• Title/Summary/Keyword: Surface Model

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Effector Memory CD8+ and CD4+ T Cell Immunity Associated with Metabolic Syndrome in Obese Children

  • Yang, Da-Hee;Lee, Hyunju;Lee, Naeun;Shin, Min Sun;Kang, Insoo;Kang, Ki-Soo
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.24 no.4
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    • pp.377-383
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    • 2021
  • Purpose: We investigated the association of effector memory (EM) CD8+ T cell and CD4+ T cell immunity with metabolic syndrome (MS). Methods: Surface and intracellular staining of peripheral blood mononuclear cells was performed. Anti-interleukin-7 receptor-alpha (IL-7Rα) and CX3CR1 antibodies were used to stain the subsets of EM CD8+ T cells, while anti-interferon-gamma (IFN-γ), interleukin-17 (IL-17), and forkhead box P3 (FOXP3) antibodies were used for CD4+ T cell subsets. Results: Of the 47 obese children, 11 were female. Children with MS had significantly higher levels of serum insulin (34.8±13.8 vs. 16.4±6.3 µU/mL, p<0.001) and homeostasis model assessment of insulin resistance (8.9±4.1 vs. 3.9±1.5, p<0.001) than children without MS. Children with MS revealed significantly higher frequencies of IL-7Rαlow CD8+ T cells (60.1±19.1% vs. 48.4±11.5%, p=0.047) and IL-7RαlowCX3CR1+ CD8+ T cells (53.8±20.1% vs. 41.5±11.9%, p=0.036) than children without MS. As the serum triglyceride levels increased, the frequency of IL-7RαlowCX3CR1+ and IL-7RαhighCX3CR1- CD8+ T cells increased and decreased, respectively (r=0.335, p=0.014 and r=-0.350, p=0.010, respectively), in 47 children. However, no CD4+ T cell subset parameters were significantly different between children with and without MS. Conclusion: In obese children with MS, the changes in immunity due to changes in EM CD8+ T cells might be related to the morbidity of obesity.

A Study on Ground Heave Characteristics of Soft Ground with DCM (DCM으로 개량된 연약점토지반의 지반융기에 관한 고찰)

  • You, Seung-Kyong;Hong, Gigwon
    • Journal of the Korean Geosynthetics Society
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    • v.19 no.4
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    • pp.75-84
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    • 2020
  • This paper described the analysis result on heaving of soft ground with DCM column type, based on the results of laboratory model tests on the soft ground with DCM column. The heave characteristics of the soft ground were evaluated according to the application of DCM column in soft ground. The results showed that the heaving of soft ground without DCM column occurred rapidly when the lateral deformation of soft ground increased significantly under the 4th load step condition. In addition, the heaving of soft ground in final load step caused tensile failure of the ground surface. The maximum heaving of the soft ground with the DCM column occurred in the final load step, and the heaving quantity decreased in the order of pile, wall, and grid type. Especially, the soft ground with DCM of grid type effectively resisted ground heaving, even if it was extremely failure in the bottom ground of embankment. The results of the maximum heaving according to the measurement point showed that the heaving of the soft ground with DCM of grid type was 3.1% and 1.6% compared to that of the pile and wall type at the location of LVDT-1, and the heaving of the LVDT-2 position was 1.0% and 2.1%, respectively.

Evaluation of Ventilation Deficiecy in Elementary, Middle, and High Schools using Monte Carlo Simulation (Monte-Carlo 모의실험을 이용한 초·중·고등학교의 환기부족 평가)

