• KSII Transactions on Internet and Information Systems (TIIS)
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• 제16권8호
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• pp.2490-2506
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• 2022

In Mobile Edge Computing (MEC), attackers can speculate and mine sensitive user information by eavesdropping wireless channel status and offloading usage pattern, leading to user privacy leakage. To solve this problem, this paper proposes a Privacy-preserving and Energy-efficient Offloading Algorithm (PEOA) based on Lyapunov optimization. In this method, a continuous Markov process offloading model with a buffer queue strategy is built first. Then the amount of privacy of offloading usage pattern in wireless channel is defined. Finally, by introducing the Lyapunov optimization, the problem of minimum average energy consumption in continuous state transition process with privacy constraints in the infinite time domain is transformed into the minimum value problem of each timeslot, which reduces the complexity of algorithms and helps obtain the optimal solution while maintaining low energy consumption. The experimental results show that, compared with other methods, PEOA can maintain the amount of privacy accumulation in the system near zero, while sustaining low average energy consumption costs. This makes it difficult for attackers to infer sensitive user information through offloading usage patterns, thus effectively protecting user privacy and safety.

• 대한한방내과학회지
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• 제44권6호
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• pp.1256-1270
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• 2023

Objectives: This study analyzes domestic research trends on herbal medicine treatments for ulcerative colitis (UC) by examining 28 selected domestic papers using the Oriental Medicine Advanced Searching System (OASIS) as the main search source. Methods: A total of 28 domestic papers were selected on the OASIS platform as the main search source using the keywords "(궤양성 대장염) or (궤양성 대장병)" and "(한약) or (한의학)". Results: There were 11 case report studies and 17 case-control studies published from 2002 to 2022. All the case-control studies only dealt with mice and did not include human subjects. The most common pathologies were damp heat and Changpung. Hwangryunhaedok-tang was the most frequently prescribed herbal formula, and Coptidis Rhizoma was the most commonly used herb across all studies. The results showed that many studies demonstrated the significant effects of herbal treatment. Conclusion: Herbal medicine may exhibit therapeutic effects on various aspects of UC. However, evidence-based studies, such as clinical trials involving human subjects, are needed.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제12권8호
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• pp.3542-3566
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• 2018

In this paper, we investigate a buffer-aided wireless powered cooperative communication network (WPCCN), in which the source and relay harvest the energy from a dedicated power beacon via wireless energy transfer, then the source transmits the data to the destination through the relay. Both the source and relay are equipped with an energy buffer to store the harvested energy in the energy transfer stage. In addition, the relay is equipped with a data buffer and can temporarily store the received information. Considering the buffer-aided WPCCN, we propose two buffer-aided relaying protocols, which named as the buffer-aided harvest-then-transmit (HtT) protocol and the buffer-aided joint mode selection and power allocation (JMSPA) protocol, respectively. For the buffer-aided HtT protocol, the time-averaged achievable rate is obtained in closed form. For the buffer-aided JMSPA protocol, the optimal adaptive mode selection scheme and power allocation scheme, which jointly maximize the time-averaged throughput of system, are obtained by employing the Lyapunov optimization theory. Furthermore, we drive the theoretical bounds on the time-averaged achievable rate and time-averaged delay, then present the throughput-delay tradeoff achieved by the joint JMSPA protocol. Simulation results validate the throughput performance gain of the proposed buffer-aided relaying protocols and verify the theoretical analysis.

