• Korean Chemical Engineering Research
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• v.56 no.2
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• pp.229-239
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• 2018

The purpose of this study was to effectively produce the biosugar from cell wall of lipid extracted microalgae (LEA) by using microwave-assisted pretreatment without enzymatic hydrolysis process. Response surface methodology (RSM) was applied to optimization of microwave-assisted pretreatment conditions for the production of biosugar based on enzyme-free process from LEA. Microwave power (198~702 W), extraction time (39~241 sec), and sulfuric acid (0~1.0 mol) were used as independent variables for central composite design (CCD) in order to predict optimum pretreatment conditions. It was noted that the pretreatment variables that affect the production of glucose (C6) and xylose (C5) significantly have been identified as the microwave power and extraction time. Additionally, the increase in microwave power and time had led to an increase in biosugar production. The superimposed contour plot for maximizing dependent variables showed the maximum C6 (hexose) and C5 (pentose) yields of 92.7 and 74.5% were estimated by the predicted model under pretreatment condition of 700 w, 185.7 sec, and 0.48 mol, and the yields of C6 and C5 were confirmed as 94.2 and 71.8% by experimental validation, respectively. This study showed that microwave-assisted pretreatment under low temperature below $100^{\circ}C$ with short pretreatment time was verified to be an effective enzyme free pretreatment process for the production of biosugar from LEA compared to conventional pretreatment methods.

• Journal of Biomedical Engineering Research
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• v.21 no.3 s.61
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• pp.295-301
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• 2000

It is known that among many factors, relative micromotion at bone/implant interfaces can hinder bone ingrowth into surface pores of an implant. Loading conditions, mechanical properties of spinal materials, friction coefficients at the interfaces and geometry of spinal segments would affect the relative micromotion and spinal stability. A finite clement model of the human lumbar spine segments (L4-L5) was constructed to investigate the mechanical sensitivity at the interfaces between bone and cage. Relative micromotion. Posterior axial displacement. bone stress, cage stress and friction force were predicted in changes of friction coefficients, loading conditions. bone density and age-related material/geometric properties of the spinal segments. Relative micromotion (slip distance in a static loading means relative micromotion in routine activity) at the interfaces increased significantly as the mechanical properties of cancellous bone, annulus fibers or/and ligaments decrease or/and as the friction coefficient at the interfaces decreases. The contact normal force at the interfaces decreased as cancellous bone density decreases or/and as the friction coefficient increases A significant increase of slip distance at anterior annulus occurred with an addition of torsion to compressive preload. Relative micromotion decreased with an increase of disc area. In conclusion. relative micromotion, stress response. Posterior axial displacement and contact normal force are sensitive to the friction coefficient of the interfaces, bone density, loading conditions and age-related geometric/material changes.

• Wind and Structures
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• v.16 no.4
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• pp.301-322
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• 2013

Recent major post-hurricane damage assessments in the United States have reported that the most common damages result from the loss of building roof coverings and subsequent wind driven rain intrusion. In an effort to look further into this problem, this paper presents a full-scale (Wall of Wind --WoW--) investigation of external and underneath wind pressures on roof tiles installed on a low-rise building model with various gable roofs. The optimal dimensions for the low-rise building that was tested with the WOW are 2.74 m (9 ft) long, 2.13 m (7 ft) wide, and 2.13 m (7 ft) high. The building is tested with interchangeable gable roofs at three different slopes (2:12; 5:12 and 7:12). The field tiles of these gable roofs are considered with three different tile profiles namely high (HP), medium (MP), and low profiles (LP) in accordance with Florida practice. For the ridge, two different types namely rounded and three-sided tiles were considered. The effect of weather block on the "underneath" pressure that develops between the tiles and the roof deck was also examined. These tests revealed the following: high pressure coefficients for the ridge tile compared to the field tiles, including those located at the corners; considerably higher pressure on the gable end ridge tiles compared to ridge tiles at the middle of the ridge line; and marginally higher pressure on barrel type tiles compared to the three-sided ridge tiles. The weather blocking of clay tiles, while useful in preventing water intrusion, it doesn't have significant effect on the wind loads of the field tiles. The case with weather blocking produces positive mean underneath pressure on the field tiles on the windward side thus reducing the net pressures on the windward surface of the roof. On the leeward side, reductions in net pressure to a non-significant level were observed due to the opposite direction of the internal and external pressures. The effect of the weather blocking on the external pressure on the ridge tile was negligible.

