• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.3851-3855
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• 2012

Introduction: The worldwide incidence of breast cancer has increased rapidly in recent years. The scenario of Eastern India is also showing the same trend. It is necessary to study the utility of HER-2/neu as a prognostic factor in breast cancer survival. However, there have not been detailed studies in this respect with the breast cancer patients of Eastern India. Thus this study was conducted. Materials and Methods: In this hospital-based study 86 breast cancer patients attending a breast clinic of a reputed institute of Eastern India and having invasive ductal carcinomas were observed for a period of 5 years after surgery. Associations between 5 years observed survival and status of ER, PR and HER-2/neu of the patients were critically evaluated. Results: There was statistically significant association between survival pattern for 5 years and the HER-2/neu status (p=0.00001). Better survival was observed for the patients with HER-2/neu negative tumors 67(100%) compared to HER-2/neu positive tumors 7(36.8%). Conclusions: There is strong interaction between survival and HER-2/neu expression of breast cancer patients. Thus the patients with HER-2/neu positive tumors need to be treated aggressively.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.5081-5084
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• 2015

Background: Breast cancer is a malignant tumor that starts from cells of the breast and is seen mainly in women. It's the most common cancer in women worldwide and is a major threat to health. The purpose of this study was to fit a Cox proportional hazards model for prediction and determination of years of survival in Iranian patients. Materials and Methods: A total of 366 patients with breast cancer in the Cancer Research Center were included in the study. A Cox proportional hazard model was used with variables such as tumor grade, number of removed positive lymph nodes, human epidermal growth factor receptor 2 (HER2) expression and several other variables. Kaplan-Meier curves were plotted and multi-years of survival were evaluated. Results: The mean age of patients was 48.1 years. Consumption of fatty foods (p=0.033), recurrence (p<0.001), tumor grade (p=0.046) and age (p=0.017) were significant variables. The overall 1- year, 3-year and 5-year survival rates were found to be 93%, 75% and 52%. Conclusions: Use of covariates and the Cox proportional hazard model are effective in predicting the survival of individuals and this model distinguished 4 effective factors in the survival of patients.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup3
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• pp.245-252
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• 2016

Due to increasing incidence of breast cancer, recognition of risk factors has become increasingly important. Over the past few decades, among risk factors of this disease, stressful life events have attracted particular attention, but their relationship with breast cancer incidence and survival remains a mystery. This study aimed to examine the relationship between severe stressful life events and incidence and survival of women with breast cancer. In this case-control study, using a structured telephone interview with 355 women with breast cancer and also with 516 women with benign breast diseases who were matched in demographic characteristics, necessary information about the experience of major stressful events in the years before the diagnosis were collected. Data were analyzed using statistical methods of ${\chi}^2$, t, and Kaplan-Meier with a significance level of <0.05. Generally, in the case and control groups, there were no significant association between experience of stressful life events and incidence of breast cancer. Regarding associations between each of the events and incidence of breast cancer only "severe interpersonal problems with spouse" was significant. In the breast cancer group, even after controlling confounding variables, there was no significant association between major stressful events and disease-free survival, or overall 5-and 10-year survival. In this study, only "severe interpersonal problems with spouse" was confirmed as a risk factor. This result can be useful in developing preventive policies. More research regarding the interactive effects of psycho-social factors in the incidence and survival of breast cancer with stressful life events is recommended.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.36 no.6
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• pp.591-595
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• 2003

Settlement of larvae, growth, and survival of juvenile abalone (Haliotis discus hannai) were examined after feding of 5 species of benthic diatoms (Cocconeis suctellum, Navicula sp Nitzschia longissima Bacillavia paxillifera, Licmophora flabellata). All of the benthic diatoms were isolated from natural populations on plastic plates for the abalone. The settlement of larvae, shell growth, and survival rate of juvenile abalone varied by diatoms species. The highest settlement rate of larvae was $43.1\%$ with the Cocconeis suctellum diet. Daliy growth rate reached a maximum at 64.1 ${\mu}m/day$ with the Navicula sp. diet and a minimum at 22.4 ${\mu}m/day$ with the Licmophora flabellata diet. Survival rate of the juvenile abalone was highest at $62.0\%$ with the Navicula sp., Cocconeis suctellum , and Nitzschia longissima diets. Survival rate of the Juvenile abalone was significantly higher than the control group with mixed diatom population diets (P<0.05). Therefore, diatom . species composition in diets can be a controling factor for the settlement, growth, and survival rates of Juvenile abalone.

