• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3021-3027
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• 2014

Background: The multidrug resistance 1 gene (MDR1) C3435T polymorphism has been demonstrated to influence the P-glycoprotein (P-gp) activity level which is related to inflammation and carcinogenesis. This meta-analysis was performed to estimate the association between the MDR1 C3435T polymorphism and the risk of gastric cancer (GC) and peptic ulcer (PU). Materials and Methods: A literature search was conducted with PubMed, Embase and the Cochrane library up to November 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Data were analyzed using Review Manager (Version 5.2), and Stata package (version 12.0) for estimation of publication bias. Results: Six case-control studies were included, of which five were for GC and two for PU. Overall, no evidence was found for any association between the MDR1 C3435T polymorphism and the susceptibility to GC and PU. In the stratified analysis by H. pylori infection status, stage and histology classification of GC, and PU type, there was still no significant association between them. Conclusions: This meta-analysis suggested that the MDR1 C3435T polymorphism is not associated with susceptibility to GC and PU. Large and well-designed studies are warranted to validate our findings.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제47권4호
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• pp.291-314
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• 2021

Squamous cell carcinoma (SCC) of the retromolar trigone (RMT) is a rare but potentially fatal disease that carries a poor prognosis due to its unique anatomic position. RMT SCCs tend to spread to vital nearby structures, including the tonsillar pillar, masticatory muscles, and underlying mandibular bone, even in their early stages, and aggressive treatment is often warranted. This systematic review appraises and qualitatively analyzes all available literature regarding the survival outcomes and prognosis of RMT SCC. Four databases were searched to identify all eligible articles published since January 1980. Of the 1,248 studies, a total of 15 studies representing 4,838 cases met the inclusion criteria. The evaluated patients had a high rate of advanced tumor stage (T3 or T4: 61.4%), lymph node metastasis (38.8%), and mandibular bone invasion (24%) at the time of diagnosis. Aggressive surgical treatments such as lip-splitting (92%), segmental mandibulectomy (61.1%), radical neck dissection (44.1%), and reconstruction using free flaps (49.5%) was undertaken for 92% of the pooled patient population. The mean rates for local, regional, and systemic recurrence were 23.40%, 8.40%, and 8.50%, respectively. The mean 5-year overall survival rate was 38.90%. Osteonecrosis was noted in 11.6% of the 328 patients who received radiotherapy. In conclusion, RMT SCC is generally associated with high recurrence, low survival, and high postoperative complication rates. Early diagnosis and aggressive treatment are thus warranted. However, significant methodological problems hamper current knowledge. Future studies of this topic that use randomized or cohort designs are thus needed.

• 한국산학기술학회논문지
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• 제21권2호
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• pp.85-93
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• 2020

현대 의학의 눈부신 발전에도 불구하고 감염병의 유행 발생과 전파는 지속적으로 인류를 위협하고 있으며, 이러한 감염병의 사람 간 전파는 사회적 접촉에 의한다. 그러나 사회적 접촉에 관한 국내 연구는 초기 단계다. 본 연구에서는 체계적 문헌 고찰을 통해서 각국의 사회적 접촉의 실태를 파악하여 국내 연구를 위한 기초자료를 제공하고자 한다. 문헌 선정기준은 2000년 이후부터 2017년 12월까지 영어로 발표된 전국적인 규모의 사회적 접촉 논문 12편을 최종선정하였다. 후향적 접촉일지(7건, 58.3%), 무작위 추출법(9건, 75%)을 연구방법으로 가장 많이 이용하고 있었으며, 접촉자 수는 4.9명-17.7명/일, 주중에 주말보다 더 많았으며, 매일 만나는 관계에 있는 사람과 주로 접촉하였고, 신체적 접촉은 가정 내에서 빈번하였다. 접촉 빈도가 가장 높은 연령은 5-19세로 감염병 유행 발생 시에는 이 연령층에 의한 감염전파가 우려된다고 볼 수 있다. 특히 동질성혼합(assortative mixing)은 5-20세 군에서 높아 이 연령층은 동일한 연령대와의 접촉으로 인한 감염전파 가능성이 큼을 시사하므로 이 연령층에 대한 감염 예방대책이 필요함을 보여주고 있었다. 그러므로 국내에서도 새로운 감염병 또는 재유행 감염병의 발생이나 관리의 정확한 예측을 위해서 국내 기반의 사회적 접촉양상을 파악하여, 이를 기초로 국내 감염병 유행 발생의 예측과 감염 예방대책 수립이 이루어져야 할 것이다.

