• Structural Engineering and Mechanics
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• v.83 no.2
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• pp.167-178
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• 2022

Surrogate models aim to approximate the performance function with an active-learning design of experiments (DoE) to obtain a sufficiently accurate prediction of the performance function's sign for an inexpensive computational demand in reliability analysis. Nevertheless, many existing active-learning methods are limited to the Kriging model, while the uncertainties of the Kriging itself affect the reliability analysis results. Moreover, the existing general active-learning methods may not achieve a fully satisfactory balance between accuracy and efficiency. Therefore, a novel active-learning method GLM-CM is constructed to yield the issues, which conciliates several merits of existing methods. To demonstrate the performance of the proposed method, four examples, concerning both mathematical and engineering problems, were selected. By benchmarking obtained results with literature findings, various surrogate models combined with the proposed method not only provide an accurate reliability evaluation while highly alleviating the computational burden, but also provides a satisfactory balance between accuracy and efficiency compared to the other reliability methods.

• The KSFM Journal of Fluid Machinery
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• v.14 no.5
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• pp.55-62
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• 2011

Shape optimization of a Printed circuit heat exchanger (PCHE) has been performed by using three-dimensional Reynolds-Averaged Navier-Stokes (3-D RANS) analysis and surrogate modeling techniques. The objective function is defined as a linear combination of effectiveness of the PCHE term and pressure drop in the cold channels of the PCHE. The cold channel angle and the ellipse aspect ratio of the cold channel are used as design variables for the optimization. Design points are selected through Latin-hypercube sampling. The optimal point is determined through surrogate-based optimization method which uses 3-D RANS analyses at design points. The results of three types of surrogate model are compared each other. The results of the optimizations indicate improved performance in friction loss but low performance in effectiveness than the reference shape.

• Smart Structures and Systems
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• v.29 no.2
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• pp.321-336
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• 2022

Model uncertainty is a key factor that could influence the accuracy and reliability of numerical model-based analysis. It is necessary to acquire an appropriate updating approach which could search and determine the realistic model parameter values from measurements. In this paper, the Bayesian model updating theory combined with the transitional Markov chain Monte Carlo (TMCMC) method and K-means cluster analysis is utilized in the updating of the structural model parameters. Kriging and polynomial chaos expansion (PCE) are employed to generate surrogate models to reduce the computational burden in TMCMC. The selected updating approaches are applied to three structural examples with different complexity, including a two-storey frame, a ten-storey frame, and the national stadium model. These models stand for the low-dimensional linear model, the high-dimensional linear model, and the nonlinear model, respectively. The performances of updating in these three models are assessed in terms of the prediction uncertainty, numerical efforts, and prior information. This study also investigates the updating scenarios using the analytical approach and surrogate models. The uncertainty quantification in the Bayesian approach is further discussed to verify the validity and accuracy of the surrogate models. Finally, the advantages and limitations of the surrogate model-based updating approaches are discussed for different structural complexity. The possibility of utilizing the boosting algorithm as an ensemble learning method for improving the surrogate models is also presented.

• Structural Engineering and Mechanics
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• v.84 no.3
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• pp.323-335
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• 2022

The main idea of the framework is to seamlessly combine a reasonably accurate and fast surrogate model with the importance sampling strategy. Developing a surrogate model for predicting structures' dynamic responses is challenging because it involves high-dimensional inputs and outputs. For this purpose, a novel surrogate model based on cutting-edge deep learning architectures specialized for capturing temporal relationships within time-series data, namely Long-Short term memory layer and Transformer layer, is designed. After being properly trained, the surrogate model could be utilized in place of the finite element method to evaluate structures' responses without requiring any specialized software. On the other hand, the importance sampling is adopted to reduce the number of calculations required when computing the failure probability by drawing more relevant samples near critical areas. Thanks to the portability of the trained surrogate model, one can integrate the latter with the Importance sampling in a straightforward fashion, forming an efficient framework called TTIS, which represents double advantages: less number of calculations is needed, and the computational time of each calculation is significantly reduced. The proposed approach's applicability and efficiency are demonstrated through three examples with increasing complexity, involving a 1D beam, a 2D frame, and a 3D building structure. The results show that compared to the conventional Monte Carlo simulation, the proposed method can provide highly similar reliability results with a reduction of up to four orders of magnitudes in time complexity.

