of Korea Association of Health Promotion
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    • v.4 no.1
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    • pp.75-84
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    • 2006
  • Background : Osteoporosis and atrophic cell pattern in Pap smear are frequent findings In postmenopausal women due to loss of ovarian function, The present study attempted to find out possible correlation between morphologic characteristics of Pap smear and osteoporosis. Material & methods: The subjects were 825 women(age from 35 to 80) who had undergone Pap smear and bone mineral density(BMD) at The Korea Association of Health Promotion, Seoul Branch, from March 8 to May 10, 2005. Pap smears from 825 women were reviewed and classified either mature cell pattern or atrophic cell pattern by their cytologic patterns, BMD were measured using LUNAR DPX MdIQ(Minster, Ohio, USA). BMD value of lumbar spine(Ll, L2,L3 and L4) were measured from 825 women and BMD value of proximal region off emur(neck NK, Wards triangle WT, and trochanter TR) were measured from 818 women and their bone status were classified as normal( T-sore:>-1.0), osteopenia (T-score: -l~<-2,5) and osteoporosis(T-score: ≤ -2.5). And age distribution of Pap smear, average T-value andfrequency ofsteoporo-sis of each region of the bone, percentage of osteoporosis of each boneregion by age group and changing pattern of percentage of osteopenia and osteoporosis in certain postmenopausal period were compared between mature and atrophic cell pattern. Results: Pap smears revealed total mature cell pattern 53,9%(445/825) and total atrophic cell pattern 46.1%(380/825), Percentage of mature cell pattern decreased from 98.2%(168/171)under 44 age group to 13,3%(17/128) over 65 age group and mature cell pattern increased from 1.8%(3/171) under 44 age group to 86.7%(111/128) oyer 65 age group. Mean T-value of each region of lumbar spine and femur of mature cell pattern were lower than that of atrophic cell pattern about -1,5. And osteoporosis has noted in atrophic cell pattern showing odds ratio Ll 13.9, L2 15.3, L3 12.0, L4 10,4, UK 6.7, WT 10.9 and TR 4.1.Atrophic cell pattern started to increase after 45 years of age and osteoporosis of a trophic cell pattern started after 55 years of age. During 50 to 64 years of age period, L3, L4 and WT revealed parallel increased of osteopenia and osteoporosis and Ll, L2 revealed decreased of osteopenia and increased of osteoporosis. nia Conclusion: Above findings suggest that atrophic cell pattern of Pap smear precedes osteoporosis about 10 years and one of predictor of osteoporosis.

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Distribution of Biomass and Production of Pinus rigida and Pinus rigida×taeda Plantation in Kwangju District (광주지방(光州地方)의 리기다소나무 및 리기테다소나무조림지(造林地)의 물질생산량(物質生産量)에 관(關)한 연구(研究))

  • Lee, Kyong Jae;Kim, Kap Duk;Kim, Jae Saeng;Park, In Hyeop
    • Journal of Korean Society of Forest Science
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    • v.69 no.1
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    • pp.28-35
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    • 1985
  • To estimate the aboveground biomass of Pinus rigida and Pinus rigida ${\times}$ taeda 22-year-old plantations, the experimental plots of $200m^2$ in size located in Kwangju of Jeonlanam-do were selected. Nine sample trees selected at each plot taking account of DBH distribution were felled and the diagram of oven-dry weight distribution of stem, branch, and needle for each 1m segment was constructed. The logarithmic regression equations between dry weight of each component (stems, branches, and needles) and the variable of $(DBH)^2{\cdot}H$ were obtained. The aboveground standing crops was estimated to be as much as 71.61 and 142.32 tons of dry matter per hectare in P. rigida and P. rigida ${\times}$ taeda stand respectively. The net production was estimated as 10.81 and 10.46 t/ha/yr and the net assimilation rate 1.32 and 1.00 kg/kg/yr in P. rigida and P. rigida ${\times}$ taeda stand respectively. And the efficiency of needles to produce stem was 0.97 and 0.81 kg/kg/yr in same order.

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High LO-RF Isolation W-band MIMIC Single-balanced Mixer (높은 LO-RF 격리 특성의 W-band MIMIC Single-balanced 믹서)

  • An Dan;Lee Bok-Hyung;Lim Byeong-Ok;Lee Mun-Kyo;Lee Sang-Jin;Jin Jin-Min;Go Du-Hyun;Kim Sung-Chan;Shin Dong-Hoon;Park Hyung-Moo;Park Hyim-Chang;Kim Sam-Dong;Rhee Jin-Koo
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.42 no.6 s.336
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    • pp.67-74
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    • 2005
  • In this paper, high LO-RF isolation W-band MIMIC single-balanced mixer was designed and fabricated using a branch line coupler and a $\lambda$/4 transmission line. The simulation results of the designed 94 GHz balun show return loss of -27.9 dB, coupling of -4.26 dB, and thru of -3.77 dB at 94 GHz, respectively. The isolation and phase difference were 23.5 dB and $180.2^{\circ}$ at 94 GHz. The W-band MIMIC single-balanced mixer was designed using the 0.1 $\mu$m InGaAs/InAlAs/GaAs Metamorphic HEMT diode. The fabricated MHEMT was obtained the cut-off frequency(fT) of 189 GHz and the maximum oscillation frequency(fmax) of 334 GHz. The designed MIMIC single-balanced mixer was fabricated using 0.1 $\mu$m MHEMT MIMIC Process. From the measurement, the conversion loss of the single-balanced mixer was 23.1 dB at an LO power of 10 dBm. Pl dB(1 dB compression point) of input and output were 10 dBm and -13.9 dBm respectively. The LO-RF isolations of single-balanced mixer was obtained 45.5 dB at 94.19 GHz. We obtained in this study a higher LO-RF isolation compared to some other balanced mixers in millimeter-wave frequencies.

