• 동의신경정신과학회지
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• 제30권4호
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• pp.305-317
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• 2019

Objectives: The purpose of this study was to analyze domestic qualitative research papers of the Satir Transformational Systemic Therapy and suggest the possibility of applying it to Korean medicine counseling. Methods: Domestic research papers were gathered by keywords 'Satire Counseling' or 'Satir Transformational Systemic Therapy' and 'Qualitative Research' in RISS (http://www.riss.kr/), KISS (http://kiss.kstudy.com/), OASIS (http://oasis.kiom.re.kr/). The results were seven papers. Seven papers were selected based on grounded theory and case studies. Researchers analyzed the phenomena during the course of counseling to discuss the mechanism of the Satir Transformational Systemic Therapy and consider its applicability to Korean medicine psychotherapy. Results: The Satir Transformational Systemic Therapy has three points: 'Self', 'Communication', and 'Family'. Positive changes such as 'Self-recovery', 'Consistent communication', and 'Recovery of relationships' are derived from these three points. And techniques such as iceberg exploration, family maps, three-members in a born family, and the family sculpture are also effective means. Conclusions: The Satir Transformational Systemic Therapy is valuable in the clinical fields of Korean medicine counseling, especially relative to problems stemming from relationships.

• 고신대학교 의과대학 학술지
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• 제33권3호
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• pp.289-296
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• 2018

Objectives: In these days, patients with stage I breast cancer have increased by regular health examination and diagnostic tool development. The aim of this retrospective study is to identify systemic recurrence related factors after breast conserving surgery (BCS) for stage I breast cancer. Methods: In this study, we analyzed the correlation between systemic recurrence and pathologic factors. We reviewed 223 patients who underwent BCS for stage I breast cancer. Postoperative pathologic factors, recurrent rates and sites were studied. In addition, preoperative patients'data were also collected. Statistical analysis was done by using PASW 16.0 (SPSS Inc., Chicago, IL, USA). Results: Systemic recurrence was found in 16 patients (7.17%) within 5 years after primary surgery. 5 patients had lymphatic invasion and 6 patients had vascular invasion. Lymphatic and vascular invasion had statistical correlation with systemic recurrence (P = 0.004, P = 0.001). Conclusions: In this retrospective study, we can conclude that vascular invasion and lymphatic invasion are related systemic recurrence after BCS for stage I patients. Further studies with large cohort will be required to fully understand the risk factors of systemic recurrence for stage I breast cancer patients.

• 치위생과학회지
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• 제16권1호
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• pp.9-17
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• 2016

이번 연구의 목적은 치과위생사의 전신질환 지식 확산 정도를 파악하는 것이다. 종합(대학)병원 치과, 치과 병 의원 및 보건(지)소에 근무하고 있는 치과위생사 211명을 대상으로 2015년 8월 31일부터 9월 20일에 걸쳐 설문지를 배부하여 조사하였으며 회수된 자료는 서술통계와 t-검정, 일원분산분석으로 분석하여 다음과 같은 결과를 얻었다. 치과위생사의 전신질환 관련 지식 정도는 전체 평균 0.64점으로 나타났다. 치과위생사의 일반적 특성에 따른 전신질환 지식에서는 연령, 학력, 경력, 교육경험에서 유의한 차이가 나타났다(p<0.01). 치과위생사의 전신질환 관련 지식에 대한 유용성 인식 정도는 전체 평균점수가 0.61점(1점 만점)으로 나타났다. 전신질환 관련 지식의 유용성 인식에서는 연령(p<0.001), 학력(p<0.01), 경력(p<0.001), 교육경험(p<0.01)에서 유의한 차이가 나타났다. 치과위생사의 전신질환 관련 지식에 대한 실무적용 정도는 전체 평균 0.86점(2점 만점)으로 나타났다. 전신질환 관련 지식 실무적용에서는 연령(p<0.01), 학력(p<0.01), 경력(p<0.01), 교육경험(p<0.001)에서 유의한 차이가 나타났다. 치과위생사의 전신질환 지식 확산정도는 2.17점으로 '실무에 유용하다고 생각함' 단계로 나타났다. 이상의 결과로 볼 때 치과위생사의 전신질환 지식의 확산 과정을 파악하고 장애요인을 파악하는 연구가 필요하다. 아울러 치과위생사에게 전신질환 지식에 대한 실무 교육 기회를 제공하기 위해 교육 프로그램을 개발하고 그 효과를 확인하는 연구가 필요하다.

• 한국융합학회논문지
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• 제9권9호
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• pp.135-142
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• 2018

본 연구는 주관적 전신건강상태와 건강행위가 구강건강관련 삶의 질에 미치는 영향을 융합연구를 통해 파악하고자 하였으며, 부산광역시에 거주하는 성인을 대상으로 설문조사에 의해 수집된 자료를 SPSS 21.0 프로그램을 통해 분석하였다. 비 흡연 그룹의 구강건강관련 삶의 질이 흡연 그룹보다 높게 나타났고, 주관적 전신건강상태와 건강행위에 대한 고 그룹이 저 그룹에 비해 구강건강관련 삶의 질이 높게 나타났다. 주관적 전신건강상태와 건강행위 모두 구강건강관련 삶의 질에 정(+)의 영향을 주는 것으로 나타났으며 특히, 주관적 전신건강상태가 더 큰 영향을 미쳤다. 따라서 전신건강을 통한 구강건강 관련 삶의 질이 향상될 것으로 기대됨에 따라 전신과 구강의 융합 교육프로그램의 개발은 전신건강과 구강건강의 연관된 중요성을 교육할 수 있는 중요한 매체가 될 것으로 판단된다.

