• Title/Summary/Keyword: Surface activation

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Binding of Galectin-1 to Neutrophils Enhanced by Activation

  • Cho, Somi K.;Cho, Moonjae
    • Journal of Applied Biological Chemistry
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    • v.43 no.3
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    • pp.131-135
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    • 2000
  • Human polymorphonuclear neutrophils undergo diaphoresis after a selectin-mediated rolling on the endothelial cells of the blood vessel wall. Extravasation is believed to be an integrin-mediated process. Galectin-1 is a small dimeric beta-galactoside-binding protein synthesized by the endotherial cells and present in the perivascular connective tissue. In this study we suggest the possible role of galectin-1 in extravasation of the activated neutrophils. MAL lectin binding study showed, that f-MetLeuPhe-activated neutrophils decrease surface sialylation and increase galectin-1 binding via exposure of new galectin-1 binding sites. Desialylated HL-60 cells also show the same decrease in MAL binding and increase in galectin-1 binding, an increase which was not observed in the presence of lactose. Galectin-1 blotting analysis detected two possible major ligands (approximately 120 and 160 kDa) of galectin-1 from the desialylated HL-60 cell lysates.

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Improved Anti-Cancer Effect of Curcumin on Breast Cancer Cells by Increasing the Activity of Natural Killer Cells

  • Lee, Hwan Hee;Cho, Hyosun
    • Journal of Microbiology and Biotechnology
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    • v.28 no.6
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    • pp.874-882
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    • 2018
  • Curcumin is known to possess various biological functions, including anti-inflammatory, anti-oxidative, and anti-cancer activities. Natural killer (NK) cells are large lymphocytes that directly kill cancer cells. However, many aggressive cancers, including breast cancer, were reported to escape the successful killing of NK cells in a tumor microenvironment. In this study, we investigated the anti-cancer effect of curcumin in coculture of human breast carcinoma MDA-MB-231 and NK (NK-92) cells. We found that curcumin had an immune-stimulatory effect on NK-92 by increasing the surface expression of the $CD16^+$ and $CD56^{dim}$ population of NK-92. We confirmed that the cytotoxic effect of NK-92 on MDA-MB-231 was significantly enhanced in the presence of curcumin, which was highly associated with the activation of Stat4 and Stat5 proteins in NK-92. Finally, this improved anticancer effect of curcumin was correlated with decreased expression of pErk and PI3K in MDA-MB-231.

A Study on the Prediction of Quality Chanties of Citrus unshiu during Short-term Storage and Marketing (조생온주 밀감의 단기 저장 및 유통 중 품질변화 예측을 위한 연구)

  • 정신교;이재호
    • Food Science and Preservation
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    • v.4 no.2
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    • pp.123-130
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    • 1997
  • To develop the prediction program for quality change of Citrus unshiu during marketing, we examined the quality characteristics of Citrus unshiu stored at experimental refrigerator set to 4, 8, 12 and 16$^{\circ}C$ for 2 months. According to the storage temperature the changes of quality characteristics were different respectively, but it was most severe during 16$^{\circ}C$ storage. Activation energy and Q10 value were 6683.16 cal/mol K and 1.53 respectively. The determination coefficient of regression equation of pH, acidity and vitamin C by surface response analysis were over 0.85. Using these regression equation, we developed the prediction program for the change of pH, acidity and vitamin C contents. The calculated values and experimental values of pH, acidity and vitamin C contents for short-term storage of Citrus unshiu were coincided well.

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The Fabrication of the $ZrO_2$ Thin Film by Chemical Vapor Deposition and the Effect of the Reaction Parameters on the Deposition Characteristics (화학증착법에 의한 $ZrO_2$ 박막의 제조 및 반응변수에 따른 증착특성)

  • 최준후;김호기
    • Journal of the Korean Ceramic Society
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    • v.28 no.1
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    • pp.1-10
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    • 1991
  • Zirconium dioxide(ZrO2) thin films have been deposited by chemical vapor deposition technique involving the application of gas mixture of ZrCl4, and H2O into silicon wafers. The relationships between the deposition rate and various reaction parameters such as the deposition time, the gas flow rate, the deposition temperature, and the composition of reactant gases were studied. The film was identified as nearly stoichiometric monoclinic ZrO2. The apparent activation energy is about 19Kcal/mole at surface chemical reaction controlled region. The deposition rate is mainly influenced by the H2O-forming reacting between CO2 and H2.

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Studies on Hydrophobic Drug-Soluble Carrier Coprecipitates(1)

  • Shin, Sang-Chul
    • Archives of Pharmacal Research
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    • v.2 no.1
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    • pp.35-47
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    • 1979
  • In order to increase the dissolution rate of furosemide(4-choro-N-furfury1-5-sulfamoy1 anthranilic acid_, various ratio coprecipitates with water-soluble polymers, such as polyvinylpyrrolidone and polythylene glycol, of different molecular weight, were prepared and quantitatively studied by comparing their dissolution characteristics of furosemide at powder state and at nondisintegrating disk state containing constant surface area at various temperatures and rotating velocities. The dissolution characteristics of furosemide from pure furosemide disks and 1:2(w/w) furosemide-PVP coprecipitate disks were in accordance with Noyes-Nernst equation and the rate constant of dissolution was proportional to the square root of rotating velocity of the disks. The intrinsic rate of dissoluton at 150 rpm, 37.deg.C was $2.21{\times}10^{-7}$ for the PVP 10, 000 COPRECIPITATE, $1.64{\times}10^{-7}$ for the PVP 40, 000 coprecipitate, and$ 1.44 {\times} 10^{-7}$for the PVP 360, 000 corprecipitate, while the rate was $1.27{\times}10^{-8}M/cm^{2} min$ for pure furosemide, repectively. The activation energy of dissolution was about 17, 000 for furosemide and about 7, 300 cal/mole for the 1:2 furosemide PVP 40, 000 coprecipitate, respectively.

