• Bulletin of the Korean Chemical Society
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• v.31 no.4
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• pp.929-933
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• 2010

A new compound, 4-methoxyl 5-hydroxymethyl benzoic 3-O-$\beta$-D-glucopyranoside (1), has been isolated from the leaves and stems of Acer mandshuricum, along with nine known compounds (2-10). Their structures were determined by a variety of spectroscopic analyses. The effect of compounds 1-10 on the function of osteoblastic MC3T3-E1 cells was examined by determining alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization. Compound 1 significantly increased the function of osteoblastic MC3T3-E1 cells; $5.0\;{\mu}M$ of 1 increased ALP activity, collagen synthesis, and mineralization of MC3T3-E1 cells to 114.7, 119.5, and 108.2% (P < 0.05) of the basal value, respectively. In addition, compounds 2-10 also potently increased the function of osteoblastic MC3T3-E1 cells.

• Korean Journal of Weed Science
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• v.30 no.4
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• pp.396-404
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• 2010

Phenolic compounds, which are products of secondary metabolism, have been demonstrated to be widespread growth substances in plants. The objectives of this study were to identify the phenolic compounds in common ragweed (Ambrosia artemisiifolia var. elatior) by HPLC and to evaluate their effects on germination and seedling growth of three weed species. Under controlled conditions in Petri dishes at $25^{\circ}C$, $10^{-3}$ and $10^{-4}$ M solutions of phenolic compounds were evaluated in seed germination tests. Four phenolic compounds (caffeic acid, O-coumaric acid, ${\rho}$-coumaric acid and ferulic acid) in common ragweed plant were identified and their concentration was increased from the stage before flowering through full flowering stage. Treatment of O- and ${\rho}$-coumaric acids delayed the seed germination of Digitalia ciliaris, while the treatment of caffeic acid delayed the seed germination of Echinochloa crus-galli. In time to 50% germination ($T_{50}$), phenolic compounds at $10^{-4}$ M promoted in Cyperus microiria and E. crus-galli but the level of $10^{-3}$ M delayed the $T_{50}$ of those weeds. The O-coumaric acid inhibited seed germination and seedling growth of the tested weeds and especially it perfectly inhibited the root growth of E. crus-galli.

• Journal of Applied Biological Chemistry
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• v.65 no.3
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• pp.215-219
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• 2022

The flowers of Cosmos bipinnatus were extracted with solvent made with methanol:water (4:1) and the concentrates were partitioned into ethyl acetate (EtOAc), n-butanol (n-BuOH), and water (H₂O) fractions. The octadecyl silica gel (ODS) and silica gel (SiO₂) column chromatographies were repeated for the EtOAc fraction to isolated of two phenolic compounds. The chemical structure of the isolated compounds were identified as benzyl O-β-ᴅ-glucopyranoside (1), and 2-phenylethyl O-β-ᴅ-glucopyranoside (2) through spectroscopic datas such as nuclear magnetic resornance, infrarad spectroscopy, and mass spectroscopy. These two compounds were first isolated from C. bipinnatus flowers through this study. To evaluate the anti-atopic activity of the two isolated compounds using a HaCaT cell line induced by ultraviolet light, several experiments were conducted and neither both compounds showed toxicity in the concentration range of 1 to 1,000 ㎍/mL. In the results of anti-atopic activity through Thymus and activation regualted chemokine (TARC) assay, both compounds showed dose-dependent TARC inhibitory activity. In particular, compound 1 showed significant activity even in a low concentration range of 10 ㎍/mL, and in different concentration ranges. Also compound 1 showed higher inhibitory activity than other compound, confirming that the anti-atopic activity was the most excellent. Based on these results, it is considered that it can be used as a functional cosmetic material.

• Biomolecules & Therapeutics
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• v.11 no.1
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• pp.1-4
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• 2003

Plants are known as important source in the search for new drugs. The twelve compounds from Viscum album (Loranthaceae), lupeol (1), betulonic acid (2), betulinic acid (3), terminic acid (4), ursolic acid (5), $\beta$-sitosterol (6), $\alpha$-spinasterol (7), oleanolic acid (8), 5-hydroxy-1-(4′-hydoxyphenyl)-7-(4"-hydroxyphenyl)-hepta-1-en-3-on (9), 2′-hydroxy-4′,6′-dimethoxychalcone-4-O-glucoside (10), 2′-hydroxy-4′,6′-dimethoxychalcone-4-O-[apiosyl(l$\longrightarrow$2)]glucoside (11) and syringin (12) were evaluated for their immunomodulatory properties. Compounds 6 and 11 induced the macrophage tumoricidal activity and the lymphocyte blastogenesis. In addition, these compounds stimulated the macrophages to induce the production of TNF-$\alpha$ and NO. These findings suggest that compounds 6 and 11 are modulating various elements of the host immune response.