• Biomolecules & Therapeutics
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• 제32권4호
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• pp.432-441
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• 2024

Systemic sclerosis is an autoimmune disease characterized by inflammatory reactions and fibrosis. Myofibroblasts are considered therapeutic targets for preventing and reversing the pathogenesis of fibrosis in systemic sclerosis. Although the mechanisms that differentiate into myofibroblasts are diverse, transforming growth factor β (TGF-β) is known to be a key mediator of fibrosis in systemic sclerosis. This study investigated the effects of extracellular vesicles derived from human adipose stem cells (ASC-EVs) in an in vivo systemic sclerosis model and in vitro TGF-β1-induced dermal fibroblasts. The therapeutic effects of ASC-EVs on the in vivo systemic sclerosis model were evaluated based on dermal thickness and the number of α-smooth muscle actin (α-SMA)-expressing cells using hematoxylin and eosin staining and immunohistochemistry. Administration of ASC-EVs decreased both the dermal thickness and α-SMA expressing cell number as well as the mRNA levels of fibrotic genes, such as Acta2, Ccn2, Col1a1 and Comp. Additionally, we discovered that ASC-EVs can decrease the expression of α-SMA and CTGF and suppress the TGF-β pathway by inhibiting the activation of SMAD2 in dermal fibroblasts induced by TGF-β1. Finally, TGF-β1-induced dermal fibroblasts underwent selective death through ASC-EVs treatment. These results indicate that ASC-EVs could provide a therapeutic approach for preventing and reversing systemic sclerosis.

• Radiation Oncology Journal
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• 제32권4호
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• pp.266-271
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• 2014

In the clinical state of oligometastases or oligorecurrence, a transitional state between localized and widespread systemic disease, local control of the disease may yield improved systemic control. Radiotherapy may be a good means for controlling oligometastatic tumors, particularly in very old patients for whom surgery may be infeasible. A combination of systemic therapy and local therapy is necessary to prevent systemic progression. Some kinds of cancers found in the elderly are known to be somewhat indolent for systemic progression. So, for very old patients who refuse or cannot tolerate chemotherapy, the use of radical radiotherapy alone to treat oligorecurrences may be very helpful. We successfully treated an 87-year-old patient who had been diagnosed with oligorecurrences three times over six years with radiotherapy alone. The patient is now, about four years after his first radiotherapy for liver metastasis, alive without any evidence of cancer and with fully active performance status.

• BMB Reports
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• 제43권12호
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• pp.781-788
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• 2010

An often overlooked issue in the field of adenovirus (Ad)-mediated cancer gene therapy is its limited capacity for effective systemic delivery. Although primary tumors can be treated effectively with intralesional injection of conventional Ad vectors, systemic metastasis is difficult to cure. Systemic administration of conventional naked Ads leads to acute accumulation of Ad particles in the liver, induction of neutralizing antibody, short blood circulation half-life, non-specific biodistribution in undesired organs, and low selective accumulation in the target disease site. Versatile strategies involving the modification of viral surfaces with polymers and nanomaterials have been designed for the purpose of maximizing Ad anti-tumor activity and specificity by systemic administration. Integration of viral and non-viral nanomaterials will substantially advance both fields, creating new concepts in gene therapeutics. This review focuses on current advances in the development of smart Ad hybrid nanocomplexes based on various design-based strategies for optimal Ad systemic administration.

• 한국경영과학회지
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• 제40권4호
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• pp.35-48
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• 2015

We analyze the systemic risk based on the information flows using the variance decomposition, DebtRank methods, and the Industry Sector Indices during 2001. 01 to 2015. 08. Using the KOSPI stock market as our setting, we find that (i) the systemic risk calculated by information flows of variance decompositions method shows strong positive relations with the market volatility, (ii) the magnitude of systemic risk measured from the information flows network by DebtRank method increases after the subprime financial crisis.

• 대한한방내과학회지
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• 제43권3호
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• pp.469-476
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• 2022

Objectives: This study aimed to report on a systemic sclerosis patient diagnosed with Yulgyuk and Banui syndrome improved by Korean medical treatment. Methods: We treated a 70-year-old woman who had swallowing disorders and frequent vomiting caused by systemic sclerosis with herbal medicine and acupuncture treatment for six months. Treatment was evaluated with a numerical rating scale (NRS). Results: After treatment, swallowing disorders and frequent vomiting decreased. The NRS decreased from 8 to 3. Conclusions: This case suggests that Korean medical treatment was effective for alleviating a swallowing disorder and frequent vomiting caused by systemic sclerosis as a conservative treatment.

• 턱관절균형의학회지
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• 제13권1호
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• pp.32-38
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• 2023

Objectives: The purpose of this study is to report the effect of Korean medicine on trigeminal neuralgia in a patient with systemic sclerosis. Methods: We treated a 49-year-old male patient who has systemic sclerosis and trigeminal neuralgia by Korean medicine. He was treated from October 29th, 2022 to November 12th, 2022. The treatment applied was herbal medicine, acupuncture, pharmacopuncture. The evaluation was conducted by Visual Analogue Scale (VAS). Results: After 14 days of treatment, the symptoms were alleviated. Facial pain and dullness of taste improved. VAS of discomfort was decreased from 10 to 2. Conclusions: These results showed that Korean medicine may have an effect on reducing symptoms of systemic sclerosis and trigeminal neuralgia.