  • Choe, Youngtae;Park, Jinhyeon;Kim, Eunchae;Ryu, Hyoensu;Kim, Dong Jun;Min, Kihong;Jung, Dayoung;Woo, Byung Lyul;Cho, Mansu;Yang, Wonho
    • Journal of Environmental Health Sciences
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    • v.46 no.6
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    • pp.627-635
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    • 2020
  • Objectives: Indoor air quality has become more important aspeople spend most of their times indoors. Since students spend most of their times at home or at school, they are more likely to be exposed to indoor air pollutants. Ventilation in school classrooms can affect health and learning performance. In this study, ventilation deficiency was evaluated in school classrooms using Monte Carlo simulation. Methods: This study used sensor-based monitoring for six months to measure carbon dioxide (CO2) concentrations in classrooms in elementary, middle, and high schools. The volume of the classroom and the number of students were investigated, and the students' body surface area was used to calculate the CO2 emission rate. The distribution of ventilation rates was estimated by measured CO2 concentration and a mass-balance model using Monte Carlo simulation. Results: In the elementary, middle, and high schools, the average CO2 concentrations exceeded 1000 ppm, indicating that the ventilation rates were insufficient. The ventilation rates were deficient from July to August and in December, but showed relatively high ventilation rates in October. Forty-three percent of elementary schools, 56% of middle schools, and 62% of high schools showed insufficient ventilation rates. Conclusions: The ventilation rates calculated in elementary, middle and high schools were found to be quite insufficient. Therefore, proper management is needed to overcome the lack of ventilation and improve air quality.

Characteristics and Mechanisms of Phosphate Sorption by Calcined Oyster Shell (소성 굴패각에 의한 인산염의 흡착특성 및 메커니즘)

  • Park, Jong-Hwan;Heo, Jae-Young;Lee, Su-Lim;Lee, Jae-Hoon;Hwang, Se-Wook;Cho, Hyeon-Ji;Kwon, Jin-Hyeuk;Chang, Young-Ho;Seo, Dong-Cheol
    • Korean Journal of Environmental Agriculture
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    • v.40 no.1
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    • pp.40-48
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    • 2021
  • BACKGROUND: Although the calcined oyster shell can be used as a calcium-rich adsorbent for phosphate removal, information about it is limited. The purpose of this study was to evaluate the phosphate adsorption characteristics and its mechanism using calcined oyster shells. METHODS AND RESULTS: In this study, calcined oyster shell (C-OS600) was prepared by calcining oyster shells (P-OS) at 600℃ for 20 min. Phosphate adsorption by C-OS600 was performed under various environmental conditions. Phosphate adsorption by C-OS600 occurred rapidly at the beginning of the reaction, and the time to reach equilibrium was less than 1 h. The optimal isotherm and kinetic models for predicting the adsorption of phosphate by C-OS600 were the Langmuir isotherm and pseudo-second order kinetic model, respectively, and the maximum adsorption capacity derived from the Langmuir isotherm was 68.0 mg/g. The adsorption properties of phosphate by C-OS600 were dominantly influenced by the initial pH and C-OS600 dose. In addition, SEM-EDS and FTIR analysis clearly showed a difference in C-OS600 before and after phosphate adsorption, which proved that phosphate was adsorbed on the surface of C-OS600. CONCLUSION: Overall, the calcined oyster shell can be considered as an useful and effective adsorbent to treat wastewater containing phosphate.

Effect of Etching Treatment of SAPO-34 Catalyst on Dimethyl Ether to Olefins Reaction (DTO 반응에 미치는 SAPO-34 촉매의 식각 처리 효과)

  • Song, Kang;Yoon, Young-Chan;Park, Chu-Sik;Kim, Young-Ho
    • Applied Chemistry for Engineering
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    • v.32 no.1
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    • pp.20-27
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    • 2021
  • Effects of the etching treatment of SAPO-34 catalyst were investigated to improve the catalytic lifetime in DTO reaction. The aqueous NH3 solution was a more appropriate treatment agent which could control the degree of etching progress, compared to that of using a strong acid (HCl) or alkali (NaOH) solution. Therefore, the effect on characteristics and lifetime of SAPO-34 catalyst was observed using the treatment concentration and time of aqueous NH3 solution as variables. As the treatment concentration or time of aqueous NH3 solution increased, the growth of erosion was proceeded from the center of SAPO-34 crystal plane, and the acid site concentration and strength gradually decreased. Meanwhile, it was found that external surface area and mesopore volume of SAPO-34 catalyst increased at appropriate treatment conditions. When the treatment concentration and time were 0.05 M and 3 h, respectively, the lifetime of the treated SAPO-34 catalyst was the longest, and was significantly enhanced by ca. 36% (based on DME conversion of > 90%) compared to that of using the untreated catalyst. The model for the etching progress of SAPO-34 catalyst in a mild treatment process using aqueous NH3 solution was also proposed.

