• Physical Therapy Rehabilitation Science
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• 제5권2호
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• pp.106-112
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• 2016

Objective: This study was conducted to investigate the effects of resistant exercise on the gait performance of a patient with systemic lupus erythematosus (SLE) patient. Design: A case study. Methods: A 30-year-old male adult who had been diagnosed with systemic lupus erythmatosus (SLE) in April 2013, right middle cerebral artery infarction, and with left hemiplegia agreed to participate in this case study. Patient was unable to walk due to being affected with adynamia. Due to developing necrotizing vasculitis on the left lower extremity, patient underwent a myotomy on the left thigh. The patient was trained with a progressive resistant exercise program for 8 weeks. An intensity of 15 RM was used for the resistant exercises and the resistance level was increased progressively in order to improve the muscle power of the patient. Methods used to increase resistance included changing positions, providing mechanical resistance instead of manual resistance, transitioning from open kinetic chain to closed kinetic chain exercises, and changing the colors of the theraband to those with increase level of resistance. Outcome measures included the 5-repetition sit-to- stand test (5RSST), Timed Up & Go (TUG), and 10-meter walk test (10MWT). In addition, the GAITRite was used to assess the spatio-temporal gait variables, including gait speed, cadence, stride length of the left side, and double limb support pre and post-intervention. Results: The patient was able to perform sit-to- stand after two weeks of performing the resistant exercises. The patient was able to walk after 4 weeks, and the patient's overall gait performance had improved after 8 weeks. All of the variables had improved after each week. Conclusions: The results of this case study may be used to enhance future efforts to objectively evaluate resistant exercises during gait performance in persons affected by SLE.

• Tuberculosis and Respiratory Diseases
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• 제62권1호
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• pp.67-70
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• 2007

흉선암종은 드문 종격동의 악성 종양으로서 흉선상피세포에서 기원하지만 흉선종과는 조직학적 특징이 다르다. 흉선종이 자가면역질환을 종종 동반하는데 반해 흉선암종에서 자가면역질환이 동반되는 예는 드물다. 국내에서는 흉선암종과 자가면역질환이 동반된 예가 보고된 적이 없는데 저자들은 전신 근육통을 주소로 내원한 49세 남자 환자가 전신홍반루프스와 흉선암종을 동시에 진단받고 항암치료를 시작한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• 대한한의학회지
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• 제29권1호
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• pp.67-84
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• 2008

Objective : The main purpose of this study was to evaluate the effect of Jasinwhalhyul-tang (Zishenhuoxue-tang, JWT) on MRL/MpJ-Ipr/Ipr mouse model with systemic lupus erythematosus. Methods: The effect of JWT on MRL/MpJ-Ipr/Ipr mice that have autoimmune disease similar to SLE in humans was evaluated after JWT per oral in the present study. Mice were administered with Jasinwhalhyul-tang (Zishenhuoxue-tang, JWT) (80 or 400mg/kg) or distilled water for control group from experimental week 10 for 22 weeks. Results : The amount of erythematosus skin lesion and proteinuria were significantly decreased. The size and weight of cervical lymph nodes and spleen were significantly reduced. The ratio between activated $CD3^+CD69^+$ T-cells and undifferentiated $CD3^+CD4^-CD8^-$ T-cells in lymph nodes, spleen and kidney was effectively reduced. The gene expression of TGF-$\beta$ in spleen and kidney was increased. The amount of anti-dsDNA IgG in blood was decreased. The gene expression of TGF-$\beta$ in normal mouse spleen cells was increased depending on concentration by treatment of with T cell stimulating agent. In the histological examination of skin and kidney, the amount of infiltration of immune cells involved in the inflammatory response was decreased. Conclusions : According to the above results, JWT should be considered as an applicable therapeutic agent to SLE in clinical practice. Further research is required to investigate other efficacies of JWT on SLE.

• Natural Product Sciences
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• 제16권4호
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• pp.271-279
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• 2010

Systemic lupus erythematosus (SLE) is characterized by systemic inflammation through production of inflammatory mediators and signaling abnormalities between T- and B- cells, leading to autoantibody production and multiorgan injuries. This study was investigated whether bamboo culm extract (BC) attenuates development of lupus systemic inflammation in the early stage in pristane-induced lupus mice. The pristane-induced lupus mice were administrated with BC 0.5 ml/kg or PBS and healthy mice with PBS orally once a day for 14 days. Our results showed that BC remarkably attenuated levels of serum TNF-$\alpha$, IL-6, IL-10, IFN-$\gamma$, $PGE_2$, and VEGF, production of macrophages IL-6 and $PGE_2$ and expression of macrophages IL-6 and COX-2 mRNA in the presence or absence of LPS in pristane-induced lupus mice. Also, BC remarkably reduced expression of CD40L on the splenic T cells and CD80 on the splenic B cells and upregulated the reduced apoptosis of splenic T cells and CD4+ T cells in pristane-induced lupus mice. Therefore, these findings suggest that BC may attenuate early development of lupus systemic inflammation via downregulation of inflammatory mediators and amelioration of abnormal signaling between T cells and B cells.