• KEPCO Journal on Electric Power and Energy
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• v.1 no.1
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• pp.181-188
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• 2015

The non-contact permanent magnet gear has advantages of high efficiency and improved reliability. It has other advantages of no mechanical friction loss, very little noise and vibration, and no need for lubricant. With these advantages, the non-contact permanent magnet gear that solves the physical contact problem of the mechanical gear has drawn attention. Due to this unique non-contact characteristic, the non-contact permanent magnet gear which is capable of non-contact torque transmission has replaced mechanical gear. The mechanical gears which is in many fields of the modern industry, is used mostly for power transmitting mechanical devices. However, it also has the problem of a low torque density, which requires improvement. In this paper, a novel pole piece shape is proposed in order to improve the problem of low torque density of the non-contact permanent magnet gear. The experiment data required for predicting the relationships among them are obtained using finiteelement Operating method based on two-dimensional (2-D) numerical analysis. Therefore, this paper derived an optimal model for thenon-contact permanent magnet gear with the novel pole piece using the Box-Behnken design, and the validity of the optimal design of the proposed pole piece shape through variance analysis and regression analysis demonstrated. In this paper, we performed the thransfer torque analysis in order to improve the torque density and power density, we have performed on optimal design of proposed pole piece shape using box-behnken.

• The Journal of Korean Academy of Prosthodontics
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• v.32 no.4
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• pp.484-514
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• 1994

Cantilever bridge is widely used by mny clinicians, but its worst mechanical character, so called Class I lever system, makes dentists hesitate to restore the missing tooth with it. Therefore it is important to study stress of the cantilever bridge. In this study, two models of cantilever bridges that restores the missing mandibular second molar with two abutment teeth were constructed. One model was a type of cantilever bridge supported by a normal alveolar bone, the other one was supported by an alveolar bone resorbed to its 1/3 of root length. Maximum bite force(550N) and funtional maximum bite force(300N) were vertically applied to the distal end of the pontic, distal 1/3, and distal half of the pontic. And each force was also applied to centric occlusal contacts as a distributed force. Total 16 loading cases were compared and analyzed with 3-dimensional finite element method. The results were as follows: 1. The stress was concentrated on the joint of the pontic and the retainer, grooves, and distal cervical margin of the posterior retainer. 2. In case of maximum bite force(550N) at the end of the pontic, the risk of fracture at the joint of the pontic and the retainer was high. 3. In case of distributed force in centric occlusion and functional maximum bite force(300N), the stresses were less than the yield strength of the type VI gold for any loading cases. 4. In case of alveolar bone resorption, the occlusal force to the cantilever pontic caused more stress on the root apex and less stress on the alveolar crest region of the distal surface of the posterior abutment. 5. In case of alveolar bone resorption, the displacement was larger than that of normal alveolar bone in all loading cases.

• Journal of Pharmaceutical Investigation
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• v.20 no.4
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• pp.223-228
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• 1990

The contribution of endogenous transport systems to the blood-brain barrier (BBB) transport of basic and acidic drugs was studied by using a carotid injection technique in rats and an isolated bovine cerebrovascular disease state were compared between the normotensive rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP) which have been well established as an animal model with pathogenic similarities to humans. Basic drugs such as eperisone, thiamine and scopolamine inhibited, in a concentration dependent manner the in vivo uptake of $[{^3}H]choline$ through BBB, whereas amino acids and acidic drugs such as salicylic acid and valproic acid did not inhibit the uptake. The uptake of $[^3H]choline$ by B-CAP increased with time and showed a remarkable temperature dependency. The uptake of $[^3H]choline$ by B-CAP showed the very similar inhibitory effects as observed in the in vivo brain uptake, and was competitively inhibited by a basic drug, eperisone. The in vivo BBB uptakes of $[^3H]acetic$ acid and $[^{14}C]salicylic$ acid were dependent on pH of the injectate and the concentration of drugs. Several acidic drugs such such as salicylic acid, benzoic acid and valproic acid inhibited the in vivo uptake of $[^3H]acetic$ acid, whereas amino acid, choline and a basic drug such as eperisone did not inhibit the uptake. The uptake of acetic acid by B-CAP was competitively inhibited by salicylic acid. The permeability surface area product (PS) through BBB for $[^3H]choline$ in SHRSP was significantly lower than that in WKY. The concentration of choline in the brain dialysate in SHRSP was about half of that in WKY, while no significant difference was observed in the plasma concentration of choline between SHRSP and WKY. No significant difference was observed in the transport of monocarboxylic acids, glucose and neutral amino acid through BBB between SHRSP and WKY. From these results, it was concluded that BBB transport system of choline contributes to the transport of basic drugs through BBB, that acidic drugs can be transported via a moncarboxylic acid BBB transport system and that the specific dysfuntion of the BBB choline transport in SHRSP was ascribed to the reduction of the maximum velocity of choline concentration in the brain interstitial fluids.

