• Journal of Acupuncture Research
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• 제20권5호
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• pp.151-158
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• 2003

Objective: There have not been so many study about the quality of acupuncture needle tip. In order to ensure safe acupuncture treatment, the quality of needle tip is essential. Therefore we investigated the current condition of the tip of the acupuncture needles in Korea. Methods: We have selected the needles that made by 8 companies in Korea, and selected 50 pieces from 1000 pieces each company by randomized methods. and observed the tip of each needle using a scanning electron microscope at ${\times}800$ magnification. Results & Discussion: We found that needles had several defects such as scratch marks on the surface, metallic scuff, lumps and irregularities of the needle tips, stubbed or malformed tips, tips of point off-center, peeled off coated tips. There was much difference on the quality of needle among the manufacturer, and some needles seem to need to do- thorough quality control. It is necessary to intensify quality management and a concentrated control on manufacturing process of acupuncture needles.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2001년도 추계학술대회 논문집 Vol.14 No.1
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• pp.3-6
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• 2001

In common globular proteins, the native form is in its most stable state. However, the native form of inhibitory serpins (serine protease inhibitors) and some viral membrane fusion proteins is in a metastable state. Metastability in these proteins is critical to their biological functions. Our previous studies revealed that unusual interactions, such as side-chain overpacking, buried polar groups, surface hydrophobic pockets, and internal cavities are the structural basis of the native metastability. To understand the mechanism by which these structural defects regulate protein functions, cavity-filling mutations of a 1-antitrypsin, a prototype serpin, were characterized. Increasing conformational stability is correlated with decreasing inhibitory activity. Moreover, the activity loss appears to correlate with the decrease in the rate of the conformational switch during complex formation with a target protease. We also increased the stability of a 1-antitrypsin greatly via combining various stabilizing single amino acid substitutions that were distributed throughout the molecule. The results showed that a substantial increase of stability, over 13 kcal/mol, affected the inhibitory activity with a correlation of 11% activity loss per kcal/mol. The results strongly suggest that the native metastability of proteins is indeed a structural design that regulates protein functions and that the native strain of a 1-antitrypsin distributed throughout the molecule regulates the inhibitory function in a concerted manner.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2001년도 추계학술대회 논문집
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• pp.3-6
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• 2001

In common globular proteins, the native form is in its most stable state. However, the native form of inhibitory serpins (serine protease inhibitors) and some viral membrane fusion proteins is in a metastable state. Metastability in these Proteins is critical to their biological functions. Our previous studies revealed that unusual interactions, such as side-chain overpacking, buried polar groups, surface hydrophobic pockets, and internal cavities are the structural basis of the native metastability. To understand the mechanism by which these structural defects regulate protein functions, cavity-filling mutations of ${\alpha}$1-antitrypsin, a prototype serpin, were characterized. Increasing conformational stability is correlated with decreasing inhibitory activity. Moreover, the activity loss appears to correlate with the decrease in the rate of the conformational switch during complex formation with a target protease. We also increased the stability of ${\alpha}$1-antitrypsin greatly via combining various stabilizing single amino acid substitutions that were distributed throughout the molecule. The results showed that a substantial increase of stability, over 13 kcal/mol, affected the inhibitory activity with a correlation of 11% activity loss per kcal/mol. The results strongly suggest that the native metastability of proteins is indeed a structural design that regulates protein functions and that the native strain of e 1-antitrypsin distributed throughout the molecule regulates the inhibitory function in a concerted manner.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2007년도 제38회 하계학술대회
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• pp.2040-2041
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• 2007

In this paper, the UHF PD(Partial Discharge) sensors for $SF_6$ insulated MV $SF_6$ switchgear have been proposed and related investigations have been performed in order to detect the PD which were produced inside the MV $SF_6$ switchgear. Firstly, the internal type UHF PD sensor based on spiral antenna theory has been developed. This type sensor is highly sensitive and has lowly effect on by on-site noise. Secondly, the external type UHF PD sensor was developed based on log periodic antenna concept. This type sensor is removable and detectable for operating switchgear. These sensors were designed and simulated using RF simulation tool. In order to verify the sensitivity of these sensors, we performed the on-site test using the mock-up switchgears including the artificial defects which were the protrusion on high voltage conductor, free moving metal particle and surface defect on insulator. These mock-up switchgear were installed on the test distribution line.

• 산업기술연구
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• 제19권
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• pp.269-278
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• 1999

When a variety of repeated loads are given, most steel structures failed in much lower level of loads than static failure loads. In addition, bridge always includes the internal defects or discontinuities. from these, fatigue cracks initiates and can lead to sudden failure. Thus, in this study, tensile specimens by the cover plate shapes were used as the test specimens. The fatigue test was performed by constant amplitude fatigue loading and beach mark. From the results of this study, each specimen's fatigue section was observed. in addition, stress intensity factor at crack tip was calculated by using the Green's function which applied to discontinuous section where causing stress concentration. Therefore, the fatigue life of structural detail was investigated by adopting the theories of fracture mechanics. each specimen's crack shape is a semi-elliptical surface crack or center crack sheet, stress gradient correction factor, Fg is the most subjective of all stress intensity correction factors and fatigue life should be predicted by previous proposed function and finite element analysis.

