• The Transactions of the Korea Information Processing Society
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• v.3 no.1
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• pp.200-210
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• 1996

Re-engineering has the potential to improve software productivity and quality y across the entire life cycle. It involves improving the software maintenance process and improving existing systems by applying new technologies and tools to software maintenance. Re-engineering can help us understanding existing systems and discover software components(e.g., design structure, data structure that are common across systems. These common components then can be reused in the development (or redevelopment )of systems, thereby significantly shortening the time and lessening the risk of developing systems. The Object-Oriented paradigm has been known to improve software maintainability. There still exist many problems in recognizing object, attributes and operations that are conceptually integrated and constructing of object class. In this paper, we propose a method that defines a fundamental theories of re-engineering and a concept recognition for object- oriented paradigm. We also describe the re-engineering tool that translates the existing procedure-oriented program into object-oriented system. This tool has a strength to solve the conceptual integrity problem in object-oriented recognition.

• Korean Journal of Poultry Science
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• v.35 no.3
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• pp.225-240
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• 2008

Marek's disease virus(MDV) is a highly cell-associated, lymphotropic $\alpha$-herpesvirus that causes paralysis and neoplastic disease in chickens. The disease has been controlled by vaccination which was provided the first evidence for a malignant cancer being controlled by an antiviral vaccine. Marek's disease pathogenesis is complex, involving cytolytic and latent infection of lymphoid cells and oncogenic transformation of $CD4^+$ T cells in susceptible chickens. MDV targets a number of different cell types during its life cycle. Lymphocytes play an essential role, although within them virus production is restricted and only virion are produced. Innate and adaptive immune responses develop in response to infection, but infection of lymphocytes results in immunosuppressive effects. Hence in MDV-infected birds, MDV makes its host more vulnerable to tumour development as well as to other pathogens. All chickens are susceptible to MDV infection, and vaccination is essential to protect the susceptible host from developing clinical disease. Nevertheless, MDV infects and replicates in vaccinated chickens, with the challenge virus being shed from the feather-follicle epithelium. The outcome of infection with MDV depends on a complex interplay of factors involving the MDV pathotype and the host genotype. Host factors that influence the course of MD are predominantly the responses of the innate and adaptive immune systems, and these are modulated by: age at infection and maturity of the immune system; vaccination status; the sex of the host; and various physiological factors.

• Korean Journal of Construction Engineering and Management
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• v.11 no.5
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• pp.53-64
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• 2010

Remodeling becomes the significant issue in the aspect of the resource recycling, because it does not demolishes the whole buildings, but a part of main structure. However, compared with new construction, remodeling has several problems of adding the repair and rehabilitation works, using the partial demolition method, and having difficulties of making decision due to disagreement between several owner organizations. BIM, which is the total solution for managing and producing information during whole life cycle of the buildings, seems to be the right solution for the way to address these issues. has a possibility for solving the problems. Therefore this paper provided the framework and database for applying the BIM in the remodeling, and proved the applicability of the BIM database in the remodeling project through the case studies.

• BMB Reports
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• v.53 no.3
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• pp.166-171
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• 2020

A chemical library comprising 2,354 drug-like compounds was screened using a transcription and replication-competent viruslike particle (trVLP) system implementing the whole Ebola virus (EBOV) life cycle. Dose-dependent inhibition of Ebola trVLP replication was induced by 15 hit compounds, which primarily target different types of G protein-coupled receptors (GPCRs). Based on the chemical structure, the compounds were divided into three groups, diphenylmethane derivatives, promazine derivatives and chemicals with no conserved skeletons. The third group included sertindole, raloxifene, and ibutamoren showing prominent antiviral effects in cells. They downregulated the expression of viral proteins, including the VP40 matrix protein and the envelope glycoprotein. They also reduced the amount of EBOV-derived tetracistronic minigenome RNA incorporated into progeny trVLPs in the culture supernatant. Particularly, ibutamoren, which is a known agonist of growth hormone secretagogue receptor (GHSR), showed the most promising antiviral activity with a 50% effective concentration of 0.2 μM, a 50% cytotoxic concentration of 42.4 μM, and a selectivity index of 222.8. Here, we suggest a strategy for development of anti-EBOV therapeutics by adopting GHSR agonists as hit compounds.

• Fisheries and Aquatic Sciences
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• v.19 no.9
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• pp.41.1-41.7
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• 2016

Background: The transgenic approach using estrogen-responsive regulator in fish has been given much attention as a potential means to detect and/or address estrogen-related aquatic pollutions. In order to address the development stage- and reproduction status-dependent expression patterns of the chgH-rfp transgene (red fluorescent protein transgene driven by choriogenin H promoter) in marine medaka Oryzias dancena, naturally occurring red fluorescent protein (RFP) signals under non-exposed conditions as well as the transgenically induced RFP signals under estrogen-exposed conditions were assayed. Results: Female transgenics begun to show naturally occurring RFP signals from the age of 7 weeks post hatching (WPH) without experimental estrogen exposure. Afterward, these RFP signals in female transgenics became robust with the progress of ovarian maturation. On the other hand, male transgenics did not show any naturally occurring RFP signal under non-exposed conditions irrespective of developmental stages and maturation statue. Upon exposures using estradiol-$17{\beta}$ (E2) and $17{\alpha}$-ethinylestradiol (EE2), RFP signals were significantly induced specifically in the livers of transgenic males. Conclusions: Male chgH-rfp transgenics were able to keep the "off" state of RFP expression during their entire life cycle unless exposed to exogenous estrogens. Owing to their tight regulation capability of estrogen-responsive transgene, transgenesis of chgH-rfp in male marine medaka could offer a useful model system for future ecotoxicogenomic studies regarding estrogenicity-related issues in aquatic and marine environments.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.9
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• pp.389-400
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• 2020

