• Journal of Korean Neurosurgical Society
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• v.47 no.4
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• pp.287-290
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• 2010

Objective : The authors evaluated the accuracies and ease of use of several commonly used microanastomosis training models (synthetic tube, chicken wing, and living rat model). Methods : A survey was conducted among neurosurgeons and neurosurgery residents at a workshop held in 2009 at the authors' institute. Questions addressed model accuracy (similarity to real vessels and actual procedures) and practicality (availability of materials and ease of application in daily practice). Answers to each question were rated using a 5-point scale. Participants were also asked what types of training methods they would chose to improve their skills and to introduce the topic to other neurosurgeons or neurosurgery residents. Results : Of the 24 participants, 20 (83.3%) responded to the survey. The living rat model was favored for model accuracy (p<0.001; synthetic tube $-0.95{\pm}0.686$, chicken wing, $0.15{\pm}0.587$, and rat, $1.75{\pm}0.444$) and the chicken wing model for practicality (p<0.001; synthetic tube $-1.55{\pm}0.605$, chicken wing, $1.80{\pm}0.523$, and rat,$1.30{\pm}0.923$). All (100%) chose the living rat model for improving their skills, and for introducing the subject to other neurosurgeons or neurosurgery residents, the chicken wing and living rat models were selected by 18 (90%) and 20 (100%), respectively. Conclusion : Of 3 methods examined, the chicken wing model was found to be the most practical, but the living rat model was found to represent reality the best. We recommend the chicken wing model to train surgeons who have mastered basic techniques, and the living rat model for experienced surgeons to maintain skill levels.

• Interdisciplinary Bio Central
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• v.3 no.4
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• pp.15.1-15.11
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• 2011

Background: Histone deacetylase (HDAC) 8 is one of its family members catalyzes the removal of acetyl groups from N-terminal lysine residues of histone proteins thereby restricts transcription factors from being expressed. Inhibition of HDAC8 has become an emerging and effective anti-cancer therapy for various cancers. Application computational methodologies may result in identifying the key components that can be used in developing future potent HDAC8 inhibitors. Results: Facilitating the discovery of novel and potential chemical scaffolds as starting points in the future HDAC8 inhibitor design, quantitative structure-activity relationship models were generated with 30 training set compounds using genetic function approximation (GFA) and Bayesian algorithms. Six GFA models were selected based on the significant statistical parameters calculated during model development. A Bayesian model using fingerprints was developed with a receiver operating characteristic curve cross-validation value of 0.902. An external test set of 54 diverse compounds was used in validating the models. Conclusions: Finally two out of six models based on their predictive ability over the test set compounds were selected as final GFA models. The Bayesian model has displayed a high classifying ability with the same test set compounds and the positively and negatively contributing molecular fingerprints were also unveiled by the model. The effectively contributing physicochemical properties and molecular fingerprints from a set of known HDAC8 inhibitors were identified and can be used in designing future HDAC8 inhibitors.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.39 no.2
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• pp.183-194
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• 2011

Synthetic aperture radar (SAR) is widely used because of high resolution imaging capability in all weather and day/night condition. In this paper development of Spotlight SAR simulator is proposed for image quality analysis. Proposed SAR simulator is based on the SAR system design parameters so that SAR image performance can be expected which is essential throughout the full system development procedure from the initial concept design stage to the final in-flight calibration and validation stage. The raw data of ideal point target is first generated by taking account of the flight and imaging geometry and the various SAR system design parameters, and the Spotlight image formation algorithm is implemented in order to obtain the point target response. Finally the image quality of the generated raw data is analyzed in terms of spatial resolution, peak to sidelobe ratio and integrated sidelobe ratio.

• Journal of Korea Water Resources Association
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• v.46 no.5
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• pp.547-558
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• 2013

Improved methodology of Synthetic Unit Hydrograph (SUH) utilized generally in hydrologic design work was suggested. In this study, regression analysis between peak hydrological data and geospatial data was applied to estimate specific peak flow and peak time for determining shape of SUH. Regression formulas for specific peak flow with respect to shape factors show higher coefficient of determination (0.73~0.81) than the ones with geospatial components only (0.52~0.69). The areal limitation of unit hydrograph application is regarded as 500~700 $km^2$. The validation through rainfall-runoff simulation shows encouraging results that relative error is 1.7~29.0%(Avg. 11.6%) for the case of using SUH developed in this study and 35.0~ 64.9% (Avg. 46.7%) for the SUH in the previous study except for the extraordinary cases.

• Journal of Conservation Science
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• v.35 no.1
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• pp.19-31
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• 2019

To study the cleaning effects and post-treatment stability assessment of various methods of cleaning textiles with metal thread, six naturally-soiled historical textiles with metal thread were investigated at the Metropolitan Museum of Art, New York. Prior to the cleaning of fabricated gold, silver, and copper thread that had been glued onto a paper substrate, the artificial deterioration was carried out in a controlled environment with light(UV and daylight), and temperature and humidity factors which would weaken and damage the samples. A synthetic soil mixture was applied to the samples to imitate soil found on the historic and archaeological textiles with metal thread; the cleaning effect and post-treatment assessment were investigated by use of three textile cleaning methods: mechanical cleaning, wet cleaning, and solvent cleaning. While investigating the naturally-soiled textiles with metal thread, it was determined that the soil colors and sizes of contaminating particles of each textile were different due to the diversity of original environmental factors and conditions. After cleaning with kneaded rubber, Stoddard solvent, n-decane or n-hexane, a bright, clean effect was apparent. Kneaded rubber was successful in picking up both large and small particles, but its stickiness caused some of the metal leaf to peel off. Stoddard solvent produced a good cleaning effect, but after use of n-hexane and n-decane in the cleaning process, a white layer of residue remained on the textile's surface. Wet cleaning was not effective and the rapid humidity changes between wet and dry conditions caused the edges of the paper substrate to lose their original shape.

