• 한국콘텐츠학회논문지
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• 제21권8호
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• pp.662-674
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• 2021

대사증후군은 심혈관질환과 밀접한 연관성을 가지며, 최근 대사증후군의 예측을 통한 예방에 관심이 증가하고 있다. 본 연구의 목적은 최근 한국인을 대상으로 한 대사증후군의 발병을 예측하는 논문을 수집, 분석, 종합하여 체계적 문헌고찰을 위한 것이다. 체계적 문헌고찰을 위해 자료검색은 Pubmed, WOS의 해외DB와 DBPia, KISS의 국내DB에서 검색하였으며, 'Metabolic Syndrome', 'predict', 'Korea' 세개의 키워드를 AND 조건으로 2011~2020년에 게재된 논문을 대상으로 검색하였다. 총 560편의 논문이 검색되었고 자료선정기준에 따라 최종 22편의 논문이 선별되었다. 대사증후군 예측에 가장 활용도가 높은 변수는 WHtR(AUC=0.897)이고, 가장 많이 사용된 분석방법은 로지스틱 회귀분석(63.6%), 가장 높은 정확도를 보이는 분석방법은 XGBOOST(AUC=0.879)였다. 또한 한의학적 체질 분류를 적용하는 경우 예측 정확도가 약간 향상되었다. 본 연구 결과를 토대로 한국인의 최적의 대사증후군 예측과 관리를 위한 대규모의 지속적 연구가 수반되어야 할 것으로 생각된다.

• 대한한방내과학회지
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• 제43권1호
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• pp.22-40
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• 2022

Objectives: The purpose of this study is to assess the antidiabetic effect and safety of Galgunhwangryunhwanggum-tang for type 2 diabetes without complications by analyzing related research. Methods: For a systematic review and meta-analysis, we searched for the antidiabetic effect and safety of Galgunhwangryunhwanggum-tang for type 2 diabetes without complications in 10 databases up to September 2021. Only randomized controlled trials were chosen. Results: In the treatment effectiveness analysis and meta-analysis, Galgunhwangryunhwanggum-tang had significant improvement effects on fasting plasma glucose level, 2-hour postprandial glucose level, glycated hemoglobin, fasting insulin, and homeostasis model assessment for insulin resistance compared to the control group when treated in parallel with oral glycemic drugs. Conclusion: Galgunhwangryunhwanggum-tang is effective in improving blood sugar and insulin resistance in type 2 diabetes patients without complications and can especially be considered in parallel treatment with oral hypoglycemic drugs. A large-scale randomized controlled clinical trial is required to complement the limitations presented in this study in the future.

• 대한본초학회지
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• 제28권1호
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• pp.65-71
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• 2013

Objectives : Asthma is a chronic, complex respiratory disease, caused by airway obstruction, airway eosinophilic inflammation(AEI), and airway hyperresponsiveness(AHR). This study was conducted to determine whether oral administration of crude water extracts of Pinellia ternate Breitenbach(PTB) has an antiasthmatic potential in the treatment of asthma in mice. Methods : Asthmatic AEI and AHR were induced by systemic sensitization to ovalbumin(OVA) by intratracheal instillation with 0.1 mg/mL suspension of diesel exhaust particles(DEP) once a week for 10 weeks in BALB/c mice. Crude PTB water extracts(50 mg/kg and 200 mg/kg) were orally administered 5 times a week for 10 weeks. Cyclosporin(10 mg/kg) was administrered the same manner as a positive control. Results : Long-term treatment with crude PTB water extracts suppressed the infiltration of inflammatory cells, including eosinophils, into airways from blood. It also reduced asthmatic AEI and AHR by attenuating the increase in the levels of cytokines such as interleukin(IL)-4, IL-5 and IL-13 in bronchoalveolar lavage fluid(BALF), as well as the levels of histamine and OVA-specific IgE in blood. However, the effect of crude PTB water extracts(200 mg/kg) was not likely to be stronger than that of cyclosporin(10 mg/kg). Conclusion : These results suggest that crude PTB water extracts have inhibitory effects on AEI and AHR in a mouse model of asthma and may act as a potential Th2 cytokine antagonist, and have a therapeutic effect on allergic asthma.

• 한국임상약학회지
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• 제32권1호
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• pp.37-46
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• 2022

