• 공업화학
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• 제8권6호
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• pp.881-885
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• 1997

본 연구에서는 유용성 염료인 sudan III를 이용하여 비이온 계면활성제인 GL-12와 범용 음이온 계면활성제인 linear laurylbenzene sulfonate(LAS) 또는 sodium polyoxyethylene(3) glycol lauryl ether sulfate (SLES) 혼합 용액의 가용화력에 대하여 조사하였다. 두 계면활성제 혼합계 (GL-12/LAS, GL-12/SLES)의 가용화력은 각각 계면활성제 혼합비에 크게 영향을 받았으며 GL-12의 함량이 증가할수록 가용화력도 증가 하였다. 용액의 가용화력에 NaCl이 미치는 영향으로부터 GL-12/LAS계에서는 solubilizate인 sudan III가 가용화 후 미셀내 palisade 층 근처에 위치하고 GL-12/SLES 혼합계에서는 solubilizate가 미셀의 core부근에 위치함을 알 수 있었고 이는 LAS와 SLES의 분자구조 차이에 기인한다.

• 대한화장품학회지
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• 제10권1호
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• pp.13-23
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• 1984

The fluorescence intensity rations (F2.F1) of excimer (F2) to monomer (F1) of pyrene were measured as a function of the concentration of sodium dodecyl sulfate (SDS). It was found that there were not gross changes in size and shape of sphere-shape micelles in the first micelle concentration, while at concentrations above the second critical micelle concentration (CMC) the micelles grew in size with increasing concentration. Fluorescence intensities of 8-anilinonaphthalene 1-sulfonate (ANS) were also monitored as a micellar probe with varying concentrations of SDS. Results suggested that a phase transition from sphere-shaped micelles to hemicapped rod-like micelles occurred at the second CMC (17). A general formula for the axial ratio of ellip-soil-shaped micelle in the first micelle concentration was suggested. According to this general formula, the axial ratio of SDS, sodium lauryl ether sulfate and sodium laurate were 1:1, 5:2, and 5:3, respectively. The electrolyte-induced phase transition from spherical to hemicapped rod-like micelles occurred and the size of hemicapped rod-like micelles grew with increasing electrolyte concentrations. The maximum concentrations of solubilzed benzene in sphere-shaped micelles and hemicapped rod-like micelles were measured by differential spectrohpotometry. The hemicapped rod-like micelles in the presence of electrolytes grew in size with increasing amount of benzene solubilized.

• 생명과학회지
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• 제17권1호
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• pp.39-44
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• 2007

분열형 효모에서 Rqh1은 Top3과 함께 vegetative growth에 필수적이다. $rqh^-$ 돌연변이는 DNA damaging agent에 민감성을 보이는데 이때, 부적절한 유전자 발현, 세포 신장, 염색체의 불안전성, 비정상적인 다중격막, 발아의 결핍을 포함한 넓은 범위의 표현형을 보인다. rqh1-overexpression cell 역시 rqh1 deletion mutant에서 보이는 DNA damaging agent 민감성을 관찰할 수 있다. 논문은 nmtl promoter를 가지는 PREP vector에 Rqhl이 과발현 할 때 나타나는 DNA damaging agent 민감성를 보상하는 유전자를 찾아 $rqh1^+$의 기능을 알아보는 것이다. 여기서 보상능이 보이는 rqh156, rqh172 두 개의 돌연변이를 골라냈다. rqhl deletion mutant의 DNA damaging agent 민감성은 rqh156, rqh172의 발현에 의해 보상 되어지는 것을 확인하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제20권4호
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• pp.399-406
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• 2016

Early life neuronal exposure to environmental toxicants has been suggested to be an important etiology of neurodegenerative disease development. Perfluorohexanesulfonate (PFHxS), one of the major perfluoroalkyl compounds, is widely distributed environmental contaminants. We have reported that PFHxS induces neuronal apoptosis via ERK-mediated pathway. Imperatorin is a furanocoumarin found in various edible plants and has a wide range of pharmacological effects including neuroprotection. In this study, the effects of imperatorin on PFHxS-induced neuronal apoptosis and the underlying mechanisms are examined using cerebellar granule cells (CGC). CGC were isolated from seven-day old rats and were grown in culture for seven days. Caspase-3 activity and TUNEL staining were used to determine neuronal apoptosis. PFHxS-induced apoptosis of CGC was significantly reduced by imperatorin and PD98059, an ERK pathway inhibitor. PFHxS induced a persistent increase in intracellular calcium, which was significantly blocked by imperatorin, NMDA receptor antagonist, MK801 and the L-type voltage-dependent calcium channel blockers, diltiazem and nifedipine. The activation of caspase-3 by PFHxS was also inhibited by MK801, diltiazem and nifedipine. PFHxS-increased ERK activation was inhibited by imperatorin, MK801, diltiazem and nifedipine. Taken together, imperatorin protects CGC against PFHxS-induced apoptosis via inhibition of NMDA receptor/intracellular calcium-mediated ERK pathway.