• 동의생리병리학회지
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• 제33권4호
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• pp.207-218
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• 2019

It is necessary to investigate the efficacy of commercial Korean herbal medicine for cognitive disorder. The purpose of this study is to select candidates among licensed herbal medicines that are expected to be effective in the treatment of cognitive disorders and can be used in future clinical trial. From laboratory experiments, we first found individual single herbal drugs that could be effective for cognitive disorder, and then through experts recommendation, selected five priorities of single herbal drug and obtained the information of the best herb as a combination of each herbal drug. To derive the final herbal prescriptions, we searched the KFDA drug information system for licensed herbal medicines containing each drug and its combination. As a result of laboratory experiments and experts recommendation, we found that the five effective single herbal drugs for cognitive disorders. They are Ginseng Radix, Acori Graminei Rhizoma, Cyperi Rhizoma, Coptidis Rhizoma, Pinelliae Rhizoma, Hoelen cum Pini Radix, and Rehmanniae Radix Preparata(Pinelliae Rhizoma, Hoelen cum Pini Radix, and Rehmanniae Radix Preparata were tied for $5^{th}$). And licensed herbal prescriptions derived from the planned search are Palbohoichoon-tang, Taehwa-hwan, Bosim-hwan, and so on. Among these, in consideration of the feasibility of research and possibility of success in development, Yukgunja-tang, Samhwangjichul-hwan can be selected as future study subjects. Through experimental studies and expert recommendations, we have derived herbal prescriptions that can be effective in treating cognitive disorders from licensed herbal medicines.

• Genes and Genomics
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• 제40권12호
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• pp.1351-1361
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• 2018

A new cold tolerant germplasm resource named glutinous rice 89-1 (Gr89-1, Oryza sativa L.) can overwinter using axillary buds, with these buds being ratooned the following year. The overwintering seedling rate (OSR) is an important factor for evaluating cold tolerance. Many quantitative trait loci (QTLs) controlling cold tolerance at different growth stages in rice have been identified, with some of these QTLs being successfully cloned. However, no QTLs conferring to the OSR trait have been located in the perennial O. sativa L. To identify QTLs associated with OSR and to evaluate cold tolerance. 286 $F_{12}$ recombinant inbred lines (RILs) derived from a cross between the cold tolerant variety Gr89-1 and cold sensitive variety Shuhui527 (SH527) were used. A total of 198 polymorphic simple sequence repeat (SSR) markers that were distributed uniformly on 12 chromosomes were used to construct the linkage map. The gene ontology (GO) annotation of the major QTL was performed through the rice genome annotation project system. Three main-effect QTLs (qOSR2, qOSR3, and qOSR8) were detected and mapped on chromosomes 2, 3, and 8, respectively. These QTLs were located in the interval of RM14208 (35,160,202 base pairs (bp))-RM208 (35,520,147 bp), RM218 (8,375,236 bp)-RM232 (9,755,778 bp), and RM5891 (24,626,930 bp)-RM23608 (25,355,519 bp), and explained 19.6%, 9.3%, and 11.8% of the phenotypic variations, respectively. The qOSR2 QTL displayed the largest effect, with a logarithm of odds score (LOD) of 5.5. A total of 47 candidate genes on the qOSR2 locus were associated with 219 GO terms. Among these candidate genes, 11 were related to cell membrane, 7 were associated with cold stress, and 3 were involved in response to stress and biotic stimulus. OsPIP1;3 was the only one candidate gene related to stress, biotic stimulus, cold stress, and encoding a cell membrane protein. After QTL mapping, a total of three main-effect QTLs-qOSR2, qOSR3, and qOSR8-were detected on chromosomes 2, 3, and 8, respectively. Among these, qOSR2 explained the highest phenotypic variance. All the QTLs elite traits come from the cold resistance parent Gr89-1. OsPIP1;3 might be a candidate gene of qOSR2.