Background: Non-valvular atrial fibrillation (NVAF) is associated with ischemic stroke risk in the aging population. Observational studies have indicated beneficial effects of direct-acting oral anticoagulant (DOAC) against ischemic stroke compared to warfarin. This study aimed to investigate ischemic stroke incidence and bleeding risk in patients on DOAC therapy. Methods: Using the database of Korean Health Insurance Review and Assessment-Aged Patient Sample 2015, we conducted a retrospective cohort study. Study subjects with NVAF diagnosis and prescribed anticoagulants were enrolled. Propensity score (PS) matching by age, sex, comorbidities, and medications were used. The clinical outcomes were major adverse cerebro-cardiovascular events (MACCEs, ischemic stroke/systemic embolism, myocardial infarction, cardiac death) and bleeding events. A cox proportional hazard model analysis was performed to compare the outcomes with hazard ratio (HR) and 95% confidence interval (CI). Results: Total 4,773 elderly patients with NVAF were initially included. Four PS-matched groups including rivaroxaban vs. warfarin-only (n=1,079), dabigatran vs. warfarin-only (n=721), rivaroxaban vs. dabigatran (n=721), and switchers of warfarin to rivaroxaban vs. warfarin-only (n=287) were analyzed. Every group showed statistically similar results of MACCEs and bleeding events, except for the group of rivaroxaban vs. dabigatran. Rivaroxaban users showed higher risks of bleeding events than dabigatran users (HR 2.25, 95% CI 1.01-4.99). Conclusion: In the elderly patients with NVAF, efficacy and safety outcomes among oral anticoagulants including DOACs and warfarin were similar, while rivaroxaban are more likely to have higher bleeding risks than dabigatran. Further research using large size sample is needed.

• IMMUNE NETWORK
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• 제20권4호
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• pp.33.1-33.19
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• 2020

We tested how adjuvants effect in a cancer vaccine model using an epitope derived from an autoactivation loop of membrane-type protease serine protease 14 (PRSS14; loop metavaccine) in mouse mammary tumor virus (MMTV)-polyoma middle tumor-antigen (PyMT) system and in 2 other orthotopic mouse systems. Earlier, we reported that loop metavaccine effectively prevented progression and metastasis regardless of adjuvant types and TH types of hosts in tail-vein injection systems. However, the loop metavaccine with Freund's complete adjuvant (CFA) reduced cancer progression and metastasis while that with alum, to our surprise, were adversely affected in 3 tumor bearing mouse models. The amounts of loop peptide specific antibodies inversely correlated with tumor burden and metastasis, meanwhile both T_H1 and T_H2 isotypes were present regardless of host type and adjuvant. Tumor infiltrating myeloid cells such as eosinophil, monocyte, and neutrophil were asymmetrically distributed among 2 adjuvant groups with loop metavaccine. Systemic expression profiling using the lymph nodes of the differentially immunized MMTV-PyMT mouse revealed that adjuvant types, as well as loop metavaccine can change the immune signatures. Specifically, loop metavaccine itself induces T_H2 and T_H17 responses but reduces T_H1 and T_reg responses regardless of adjuvant type, whereas CFA but not alum increased follicular T_H response. Among the myeloid signatures, eosinophil was most distinct between CFA and alum. Survival analysis of breast cancer patients showed that eosinophil chemokines can be useful prognostic factors in PRSS14 positive patients. Based on these observations, we concluded that multiple immune parameters are to be considered when applying a vaccine strategy to cancer patients.

• Clinical and Experimental Pediatrics
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• 제51권1호
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• pp.26-32
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• 2008

목 적 : 1998년과 2005년 신체발육표준 제정사업 자료를 이용하여 2007년 소아청소년 성장곡선의 개발과정에서에 이용된 성장곡선 및 혈압분포 개발 방법론을 제시하고자 하였다. 방 법 : 성장곡선은 1998년과 2005년 자료를 이용해서 각 백분위수의 성장곡선 모형을 추정하고 LMS를 방법을 이용하여 최종 성장곡선을 생산하였다. 연령과 신장별 혈압 성장곡선은 2005년 자료를 이용하여 남녀별로 고정효과 회귀모형을 적용하여 산출하였다. 결 과 : 2007 소아청소년 성장곡선 및 혈압분포 표를 제시할 수 있었다. 결 론 : 2007년 성장곡선과 혈압분포 표는 현재 가용한 자료와 최신의 통계적 방법을 최대한 활용한 국내 최초의 결과로서 향후 지속적인 발전을 위한 논의와 연구가 필요하다.

• Nutrition Research and Practice
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• 제5권3호
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• pp.246-252
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• 2011

Bioelectrical impedance analysis (BIA) models must be validated against a reference method in a representative population sample before they can be accepted as accurate and applicable. The purpose of this study was to compare the eight-electrode BIA method with DEXA as a reference method in the assessment of body composition in Korean adults and to investigate the predictive accuracy and applicability of the eight-electrode BIA model. A total of 174 apparently healthy adults participated. The study was designed as a cross-sectional study. FM, %fat, and FFM were estimated by an eight-electrode BIA model and were measured by DEXA. Correlations between BIA_%fat and DEXA_%fat were 0.956 for men and 0.960 for women with a total error of 2.1%fat in men and 2.3%fat in women. The mean difference between BIA_%fat and DEXA_%fat was small but significant (P < 0.05), which resulted in an overestimation of $1.2{\pm}2.2$%fat (95% CI: -3.2-6.2%fat) in men and an underestimation of $-2.0{\pm}2.4$%fat (95% CI: -2.3-7.1%fat) in women. In the Bland-Altman analysis, the %fat of 86.3% of men was accurately estimated and the %fat of 66.0% of women was accurately estimated to within 3.5%fat. The BIA had good agreement for prediction of %fat in Korean adults. However, the eight-electrode BIA had small, but systemic, errors of %fat in the predictive accuracy for individual estimation. The total errors led to an overestimation of %fat in lean men and an underestimation of %fat in obese women.