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Effect of S-AITA on Mild Steel Corrosion in Acidic Medium

  • Chandrasekaran, V.;Saravanan, J.
    • Corrosion Science and Technology
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    • v.5 no.5
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    • pp.160-167
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    • 2006
  • S-Acetyl Isothiourea Acetate (S-AITA) was synthesized in the laboratory and this influence on the inhibition of corrosion of mild steel in 1.11 N hydrochloric and 1.12 N sulphuric acids was investigated by weight loss and potentiostatic polarization techniques at 303K, 353K and 403K. These results were confirmed by the impedance technique. The inhibition efficiency increased with increase in concentration of inhibitor and decreased with rise in temperature from 303K to 403K. The maximum inhibition efficiency of S-AITA was found to be 99.95% (0.5% of S-AITA) at 303K in sulphuric acid. The adsorption of this compound on the mild steel surface from the acids has been found to obey Temkin's adsorption isotherm. The potentiostatic polarization results revealed that S-AITA was a mixed type inhibitor. Some thermodynamic parameters i.e., activation energy (Ea), free energy of adsorption (${\Delta}G_{ads}$), enthalpy of adsorption (${\Delta}H$) and entropy of adsorption (${\Delta}S$) were also calculated from weight loss data.

The Effects of Tin in Bottom Surface to Ion Exchange of Float Glasses (Float 판유리에 있어서 바닥면의 Tin성분이 이온교환에 미치는 영향)

  • 이동인;이용근;이희수
    • Journal of the Korean Ceramic Society
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    • v.27 no.6
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    • pp.763-768
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    • 1990
  • The gradient and depth of tin at the side of glasses by float process were measured. The effects of tin to ion exchanged of glasses in the molten salt of KNO3 and AgNO3 were presented by means of Ag+ ion penetration depth, diffusion coefficient variation, spectral transmittance and color coordinates. The diffusion coefficient of Ag+ ion of tin side was higher than air side, and the activation energy of tin side was 0.2-0.6Kcal/mole lower than air side. Therefore Ag+ ion penetration depth of tin side is 2-10$\mu\textrm{m}$ deeper, hence it can be seen that tin promote Ag+ ion diffusion. The same treatment of ion exchange, reddish-brown oflong wavelength in case of tin present, yellowish-amber of short wavelength in case of tin absence were revealed.

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Polyethylene Film Surface Metallization Modified by Radiation Grafting of N-vinyl Pyrollidone

  • Aal, A.A.;Khutoryanskiy, V.V.;Nurkeeva, Z.S.;Mun, G.A.;Soh, D.W.
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2004.05a
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    • pp.110-112
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    • 2004
  • Poyethylene films can be modified by radiation grafting of N-vinyl pyrollidone using y-radiation. FTIR spectra were used to confirm the modification of PE films. The modified films were activated by two-step and one step methods for electroless Cu plating. Morphology of metallized films has been investigated. Electroless Cu plating onto the modified films depends mainly on the grafting degree and activation type. The conductivity of the metallized films has been investigated.

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The Effect of Flux on the Preparation of Spherical Fine Phosphor Particles (미분의 구형 형광체 제초에 있어서 융제의 영향)

  • 노현숙;강윤찬;서대종
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 1999.11a
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    • pp.570-573
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    • 1999
  • High brightness (Y$_{x}$/Gd$_{1-x}$ )$_2$O$_3$:Eu Phosphor Particles were directly Prepared in the spray Pyrolysis by adding flux materials such as LiCl and HBO$_3$. The (Y$_{x}$/Gd$_{1-x}$ )$_2$O$_3$:Eu particles prepared from solution with flux material had higher PL (photoluminescence) intensities than those prepared from solution without flux. In the spray pyrolysis, the flux acts as promoter of the growth of crystallite and activation of doping material as in the solid state reaction method. Additionally, the flux improved PL intensity of (Y$_{x}$/Gd$_{1-x}$ )$_2$O$_3$:Eu phosphor particles by densifying the internal structure and eliminating the defect existing inside and surface of (Y$_{x}$/Gd$_{1-x}$ )$_2$O$_3$:Eu phosphor particles.r particles.

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Effect of Process Parameters of UV Enhanced Gas Phase Cleaning on the Removal of PMMA (Polymethylmethacrylate) from a Si Substrate

  • Kwon, Sung Ku;Kim, Do Hyun
    • Transactions on Electrical and Electronic Materials
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    • v.17 no.4
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    • pp.204-207
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    • 2016
  • Experimental study of UV-irradiated O2/H2 gas phase cleaning for PMMA (Polymethylmethacrylate) removal is carried out in a load-locked reactor equipped with a UV lamp and PBN heater. UV enhanced O2/H2 gas phase cleaning removes polymethylmethacrylate (PMMA) better at lower process pressure with higher content of H2. O2 gas compete for UV (184.9 nm) absorption with PMMA producing O3, O(1D) and lower dissociation of PMMA. In our experimental conditions, etching reaction of PMMA at the substrate temperature between 75℃ and 125℃ had activation energy of about 5.86 kcal/mol indicating etching was controlled by surface reaction. Above the 180℃, PMMA removal was governed by a supply of reaction gas rather than by substrate temperature.