• E2M - 전기 전자와 첨단 소재
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• 제14권12호
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• pp.3-6
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• 2001

In common globular proteins, the native form is n its most stable state. However, the native form of inhibitory serpins (serine protease inhibitors) and some viral membrane fusion proteins is in a metastable state. Metastability in these proteins is critical to their biological functions. Our previous studies revealed that unusual interactions, such as side-chain overpacking, buried polar groups, surface hydrophobic pockets, ad internal cavities are the structural basis of the native metastability. To understand the mechanism by which these structural defects regulate protein functions, cavity-filling mutations of $\alpha$1-antitrypsin, a prototype serpin, were characterized. Increasing conformational stability is correlated with decreasing inhibitory activity. Moreover, the activity loss appears to correlate with the decrease in the rate of the conformational switch during complex formation with a target protease. We also increased the stability of $\alpha$1-antitrypsin greatly via combining various stabilizing single amino acid substitutions that were distributed throughout the molecule. The results showed that a substantial increase of stability, over 13 kcal/mol, affected the inhibitory activity with a correlation of 11% activity loss per kcal/mol. The results strongly suggest that the native metastability of proteins is indeed a structural design that regulates protein functions and that the native strain of $\alpha$1-antitrypsin distributed throughout the molecule regulates the inhibitory function in a concerted manner.

• Advanced Composite Materials
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• 제16권3호
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• pp.245-258
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• 2007

The single-modal Weibull model has been assessed on Tyranno ZMI Si-Zr-C-O fiber if a set of shape and scale parameters accurately reproduced the effect of the size of the diameter on strength. The tensile data of a single fiber have been divided into two expedient groups as 'small diameter' group and 'large diameter' group in deriving the parameters, which should be consistent if the Weibull model accurately reproduced the size effect. However, the derived Weibull parameters were inconsistent between the two groups. Thereby the authors have concluded that the parameters of the single-modal Weibull model are dependent on the fiber diameter, so that the model is inadequate to reproduce the strength size effect. On the other hand, Weibull parameters were found consistent between the two groups by excluding the data of 'large mirror zone' sample, which was defined as the sample around 10% mirror zone area of the fracture surface. What is more, the exclusion reduced the strength variance more drastically in the 'large diameter' group than in the 'small diameter' group, even though the 'large mirror zone' samples were found identical in the percentage between the two groups. The authors therefore conclude that diameter limitation to the 'small diameter' group level can lead to drastically less distributed strength values than the estimated strength through the Weibull scaling on the present Tyranno ZMI Si-Zr-C-O fiber.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1996년도 춘계학술대회 논문집
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• pp.819-823
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• 1996

In the large steel ingosts, void defects exhibiting microvoid shapes are inevitably formed in the V-segregation zone of the ingots during solidification. In the hot open-die forging process, material properties are improved by eliminating internal porosity. The void size is practically very small as compared with the huge large ingot. Thus, for deformation analysis of a large ingot, a massive number of elements are needed in order to describe a void surface and to uniform mesh sturcture. In the present work the Global/Local scheme has been introduced in order to reduce the computational time and to easily generate the mesh system as a void module of local mesh for obtaining the accurate solution around a void. The procedure of the global- local method consists of two steps. In the first step global analysis is carried out which seeks a reasonably good solution with a cpurse mesh system without describing a void. Then, a local analysis is performed locally with a fine mesh system under the size-criterion of a local region. The computational time has been greatly reduced. Though the work it has been shown that large ingot forging incorporation small voids can be effectively analyzed by using the proposed Global/Local scheme.

• 대한기계학회논문집A
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• 제23권11호
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• pp.1922-1928
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• 1999

Rotary bending fatigue tests were carried out to investigate the influence of artificial defects on fatigue limit in annealed and austempered ductile iron. Obtained main results are as follows : (1) Artificial defect(micro hole type, dia.<0.4 mm) on specimen surface did not bring about a obvious reduction of fatigue limit in austempered ductile iron(ADI) as compared with annealed ductile iron. (2) According to the investigation of $\sqrt{area}_c$ which is the critical defect size to crack initiation at artificial defect, $\sqrt{area}_c$ of ADI is larger than that of annealed ductile iron. This shows that the situation of crack initiation at artificial defect in ADI is more difficult in comparison with annealed ductile iron. (3) One of the reasons for the low rate of crack initiation from artificial defect in ADI is that the resistance of matrix to crack initiation is higher than that of annealed ductile iron. (4) In case that the $\sqrt{area}$ of artificial defect and graphite nodule is the same, the rate of crack initiation from graphite nodule is higher than that from artificial defect. This reason is that the serious ruggedness around graphite nodule is formed by austempering treatment.

• Korean Journal of Acupuncture
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• 제21권4호
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• pp.43-51
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• 2004

Objectives : In order to ensure safe acupuncture treatment, the quality of the needle tip is essential. But, there have not been so many studies about the quality of the acupuncture needle tip. For this reason we have been already reported about the quality of acupuncture needle tip in Korea using scanning electron microscope(SEM) in 2002, 2003. In order to compare than other society, we investigated the current condition of the tips of the acupuncture needles sold in Europe. Methods : We obtained the needles made by 7 companies, which are sold currently in Europe, and selected 50 pieces out of 100 pieces from each company by randomized methods. And then we observed the tip of each needle using a scanning electron microscope at ${\times}800$ magnification. Results and Discussion : We found that needles had several defects such as scratch marks on the surface, metallic scuff, lumps and irregularities of the needle tips, stubbed or malformed tips, tips of point off-center, peeled off coated tips, same as Korean needles. There was much difference on the quality of needles among the manufacturers, and some needles seem to need thorough quality control. Allowing for the high price, the quality of some needle in Europe generally are better than that of Korean needles. But some Korean needles hold a top position than European ones in quality. We want a good industrial standard to be made in acupuncture manufacturing fields in the near future, because the safety is not less valuable than the efficacy in medicine.