Molecular Structure and Gelatinization Properties of Turnip Starch (Brassica rapa L.)

  • Kim, Nam-Hee;Yoo, Sang-Ho
    • Food Science and Biotechnology
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    • v.14 no.4
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    • pp.470-473
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    • 2005
  • Starch was isolated from turnip (Brassica rapa L.), and to elucidate the structure-function relationship its structural and physical properties were characterized. Morphological structure of the starch was analyzed by SEM (Scanning Electron Microscopy). Most of the starch granules were spherical in shape with diameter ranging from 0.5-10mm. Apart from larger granules ($<10\;{\mu}m$) which dominated the population size of turnip starch, significant amount of small ($0.5-2\;{\mu}m$) and mid-size granules (${\sim}\;{\mu}m$) were also detected. It was revealed that presumably, erosion damages occurred due to the attack of amylase-type enzymes on the surface of some granules. Branch chain-length distribution was analyzed by HPAEC (High-Performance Anion-Exchange Chromatography). The chain-length distribution of turnip starch revealed a peak at DP12 with obvious shoulder at DP18-21. The weight-average chain length ($CL_{avg}$) was 16.6, and a large proportion (11.8%) of very short chains (DP6-9) was also observed. The melting properties of starch were determined by DSC (Differential Scanning Calorimetry). The onset temperature ($T_o$) and the enthalpy change (${\Delta}H$) of starch gelatinization were $50.5^{\circ}C$ and 12.5 J/g, respectively. The ${\Delta}H$ of the retrograded turnip starch was 3.5 J/g, which indicates 28.2% of recrystallization. Larger proportion of short chains as well as smaller average chain-length can very well explain relatively lower degree of retrogradation in turnip starch.

A DFT Study on CO2 Interaction with a BN Nano-Cage

  • Baei, Mohammad T.;Peyghan, Ali Ahmadi;Bagheri, Zargham
    • Bulletin of the Korean Chemical Society
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    • v.33 no.10
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    • pp.3338-3342
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    • 2012
  • Covalent functionalization of a $B_{12}N_{12}$ nano-cage with $CO_2$ molecule has been investigated using density functional theory in terms of energetic, geometric, and electronic property analyses. Results show that besides two physisorption configurations, $CO_2$ preferably tends to perform [2+2] addition on B-N bonds of the cluster which are shared between six-membered and four-membered rings, releasing energy of 14.99 kcal/mol for adsorption of the first $CO_2$ and of 15.45 kcal/mol for the second one (per each molecule). On the basis of calculated density of states, we have found that the electronic properties of the physisorbed $B_{12}N_{12}$ by $CO_2$ have not changed, while slight changes have been predicted in the functionalized cases. Present results might be helpful to provide an effective way to modify the $B_{12}N_{12}$ properties for further purifications and applications.

Notes on Some Tineids from Korea and Russian Far East, with Description of Four New Species (Lepidoptera: Tineidae) (한국과 극동러시아의 좀나방과 4 신종 기재 및 미기록종)

  • M. G. PONOMARENKO;K. T. Park
    • Korean journal of applied entomology
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    • v.35 no.4
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    • pp.273-279
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    • 1996
  • Based on the material in the Center for Insect Systematics, Chuncheon, Korea and Institute of Biology and Pedology, Vladivostok, Russia, 4 species of tineids are described as new to science: Morophaga parabucepkala sp. nov., Ceratutzcus orientatzus sp. nov., Gerontha ampliptera sp. nov., and G. namhaensis sp. nov. Furthermore 6 species are recognized new to Korea: , and 4 species new to Russian Far East:

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A Design of a Shader Processor based on a dual-phase pipeline architecture (듀얼 페이즈 명령어 파이프라인구조의 쉐이더 프로세서 설계)

  • Jeong, Hyung-Ki;Nam, Ki-Hun;Lee, Gwang-Yeob
    • Journal of IKEEE
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    • v.12 no.4
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    • pp.246-254
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    • 2008
  • This paper represents a design of a 4 way SIMD processor with multi-thread and dual phase instruction pipeline. 8 threads can be performing in round-robin order, so any hazards can’t occur. The dual phase pipeline makes a pipeline operate as two pipelines, and it can fetch maximum 4 unit instructions at once. This variable length instruction set divide into first phase and second phase instructions, and with this function, complex branch and addressing can be executed at one clock cycle. This processor reduces the code size to quarter, pull out the doubled performance improvement than normal SIMD architecture.

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