• 과학교육연구지
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• 제41권3호
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• pp.426-446
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• 2017

본 연구의 목적은 암석에 관한 문제를 해결하는 대학생들의 사고 과정을 분석하여 지구과학의 귀추적 추론에서 결정적 증거(CE)와 결정적 자원 모델(CRM)의 역할과 중요성을 살펴보는 것이었다. 한 교육대학교에서 과학 심화 전공 과목을 수강하는 20명의 4학년 학생들이 연구에 참여하였다. 이들에게 많은 구멍이 발달한 퇴적암의 지질학적 과정을 귀추적으로 추론하여 모델로 나타내게 하고, 그 과정을 모델링 중심의 귀추적 추론에 관한 도식에 따라 분석하였다. 그 결과, 문제를 성공적으로 해결한 학생들의 추론은 다양한 알갱이와 많은 구멍을 CE로 삼아 퇴적암의 생성 과정과 풍화 작용을 CRM으로 각각 활성화하고 이들을 결합하여 과학적으로 타당한 설명 모델(SSEM)을 구성하는 특징이 있었다. 반면 문제 암석에 관하여 SSEM을 제안하지 못한 추론에서는 학생들이 많은 구멍이라는 증거로부터 화성암(현무암)의 생성 과정을, 다양한 알갱이라는 증거로부터 퇴적 작용을 자원 모델(RM)로 활성화하고, 이들로부터 자신들의 설명 모델(EM)을 구성하였다. 학생들이 SSEM을 구성하여 암석에 관한 지구과학 문제를 수월하게 해결하기 위해서는 문제 상황에 맞는 CE가 무엇인지 알고, 암석의 특징에 관하여 통합적 또는 시스템적으로 접근하며, 복수의 RM을 활용하고, 증거에 비추어 RM이나 EM을 평가할 필요가 있음을 제안하였다.

• Journal of Microbiology and Biotechnology
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• 제26권10호
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• pp.1817-1823
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• 2016

Areca nut (AN) chewing is a habit in many countries in Central, Southern, and Southeast Asia. It is strongly associated with the occurrence of oral, pharyngeal, and esophageal cancer as well as systemic inflammation. However, the association between AN intake and the development of gastric lesions has not yet been identified. The aim of this study was to investigate the effect of AN on gastric diseases using a mouse model for Helicobacter pylori infection. We studied four groups of mice: those fed a normal diet (ND), those fed a diet containing 2.5% AN (AD), those fed ND and infected with H. pylori PMSS1 strain (ND/HP), and those fed AD and infected with H. pylori PMSS1 strain (AD/HP). Food intake and body weight were monitored weekly during the experiments. At 10 weeks, the mice were sacrificed, and the stomach weight, H. pylori colonization, and gastric inflammation were evaluated. The stomach weight had increased significantly in the ND/HP and AD/HP groups along with increases in H. pylori colonization; however, there was no significant difference between these two groups with respect to stomach weight and colonization. On histological grading, mononuclear cell infiltration was severer in the AD/HP group than in the ND/HP group. These data suggest that chronic gastric inflammation was aggravated by AN treatment in the mice with H. pylori-induced gastric lesions. Furthermore, as previously suggested, this animal model is useful to determine the effect of potential carcinogens on gastric lesions induced by H. pylori infection.

• 한국산학기술학회논문지
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• 제19권1호
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• pp.121-126
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• 2018

중환자실에 입원한 환자들의 구강위생은 매우 중요한 문제이다. 중환자들은 기본적으로 면역이 저하된 환자들로 각종 병원성 세균들에 의한 감염의 기회가 높기 때문이다. 구강문제는 감염의 1차 방어선인 구강이 감염의 우선적인 부위로 작용될 뿐 아니라 전신감염을 초래하기도 한다. 본 연구에서는 중증환자의 구강청소를 용이하게 하는 마우스 피스 형태의 새로운 진공 구강 세정기 설계에 관한 연구를 수행하였다. 이중 구조 방식의 세정기와 표준 치아 모델로써 3D CAD 모델링 및 유동해석 모델을 수립하고 압력 및 유동특성을 분석하였다. 세정기 내부의 압력은 거의 일정한 분포를 보였으나, 속력분포의 경우 치아 안쪽과 바깥쪽에서 큰 차이를 보였다. 치아 안쪽에서도 가운데 부분의 속도가 가장 높고 가운데에서 멀어질수록 속력이 감소하는 특성을 보였다. 세정기의 흡입관과 배출관을 바꾸어 해석한 결과 치아 바깥쪽 가운데 부분의 속도가 가장 높게 나타났다. 세정기의 효과를 높이기 위해서 흡입-배출을 교대로 바꾸는 교번식을 제안하고, 어금니 부위의 속력을 높이는 설계 보완이 요구된다.