• 아태비즈니스연구
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• 제5권1호
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• pp.43-53
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• 2014

Social and economic changes in the world, along with changes in the culture of government and structural changes in the relationship between the state, the market and higher education institutions, have resulted in new approaches pursued by states towards higher education (Konstantinov & Philonovich, 2007; Peterka, 2011). Higher education institutions, in its turn, enjoy more freedom in choosing to focus on various tasks and goals to their academic activities. This contributes to the diversity of expectations when it comes to the various roles modern academic institutions take on with regard to their development. Among many existing concepts in the current academic environment, the concept of "entrepreneurial university" is becoming a critically important concept in Russia. In this article, we consider the concept of the Entrepreneurial University as developed in Clark and Etzkowitz's theories, and the ways the concept is being adjusted in the higher education system in Russia. We analyze comparatively both contemporary and prior historical [1990s-mid2000s] state policies pertaining to higher-education institutions in Russia in order to provide an insight into how the national market of knowledge intensive production is being established in the country. As a consequence of these analyses, we present a new model of how universities can take a more systemic and meaningful approach to creating research-based innovation entrepreneurial activities. This approach is also viewed as making universities' innovation activities more sustainable and thus less dependent on the state support.

• 디지털융복합연구
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• 제9권1호
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• pp.107-114
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• 2011

In order to have the highest level of a certain society's technology be evaluated as digital contents technology the value concept of such technology's social utilization must be established while active investment on the technology takes place and makes it the subject of social capitalization. This study wishes to discuss the strategies and methods of establishing and managing IP holding company which requires business activation with digital contents technology at its base, research ways of vitalizing IP holding company to expand social utility values of contents technology, suggest necessary systemic improvements and investment activation methods, management structure, and governance structure by investigating ways to stimulate the industrialization of contents technology through the establishment and management of this IP holding company, and finally come up with a realistic measure to establish and manage a IP holding company. Strategies on commercialization of digital contents technology and acceleration of technology development, as well as activation of venture business set-ups will be analyzed and suggested based on such suggestions while IP holding company's digital contents technology investment activation model will be established to produce means to realize discovering superior contents companies and activation of investment, and activating high quality contents production for the global market.

• 한국약용작물학회지
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• 제20권2호
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• pp.129-135
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• 2012

The feature of asthma are airway inflammation (AI), reversible airway obstruction, and an increased sensitivity to bronchoconstricting agents, elevated airway hyperresponsiveness (AHR), excess production of Th2 cytokines, and eosinophil accumulation in the lungs. This study was performed to investigate if oral administration of $Scutellaria$ $baicalensis$ Georgi water extracts (SBG) have the antiasthmatic potential for the treatment of asthma. Asthmatic HI and AHR were induced by systemic sensitization to ovalbumin (OVA) with intratracheal instillation with 0.1 mg/mL of diesel exhaust particles (DEP) suspension once a week for 10 weeks in BALB/c mice. SBG was orally administered with the concentraion of 200 mg/kg 5 days a week for 10 weeks. Long-term SBG treatment suppressed the eosinophil infiltration into airways from blood, the asthmatic AI and AHR by attenuating the production of cytokine IL-4, IL-5 and IL-13, histamine and OVA-specific IgE. Our data suggest that SBG has inhibitory effects on AI and AHR in a mouse model of asthma, may act as a potential Th2 cytokine antagonist, and may have a therapeutic effect on allergic asthma.

• 약학회지
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• 제60권1호
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• pp.21-28
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• 2016

Systemic lupus erythematosus (SLE) is characterized by dysregulatory production of proinflammatory cytokines and helper T (Th) cytokine-dependent autoantibody production. This study aims to investigate the protective effect of baicalin on the dysregulatory production of proinflammatory cytokines and Th cytokines in pristane-induced lupus mice. Mice were received i.p. a single injection of 0.5 ml of pristane, and then, later about 3 months, were used as a pristane-induced lupus model. The pristane-induced lupus mice were administrated orally with baicalin 50 mg/kg once in a day for 10 days. Immune cells obtained from the pristane-primed lupus control group (lupus control) and baicalin-treated pristaneprimed lupus mouse group (BAC lupus) were cultured for 24 h or 36 h with/without mitogens. These results demonstrated that LPS-induced production of macrophage and splenic TNF-${\alpha}$ and Con A-induced production of thymic IFN-${\gamma}$ were attenuated in BAC lupus compared to lupus control, while LPS-stimulated production of macrophage IL-10, Con A-stimulated production of splenic IL-10 and, $PGE_2$-reduced production of splenic IFN-${\gamma}$ enhanced. Therefore, these findings suggest that baicalin may protect from autoimmunity and disease activity in lupus via modulatory effect of proinflammatory cytokine overproduction and Th cytokine imbalance.

• 지역사회간호학회지
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• 제23권4호
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• pp.376-385
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• 2012

Purpose: The aim of this study was to evaluate the effects of tailored case management using a gatekeeper on depression and life satisfaction in the single-household elderly population. Methods: The design of Quasi experiment was applied to compare the variables before and after the management. Ninety-seven people who had depression categorized by the Korean Geriatric Depression Scale. Results: Depression (t=11.22, p<.001) and life satisfaction (t=-5.36, p<.001) were improved after management in comparison to the results of pre-tests, and the differences were statistically significant. The difference in the pre-test and post-test scores of the support system ($x^2$=13.89, p<.001) were significant, while the differences in the perception of depression ($x^2$=.02, p=.891) and coping methods ($x^2$=.34, p=.558) were not statistically significant. Conclusion: Tailored case management using a gatekeeper is effective to reduce the degree of depression and improve life satisfaction in the single-household elderly population having depression. This study offers a model of individualized as well as systemic mental health care for the community of single-house hold elderly people as an effective means for prevention of and early intervention in depression.

