• IMMUNE NETWORK
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• v.24 no.1
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• pp.9.1-9.21
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• 2024

The cytokine IL-7 plays critical and nonredundant roles in T cell immunity so that the abundance and availability of IL-7 act as key regulatory mechanisms in T cell immunity. Importantly, IL-7 is not produced by T cells themselves but primarily by non-lymphoid lineage stromal cells and epithelial cells that are limited in their numbers. Thus, T cells depend on cell extrinsic IL-7, and the amount of in vivo IL-7 is considered a major factor in maximizing and maintaining the number of T cells in peripheral tissues. Moreover, IL-7 provides metabolic cues and promotes the survival of both naïve and memory T cells. Thus, IL-7 is also essential for the functional fitness of T cells. In this regard, there has been an extensive effort trying to increase the protein abundance of IL-7 in vivo, with the aim to augment T cell immunity and harness T cell functions in anti-tumor responses. Such approaches started under experimental animal models, but they recently culminated into clinical studies, with striking effects in re-establishing T cell immunity in immunocompromised patients, as well as boosting anti-tumor effects. Depending on the design, glycosylation, and the structure of recombinantly engineered IL-7 proteins and their mimetics, recombinant IL-7 molecules have shown dramatic differences in their stability, efficacy, cellular effects, and overall immune functions. The current review is aimed to summarize the past and present efforts in the field that led to clinical trials, and to highlight the therapeutical significance of IL-7 biology as a master regulator of T cell immunity.

• Design & Manufacturing
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• v.2 no.5
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• pp.16-20
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• 2008

Almost all injection molds have multi-cavity runner system for mass production, which are designed with geometrically balanced runner system in order to accomplish filling balance between cavity to cavity during processing; However, even though geometrically balanced runner is used, filling imbalances have been observed. In these day, the CAE has been used widely in injection molding. However, CAE with fusion mesh can't indicate such as jetting, flow mark and filling imbalance in multi cavity mold. In this study, we investigated the filling imbalance according to runner shapes by CAE analysis. As a result in CAE, in case of binary branch runner system, filling imbalance was indicated between cavity to cavity, but the flow pattern of each cavity uniformed in unary branch runner system.

• Proceedings of the KSME Conference
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• 2001.06d
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• pp.110-114
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• 2001

A numerical analysis has been perfonned to estimate the effect of turbulent penetration and thermal stratified flow in the branch lines piping. This phenomenon of thermal stratification are usually observed in the piping lines of the safety related systems and may be identified as the source of fatigue in the piping system due to the thermal stress loading which are associated with plant operating modes. The turbulent penetration length reaches to $1^{st}$ valve in safety injection piping from reactor coolant system (RCS) at normal operation for nuclear power plant when a coolant does not leak out through valve. At the time, therefore, the thermal stratification does not appear in the piping between RCS piping and $1^{st}$ valve of safety injection piping. When a coolant leak out through the $1^{st}$ valve by any damage, however, the thermal stratification can occur in the safety injection piping. At that time, the maximum temperature difference of fluid between top and bottom in the piping is estimated about $50^{\circ}C$.

• Journal of ILASS-Korea
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• v.1 no.3
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• pp.37-50
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• 1996

Computational fluid dynamics was used to optimize an A/C duct. Three dimensional flow analysis in an automotive A/C duct was performed computationally using various turbulence models and compared numerical predictions such as outlet flow split, surface pressure distribution along the duct to experimental data. Additionally, we studied the effect of location variation of 2nd branch on exit flow ratio and could find optimal location of 2nd branch. The design of an A/C duct was modeled and calculated to enhance the airflow distribution in each outlet using the STAR-CD computational fluid dynamics software. In results, modified $k-\varepsilon$ turbulence model allows a successful prediction of static pressure distribution particulary at around strong curvature but little improvement flow split. In the future, adoption of CFD to design an A/C duct with modified $k-\varepsilon$ model will bring benefits of producing more accurate prediction, and also give designers more detail information much more than now.

• International Journal of Aeronautical and Space Sciences
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• v.14 no.2
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• pp.193-199
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• 2013

This work investigates the orbital perturbations of the cubesats that lie on LEO due to Earth albedo. The motivation for this paper originated in the investigation of the orbital perturbations for closed- Earth pico-satellites due to the sunlight reflected by the Earth (the albedo). Having assumed that the Sun lies on the equator, the albedo irradiance is calculated using a numerical model in which irradiance depends on the geographical latitude, longitude and altitude of the satellite. However, in the present work the longitude dependency is disregarded. Albedo force and acceleration components are formulated using a detailed model in a geocentric equatorial system in which the Earth is an oblate spheroid. Lagrange planetary equations in its Gaussian form are used to analyze the orbital changes when $e{\neq}0$ and $i{\neq}0$. Based on the Earth's reflectivity data measured by NASA Total Ozone Mapping Spectrometer (TOMS project), the orbital perturbations are calculated for some cubesats. The outcome of the numerical test shows that the albedo force has a significant contribution on the orbital perturbations of the pico-satellite which can affect the satellite life time.