• Journal of Gynecologic Oncology
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• v.29 no.6
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• pp.82.1-82.13
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• 2018

Objective: The impact of beta blockers (BBs) on survival outcomes in ovarian cancer was investigated. Methods: By using Korean National Health Insurance Service Data, Cox proportional hazards regression was performed to analyze hazard ratios (HRs) with 95% confidence intervals (CIs) adjusting for confounding factors. Results: Among 866 eligible patients, 206 (23.8%) were BB users and 660 (76.2%) were non-users. Among the 206 BB users, 151 (73.3%) were non-selective beta blocker (NSBB) users and 105 (51.0%) were selective beta blocker (SBB) users. BB use in patients aged ${\geq}60$ years, longer duration use (${\geq}1$ year), in patients with Charlson Comorbidity Index (CCI) ${\geq}3$, and in cardiovascular disease including hypertension was associated with better survival outcome. These findings were observed in both NSBB and SBB. When duration of medication was analyzed based on number of days, NSBB (${\geq}180$ days) was associated with improved overall survival (OS) with a relatively shorter period of use compared to SBB (${\geq}720$ days). In multivariate Cox proportional hazards model, longer duration of BB medication (${\geq}1$ year) was an independent favorable prognostic factor for both OS and disease-specific survival in ovarian cancer patients. Conclusion: In our nationwide population-based cohort study, BB use was associated with better survival outcomes in ovarian cancer in cases of long term duration of use, in older patients, and in cardiovascular and/or other underlying disease (CCI ${\geq}3$).

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2022.10a
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• pp.297-299
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• 2022

Malignant glioma has a poor prognosis with the reported median survival of between 6 months to 14 months. Thus, it is crucial to predict the accurate survival of patients with malignant glioma. In this paper, we propose a convolutional neural network to predict the overall survival and age of the patients. A total of four MRI modalities, T1, T1-contrast enhanced, T2, and fluid-attenuated inversion recovery, which effectively capture spatial characteristics of malignant glioma, were used as input images. Age is an important factor impacting the overall survival, thus incorporating it into the model will thereby improve the performance of the proposed model. Our model successfully predicted overall survival and age of the patients with pearson correlation coefficients of 0.1748 and 0.3056, respectively.

• Journal of Korean Society of Rural Planning
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• v.12 no.3 s.32
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• pp.39-42
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• 2006

The purpose of this study is to develop rural population model adapting cohort survival method with sift-share effects. Administrative district in this study is below Myun: about 2,000 population. Population data of rural area in 1990, 1995, and 2000 by age cohort were selected for applying developed model. Damping coefficient from population data was calculated as 7% and results applying this coefficient in rural population data below the error from 12% to 1.06%. In detail, most of cohorts fitted with developed model except from 15 to 29 age groups. Application result of small population area; DaesulMyun revealed that main factor of population change is not natural change but migration.

• Journal of the military operations research society of Korea
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• v.17 no.1
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• pp.159-176
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• 1991

The probability of target survival is the most important factor in the target assignment, Most of the studies about it have assumed the case of one target and ane weapon type. Therefore, they can not be applied to the real situation. In this paper. the quantity and type of enemy assets of the friendly force are considered simultaneously. Considered defense type is the coordinated defense with no impact point prediction. The objective function is to minimize the expected total survival value of targets which are scattered in the defense area. The rules of aircraft assignment are as follows : first, classify targets into several groups, each of those has the same desired damage level secondly. select the critical group which has the least survival value in accordance with the additional aircraft assignment, and finally. assign the same number of attack assets against each target in the critical group. In this paper, the attack assets, the escort assets, and the defense assets are considered. The model is useful to not only the simple aircraft assignment problem but also the complicated wargame models.

• Proceedings of the Korea Society of Environmental Biology Conference
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• 2004.12a
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• pp.124-126
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• 2004

Molinate is thiocarbamate herbicide used primarily in rice production. Chondrogenesis is a multistep process that is essential for endocondral bone formation. The transcription factor Sox9 has an essential role during the sequential steps of chondrocyte differentiation. Bombina orientalis is one of the most common amphibians in the world and comprises a large proportion of their total number. We examined the embryotoxic and survival effects of molinate at various concentration in B. orientalis embryos. The survival rates of embryos at 312h post fertilization treated with molinate was decreased with concentration dependent manner. Also, developmental malformations appeared by molinate in B. orientalis embryos. the expression levels of Sox9 mRNA was examined by RT-PCR. In our result showed that Sox9 expression was found to be increased in malformed tadpole compared to normal tadpole. These results suggested that molinate was detrimental for survival and development of B. orientalis embryo.

• Communications for Statistical Applications and Methods
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• v.24 no.2
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• pp.115-127
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• 2017

This paper proposes a Bayesian test for the equivalence of survival functions in multiple groups. Proposed Bayesian test use the model of Cox's regression with time-varying coefficients. B-spline expansions are used for the time-varying coefficients, and the proposed test use only the partial likelihood, which provides easier computations. Various simulations of the proposed test and typical tests such as log-rank and Fleming and Harrington tests were conducted. This result shows that the proposed test is consistent as data size increase. Specifically, the power of the proposed test is high despite the existence of crossing hazards. The proposed test is based on a Bayesian approach, which is more flexible when used in multiple tests. The proposed test can therefore perform various tests simultaneously. Real data analysis of Larynx Cancer Data was conducted to assess applicability.