• 대한한의학회지
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• 제31권1호
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• pp.162-173
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• 2010

Objectives: In order to confirm a remedial effect and related influence of the clinic treatment by prescribing herb medicines to hypertensives experiencing angiotensin converting enzyme (ACE) inhibitor dosage and suffering from common side effect generally known as dry cough. Methods: 1. We selected the 19 patients who visited National Oriental Medical Center, from August 21, 2007 to August 16, 2008 and suffering from dry cough caused by taking ACE inhibitor, with no other possible diseases causing dry cough. 2. We separated the 19 patients into two groups (Type 1: Bi-Qi hie (脾氣虛) group prescribed Samchuljojung-tang & Type 2: Qi-hie dam-wul (氣虛痰鬱) group prescribed Samsoumgamibang). 3. We then observed the symptom level and post-treatment effect, and recorded changes of dry cough intensity level for each group. Results: 1. Type 1: In the survey of 12 patients, initial level recorded 16.33 at entry diagnosis, and next level meant changing of symptoms, recorded as 2.75 at Stage 1 and reaching 3.33 at Stage 2. 2. Type 2: 7 patients, with initial level recorded as 18.71 at entry diagnosis, and 1.86 at Stage 1 and reaching to 3.29 at Stage 2. 3. No additional prescriptions were issued at Stage 2 or afterwards, and final result indicates that the mean value ended at 3.95 in the total group. Conclusions: It is concluded that there is a significant remedial effect and related influence of the clinic treatment between the Oriental medicine treatment and one of the common side effects of ACE inhibitor, dry cough.

• 대한한방내과학회지
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• 제10권1호
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• pp.65-80
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• 1989

About Oui-Ga-Sil(胃家實) in order to considerate the contents recorded in Nai-Gyung Sang-Han-Lon and latter literature, definition, etiopathology, syndrome, differential diagnosis, therapy, Prognosis and prevention were classified. And the results were as follows: 1. Oui-Ga(胃家)was a term which indicated the whole digestive system such as stomach, small intestine, large intestine, rectum and anus. Sil(實)could be defined as the peculiar concept pertaining to the acute and last stage which was invaded to inside bowels because of abundance with evil influence. 2. Eliology of Oui-Ga-Sil was abunt gastric fever originally, injured mucus because of mistreatment, the invasion to inside of outside evil influence through meridian. Pathology was the opening and shutting appearance of gastric abundance with intestinal emptiness, and intestinal abundance with gastric emptiness, Oui-Ga-Sil could be occurred because of gastric abundant dryness and splenic humidifying capacity decrease. 3. Symptom of Oui-Ga-Sil was classified as for the sunlight outside syndrome and the inside abundant syndrome. The sunlight outside syndrome was body fever, sweating, no chilling, on the contrary hatred of fever. The chief complaint of inside abundant syndrome was daily fever, talking in delirium, hand and foot sweating, abdominal distention, difficult defection and those could be pertained to sunlight bowel syndrome. 4. Diagnostic views of Oui-Ga-Sil were that pulse was descending abundant large strong and smooth quick, a coated tongue was yellow, deep yellow, old yellow, thick, scorching dry rough or gray black. On abdominal diagnosis, pressing by hand, patient was conscious of pain, excessive pain, rejection against press, impossible press or intermittent abdominal pain and bowel cutting pain without press. 5. Differential diagnosis was that the sunlight of Nai-Gyung-Fever-Theory was outside desease making meridian the prime object, Baik-Ho-Tang syndrome was making figureless abundant fever the pivotal point. And important differential standard of splenic shrink syndrome was that a daily fever, an irritation with fever were not occurred. 6. Theory of Oui-Ga-Sil was that Seng-Gi-Tang classes had been used in attacking downward or making balance, and moxibustion on Jung-Wan, honey boiling induction theory had been also used. Attacking downward therapy was invigorating method to preserve mucus, and if mucus had been exausted with complicating emptiness prognosis had been appeared badly. 7. Preventing from Oui-Ga-Sil diet by rule, fitness to cold and warmth may be needed to prevent outside evil influence attack and inside evil influence occurrence. Prudence with being very busy, fatigue, wine and woman may be also needed not to be an injury to splanic and gastric spirit.