• Bulletin of the Korean Chemical Society
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• v.34 no.1
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• pp.225-230
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• 2013

A new heteropolyanion-based ionic ($[Hmim]_5PMo_{10}V_2O_{40}$) was synthesized by the reaction of molybdovanadophosphoric acid ($H_5PMo_{10}O_{40}$) with N-methylimidazole. [$[Hmim]_5PMo_{10}V_2O_{40}$ showed a high catalytic activity in the oxidative desulfurization of sulfur-containing compounds in 1-methylimidazolium tetrafluoroborate ($[Hmim]BF_4$) ionic liquid using 30% aqueous $H_2O_2$ as the oxidant. The catalytic system was of high activity, simplified workup and flexible recyclability. The catalytic oxidation reactivity of sulfur-containing compounds decreased in the order dibenzothiophene (DBT) > 4,6-dimethyldibenzothiophene (4,6-DMDBT) > benzothiophene (BT). The influences of various parameters including reaction time (t) and temperature (T), catalyst dosage, and oxidant to sulfur molar ratio n(O)/n(S) on the desulfurization of model oil were investigated in details. 99.1% of DBT conversion in the model oil was achieved at atmospheric pressure under the optimal conditions: n(O)/n(S) = 4:1, $60^{\circ}C$, 100 min and molar ratio of catalyst to sulfur of 0.062. The ionic liquid can be recycled six times without significant decrease in activity.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.2
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• pp.441-445
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• 2005

Tripterygium regelii has been used as an oriental medicine, especially antiparasitic, anti-inflammatory and detoxifying agents in East asia. During our research to develop new antitumor agents from natural products, MeOH ext. and CH2Cl2 ext. of Tripterygium regelii showed the potent antitumor activity. In order to purify active compounds from Tripterygium regelii, activity-guided fractionation was carried out. Silica gel and RP-18 column chromatography for the active fraction led to the isolation of two compounds and their antitumor activities were studied. Those two compounds didn't show potent antitumor activity against human tumor cell lines. The structure of two compounds were determined by $^1H-NMR$, $^{13}C-NMR$, DEPT, $^1H-^{13}C$ COSY and IR spectrum. Compound I and Compound II were turned out to be Celastrol, and ${\beta}-sitosteryl-3-o-{\beta}-D-glucopyranoside$ respectively.

• Journal of Environmental Science International
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• v.14 no.1
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• pp.81-89
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• 2005

As a typical example of simultaneous analysis of the odorous compounds, the volatile organic compounds from inventory sources in Seongseo industrial area were concentrated and analyzed with thermal desorber/GC/MSD, and major malodorous compounds were estimated. Odor intensity and odor concentration was analyzed simultaneously During a period from November in 2002 to December in 2003, this study was conducted to evaluate malodor emission characterization in major treatment facilities. The major components were Dimethyl sulfide, Dimethyl disulfide, Methyl mercaptane, Ammonia, Benzene, Toluene, m,p-xylene, o-xylene, Styrene, 1,2,4­T.M.B and 1,3,5-T.M.B. Among the six major inventory sources, the odor unit concentration of Night-soil disposal facilities was the highest, $669\~2344\;ou/m^{3}.$

• Journal of Korean Society of Water and Wastewater
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• v.21 no.3
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• pp.341-348
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• 2007

The efficiency of powdered activated carbon (PAC) for removing taste and odor (T&O) in drinking water supplies is dependent on the contact time, quality of mixing, and the presence of competing compounds. All of these are strongly influenced by the stage in the treatment process at which the PAC is added. In conventional water treatment plants (WTPs), PAC is commonly added into the rapid mixing basin where chemicals such as coagulants, alkaline chemicals, and chlorine, are simultaneously applied. In order to prevent interference between PAC and other water treatment chemicals, alternative locations for addition of PAC, such as at transmission pipe in the water intake tower or into a separated PAC contactor, were investigated. Whatever the location, addition of PAC apart from other water treatment chemicals was more effective for geosmin removal than simultaneous addition. Among several combinations, the sequence 'chlorine-PAC-coagulant' produced the best result with respect to geosmin removal efficiency. Consequently, when PAC has to be applied to cope with T&O problems in conventional WTPs, it is very important to prevent interference with other water treatment chemicals, such as chlorine and coagulant. Adequate contact time should also be given for adsorption of the T&O compounds onto the PAC. To satisfy these conditions, installation of a separated PAC contactor would be the superior alternative if there is space available in the WTP. If necessary, PAC could be added at transmission pipe in the water intake tower and still provide some benefit for T&O treatment.

• Journal of the Korean Society for Heat Treatment
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• v.25 no.4
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• pp.190-195
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• 2012

This study aims to investigate and compare the microstructures and room temperature tensile properties for AZ91 and ECO-AZ91 (AZ91+0.3%CaO) alloys in as-cast, T4 and T6 states, respectively. In as-cast state, the ECO-AZ91 alloy has finer microstructure than the AZ91 alloy. The AZ91 alloy exhibits greater ductility, while YS and UTS are inferior to those of the ECO-AZ91 alloy. After T4 treatment, most of ${\beta}$ compounds disappear in the AZ91 alloy, whereas ${\beta}$ phase is still observed in the ECO-AZ91 alloy due to its enhanced thermal stability, resulting in lower values of ductility and UTS. In T6 state, YS and UTS are better in the ECO-AZ91 alloy.

• Korean Journal of Pharmacognosy
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• v.42 no.4
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• pp.302-308
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• 2011

As a part of our ongoing program on finding biologically active components from natural source we found three known constituents from the EtOH extract of the wheat bran. The known compounds were identified as tachioside (1), pinellic acid (2) and tryptophan (3). The structure and relative stereochemistry were determined from MS, 1D and extensive 2D NMR techniques as well as by comparison of their data with the published values. All isolates were tested their inhibitory effects on the adipogenesis in 3T3-L1 cells. The effect of compounds from wheat bran on 3T3-L1 adipocyte differentiation were measured by Oil Red O staining. These results demonstrate that tachioside (1) and pinellic acid (2) decreased lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis. These compounds had shown antiobesity activities.