• 대한핵의학회지
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• 제37권5호
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• pp.325-330
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• 2003

Purpose: We describe a 54-year-old woman with systemic lupus erythematosus (SLE) who suddenly presented with chorea and had positive antiphospholipid antibodies. F-18 FDG PET showed abnormally increased glucose metabolism in bilateral putamen and primary motor cotex. Tc-99m ECD SPECT also showed abnormally increased regional cerebral blood flow in bilateral putamen. She was treated with corticosteroid and aspirin after which the symptoms improved. Four months later, follow up F-18 FDG PET showed improvement with resolution of hypermetabolism in bilateral putamen. This case suggests that striatal hypermetabolism is associated with chorea in SLE.

• Journal of Yeungnam Medical Science
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• 제34권2호
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• pp.260-264
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• 2017

Klinefelter's syndrome is the most common congenital abnormality that causes primary hypogonadism. It is associated with diseases that predominantly affect women, such as systemic lupus erythematosus (SLE), and it can sometimes cause veno-occlusive disease. We experienced a case of Budd-Chiari syndrome (BCS) in a 33-year-old man with Klinefelter's syndrome presented with hematemesis and edema in both lower extremities. The clinical and laboratory findings were compatible with SLE, antiphospholipid syndrome, and BCS. To the best of our knowledge, this is the first case report to describe a simultaneous presentation of these four clinical syndromes in a single patient.

• Journal of Genetic Medicine
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• 제15권2호
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• pp.92-96
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• 2018

Chronic mucocutaneous candidiasis (CMC) is characterized by increased susceptibility to chronic and recurrent infections of the skin, mucous membranes, and nails by Candida species. It is a primary immunodeficiency disorder that is difficult to diagnose because of its heterogeneous clinical manifestations and genetic background. A 20-month-old boy who did not grow in height for 3 months was diagnosed as having hypothyroidism and he had hepatitis which was found at 5 years old. He presented with persistent oral thrush and vesicles on the body, the cause of which could not be identified from laboratory findings. No microorganism was detected in the throat culture; however, the oral thrush persisted. Immunological tests showed that immunoglobulin (Ig) subclass IgG and cluster of differentiation (CD)3, CD4, and CD8 levels were within normal limits. We prescribed oral levothyroxine and fluconazole mouth rinse. The patient was examined using diagnostic exome sequencing at the age of 6 years, and a c.1162A>G (p.K388E) STAT1 gene mutation was identified. A diagnosis of CMC based on the STAT1 gene mutation was, thus, made. At the age of 8 years, the boy developed a malar-like rash on his face. We conducted tests for detection of antinuclear antibodies and anti-dsDNA antibodies, which showed positive results; therefore, systemic lupus erythematosus (SLE) was also suspected. Whole exome sequencing is important to diagnose rare diseases in children. A STAT1 gene mutation should be suspected in patients with chronic fungal infections with a thyroid disease and/or SLE.

• 대한영상의학회지
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• 제82권5호
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• pp.1281-1286
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• 2021

척추기저동맥의 혈류공급감소로 인한 뇌간 경색은 매우 드문 전신성 루푸스 환자의 초기 증상으로, 경색의 직접적인 원인으로 매우 작은 기저동맥 분지인 교뇌공급혈관의 박리성 동맥류는 보고된 사례가 없다. 이에 저자들은 디지털감산 혈관조영술과 고해상도 혈관벽 자기공명영상를 이용하여 작은 교뇌공급혈관의 박리성 동맥류의 진단과 추적관찰 중 치유된 20세 여성의 사례를 보고하고자 한다. 전신성 루푸스의 진단은 신경학적장애의 유무와 혈액화학검사 결과를 바탕으로 하였다. 추적 고해상도 혈관벽 자기공명영상에서 환자의 교뇌천공지의 박리성동맥류는 폐색되어 있었고 우측 척추동맥의 박리성동맥류는 치유되어 보이지 않았다. 환자는 퇴원 시 수정랭킨척도 점수가 1점으로 증상 개선을 보였으며 3개월과 12개월 추적관찰에서도 증상이 악화되지 않고 1점을 유지하였다.

• Journal of Yeungnam Medical Science
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• 제4권2호
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• pp.185-191
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• 1987

저자들은 임상소견, 혈액학적 소견, 면역학적 소견 및 신생검을 통해 낭창성 신염으로 진단된 2례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 대한한의학방제학회지
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• 제13권1호
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• pp.215-222
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• 2005

About the case of the patient who has diagnosed Systemic Lupus Erythematosus and admissed to our hospital from 27. January. 2005 to 28. February 2005, we could controll by herb medications userd differently patients-to-patients. SLE does not exactly correspond to any specific category of oriental medicine. But, according to previous reports, it can be controlled by oriental differential diagnosis of symptoms and signs. Because we diagnosed and treated her as at the point of Oriental Medicine and got the improvement, so we report. We think that the patient must get the screen test exactly and treat the disease proper ly, and if we apply this result to clinical cases at the point of Oriental Medical base from gathering and researching more cases, it will arouse sympathy-the excellence of Oriental Medicine and make the necessity of the further research and report from now on.