• 한국전기전자재료학회논문지
• /
• 제23권11호
• /
• pp.831-836
• /
• 2010

In this paper, Plasma Enhanced Chemical Vapor Deposition (PECVD) $SiO_2$ film properties are modeled using statistical analysis and neural networks. For systemic analysis, Box-Behnken's 3 factor design of experiments (DOE) with response surface method are used. For characterization, deposited film thickness and film stress are considered as film properties and three process input factors including plasma RF power, flow rate of $N_2O$ gas, and flow rate of 5% $SiH_4$ gas contained at $N_2$ gas are considered for modeling. For film thickness characterization, regression based model showed only 0.71% of root mean squared (RMS) error. Also, for film stress model case, both regression model and neural prediction model showed acceptable RMS error. For sensitivity analysis, compare to conventional fixed mid point based analysis, proposed sensitivity analysis for entire range of interest support more process information to optimize process recipes to satisfy specific film characteristic requirements.

• 인터넷정보학회논문지
• /
• 제13권5호
• /
• pp.77-92
• /
• 2012

본 연구에서는 21세기 새로운 교육 패러다임으로 인정받고 있는 스마트교육이 실제 학교 현장에서 어떤 방향으로 이루어져야 하는지 그 방향성을 탐색하기 위하여 스마트교육 관련 현장 전문가를 대상으로 델파이 조사를 실시하였다. 그 결과 스마트교육의 교육목표, 교육 내용, 교육 방법, 교육 평가, 교육 환경으로 구성된 각 영역에서 전문가들의 합의점을 도출할 수 있었으며, 이를 바탕으로 실제 교육 현장에서 지침을 제공할 수 있는 스마트교육 모형을 개발하였다. 스마트교육 모형은 21세기를 살아갈 학습자들이 협업과 의사소통을 통해 문제를 해결하고 창의성을 높이며 바른 인성을 함양하도록 전개되어야한다는 교육 목표 아래, 교육 내용, 교육 방법, 교육 평가, 교육 환경이 일관성 있게 유기적으로 연결된 체제적 교육 모형이다. 본 연구가 스마트교육이 실제로 이루어지는 학교현장에 작은 보탬이 되기를 기대한다.

• The Korean Journal of Physiology and Pharmacology
• /
• 제20권4호
• /
• pp.367-378
• /
• 2016

Recently, it was reported that the role of mitochondria-reactive oxygen species (ROS) generating pathway in cisplatin-induced apoptosis is remarkable. Since a variety of molecules are involved in the pathway, a comprehensive approach to delineate the biological interactions of the molecules is required. However, quantitative modeling of the mitochondria-ROS generating pathway based on experiment and systemic analysis using the model have not been attempted so far. Thus, we conducted experiments to measure the concentration changes of critical molecules associated with mitochondrial apoptosis in both human mesothelioma H2052 and their ${\rho}^0$ cells lacking mitochondrial DNA (mtDNA). Based on the experiments, a novel mathematical model that can represent the essential dynamics of the mitochondrial apoptotic pathway induced by cisplatin was developed. The kinetic parameter values of the mathematical model were estimated from the experimental data. Then, we have investigated the dynamical properties of this model and predicted the apoptosis levels for various concentrations of cisplatin beyond the range of experiments. From parametric perturbation analysis, we further found that apoptosis will reach its saturation level beyond a certain critical cisplatin concentration.

• 한국가스학회지
• /
• 제6권1호
• /
• pp.59-65
• /
• 2002

본 연구는 가스 산업체에서 안전관리, 건설공정, 운영관리 등을 통합할 수 있는 새로운 정보화 모델, 즉 PIIS 모델을 제안하고자 한다. 여기서 개발된 PIIS 모델을 기반으로 가스설비를 통합관리 한다면 안전 및 위험관리를 극대화 할 수 있고, 동시에 생산성과 원가절감 효과를 증대시킬 수 있는 장점이 있다. 따라서 PIIS 시스템의 도입은 동기화와 통합화를 안정적으로 가져갈 수 있다는 측면에서 가스 공급자와 소비자 상호간에 이윤을 공유하게 된다. 결과, PIIS 운영체계는 인수기지의 건설단계에서 도입하는 것이 보다 효과적이지만. 천연가스의 탐사 단계부터 최종 소비자에게 공급되는 전체 라인에 적용하는 것이 가스업체의 생산성, 안전성, 경제성에 분명한 이익을 제공할 것이다.