• Journal of Microbiology and Biotechnology
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• v.29 no.5
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• pp.776-784
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• 2019

Polyhydroxybutyrate (PHB), the most well-known polyhydroxyalkanoate, is a bio-based, biodegradable polymer that has the potential to replace petroleum-based plastics. Lignocellulose hydrolysate, a non-edible resource, is a promising substrate for the sustainable, fermentative production of PHB. However, its application is limited by the generation of inhibitors during the pretreatment processes. In this study, we investigated the feasibility of PHB production in E. coli in the presence of inhibitors found in lignocellulose hydrolysates. Our results show that the introduction of PHB synthetic genes (bktB, phaB, and phaC from Ralstonia eutropha H16) improved cell growth in the presence of the inhibitors such as furfural, 4-hydroxybenzaldehyde, and vanillin, suggesting that PHB synthetic genes confer resistance to these inhibitors. In addition, increased PHB production was observed in the presence of furfural as opposed to the absence of furfural, suggesting that this compound could be used to stimulate PHB production. Our findings indicate that PHB production using lignocellulose hydrolysates in recombinant E. coli could be an innovative strategy for cost-effective PHB production, and PHB could be a good target product from lignocellulose hydrolysates, especially glucose.

• Economic and Environmental Geology
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• v.53 no.6
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• pp.793-807
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• 2020

The policy for Green New Deal will promote the shift of the application to coal as feedstock from coal as fuel. Coal can be used as fuel for production of hydrogen and as feedstock materials such as synthetic graphite or activated carbon. Hydrogen is obtained from syngas produced through Steam carbon(SC), Water-Gas Shift(WGS), and Carbonation reactions, and these processes should be used in conjunction with CO2 sequestration technology. Anthracite has a potential in terms of cost advantage as a feedstock compared to a petroleum pitch, because Synthetic graphite is prepared by heat treating an anthracite with high rank to a graphitization temperature which is in the range of 2400~2800℃, in the presence of inorganic catalyst such as silicon or iron. From several studies, it has been confirmed that coal-based activated carbon(AC) is manufactured with quality similar to the large specific surface area and much micropore volume of lignin-based AC, can be prepared. Therefore it is expected that lignin-based AC is replaced to coal-based AC.

• Journal of the Korea Society for Simulation
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• v.19 no.4
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• pp.235-247
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• 2010

An environmental factor is very important in a war game model supporting military training. Most war game models in Korean armed forces apply the same weather conditions to all operation areas. As a result, it fails to derive a high-fidelity simulation result. For this reason this study attempts to develop factor techniques for a high-fidelity war game that can apply distributed synthetic atmospheric environment modeling data to a military simulation. The major developed factor technology of this study applies regional distributed precipitation data to the 2D-GIS based Simplified Detection Probability Model(SDPM) that was developed for this study. By doing this, this study shows that diversely distributed local weather conditions can be applied to a military simulation depending on the model resolution from theater level to engineering level, on the use from training model to analytical model, and on the description level from corps level to battalion level.

• Korean Journal of Remote Sensing
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• v.40 no.3
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• pp.285-293
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• 2024

This study explores the use of Sentinel-1 Synthetic Aperture Radar (SAR), processed through Google Earth Engine (GEE), to monitor changes in the areas of Antarctic ice shelves. Focusing on the Campbell Glacier Tongue (CGT) and Drygalski Ice Tongue (DIT),the research utilizes GEE's cloud computing capabilities to handle and analyze large datasets. The study employs Otsu's method for image binarization to distinguish ice shelves from the ocean and mitigates detection errors by averaging monthly images and extracting main regions. Results indicate that the CGT area decreased by approximately 26% from January 2016 to January 2024, primarily due to calving events,while DIT showed a slight increase overall,with notable reduction in recent years. Validation against Sentinel-2 optical images demonstrates high accuracy,underscoring the effectiveness of SAR and GEE for continuous, long-term monitoring of Antarctic ice shelves.

• Journal of the Korean Society of Marine Environment & Safety
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• v.13 no.4
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• pp.21-26
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• 2007

A study on analysis and application of ocean currents information extracted from SAR (Synthetic Aperture Radar) satellite image. The current information extracted from SAR satellite image is not real vector information but scalar information in normal direction of orbital path. To correct current information extracted from satellite image, observation of currents in the field is carried out at the same time and area as those of satellite image. In the analysis, current information extracted from satellite image is corrected by using observed ones. By this correction, the speed and the direction of current can be estimated. The extract current information seem to agree well with the observed ones.