• Environmental Engineering Research
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• 제15권1호
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• pp.29-33
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• 2010

In 2004, the Korean government launched comprehensive measures for nonpoint pollution that were intended to reduce their amount by 34.3% over of those forecast by 2020. During the first and second stages of their implementation; from 2004 to 2011, nonpoint source (NPS) measures have focused on systemic improvements and project management, as well as the introduction of optimal management techniques; accordingly, reductions have been small. However, during the third stage in 2011, serious reductions will be pursued. Accordingly, the gradual expansion of sites subject to NPS measures has focused on the establishment of a basis for reduction measures in connection with model projects during the first half of the plan, with full scale enforcement due in the second half. For Korea, rather than commencing NPS management en masse, it has been more appropriate to gradate NPS management into stages tailored to the different needs of new and existing businesses, as well as to the needs of large and small-scale businesses, in consideration of their specific circumstances. This has allowed sufficient time for such businesses to become accustomed to the concept of NPS management.

• The Journal of Asian Finance, Economics and Business
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• 제8권5호
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• pp.829-837
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• 2021

The study investigates the impact of the Counter-Cyclical Buffer Policy (CCB) on regional development bank profitability in Sumatra, Indonesia. CCB requires banks to hold capital at times when credit is growing rapidly so that the buffer can be reduced if the financial cycle turns down or the economic and financial environment becomes substantially worse. This study employs time series data of regional development banks (RDBs) in Sumatra Island, Indonesia. The methodology applied in this study is a panel dynamic model with Generalized Methods of Moments (GMM). The results show that increasing capital through the implementation of CCB did not have a significant effect on RDBs' profitability. The findings of this study suggest that the activation and implementation of CCB lead to an increase in the amount and cost of loans to companies but do not affect the profitability of RDBs. The value of a Non-Performing Loan (NPL) proved to have a negative and significant effect on bank profitability. The CCB policy aims to overcome the pro-cyclicality of credit growth and improve bank resilience through increased capital which is expected to reduce excessive credit growth as a source of systemic risk. This causes a lack of lending to the community so that the profits obtained by the bank decrease.

• Natural Product Sciences
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• 제25권3호
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• pp.215-221
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• 2019

Inflammation is the crucial biological process of immune system which acts as body's defense and protective response against the injuries or infection. However, the systemic inflammation devotes the adverse effects such as multiple inflammation associated diseases. One of the best ways to treat this entity is by blocking the tumor necrosis factor alpha ($TNF-{\alpha}$) and TNF-related apoptosis-inducing ligand (TRAIL) to avoid the proinflammation cytokines production. Thus, this study aims to evaluate the potency of Sambucus bioactive compounds as anti-inflammation through in silico approach. In order to assess that, molecular docking was performed to evaluate the interaction properties between the $TNF-{\alpha}$ or TRAIL with the ligands. The 2D structure of ligands were retrieved online via PubChem and the 3D protein modeling was done by using SWISS Model. The prediction results of the study showed that caffeic acid (-6.4 kcal/mol) and homovanillic acid (-6.6 kcal/mol) have the greatest binding affinity against the $TNF-{\alpha}$ and TRAIL respectively. This evidence suggests that caffeic acid and homovanillic acid may potent as anti-inflammatory agent against the inflammation associated diseases. Finally, this study needs further examination and evaluation to validate the potency of Sambucus bioactive compounds.

• 한국치위생학회지
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• 제22권4호
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• pp.249-257
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• 2022

Objectives: This study aimed to investigate the effect of the oral health status on risk factors for obstructive sleep apnea (OSA) using data from the 2019 National Health and Nutrition Examination Survey. Methods: Of a total of 2,422 persons, 1,295 and 1,127 were categorized into the control group (CG) and OSA risk group (OSARG), respectively. The effect of the oral health status on OSA risk factors was presented in Model 1 by performing a complex sample linear regression analysis. Results: Our findings showed that OSA risk factors decreased by 0.075 points when there were no speaking problems with demographic characteristics adjusted. In addition, when systemic diseases were adjusted for, OSA risk factors decreased to 0.074 points (p<0.05). Conclusions: Therefore, in order to reduce oral problems that affect OSA risk factors, dentists and dental hygienists should seek accurate recognition of OSA and effective oral care methods.

• Current Optics and Photonics
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• 제6권2호
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• pp.151-160
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• 2022

Fundus images can reflect ocular diseases and systemic diseases such as glaucoma, diabetes mellitus, and hypertension. Thus, research on fundus-detection equipment is of great importance. The fundus camera has been widely used as a kind of noninvasive detection equipment. Most existing devices can only obtain two-dimensional (2D) retinal-image information, yet the fundus of the human eye also has spectral characteristics. The fundus has many pigments, and their different distributions in the eye lead to dissimilar tissue penetration for light waves, which can reflect the corresponding fundus structure. To obtain more abundant information and improve the detection level of equipment, a snapshot nonmydriatic fundus imaging spectral system, including fundus-imaging spectrometer and illumination system, is studied in this paper. The system uses a microlens array to realize snapshot technology; information can be obtained from only a single exposure. The system does not need to dilate the pupil. Hence, the operation is simple, which reduces its influence on the detected object. The system works in the visible and near-infrared bands (550-800 nm), with a volume less than 400 mm × 120 mm × 75 mm and a spectral resolution better than 6 nm.