• Proceedings of KOSOMES biannual meeting
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• 2003.11a
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• pp.167-174
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• 2003

Oceanic conditions of the Tsushirm Wann Current (1WC) region in the southern area if the East Sea (the Japan Sea) are examined using data obtained from a CREAMS (Circulation Research if the East Asian Marginal Seas) cruise in June 1996. In 1990s, a lower temperature appears in $19\%$ and in this period, two branch of the TWC exist and the first branch of the TWC flows inshore if the Japanese coastal region compared to tfr1t in the other years, especially in the sfr1llower water layer at less th:1n about 2mm. The TWC cored with the higher salinity (>34.6 psu) is clearly observed over the continental shelf zone in the Japanese coastal region and offshore and identified by geostrophic calculation Intrusion if the TWC into the East Sea through the Korea Strait (the Tsushima Strait) makes the density structure in the water column change and the water mass in the TWC region is unstable based on Brunt- Vaisala frequency.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.673-676
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• 2016

Background: In the maxillofacial region, giant cell granulomas occur in 2 clinical forms, central and peripheral. Despite histopathological similarity between these 2 forms totally different clinical behaviors have been reported. The present study was undertaken to compare mast cell and vascular concentrations in these pathologic lesions. Materials and Methods: In this cross-sectional descriptive study, 20 pathological samples of central giant cell granuloma (CGCG) and 20 samples of peripheral giant cell granuloma (PGCG) were selected and examined through toluidine blue staining for mast cell assessment and immunohistochemical staining by VEGEF antibody for comparing the number of mast cells. T-test, chi-squared test and backward multivariate linear regression were used for statistical analysis using SPSS 20. Statistical significance was set at P<0.05. Results: This study showed significantly greater VEGF expression and mast cell concentrations in CGCG compared to PGCG cases. Also there was a significant correlation between VEGF expression and the concentration of mast cells. No relation was found between age, sex and site of the lesion and concentration of mast cells or VEGF expression. Conclusions: It is feasible that higher concentrations of mast cells in CGCG versus PGCG samples might lead to more aggressive clinical behavior via vascular proliferation and angiogenesis. However, other biologic mechanisms should be considered in this situation.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.2
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• pp.451-455
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• 2015

More than one million new patients suffer from breast cancer annually in the world. In developed countries, breast cancer is the most common malignancy diagnosed among women, and in developing regions, it often ranks second to cervical cancer. This study aimed to investigate the relationship between incidence of breast cancer and reproductive factors in North-West of Iran. This retrospective analytical control-case study was conducted with 235 breast cancer patients and 235 women in the control group. Data collection tools included a set of questions with interviews and patient medical records. Data were analyzed using statistical tests: t-test, Chi-square, Fisher, and Pearson correlation coefficient. Significantly increased risks were associated between breast cancer and older age at first pregnancy, age at menopause and history of contraceptive use. A trend for decreasing risk were observed with increasing parity. Findings of this study showed no association between breast cancer and age at menarche. The study results suggested that physiological and reproductive factors may play important roles in the development breast cancer among Iranian women.

• Smart Structures and Systems
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• v.18 no.4
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• pp.787-800
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• 2016

The aim of the paper is to analyze nonlinear transverse vibration of an embedded piezoelectric plate reinforced with single walled carbon nanotubes (SWCNTs). The system in rested in a Pasternak foundation. The micro-electro-mechanical model is employed to calculate mechanical and electrical properties of nanocomposite. Using nonlinear strain-displacement relations and considering charge equation for coupling between electrical and mechanical fields, the motion equations are derived based on energy method and Hamilton's principle. These equations can't be solved analytically due to their nonlinear terms. Hence, differential quadrature method (DQM) is employed to solve the governing differential equations for the case when all four ends are clamped supported and free electrical boundary condition. The influences of the elastic medium, volume fraction and orientation angle of the SWCNTs reinforcement and aspect ratio are shown on frequency of structure. The results indicate that with increasing volume fraction of SWCNTs, the frequency increases. This study might be useful for the design and smart control of nano/micro devices such as MEMS and NEMS.

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.1067-1068
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• 2008

The Operation of high speed train in year 2004 bring about a great change in railroad industry. Especially in railroad construction field we have acquired great Know-how. And up to now we are building up operation skills. But the high speed train system are totally imported, so it is necessary to investigate some of the equipment based on our own environment. In case of Toughened Glass Stem Insulator, we don't have any application case in domestic and limited in abroad. So there must be some characteristic estimation. The estimation was made in three different ways. First electrical field cause, Second physical field cause and finally in circumstance cause. In Electrical field cause, amplitude and number of time for abnormal peak voltage data are collected. And in physical field cause, amplitude and trend of vibration in to the insulator are examined. And I circumstance cause, possibility of flying gravel and ice clod are investigated. Through this basic data suitability for Toughened Glass Stem Insulator using in domestic will be accumulated.