A construction project is a designed product made up of labors, materials, and installations in the project positioned on the ground and may include the underground and ground section, and the section in water or on the water surface. It is a civil, industrial, transport, agricultural and rural development, infrastructure, or some other. A key phase in the life cycle of these construction projects is the implementation when building products are made directly with workers, equipment, materials, and managers. If there is a lack of management experience, information, and problem-solving solutions to tackle the risks faced by contractors, especially foreign ones, will fail in controlling the project's cost. This study was conducted with investigations, discussions, and evaluation of the factors that lead to cost overruns in the construction projects of international contractors in Vietnam. The principal component analysis (PCA) showed that those factors that influence cost overruns these construction projects fall into five general groups, including factors related to (i) the owners, (ii) the foreign contractors, (iii) the subcontractors and suppliers, (iv) state management, and (v) the project itself. Besides, the study proposes solutions to limit cost overruns in construction projects and improve the profitability of international contractors in Vietnam.

• Journal of KIISE:Computing Practices and Letters
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• v.7 no.1
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• pp.38-47
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• 2001

PDM is an integrated solution for managing various kinds of document and information for a whole life~cycle of product management. PDM system spans a huge and complex area and requires so many efforts and budgets for development. A framework has been considered a promising way to improve productivity by reusing the software architecture, not just one part of the design or just source code. This was the reaSon why we developed PDM (Product Data Management) framework. Framework can reduce the time and efforts to develop a new PDM application. However, it also requires supporting environment since a framework is a big set of classes where their interactions are so complex. With this supporting environment, it is easy to understand the framework at a glance and easy to identify what hot spots to be refined to meet new requirements. In this paper, a new framework-supporting reuse environment based on the meta-repository was constructed for easy and convenient reuse.

• Journal of KIISE:Computing Practices and Letters
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• v.8 no.6
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• pp.657-668
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• 2002

Software life cycle consists of requirement analysis, design, implementation, and maintenance phases, and the product of each phase has various format. The UML normalizes such products, and the class diagram, use case diagram, activity diagram and collaboration diagram are usually used for the requirement analysis phase. Because most of UML development tools store such diagrams in a file, there nay be some difficulties of information retrieval and co-work among users. To cope with the difficulties, this paper proposes a database supported methodology to store and manage the diagrams produced by the requirement analysis. In this methodology, the constituents of class, use case, activity and collaboration diagram are first analyzed and then transformed in the form of relational fables. The constituents of such diagrams are stored as tables in a database, and can be easily retrieved from the database by using some queries. This database supported methodology provides the concurrent sharing and high reuse of diagrams.

• STI Policy Review
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• v.8 no.1
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• pp.41-61
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• 2017

The literature in research policy extensively addresses the interaction between public R&D and the society. Scholars have paid particular attention to the way science and technology are diffused into the society and industry with the aim of substantiating their potential value. In practice, having recognized the importance of the said interaction, R&D entities and governmental organizations promote scientific and technological innovations that result from their R&D activities. Yet, the nature of news media exposure as their primary channel to promote R&D outcomes has been remarkably understudied. Using the results of R&D projects supported by the National Research Foundation of Korea (NRF), this study examines R&D entities' strategic use of the news media to publicize their outcomes. The empirical results suggest that the scale of an R&D project positively affects the counts of media exposure of its R&D outcomes, whereas the level of technology readiness and the technology life-cycle do not have significant influence. In addition, the results suggest that, compared to senior researchers, young researchers are more likely to publicize their R&D outcomes and that R&D outcomes from highly ranked universities are more likely to be publicized than those from lower-ranking universities despite our control for R&D outcomes. The aforementioned results suggest that in promoting the diffusion of science and technology, especially to the public, policymakers should be concerned about incentives for those who provide techno-scientific information, such as researchers. The social need for the diffusion of techno-scientific information into the public (e.g., technology transfer and diffusion) is an insignificant factor in determining the media exposure of such information, whereas personal benefits and sensitive issues related to a researcher's own R&D activities (e.g., justification for R&D activities) drive researchers to publicize their R&D outcomes. This paper suggests that policymakers, especially those concerned with better diffusion of scientific and technological innovations need to design a proper incentive system to maximize the societal benefits of media exposure.

• Journal of Korean Society of Archives and Records Management
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• v.16 no.3
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• pp.235-256
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• 2016

This study suggested a digital curation framework for supporting the digital policy of institutes that collect memory. As such, it conducted a literature review and an analysis of digital curation models, as well as a focus-group interview of historians and graduate students majoring in historical studies. In this study, digital curation framework refers to an abstract model for supporting policy development and the planning for a high-level view of the archival information service. This implications of this framework are as follows: (1) to emphasize the data life cycle and connection between stages and actions; (2) to make an infra-schema for understanding institutes that create, arrange, or store specific data as the same history contents have to be provided by different institutes and as there are differences in the data's value; (3) to check the present conditions of information services and their systems; (4) to consider the practical applications of contents that have been collected and stored; and (5) to converge all data in one system through the framework and activate diverse works in the context of the framework.