• YAKHAK HOEJI
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• v.52 no.5
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• pp.331-344
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• 2008

Recently, the FDA (Food and Drug Administration) of the United States and many advanced countries remark biomarkers and surrogate endpoints as a critical path tool on model based drug development. Economic, technical and social profit on model based drug development like a reduction of the length of research and development have been achieved. Therefore we summarize previous studies about biomarkers and surrogate endpoints and suggest a development direction of therapeutic agents. In diabetes mellitus (DM) and osteoporosis, there are remarkable increases in number of patients and most of patients take medicine during their whole lifetime. For this reason, many patients with DM and osteoporosis have a tolerance on their medicine. We expect that research and development on biomarkers and surrogate endpoints will contribute to new drug development on DM and osteoporosis. Biomarkers for DM are blood levels of glucose, insulin, ${HbA}_{1c}$, CRP, alpha-glucosidase, adiponectin and DPP-4. Among these, validated surrogate endpoints for DM are blood levels of glucose, insulin and ${HbA}_{1c}$ Biomarkers for osteoporosis are BMD, BMC, trabecular volume, ICTP, DPD, osteocalcin, the activity of osteoclast and production of osteoblast. The validated surrogate endpoints for osteoporosis are BMD only. This review summarizes all suggested biomarkers and surrogate endpoints in DM and osteoporosis. The biomarkers are classified by drugs, and the method of validation for surrogate endpoints is suggested. This information would contribute to suggest a direction of DM and osteoporosis therapeutic agent development.

• Journal of Embryo Transfer
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• v.27 no.1
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• pp.1-7
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• 2012

Somatic cell nuclear transfer (SCNT) for miniature pig has been developed for xenotransplantation and many other biomedical experiments. However, the efficiency of SCNT is still very low due to many factors. To optimize the surrogate mother condition for improvement of cloned miniature pigs efficiency, we investigated the effect of the status of surrogate mother on pregnancy, farrowed rate in SCNT pigs. After SCNT with mesenchymal stem cells as donor cells, the SCNT embryos were surgically transferred into the oviduct of surrogated pigs. To compare the effects of status of surrogate pigs on pregnancy, surrogate pigs were prepared by artificial abortion at day 20~29 (Group 1), 30~39 (Group 2), and 40~45 (Group 3) of gestation. After SCNT embryos transfer in three different status of surrogate pigs, Group 2 (56.3%) and 3 (55.6%) had significantly ($p$ <0.05) higher the pregnancy rate than group 1 (0%) at day 30 of gestation. The status of ovulation in surrogate pig also was investigated. Post-ovulation status (54.8%) had higher proportion than pre-ovulation status (38.7%) and ovulation status (6.5%). We obtained 19 cloned miniature piglets from seven surrogate gilts and five piglets are living healthy but fourteen piglets died soon after birth or stillbirth. The weights of piglets greatly differ from 254 to 1,296 g. Microsatellite analysis showed that cloned piglets were genetically different from the surrogate mother and cloned piglets were genetically equal to the donor cell. In conclusion, the present result indicates that artificially abortion method can improve the efficiency of pregnancy after SCNT in pigs. This study will provide available method for the further study and application in the field of xenotransplantation.

• Journal of Magnetics
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• v.18 no.1
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• pp.74-79
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• 2013

This paper proposes a sampling-based optimization method for electromagnetic design problems, where design sensitivities are obtained from the elaborate surrogate models based on the universal Kriging method and a local window concept. After inserting additional sequential samples to satisfy the certain convergence criterion, the elaborate surrogate model for each true performance function is generated within a relatively small area, called a hyper-cubic local window, with the center of a nominal design. From Jacobian matrices of the local models, the accurate design sensitivity values at the design point of interest are extracted, and so they make it possible to use deterministic search algorithms for fast search of an optimum in design space. The proposed method is applied to a mathematical problem and a loudspeaker design with constraint functions and is compared with the sensitivity-based optimization adopting the finite difference method.