• 대한감각통합치료학회지
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• 제8권1호
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• pp.61-72
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• 2010

목적 : 체계적 고찰을 통해 시운동기술 평가를 위해 사용된 도구, 치료접근방법, 치료의 효과를 알아보고, 아동의 시운동 기술에 가장 적합한 치료방법과 평가도구를 제시하고자 한다. 연구 방법 : 체계적 고찰을 사용하였다. 2001년 1월부터 2010년 6월까지 학회지에 게재된 논문을 PubMed을 통하여 검색하였다. 주요 검색용어는"visual motor and occupational therapy", "visuomotor and occupational therapy"," perception and motor and occupational therapy"이었고, 161개의 논문 중 총 13개 논문을 대상으로 분석하였다. 결과 : 1. 시운동기술 치료가 필요한 대상 진단군은 발달장애아동이 20.00%로 가장 많았고, 글씨쓰기에 문제가 있는 아동이 13.33%이었다. 결과 : 2. 시운동기술을 측정하기 위해 사용된 평가도구는 Developmental Test of Visual Perception(DTVP)을 사용한 논문이 33.33%로 가장 많았고, Developmental Test of Visual Motor Integration(VMI)을 사용한 논문이 26.67%이었다. 결과 : 3. 시운동기술과 관련하여 가장 많이 사용된 치료접근방법은 발달적 기술기반 프로그램으로 58.82%를 차지 하였고, 감각통합과 감각기반 치료는 23.53%를 보였다. 결과 : 4. 시운동기술과 관련하여 작업치료 효과가 유의하게 나타난 경우는 72.73%이었고, 유의하지 않는 경우가 9.09%이었다. 부모 직접적 또는 간접적 접근과 집중행동 치료에서 효과가 유의하게 나타났다. 결론 : 아동 작업치료에서 시운동기술을 평가하기 위해 사용된 도구는 DTVP와 VMI가 60%를 차지하였고, 70%이 상에서 치료에 대한 효과가 있는 것으로 나타났다. 아동의 작업수행과 관련된 영역에 대한 작업치료의 효과를 분석하는 연구가 지속되어야 할 것으로 보인다.

• 기술혁신연구
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• 제30권1호
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• pp.57-104
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• 2022

정부는 시장실패 방지, 정보의 비대칭성 완화, 자원의 효율적 배분 등 다양한 목적을 가지고 시장에 개입하여 민간기업의 기술혁신을 지원해 왔다. 2000년대 들어 국가 연구개발 예산이 급격히 증가하면서 기업에게 지원되는 정부재원도 비례하여 증가해왔으나 정부의 재정지원이 효과적이고 바람직한 정책목표를 달성했는지에 대해서는 분명하지 않다. 본 연구는 이러한 문제인식 하에 국내·외 관련 논문과 정책연구 보고서, 리뷰 페이퍼 등을 종합적·체계적으로 분석하여 다양한 정부 재정지원에 대한 문제점을 살펴보고자 하였다. 국·내외 총 168편의 연구를 체계적 문헌분석과 컨텐츠 분석을 활용하여 정책 부가성, 지원방식, 기업규모, 분석단위(unit of analysis), 분석대상, 연구방법론과 데이터 등 다양한 관점에서 입체적으로 분석하였다. 문헌 간 교차 비교를 통해 다수의 중복 수혜, 재정지원과 정책효과 간의 구조적 시차, 재정지원 효과의 비선형성, 정책간의 간섭과 교호작용, 폐쇄형 혁신과 제조업에 최적화된 조세제도 등이 현재 정부 재정지원의 문제점으로 분석되었으며, 이를 해결하기 위한 정책개선 방향으로 행동 부가성을 고려한 재정지원사업 성과지표 개발, 정부부처 간 정책협력과 조율 강화, 다양한 상황을 고려할 수 있는 정책혼합(policy mix) 도입, 디지털 혁신·서비스 연구개발 등 새로운 형태의 기술혁신에 맞는 기업 재정지원 방식, 데이터에 기반 한 증거기반 정책강화 등을 제시하였다.

• 동의신경정신과학회지
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• 제34권2호
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• pp.95-113
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• 2023