Expanded Workflow Development for OSINT(Open Source Intelligence)-based Profiling with Timeline (공개정보 기반 타임라인 프로파일링을 위한 확장된 워크플로우 개발)

  • Kwon, Heewon;Jin, Seoyoung;Sim, Minsun;Kwon, Hyemin;Lee, Insoo;Lee, Seunghoon;Kim, Myuhngjoo
    • Journal of Digital Convergence
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    • v.19 no.3
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    • pp.187-194
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    • 2021
  • OSINT(Open Source Intelligence), rapidly increasing on the surface web in various forms, can also be used for criminal investigations by using profiling. This technique has become quite common in foreign investigative agencies such as the United States. On the other hand, in Korea, it is not used a lot, and there is a large deviation in the quantity and quality of information acquired according to the experience and knowledge level of investigator. Unlike Bazzell's most well-known model, we designed a Korean-style OSINT-based profiling technique that considers the Korean web environment and provides timeline information, focusing on the improved workflow. The database schema to improve the efficiency of profiling is also presented. Using this, we can obtain search results that guarantee a certain level of quantity and quality. And it can also be used as a standard training course. To increase the effectiveness and efficiency of criminal investigations using this technique, it is necessary to strengthen the legal basis and to introduce automation technologies.

Performance Evaluation of KOMPSAT-3 Satellite DSM in Overseas Testbed Area (해외 테스트베드 지역 아리랑 위성 3호 DSM 성능평가)

  • Oh, Kwan-Young;Hwang, Jeong-In;Yoo, Woo-Sun;Lee, Kwang-Jae
    • Korean Journal of Remote Sensing
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    • v.36 no.6_2
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    • pp.1615-1627
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    • 2020
  • The purpose of this study is to compare and analyze the performance of KOMPSAT-3 Digital Surface Model (DSM) made in overseas testbed area. To that end, we collected the KOMPSAT-3 in-track stereo image taken in San Francisco, the U.S. The stereo geometry elements (B/H, converse angle, etc.) of the stereo image taken were all found to be in the stable range. By applying precise sensor modeling using Ground Control Point (GCP) and DSM automatic generation technique, DSM with 1 m resolution was produced. Reference materials for evaluation and calibration are ground points with accuracy within 0.01 m from Compass Data Inc., 1 m resolution Elevation 1-DSM produced by Airbus. The precision sensor modeling accuracy of KOMPSAT-3 was within 0.5 m (RMSE) in horizontal and vertical directions. When the difference map was written between the generated DSM and the reference DSM, the mean and standard deviation were 0.61 m and 5.25 m respectively, but in some areas, they showed a large difference of more than 100 m. These areas appeared mainly in closed areas where high-rise buildings were concentrated. If KOMPSAT-3 tri-stereo images are used and various post-processing techniques are developed, it will be possible to produce DSM with more improved quality.

Biotransformation of Ginsenoside Rd from Red Ginseng Saponin using Commercial β-glucanase (상업용 β-glucanase를 이용한 홍삼유래 사포닌으로부터 Ginsnoside Rd 의 생물 전환)