• The Journal of Engineering Geology
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• v.16 no.2 s.48
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• pp.135-143
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• 2006

This study presents the results of a series of laboratory scale slope failure experiments aimed at clarifying the process and the condition leading to the initiation of rainfall-induced slope failures. For the evaluation of hydrologic response of the model slopes in relation the process of failure initiation, measurements were focused on the changes in volumetric water content during the initiation process. The process leading to failure initiation commences by the development of a seepage face. It appears reasonable to conclude that slope failures are a consequence of the instability of seepage area formed at the slope surface during rainfall period. Therefore, this demonstrates the importance of monitoring the development seepage area for useful prediction about the timing of a particular failure event. The hydrologic response of soil slopes leading to failure initiation is characterized by three phases (phase I, II and III) of significant increase in volumetric water content in association with the ingress of wetting front and the rise of groundwater level within the slope. The period of phase III increase in volumetric water content can be used to initiate advance warning towards a failure initiation event. Therefore, for the concept outlined above, direct and continuous monitoring of the change in volumetric water content is likely to provide the possibility for the development of a reliable and effective means of predicting the occurrence of rainfall-induced slope failures.

• The Journal of Engineering Geology
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• v.16 no.4 s.50
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• pp.393-402
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• 2006

The contamination characteristics of BTEX and TPH components in silty soils with the oil leakage event from point source were studied. The over ratios of three soil pollution standard for TPH component were $1.5{\sim}1.7$ times higher than that of BTEX component. The mean and maximum values of BTEX and TPH components with sample points were B-zone > A-zone > C-zone, and the highest concentrations were measured at $1{\sim}2m$ depth below surface. BTEX and TPH components were increased with linear distance in zone within 120 m and 80 m from point source. For the zone more than 120 m, BTEX and TPH concentrations were under soil pollution standard. The cutoff values of indicator kriging using BTEX and TPH components were defined as confirmative limit, warn- ing limit and counterplan limit. The variograms of indicator-transformed data were selected linear model. The contamination ranges of BTEX and TPH components using confirmative limit and warning limit were estimated similar, but the contamination range of those using counterplan limit was much reduced. The maximum contamination probabilities were estimated by probability maps usinB confirmative limit, warning limit and counterplan limit. The maximum contamination probabilities with three soil pollution standard were estimated 26%, 26% and 13% for BTEX component, and 44%, 38% and 26% for TPH component.

• Journal of Korean Society of Environmental Engineers
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• v.34 no.3
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• pp.195-203
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• 2012

In this study, The effects of three different biological activated carbon (BAC) materials (each coal, coconut and wood based activated carbons) and anthracite, empty bed contact time (EBCT) and water temperature on the removal of MK, HHCB and AHTN in BAC filters were investigated. Experiments were conducted at three water temperatures (5, 15 and $25^{\circ}C$) and four EBCTs (5, 10, 15 and 20 min). The results indicated that coal based BAC retained more attached bacterial biomass on the surface of the activated carbon than the other BAC, increasing EBCT or increasing water temperature increased the synthetic musk compounds (SMCs) removal in BAC columns. The kinetic analysis suggested a first-order reaction model for MK, HHCB and AHTN removal at various water temperatures (5, 15 and $25^{\circ}C$). The pseudo-first-order biodegradation rate constants and half-lives were also calculated for MK, HHCB and AHTN removal at 5, 15 and $25^{\circ}C$. The pseudo-first-order biodegradation rate constants and half-lives of MK, HHCB and AHTN ranging from 0.0082 $min^{-1}$ to 0.4452 $min^{-1}$ and from 1.56 min to 84.51 min could be used to assist water utilities in designing and operating BAC filters for SMCs removal.

• Journal of Korean Society of Environmental Engineers
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• v.31 no.3
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• pp.186-192
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• 2009

In this study, The effects of three different activated carbon materials (each coal, coconut and wood based activated carbons), empty bed contact time (EBCT) and water temperature on the removal of pharmaceutical 4 species (oxytetracycline, tetracycline, trimethoprime and caffeine) in BAC filters were investigated. Experiments were conducted at three water temperature (5, 15 and $25^{\circ}C$) and four EBCTs (5, 10, 15 and 20 min). The results indicated that coal based BAC retained more attached bacterial biomass on the surface of the activated carbon than the other BAC, increasing EBCT or increasing water temperature increased the pharmaceutical 4 species removal in BAC columns. In the coal-based BAC columns, removal efficiencies of oxytetracycline and tetracycline were 87~100% and removal efficiencies of trimethoprime and caffeine were 72~99% for EBCT 5~20 min at $25^{\circ}C$. The kinetic analysis suggested a firstorder reaction model for pharmaceutical 4 species removal at various water temperatures (5~$25^{\circ}C$). The pseudo-first-order reaction rate constants and half-lives were also calculated for pharmaceutical 4 species removal at 5~$25^{\circ}C$. The reaction rate and half-lives of pharmaceutical 4 species ranging from 0.0360~0.3954 $min^{-1}$ and 1.75 to 19.25 min various water temperatures and EBCTs, could be used to assist water utilities in designing and operating BAC filters.