• 제목/요약/키워드: Suzuki group

검색결과 62건 처리시간 0.021초

Cross-Coupling Reaction of 2-halo1-methyl-1H-imidazo[4,5-b]pyridine Offers a New Synthetic Route to Mutagenic Heterocyclic Amine-PHIP and DMIP

  • Sajith, Ayyiliath M.;Muralidharan, Arayambath;Karuvalam, Ranjith P.;Haridas, Karickal R.
    • 대한화학회지
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    • 제57권3호
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    • pp.361-364
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    • 2013
  • A modified synthetic approach to the synthesis of heterocyclic food mutagens, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PHIP) and 2-amino-1,6-dimethylimidazo[4,5-b]pyridine (DMIP) is reported. This route highlights an optimized palladium catalysed Buchwald cross-coupling of 2-halo-1-methyl-imidazo[4,5-b]pyridine with benzophenoneimine followed by acidic hydrolysis to yield compound 7. Using finely tailored conditions, Suzuki cross-coupling reactions with highly efficient catalytic systems were performed as the final step on 8 to introduce the aryl group and methyl group on the heterocyclic core.

Reproductive Ecology of Korean Chipmunks in Busan

  • Suzuki, Ken-Ichi;Masaki, Mika;Han, Chang-Wook;Yoon, Myung-Hee;Kawamichi, Mieko;Kawamichi, Takeo
    • 한국생명과학회:학술대회논문집
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    • 한국생명과학회 2002년도 제35회 학술심포지움 및 춘계학술대회
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    • pp.92-92
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    • 2002
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Representations of the Braid Group and Punctured Torus Bundles

  • Morifuji, Takayuki;Suzuki, Masaaki
    • Kyungpook Mathematical Journal
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    • 제49권1호
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    • pp.7-14
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    • 2009
  • In this short note, we consider a family of linear representations of the braid group and the fundamental group of a punctured torus bundle over the circle. We construct an irreducible (special) unitary representation of the fundamental group of a closed 3-manifold obtained by the Dehn filling.

A NEW CHARACTERIZATION OF $A_p$ WHERE p AND p-2 ARE PRIMES

  • Iranmanesh, A.;Alavi, S.H.
    • Journal of applied mathematics & informatics
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    • 제8권3호
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    • pp.889-897
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    • 2001
  • Based on the prime graph of a finite simple group, its order is the product of its order components (see[4]). It is known that Suzuki-Ree groups [6], $PSL_2(q)$ [8] and $E_8(q)$ [7] are uniquely deternubed by their order components. In this paper we prove that the simple groups $A_p$ are also unipuely determined by their order components, where p and p-2 are primes.

마이크로파와 금속 촉매를 이용한 Pyrrolo[3,2-d]-pyrimidine 유도체의 다양화 (Diversification of 4,5-disubstituted Pyrrolo[3,2-d]-pyrimidines by Microwave Assisted Metal Catalyzed Reaction)

  • 변정섭;염을균;김영준
    • 대한화학회지
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    • 제66권6호
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    • pp.442-450
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    • 2022
  • 생리학적 활성을 보일 것으로 기대되는 다양한 pyrrolopyrimidine 유도체를 O-arylation과 Suzuki 짝지움 반응을 통해 합성하였다. 금속 촉매 Cu를 사용하고 마이크로파 조사 조건에서O-arylation을 성공적으로 진행하여 pyrrolo[3,2-d]pyrimidine의 4번 위치에 phenol기를 도입할 수 있었다. 또한, 금속촉매 Pd를 사용하는 Suzuki짝지움 반응도 마이크로파를 사용하여 pyrrolo[3,2-d]pyrimidine의 4번 위치에 aryl 기를 도입할 수 있었다. 유도체의 다양화를 위한 반응 조건으로 마이크로파를 사용함으로써 긴 반응 시간과 열전달 효율성 문제를 가지고 있는 전통적인 열 반응의 단점을 획기적으로 극복할 수 있었다. 본 연구 결과는 신약개발 연구에 중요한 역할을 할 것으로 기대되는 pyrrolo[3,2-d]pyrimidine 유도체를 다양화하는데 사용할 수 있다.

Bending Strength of Textured Alumina Prepared by Slip Casting in a Strong Magnetic Field

  • Suzuki, Tohru S.;Uchikoshi, Tetsuo;Morita, Koji;Hirage, Keijiro;Sakka, Yoshio
    • 한국분말야금학회:학술대회논문집
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    • 한국분말야금학회 2006년도 Extended Abstracts of 2006 POWDER METALLURGY World Congress Part2
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    • pp.1099-1100
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    • 2006
  • The mechanical properties of ceramics materials can be tailored by designing their microstructures. We have reported that development of texture can be controlled by slip casting in a strong magnetic field followed by heating even for diamagnetic ceramics such as alumina. A strong magnetic field of 12T was applied to the suspension indcuding alumina powder to rotate each particle during slip casting. The sintering was conducted at the desired temperature in air without a magnetic field. C-axis of alumina was parallel to the magnetic field. Bending strength of textured alumina depended on the direction of oriented microstructure.

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