• Environmental Analysis Health and Toxicology
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• 제9권3_4호
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• pp.91-101
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• 1994

In order to evaluate the ecotoxicological harzardousness of synthetic surfactants on Han river, Jung-ryang and Jin-Wi stream, we used the Ecotoxicological Risk Quotient (ERQ). The chemical harzardousness is evaluated by the balance of the toxicity and concentration in the environment.. Then, ERQ is defined as follows; ERQ = - log ( Concentration in the environment / Effective concentration in the test ) ERQ of chemical is a logtrighmic value of ratio of a chemical concentration and the toxicity in the laboratory. In case of small ERQ, tie chemical harzardousness is high. If ERQ equals O, the same biological effect as in the laboratory test will be observed in the enviromment by the chemicals. ERQ values of the chemicals were calculated using the maximum concentration in water environment which were cited from the annual report by our ministry of environment, and EC$_{50}$ of Daphnia magna (water flea; acute immobilization test) LC$_{50}$ of Oryzias latipes (fish; acue toxicity test) and EC$_{50}$ of chlorella vulgaris (alga; growth inhibition test), which were taken from the annual report of "Chemical in environment" by Japan EA. Liner alkylbenzene sulfonate (determined to MBAS) showed the high average values with more than 2.0 to three species in Han river and Jin-wi stream, and these results mean to be favorable to environmental safety. The areas of Jung-ryang stream were polluted, as the average values of ERQ were less than 2.0 with equal to three species, and attention should be paid. Therefore, they must be inspected again because their concentration in the environment may have changed during that period. The chemical harzardousness can be numerated with ERQ, and it can be a help to find the chemicals that should be kept under observation and to see whether the chemical pollution is improved or worsened. The determination of the chemical concentration in the environment and toxicity are essential for the effective use of ERQ.se of ERQ.

• 전기화학회지
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• 제7권2호
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• pp.89-93
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• 2004

설폰화된 폴리설폰 (sulfonated polysulfone, SPSF)과 Poly(phenylmethyl silsequioxane) (PPSQ)의 유무기 복합 전해 질막을 제조하여 이온전도도와 메탄을 투과 특성을 조사하였다 클로로트리메틸실란과 클로로설폰산의 반응 몰비와 반응시간를 변화시켜 설폰화도가 $37\~75\%$인 SPSF를 합성하였다. SPSF/PPSQ복합 전해막은 SPSF와 PPSQ를 DMF에 용해하여 캐스팅하는 방법으로 제조하였다 이 복합 전해질막의 수소 이온 전도도는 상온에서 $2.8\times10^{-3}\~4.9\times10^{-2}S/cm$이었으며 설폰화도가 증가할수록 전도도는 증가하였다. 제조된 설폰화된 폴리설폰 복합 전해질막의 메탄을 투과도는 이온전도도와 설폰화도에 비례하여 증가하였으며, PPSQ의 함량이 커질수록 메탄을 투과도가 비례적으로 감소하는 것을 확인할 수 있었다. 약 $5wt\%$ PPSO론 포함한 복합 전해질막의 이온전도도 및 메탄을 투과도는 SPSF에 비교하여 거의 동일하지만 함수율을 크게 감소시키는데 효과적이었다.

• Bulletin of the Korean Chemical Society
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• 제31권10호
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• pp.2873-2876
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• 2010

Excess free iron generates oxidative stress that may contribute to the pathogenesis of various causes of neurodegenerative diseases. Previous studies have shown that one of the primary causes of increased brain iron may be the release of excess iron from intracellular iron storage molecules. In this study, we attempted to characterize the oxidative damage of DNA induced by the reaction of ferritin with $H_2O_2$. When DNA was incubated with ferritin and $H_2O_2$, DNA strand breakage increased in a time-dependent manner. Hydroxyl radical scavengers strongly inhibited the ferritin/$H_2O_2$ system-induced DNA cleavage. We investigated the generation of hydroxyl radical in the reaction of ferritin with $H_2O_2$ using a chromogen, 2,2'-azinobis-(2-ethylbenzthiazoline-6-sulfonate) (ABTS), which reacted with ${\cdot}OH$ to form $ABTS^{+\cdot}$. The initial rate of $ABTS^{+\cdot}$ formation increased as a function of incubation time. These results suggest that DNA strand breakage is mediated in the reaction of ferritin with $H_2O_2$ via the generation of hydroxyl radicals. The iron-specific chelator, deferoxamine, also inhibited DNA cleavage. Spectrophotometric study using a color reagent showed that the release of iron from $H_2O_2$-treated ferritin increased in a time-dependent manner. Ferritin enhanced mutation of the lacZ' gene in the presence of $H_2O_2$ when measured as a loss of $\alpha$-complementation. These results indicate that ferritin/$H_2O_2$ system-mediated DNA cleavage and mutation may be attributable to hydroxyl radical generation via a Fenton-like reaction of free iron ions released from oxidatively damaged ferritin.