  • Kang, Hye Jung;Lee, Jong Woo;Park, Tae Woo;Park, Hye Yoon;Park, Junseong
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.46 no.4
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    • pp.349-360
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    • 2020
  • Bio-conversion manufacturing technology has been developed to produce ginsenoside Rd which is increasingly in demand as a cosmetic material due to various possibilities related to improving skin function. In order to convert ginsenoside Rb1 which is contained in red ginseng saponin (RGS) into Rd, several commercial enzymes were tested. Viscoflow MG was found to be the most efficient. In order to optimize the conversion of RGS to ginsenoside Rd by enzymatic transition was carried out using response surface methodology (RSM) based on Box-Behnken design (BBD). The main independent variables were RGS concentration, enzyme concentration, and reaction time. Conversion of ginsenoside Rd was performed under 17 conditions selected according to BBD model and optimization conditions were analyzed. The concentration of the converted ginsenoside Rd ranged from 0.3113 g/L to 0.5277 g/L, and the highest production volume was obtained under condition of reacting 2% RGS and 1.25% enzyme for 13.5 hours. Consequently, RGS concentration, enzyme concentration which is 0.05 less than p-value and among the interactions between the independent variables, the interaction between enzyme concentration and reaction time was confirmed to be the most influential.

FEA for RC Beams Partially Flexural Reinforced with CFRP Sheets (CFRP 시트로 부분 휨 보강된 철근콘크리트 보의 유한요소해석)

  • Kim, Kun-Soo;Park, Ki-Tae;Kim, Byeong Cheol;Kim, Jaehwan;Jung, Kyu-San
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.24 no.5
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    • pp.9-16
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    • 2020
  • A CFRP sheet has been applied as a structural reinforcement in the field, and various studies are conducted to evaluate the effect of CFRP sheets on reinforced concrete. Although many experiments were performed from previous studies, there are still limitations to analyze structural behaviors with various parameters in experiments directly. This study shows the FEA on structural behaviors of RC beams reinforced with CFRP sheets using ABAQUS software. To simulate debonding failure of CFRP sheets which is a major failure mode of RC beam with CFRP sheets, a cohesive element was applied between the bottom surface of RC beam and CFRP sheets. Both quasi-static method and 2-D symmetric FE model technique were performed to solve nonlinear problems. Results obtained from the FE models show good agreements with experimental results. It was found that reinforcement level of CFRP sheets is closely related to structural behavior of reinforced concrete including maximum strength, initial stiffness and deflection at failure. Also, as over-reinforcement of CFRP sheets could give rise to the brittle failure of RCstructure using CFRP sheets, an appropriate measure should be required when installing CFRP sheets in the structure.

Development of a DEVS Simulator for Electronic Warfare Effectiveness Analysis of SEAD Mission under Jamming Attacks (대공제압(SEAD) 임무에서의 전자전 효과도 분석을 위한 DEVS기반 시뮬레이터 개발)

  • Song, Hae Sang;Koo, Jung;Kim, Tag Gon;Choi, Young Hoon;Park, Kyung Tae;Shin, Dong Cho
    • Journal of the Korea Society for Simulation
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    • v.29 no.4
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    • pp.33-46
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    • 2020
  • The purpose of Electronic warfare is to disturbe, neutralize, attack, and destroy the opponent's electronic warfare weapon system or equipment. Suppression of Enemy Air Defense (SEAD) mission is aimed at incapacitating, destroying, or temporarily deteriorating air defense networks such as enemy surface-to-air missiles (SAMs), which is a representative mission supported by electronic warfare. This paper develops a simulator for analyzing the effectiveness of SEAD missions under electronic warfare support using C++ language based on the DEVS (Discrete Event Systems Specification) model, the usefulness of which has been proved through case analysis with examples. The SEAD mission of the friendly forces is carried out in parallel with SSJ (Self Screening Jamming) electronic warfare under the support of SOJ (Stand Off Jamming) electronic warfare. The mission is assumed to be done after penetrating into the enemy area and firing HARM (High Speed Anti Radiation Missile). SAM response is assumed to comply mission under the degraded performance due to the electronic interference of the friendly SSJ and SOJ. The developed simulator allows various combinations of electronic warfare equipment specifications (parameters) and operational tactics (parameters or algorithms) to be input for the purpose of analysis of the effect of these combinations on the mission effectiveness.