• Environmental Sciences Bulletin of The Korean Environmental Sciences Society
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• v.4 no.1
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• pp.11-23
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• 2000

Photochemical air quality models are essential tools in predicting future air quality and assessing air pollution control strategies. To evaluate air quality using a photochemical air quality model, emission inventories are important inputs to these models. Since most emission inventories are provided at a county-level, these emission inventories need to be geographically allocated to the computational grid cells of the model prior to running the model. The conventional method for the spatial allocation of these emissions uses "spatial surrogate indicators", such as population for mobile source emissions and county area for biogenic source emissions. In order to examine the applicability of such approximations, more detailed spatial surrogate indicators were developed using Geographic Information System(GIS) tools to improve the spatial allocation of mobile and boigenic source emissions, The proposed spatial surrogate indicators appear to be more appropriate than conventional spatial surrogate indicators in allocating mobile and biogenic source emissions. However, they did not provide a substantial improvement in predicting ground-level ozone(O3) concentrations. As for the carbon monoxide(CO) concentration predictions, certain differences between the conventional and new spatial allocation methods were found, yet a detailed model performance evaluation was prevented due to a lack of sufficient observed data. The use of the developed spatial surrogate indicators led to higher O3 and CO concentration estimates in the biogenic source emission allocation than in the mobile source emission allocation.llocation.

• Structural Engineering and Mechanics
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• v.41 no.1
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• pp.25-41
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• 2012

Kriging surrogate model provides explicit functions to represent the relationships between the inputs and outputs of a linear or nonlinear system, which is a desirable advantage for response estimation and parameter identification in structural design and model updating problem. However, little research has been carried out in applying Kriging model to crack identification. In this work, a scheme for crack identification based on a Kriging surrogate model is proposed. A modified rectangular grid (MRG) is introduced to move some sample points lying on the boundary into the internal design region, which will provide more useful information for the construction of Kriging model. The initial Kriging model is then constructed by samples of varying crack parameters (locations and sizes) and their corresponding modal frequencies. For identifying crack parameters, a robust stochastic particle swarm optimization (SPSO) algorithm is used to find the global optimal solution beyond the constructed Kriging model. To improve the accuracy of surrogate model, the finite element (FE) analysis soft ANSYS is employed to deal with the re-meshing problem during surrogate model updating. Specially, a simple method for crack number identification is proposed by finding the maximum probability factor. Finally, numerical simulations and experimental research are performed to assess the effectiveness and noise immunity of this proposed scheme.

• Structural Engineering and Mechanics
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• v.65 no.2
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• pp.173-181
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• 2018

In this paper, finite element (FE) model updating based on multi-objective optimization with the surrogate model for a steel plate girder bridge is investigated. Conventionally, FE model updating for bridge structures uses single-objective optimization with finite element analysis (FEA). In the case of the conventional method, computational burden occurs considerably because a lot of iteration are performed during the updating process. This issue can be addressed by replacing FEA with the surrogate model. The other problem is that the updating result from single-objective optimization depends on the condition of the weighting factors. Previous studies have used the trial-and-error strategy, genetic algorithm, or user's preference to obtain the most preferred model; but it needs considerable computation cost. In this study, the FE model updating method consisting of the surrogate model and multi-objective optimization, which can construct the Pareto-optimal front through a single run without considering the weighting factors, is proposed to overcome the limitations of the single-objective optimization. To verify the proposed method, the results of the proposed method are compared with those of the single-objective optimization. The comparison shows that the updated model from the multi-objective optimization is superior to the result of single-objective optimization in calculation time as well as the relative errors between the updated model and measurement.