• 반도체디스플레이기술학회지
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• 제14권3호
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• pp.51-55
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• 2015

We have fabricated silver nanowire (AgNW) films as a stretchable and transparent electrode on polydimethylsiloxane (PDMS) substrates using a spray coater. Inherently, they show poor surface roughness and stretchability. To tackle it, we have employed a conductive polymer, poly (3,4-ethylenedioxythiophene) : Poly(styrene sulfonate) (PEDOT : PSS). PEDTO : PSS solution is mixed with AgNWs or spin-coated on the AgNW film. Compared with AgNW film only, PEDOT : PSS film only, and polymer-mixed AgNW films, the AgNW/polymer bilayer films exhibit much better surface roughness and stretchability. It is found that spray-coating of AgNWs on uncured PDMS and spin-coating of PEDOT : PSS solution on the AgNW films enhance the surface roughness of electrodes. Such a bilayer structure also provides a stable resistance under tensile strain due to the fact that each layer acts as a detour route for carriers. With this structure, we have obtained the peak-to-peak roughness ($R_{pv}$) as low as 76.8nm and a moderate increase of sheet resistance (from $10{\Omega}/{\Box}$ under 0% strain to $30{\Omega}/{\Box}$ under 40% strain).

• 산업기술연구
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• 제9권
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• pp.29-41
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• 1989

A general study on the upgrading of mica minerals which are mainly found in pegmatite deposits was carried out for the purpose of developing a technique for recovering mica in form of comercial grade products. By the way the grade one of about 5~6% $K_2O$ still is not developed. The target of this research work is to be establish a process for the efficient concentration of muscovite, containing more than 10% $K_2O$. The tests are applied to incraese the recovery and grade of concentrates in term of variations of conditions. The test sample consists of mainly muscovite and gangue mineral such as quartz, pyrite and chlorite. Decantation and shaking table tests were ineffective to up-grade this low grade one, but flotation method gave satisfactory result. By means of grade one, but flotation method gave satisfactory result. By means of grindability tests, an optimum result could be obtained from the sample ground to -48mesh feed size. The flotation result indicates that the dodecyl ammonium chloride used as a cationic collector is effective on the negatively charged surface, while the sodium dodecyl sulfate as an anionic collector is effective on the positively charged surface. Muscovite was floated by petroleum sulfonate as well as amine type collector, it also floated by MIBC as well as pine oil frother under well condition. Fine muscovite concentrates of about 10.68% $K_2O$ was obtained with 22.4% yield, by decantation, the muscovite concentrates of 10.10% $K_2O$ was obtained with 23.54% yield, by table concentration, the muscovite concentrates of 11.51% $K_2O$ was obtained with 23.0% yield by flotation.

• Bulletin of the Korean Chemical Society
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• 제33권12호
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• pp.4145-4149
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• 2012

A novel and simple method of luminescence enhancement effect for the determination of trace amounts of bile acid was proposed. The procedure was based on the luminescence intensity of the balofloxacin-europium(III) complex that could be strongly enhanced by bile acid in the presence of sodium dodecyl benzene sulfonate (SDBS). Under the optimum conditions, the enhanced luminescence intensity of the system exhibited a good linear relationship with the bile acid concentration in the range $5.0{\times}10^{-9}-7.0{\times}10^{-7}\;mol\;L^{-1}$ with a detection limit of $1.3{\times}10^{-9}\;mol\;L^{-1}$ ($3{\sigma}$). The relative standard deviation (RSD) was 1.7% (n = 11) for $5.0{\times}10^{-8}\;mol\;L^{-1}$ bile acid. The applicability of the method to the determination of bile acid was demonstrated by investigating the effect of potential interferences and by analyzing human serum and urine samples. The possible enhancement mechanism of luminescence intensity in balofloxacin-europium(III)-bile acid-SDBS system was also discussed briefly.