Objectives: To review studies evaluating effects of acupuncture on pain and depressive symptoms in fibromyalgia. Methods: Quantitative evidences (RCTs) were systematically reviewed. Literature were searched for a combination of fibromyalgia and depression (The Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, medline (via PubMed), Kmbase, KISS, ScienceON, OASIS, CiNii, CNKI). Quantitative research findings were critically appraised by Cochrane risk of bias (RoB) tool and pooled. Meta-analysis was then conducted using Review Manager (RevMan) 5.4. Results: Eighteen studies were selected. American College of Rheumatology (ACR) classification criteria for Fibromyalgia Syndrome was most frequently used as diagnostic criteria for fibromyalgia. As for outcome measurement, Hamilton Rating Scale for Depression (HAMD), Visual Analog Scale (VAS), and Total Effective Rate (TER) were used most commonly. Meta-analysis of ten studies revealed that both Depression and VAS scores of the Acupuncture+Western Medicine group were significantly lower than those of Western Medicine group (Depression: SMD, -0.94, 95% CI, -1.17 to -0.70; VAS: MD, -1.51, 95% CI, -1.83 to -1.19). Also, TERs of both Acupuncture group and Acupuncture+Western Acupuncture+Western Medicine group were significantly higher than those of the Western Medicine group (OR: 2.38, 95% CI: 1.29 to 4.41; and OR: 7.40, 95% CI: 3.41 to 16.07). There was no significant difference in Depression or VAS score between the Acupuncture Group and the Western Medicine Group. Conclusions: Acupuncture might be an effective option for pain and depressive symptoms of fibromyalgia when it is combined with Western Medicine treatment. For more accurate results, more types of Korean medicine treatment should be conducted.

• 생물정신의학
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• 제14권1호
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• pp.5-13
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• 2007

Objectives : Depression disturbs the individual life from the loss of productivity to suicide. Furthermore the whole society is also influenced by depression in social and economic areas. Many scientific treatment methods are known to be effective in depression. But in reality more than half of patients with depression prefer self help treatment rather than medically based treatment. For the patients with mild depression and primary physicians, it is reasonable to provide the evidence based self care including self help or alternative treatment. This study is supported by the Korean Health 21 R&D Project for the Depression Center to establish the Korean treatment guideline for depression. Methods : The members of Depression Center including the authors attended the workshops where the methods of evidence based medicine such as literature search, quality evaluation of the articles, making the level of evidence were educated. The professional librarians helped the authors for get the searched articles. Among the total of 354 abstracts of systemic review and 300 abstracts of random controlled trials, 3 systemic reviews and 2 random controlled trials were the main structure of evaluation. Result : Among the 37 self care methods known to be effective for depression, 11 kinds of methods were worth of evaluation. The first step for the self care of mild depression is to use St. John's wort, exercise, bibliotherapy, and light therapy in depression during winter season. Acupuncture, negative ion therapy, massage, relaxation technique are known to be efective with evidence. Music therapy, hypnotherapy, and aromatherapy are known to be effective but until now the evidences is insufficient and further evaluations are needed. Conclusion : Among 11 listed self-care methods, several methods need more evidence especially in Korean situation. Exercise is the most recommendable evidence based self care method in Korea nowadays. St. John's wort is effective with evidence, but it is not the OTC drug in Korea, so it is not recommendable now. For the bibliotherapy, there is no book such as "Feeling Good" in Korea. Only the introductory book about depression is available. Publishing the self help book based upon cognitive behavioral approach or psychodynamic approach is needed. Light therapy is practiced in a few clinics, but not self-help style. Exposure to the sunlight is recommended in the level of commen sense. These self care methods are for the mild patient. Moderate to severe patients with depression should seek the professional treatment.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제30권1호
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• pp.65-68
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• 2004

CyberKnife is a stereotactic radiosurgery system which could be used to treat many tumors and lesions. It provides the surgeon unparalleled flexibility in targeting using a compact light linear accelerator mounted on a robotic arm. Advanced image guidance technology tracks patient and target position during treatment, ensuring accuracy without the use of an invasive head frame. CyberKnife with Dynamic Tracking Software is cleared to provide radiosurgery for lesions anywhere in the body when radiation treatment is indicated. It has often been used to radiosurgically treat otherwise untreatable tumors and malformations. Moreover, this instrument treats tumors at body sites, most of which are unreachable by other stereotactic systems. Compared with conventional radiotherapy, it is fundamentally different that using non-invasive, frameless, no excessive radiation exposure to normal tissue. In oral malignant neoplasm, surgical excision and radiation therapy should be tried first, additionally chemotherapy could be considered. However, after failure of conventional therapies, patients had poor systemic condition and surgical limitation. So, CyberKnife could be a suitable therapy. A 49 years man was referred in recurred mandibular cancer treated by radiotherapy. The tumor was considered inoperable, because of extensive invasion and was not expected to good response to conventional therapies. We experienced a case of CyberKnife after 4 cycle chemotherapies, so we report it with review of literature.

• Tuberculosis and Respiratory Diseases
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• 제44권4호
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• pp.922-929
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• 1997

저자들은 호흡곤란으로 내원한 환자에서, 외이, 코, 기관과 기관지를 침범한 재발성 다발성 연골염 1예를 경험하였기에 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제44권4호
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• pp.935-941
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• 1997

저자들은 흉통을 주소로 내원한 53세 남자 환자에서 특발성 종격동 섬유증 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.