• 생태와환경
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• 제37권1호통권106호
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• pp.47-56
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• 2004

영양염 (N, P, Si, Fe) 결핍이 팔당호내 서로 다른 3개지점의 식물플랑크톤 군집(>10 ${\mu}m$)에 어떠한 영향을 미치는지 파악하기 위하여 채수한 현장수를 결핍배지에서 일정시간 배양한 후 대조군과 비교 조사하였다. 조사결과, 현장수는 공히 영양물질과 현장수 증류에 따라 서로 다른 종 천이 및 생물량을 나타냈다. 영양염 결핍에 따른 천이는 N, P, Si 결핍군에서는 속(genus)수준에서, Fe결핍에서는 종(species) 수준에서 일어났다. 특히 Fe결핍에서 남조 Microcystis aeruginosa, N 결핍에서 Anabaena의 발달은 매우 흥미로운 결과이다. 또한 모든 결핍군에서 뚜렷한 성장저해 현상을 보였으나 Si 결핍군에서는 생물량 변동이 거의 없었다. 식물플랑크톤 군집은 영양염결핍과 채수지점에 따라 차이를 보였는데, 전체적으로 N,P 결핍군에서는 우점도 감소 및 다양도 증가를 보였으며,Si,Fe 결핍군과는 반대 결과를 보였다. 따라서 영양염 결핍은 조사지점에 따라 다소 차이를 보였으나 식물플랑크톤 종 천이, 생물량 변동 등의 뚜렷한 군집변화를 유도함으로서 수계내 문제조류의 근본적 해결의 가능성을 시사해 주었다.

• Nuclear Engineering and Technology
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• 제54권6호
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• pp.2023-2030
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• 2022

A novel pulse fitting analysis (PFA) method is presented for the acquisition of nuclear spectra. The charging process of the feedback capacitor in the resistive feedback charge-sensitive preamplifier is equivalent to the impulsive pulse, and its impulse response function (IRF) can be obtained by non-linear fitting of the falling edge of the nuclear pulse. The integral of the IRF excluding the baseline represents the energy deposition of the particles in the detector. In addition, since the non-linear fitting process in PFA method is difficult to achieve in the conventional architecture of spectroscopy system, a new multi-channel analyzer (MCA) based on Zynq SoC is proposed, which transmits all the data of nuclear pulses from the programmable logic (PL) to the processing system (PS) by high-speed AXI-Stream in order to implement PFA method with precision. The linearity of new MCA has been tested. The spectrum of ¹³⁷Cs was obtained using LaBr₃(Ce) scintillator detector, and was compared with commercial MCA by ORTEC. The results of tests indicate that the MCA based on PFA method has the same performance as the commercial MCA based on pulse height analysis (PHA) method and excellent linearity for γ-rays with different energies, which infers that PFA method is an effective and promising method for the acquisition of spectra. Furthermore, it provides a new solution for nuclear pulse processing algorithms involving regression and iterative processes.

• Journal of Microbiology and Biotechnology
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• 제18권2호
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• pp.299-307
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• 2008

Soybean seed ferritin is essential for human iron supplementation and iron deficiency anemia prevention because it contains abundant bioavailable iron and is frequently consumed in the human diet. However, it is poorly understood in regards its several properties, such as iron mineralization, subunit assembly, and protein folding. To address these issues, we decided to prepare the soybean seed ferritin complex via a recombinant DNA approach. In this paper, we report a rapid and simple Escherichia coli expression system to produce the soybean seed ferritin complex. In this system, two subunits of soybean seed ferritin, H-2 and H-1, were encoded in a single plasmid, and optimal expression was achieved by additionally coexpressing a team of molecular chaperones, trigger factor and GroEL-GroES. The His-tagged ferritin complex was purified by $Ni^{2+}$ affinity chromatography, and an intact ferritin complex was obtained following His-tagged enterokinase (His-EK) digestion. The purified ferritin complex synthesized in E. coli demonstrated some reported features of its native counterpart from soybean seed, including an apparent molecular weight, multimeric assembly, and iron uptake activity. We believe that the strategy described in this paper may be of general utility in producing other recombinant plant ferritins built up from two types of subunits.