• Toxicological Research
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• v.35 no.4
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• pp.295-301
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• 2019

In this review, we describe the absorption rates (Caco-2 cell permeability) and hepatic/plasma pharmacokinetics of 53 diverse chemicals estimated by modeling virtual oral administration in rats. To ensure that a broad range of chemical structures is present among the selected substances, the properties described by 196 chemical descriptors in a chemoinformatics tool were calculated for 50,000 randomly selected molecules in the original chemical space. To allow visualization, the resulting chemical space was projected onto a two-dimensional plane using generative topographic mapping. The calculated absorbance rates of the chemicals based on cell permeability studies were found to be inversely correlated to the no-observed-effect levels for hepatoxicity after oral administration, as obtained from the Hazard Evaluation Support System Integrated Platform in Japan (r = -0.88, p < 0.01, n = 27). The maximum plasma concentrations and the areas under the concentration-time curves (AUC) of a varied selection of chemicals were estimated using two different methods: simple one-compartment models (i.e., high-throughput toxicokinetic models) and simplified physiologically based pharmacokinetic (PBPK) modeling consisting of chemical receptor (gut), metabolizing (liver), and central (main) compartments. The results obtained from the two methods were consistent. Although the maximum concentrations and AUC values of the 53 chemicals roughly correlated in the liver and plasma, inconsistencies were apparent between empirically measured concentrations and the PBPK-modeled levels. The lowest-observed-effect levels and the virtual hepatic AUC values obtained using PBPK models were inversely correlated (r = -0.78, p < 0.05, n = 7). The present simplified PBPK models could estimate the relationships between hepatic/plasma concentrations and oral doses of general chemicals using both forward and reverse dosimetry. These methods are therefore valuable for estimating hepatotoxicity.

• The Korean Journal of Physiology and Pharmacology
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• v.23 no.6
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• pp.529-537
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• 2019

Lung cancer is the most common cause of cancer deaths worldwide and several molecular signatures have been developed to predict survival in lung cancer. Increasing evidence suggests that proliferation and migration to promote tumor growth are associated with dysregulated ion channel expression. In this study, by analyzing high-throughput gene expression data, we identify the differentially expressed $K^+$ channel genes in lung cancer. In total, we prioritize ten dysregulated $K^+$ channel genes (5 up-regulated and 5 down-regulated genes, which were designated as K-10) in lung tumor tissue compared with normal tissue. A risk scoring system combined with the K-10 signature accurately predicts clinical outcome in lung cancer, which is independent of standard clinical and pathological prognostic factors including patient age, lymph node involvement, tumor size, and tumor grade. We further indicate that the K-10 potentially predicts clinical outcome in breast and colon cancers. Molecular signature discovered through $K^+$ gene expression profiling may serve as a novel biomarker to assess the risk in lung cancer.

• Journal of Korea Port Economic Association
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• v.23 no.2
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• pp.121-144
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• 2007

In general, the design of container yard and container handling system on container terminal are focused on operation of shipside than service about chassis from outside(C/O). It is not efficient for chassis from outside. The purpose of this paper is functional assessment of efficient container terminal and for higher performance of container terminal. first, the items which are concerned with container handling at the planning of container terminal are investigated and extracted through the practical data analysis of container terminal. Also, verified problems of planning and present condition through the functional assessment. Secondly, the improvements for container throughput in container yard are proposed and examined the effectiveness of improvements about queuing time of chassis from outside and service time of transfer crane by the evaluation decision model based upon multi criteria objectives.

• Journal of the Korea Society of Computer and Information
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• v.15 no.9
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• pp.1-8
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• 2010

The key challenge in HW/SW co-design is how to choose the appropriate HW/SW partitioning from the vast array of possible options in the mapping set. In this paper we present a unique and efficient approach for addressing this problem known as Customized Heuristic Algorithm for Reducing Mapping Sets(CHARMS). CHARMS uses sensitivity to individual task computational complexity as well the computed weighted values of system performance influencing metrics to streamline the mapping sets and extract the most optimal cases. Using H.263 encoder, we show that CHARMS sieves out 95.17% of the sub-optimal mapping sets, leaving the designer with 4.83% of the best cases to select from for run-time implementation.

• KIPS Transactions on Computer and Communication Systems
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• v.10 no.12
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• pp.311-318
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• 2021

With the rapid development of the Internet of Things(IoT) technology recently, multi-access edge computing(MEC) is emerged as a next-generation technology for real-time and high-performance services. High mobility of users between MECs with limited service areas is considered one of the issues in the MEC environment. In this paper, we consider a vehicle edge computing(VEC) environment which has a high mobility, and propose a task migration algorithm to decide whether or not to migrate and where to migrate using DQN, as a reinforcement learning method. The objective of the proposed algorithm is to improve the system throughput while satisfying QoS(Quality of Service) requirements by minimizing the difference between queueing delays in vehicle edge computing servers(VECSs). The results show that compared to other algorithms, the proposed algorithm achieves approximately 14-49% better QoS satisfaction and approximately 14-38% lower service blocking rate.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.10
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• pp.3834-3857
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• 2021