• International Journal of Computer Science & Network Security
• /
• 제22권10호
• /
• pp.91-96
• /
• 2022

Article materials reflect the results of scientific research and generalization of experience concerning quality measurement of student's educational activities in the context of innovative development of the educational process, which is ensured by introducing educational innovations. The main point of monitoring of higher education students' activities and also phenomenon of education quality, particularly its results, are determined in the research. Guided by the scientific theory and personal experience of scientific and pedagogical activities, the attempt to single out the key components, important indicators and to introduce component indicator model of quality of higher education students' activities on the qualimetry base has been performed. Methodical solutions concerning the application of the developed model to determine the dynamics of pedagogical students' educational achievements by particular educational components in the process of innovative development of educational process are proposed. The advanced studies that relate to the development of methods for monitoring the quality of pedagogical higher education students' activities on the basis of systemic, competence and qualimetry approaches taking into account the levels of education and chosen specialties have been decided.

• 제어로봇시스템학회논문지
• /
• 제10권12호
• /
• pp.1164-1171
• /
• 2004

A new multi-scale simulation model is proposed to analyze heart mechanics. Electrophysiology of a cardiac cell is numerically approximated using the previous model of human ventricular myocyte. The ion transports across cell membrane initiated by action potential induce an excitation-contraction mechanism in the cell via cross bridge dynamics. Negroni and Lascano model (NL model) is employed to calculate the tension of cross bridge which is closely related to the ion dynamics in cytoplasm. To convert the tension on cell level into contraction force of cardiac muscle, we introduce a simple geometric model of ventricle with a thin-walled hemispheric shape. It is assumed that cardiac tissue is composed of a set of cardiac myocytes and its orientation on the hemispheric surface of ventricle remains constant everywhere in the domain. Application of Laplace law to the ventricle model enables us to determine the ventricular pressure that induces blood circulation in a body. A lumped parameter model with 7 compartments is utilized to describe the systemic circulation interacting with the cardiac cell mechanism via NL model and Laplace law. Numerical simulation shows that the ion transports in cell level eventually generate blood hemodynamics on system level via cross bridge dynamics and Laplace law. Computational results using the present multi-scale model are well compared with the existing ones. Especially it is shown that the typical characteristics of heart mechanics, such as pressure volume relation, stroke volume and ejection fraction, can be generated by the present multi-scale cardiovascular model, covering from cardiac cells to circulation system.

• 기록학연구
• /
• 제33호
• /
• pp.155-206
• /
• 2012

1999년 "공공기관의기록물관리에관한법률"이 제정되고 난 후 10년이 지난 현재, 기록관리에 대한 관심은 공공분야에서 문화예술분야로 점차 넓어지고 있다. 그러나 아직까지 문화예술분야 기록의 중요성에 대한 인식이 부족하여 정보의 산재, 기록의 유실 등이 빈번하게 일어나고 있다. 하나의 예로, 국내의 많은 문화재는 정확한 매매계약이나 증여증서가 없어 이를 추적하기가 매우 어려운 현실이고, 이러한 문화예술 창작품은 도굴이나 비공개 경매, 공식적이지 않은 유통경로를 통해 떠돌아다니고 있다. 문화예술 창작품은 그 나라의 문화수준을 반영하기에, 유통경로를 아는 것은 그 나라의 문화수준을 가늠하는 척도가 된다고 할 수 있다. 본 연구는 이러한 문제점에서 출발하였다. 경제의 성장과 문화예술에 대한 관심의 증대로 시각예술작품에 대한 중요성 인식이나 가치를 인정하는 사회가 되었으나, 작품에 대한 미적가치만을 앞세우는 작품만능주의 팽배로 시각예술작품의 맥락을 보여주거나 사회와의 소통 과정에서 생산된 기록정보들은 도외시 되었다. 문화예술 선진국에 비하여 국내에서는 유명 작가에 관한 기록, 작품에 녹아 있는 철학 담론에 대한 기록정보들은 흔히 찾아볼 수 없다. 작품을 전시하고 난 후 생산된 기록정보 또한 전시에 앞서 홍보자료나 참고자료로만 이용될 뿐 이를 남기려는 노력은 부족하다. 이에 시각예술기록정보에 대한 중요성을 인식하고, 후대에 예술사적 가치뿐만 아니라 역사적 가치를 전해주기 위해 체계적인 관리가 필요하다고 판단하였다. 최근 시각예술작품이나 시각예술기록정보가 전자적으로 생산된 것이 아니라 하더라도, 작품이나 기록에 대한 관리는 모두 기관의 시스템에서 이루어지고 있기 때문에 메타데이터는 체계적 관리의 필수적인 방안이라 할 수 있다. 본 연구에서는 시각예술기록정보의 특성을 반영한 다중 엔티티 데이터모델 설계로 시각예술기록을 체계적으로 관리하려 하였다. 메타데이터는 기록이 입수되는 시점부터 관리, 보존 및 활용되는 기록의 모든 과정에서 필요로 한다. 시각예술기록은 객체, 행위주체, 업무, 규정 등과 유기적인 관계를 가질 때 그 가치가 풍부해지진다. 시각예술기록정보 관리를 위한 다양한 맥락정보는 다양한 엔티티들과 함께 관계를 맺는 다중 엔티티 모델로 설계되어야 관리의 효율성이 높아지고, 기록정보에 대한 설명성 또한 높아진다. 때문에 이들을 각자 독립적인 엔티티로 설계하고, 이들의 관계를 지정해주는 방식으로 데이터모델을 설계하여 체계적으로 시각예술기록정보를 관리할 수 있는 방안을 마련하고자 하였다.