The design of cluster-based routing protocols is necessary for Wireless Sensor Networks (WSN). But, due to the lack of features, the traditional methods face issues, especially on unbalanced energy consumption of routing protocol. This work focuses on enhancing the security and energy efficiency of the system by proposing Energy Efficient Based Secure Routing Protocol (EESRP) which integrates trust management, optimization algorithm and key management. Initially, the locations of the deployed nodes are calculated along with their trust values. Here, packet transfer is maintained securely by compiling a Digital Signature Algorithm (DSA) and Elliptic Curve Cryptography (ECC) approach. Finally, trust, key, location and energy parameters are incorporated in Particle Swarm Optimization (PSO) and meta-heuristic based Harmony Search (HS) method to find the secure shortest path. Our results show that the energy consumption of the proposed approach is 1.06mJ during the transmission mode, and 8.69 mJ during the receive mode which is lower than the existing approaches. The average throughput and the average PDR for the attacks are also high with 72 and 62.5 respectively. The significance of the research is its ability to improve the performance metrics of existing work by combining the advantages of different approaches. After simulating the model, the results have been validated with conventional methods with respect to the number of live nodes, energy efficiency, network lifetime, packet loss rate, scalability, and energy consumption of routing protocol.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.6
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• pp.2964-2985
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• 2019

Global data center IP traffic is expected to reach 20.6 zettabytes (ZB) by the end of 2021. Intra-data center networks (Intra-DCN) will account for 71.5% of the data center traffic flow and will be the largest portion of the traffic. The understanding of traffic distribution in IntraDCN is still sketchy. It causes significant amount of bandwidth to go unutilized, and creates avoidable choke points. Conventional transport protocols such as Optical Packet Switching (OPS) and Optical Burst Switching (OBS) allow a one-sided view of the traffic flow in the network. This therefore causes disjointed and uncoordinated decision-making at each node. For effective resource planning, there is the need to consider joining the distributed with centralized management which anticipates the system's needs and regulates the entire network. Methods derived from Kalman filters have proved effective in planning road networks. Considering the network available bandwidth as data transport highways, we propose an intelligent enhanced SDN concept applied to OBS architecture. A management plane (MP) is added to conventional control (CP) and data planes (DP). The MP assembles the traffic spatio-temporal parameters from ingress nodes, uses Kalman filtering prediction-based algorithm to estimate traffic demand. Prior to packets arrival at edges nodes, it regularly forwards updates of resources allocation to CPs. Simulations were done on a hybrid scheme (1+1) and on the centralized OBS. The results demonstrated that the proposition decreases the packet loss ratio. It also improves network latency and throughput-up to 84 and 51%, respectively, versus the traditional scheme.

• Journal of The Korean Society For Urban Railway
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• v.6 no.4
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• pp.279-286
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• 2018

Recently, a safety control platform to monitor the safety of train operation in real time and prevent accidents and risks through control is under study. In the initial design, DDS communication method supporting distributed network is adopted for real-time processing of large amount of data according to the integration of existing distributed safety data. However, communication between server and console inside the safety control platform is applied to existing TCP socket communication. In the case of TCP socket communication, it is possible to process data for a small system of a safety control test bed by one-to-one communication. However, if the data is expanded all over the country in the future, it becomes difficult to cope with a case where communication traffic occurs due to vast amount of data. In this paper, we propose DDS communication method to support distributed network between server and console of security control platform, and demonstrate TCP socket and DDS method, and compare throughput and speed. As a result, we have found that the scalability and flexibility are improved in case of applying DDS communication to future systems.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.18 no.7
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• pp.56-62
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• 2019

The high-precision laser scriber carries out scribing alumina ceramic substrates for manufacturing ultra-small chip resistors. The ceramic substrates are loaded, aligned, scribed, transferred, and unloaded. The entire process is fully automated, thereby minimizing the scribing cycle time of the ceramic substrates and improving the throughput. The scriber consists of the laser optical system, pick-up module of ceramic substrates, pre-alignment module, TH axis drive work table, automation module for substrate loading / unloading, and high-speed scribing control S/W. The loader / unloader unit, which has the greatest influence on the scribing cycle time of the substrates, carries the substrates to the work table that carries out the cutting line work by driving the X and Y axes as well as by adsorbing the ceramic substrates. The loader / unloader unit consists of the magazine up / down part, X-axis drive part for conveying the substrates to the left and right direction, and the vision part for detecting the edge of the substrate for the primary pre-alignment of the substrates. In this paper, the laser scribing machining simulation is performed by applying the instrument mechanism of each component module. Through this study, the scribing machining process is first verified by analyzing the process operation and work area of each module in advance. In addition, the scribing machining process is optimized by comparing and analyzing the scribing cycle time of one ceramic substrate according to the alignment stage module speed.

• Journal of IKEEE
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• v.23 no.1
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• pp.58-67
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• 2019

A design of an elliptic curve cryptography (ECC) processor that supports both pseudo-random curves and Koblitz curves over $GF(2^m)$ defined by the NIST standard is described in this paper. A finite field arithmetic circuit based on a word-based Montgomery multiplier was designed to support five key lengths using a datapath of fixed size, as well as to achieve a lightweight hardware implementation. In addition, Lopez-Dahab's coordinate system was adopted to remove the finite field division operation. The ECC processor was implemented in the FPGA verification platform and the hardware operation was verified by Elliptic Curve Diffie-Hellman (ECDH) key exchange protocol operation. The ECC processor that was synthesized with a 180-nm CMOS cell library occupied 10,674 gate equivalents (GEs) and a dual-port RAM of 9 kbits, and the maximum clock frequency was estimated at 154 MHz. The scalar multiplication operation over the 223-bit pseudo-random elliptic curve takes 1,112,221 clock cycles and has a throughput of 32.3 kbps.