• BMB Reports
• /
• 제48권6호
• /
• pp.336-341
• /
• 2015

Sepsis is a life-threatening, infectious, systemic inflammatory disease. In this study, we investigated the therapeutic effect of α-cubebenoate, a novel compound isolated from Schisandra chinensis against polymicrobial sepsis in a cecal ligation and puncture (CLP) experimental model. Administration of α-cubebenoate strongly enhanced survival in the CLP model. α-cubebenoate administration also markedly blocked CLP-induced lung inflammation and increased bactericidal activity by enhancing phagocytic activity and hydrogen peroxide generation in mouse bone marrow-derived macrophages and neutrophils. Expression of two important inflammatory cytokines, IL-1 and IL-6, was strongly increased in the CLP model, and this was dramatically blocked by α-cubebenoate. Lymphocyte apoptosis and caspase-3 activation, which are associated with immune paralysis during sepsis, were markedly attenuated by α-cubebenoate. Taken together, our findings indicate that α-cubebenoate, a natural compound isolated from Schisandra chinensis, is a powerful potential anti-septic agent. [BMB Reports 2015; 48(6): 336-341]

• The Journal of Asian Finance, Economics and Business
• /
• 제3권1호
• /
• pp.33-41
• /
• 2016

Essences, needs and features of formation of national innovative development model of Kazakhstan are proved on the basis of analysis of various research approaches to realization of the modernization that exist in the world economic theory. For studying the problems of innovative development of the country, there was a need for the formulation of a number of definitions, disclosure of their contents, changing the approaches to reform, as well as adjusting their targets. In the article the general scientific research methods used dialectic, abstraction, systemic and situational approach, empirical and theoretical and analytical methods, and logic modeling. The proposed approach to the implementation of innovative development based on the use of evolutionary and institutional approaches to the study of the problems of implementing an effective innovation policy. This approach is intended to contribute to the development of a forward strategy of modernization, innovative development and higher competitiveness of the national economy. The study proved the causes and features of the implementation of innovative development model in Kazakhstan.

• 한방안이비인후피부과학회지
• /
• 제12권1호
• /
• pp.143-153
• /
• 1999

Background: The vasoreactivity of cerebral artery is currently the subject of increasing interest Transcranial Doppler The purpose of this study was to investigate the analgesic effect of acupuncture in a model of neuropathic pain produced by segmental spinal nerve injury (SSI) in rats. The left L5 and L6 spinal nerves of Sprague-Dawley rats were tightly ligated, and one week later, manual or electro-acupuncture was applied for 30 minutes to the contralateral hindlimb (right side) while the animal was lightly anesthetized with halothane. The mechanical threshold of the paw for ipsilateral (left side) hind limb flinching was determined prior to and 0.5, 1, 2, 4, and 24 hours after termination of acupuncture. The mechanical threshold for flinching was significantly elevated for about 4 hours after manual acupuncture applied to the BL. 60 (Kunlun) point or electro-acupuncture to the BL. 60 and BL. 40 (Weizhong) points. However, manual acupuncture applied to the ST. 36 (Zusanli) point was not effective. Furthermore, systemic naloxone pretreatment had no effect on the acupuncture induced threshold elevation. These data suggests that acupuncture produces a point specific, naloxone independent analgesia in a rat neuropathic pain model. ※ This paper is supported by a grant from the '1996 Jusan Foundation of Wonkwang university.)