• Toxicological Research
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• 제14권2호
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• pp.273-283
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• 1998

Single and 4 weeks oral administration of New wonbangwoohwangchungsimwon (NSCH) which was used l-muscone as substitutive material qf musk, to beagle dogs of both sexes were per-formed to investigate both acute and subacute toxicity. Beagle dogs (3 males and 3 females) in acute experiments were administered orally with single dose of 2,000 mg/kg and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NSCH, 160 mg/kg/day (low dosage group), 400 mg/kg/day (middle dosage group), 1,000 mg/kg/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Ad-ministration (l996. 4. 16). $LD_{50}$ value for beagle dogs was more than 2,000 mg/kg per oral for both male and females. In animals administered with NSCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NSCH in beagle dogs is considered to be safe.

• Toxicological Research
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• 제14권2호
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• pp.249-260
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• 1998

Single and 4 weeks oral administration of New Woohwangchungsimwon (NWCH) which was used l-muscone as substitutive material of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs(3 males and 3 females) in acute experiments were administered orally with single dose of 2,000 mg/kg and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NWCH, 160 mg/kg/day (low dosage group), 400 mg/kg/day (middle dosage group), 1,000 mg/kg/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Administration (1996. 4. 16). $LD_{50}$/ value for beagle dogs was more than 2,000 mg/kg per oral for both male and fe-males. In animals administered with NWCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NWCH in beagle dogs is considered to be safe.

• 콘크리트학회논문집
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• 제20권3호
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• pp.307-315
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• 2008

본 연구에서는 고가의 실리카퓸의 대체 재료로서 메타카올린을 사용할 목적으로 광물질 혼화재와 혼합사용한 고강도콘크리트의 특성을 검토하였다. OPC 100%와 고로슬래그시멘트, 그리고 OPC와 플라이애쉬 20% 사용한 배합을 기준배합으로 하였으며, 각각의 배합에 실리카퓸과 메타카올린을 20% 범위 내에서 혼합하여 대체하였다. 실험 결과, 목표 유동성을 만족한 기준 배합에 대하여 실리카퓸만 대체하였을 경우에는 점성이 저하되었으며, 슬럼프플로우는 감소하였고, 공기량은 증가하였다. 이에 비하여 메타카올린의 사용량이 증가할수록 콘크리트의 점성이 증가되면서 슬럼프 플로우는 증가하였고, 공기량은 감소, 그리고 고성능감수제 사용량도 감소하였다. 경화 콘크리트의 특성은 압축강도와 초음파 속도, 그리고 단위용적질량이 메타카올린 사용량에 따라 증가하였는데, 이러한 원인은 굳지 않은 콘크리트의 공기량에 영향을 받는 것으로 판단되어 고강도콘크리트는 공기량을 조절하는 것이 중요한 항목으로 나타났다. 따라서 고강도콘크리트용 혼화재로서 실리카퓸의 대체 재료로서 메타카올린의 활용이 가능할 것으로 전망되며, 혼합 사용하는 경우에는 유동성과 강도 특성을 고려하여 실리카퓸과 메타카올린은 각각 10% 정도가 적정 사용량인 것으로 판단된다.

• 한국구조물진단유지관리공학회 논문집
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• 제14권3호
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• pp.144-151
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• 2010

본 연구에서는 고비용의 실리카흄의 대체재로서 인산부산석고와 카올린을 활용한 시멘트매트릭스의 화학적, 기계적 성질에 대하여 분석하였다. 실험을 위하여 인산부산석고는 이수석고 형태인 건조석고, 반수석고, III형 무수석고, II형 무수석고로 실험용시료를 제조하였으며, $900^{\circ}C$에서 소성된 카올린은 서냉과 급냉의 형태로 제조된 메타카올린의 형태로 제조하였다. 또한 이재료를 활용하여 혼합시멘트를 제조하였으며, 제조된 시멘트를 사용하여 실리카 흄을 혼입한 시멘트 매트릭스와 재료적 성능을 비교 평가하였다. 실험결과 급냉 제조된 메타카올린이 다른 재료에 비하여 성능이 우수한 것으로 분석되었다.

• Toxicological Research
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• 제13권4호
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• pp.435-447
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• 1997

l-Muscone is synthesized for use as substitutive material of musk which is the active ingredient of woohwangchungsimwon. The objective of this investigation was to evaluate the acute and subacute toxicity of l-muscone in rats. In oral acute toxicity test, SPF Sprague-Dawley male and female rats were gayaged with l-muscone of two doses(0, 5.0 g/kg). No dead animal and abnormal autopsy findings were found in control and treated group. Body weights were slightly decreased in both sexes of rats treated with 5.0 g/kg. Therefore, oral $LD_{50}$ of l-muscone was consider to be higher than 5.0 g/kg in male and female rats. In intraperitoneal acute toxicity test, rats were injected intraperitoneally with dosages of 0, 1,000, 1,316, 1,732, 2,279 and 3.000 mg/kg. Decreased body weights and motor activities were observed at high dose group. Intraperitoneal $LD_{50}$ of l-muscone were 1,920 mg/kg in male and female rats. In the subacute study, l-muscone was administrated orally to both sexes of rats for 4 weeks as several doses(0, 10, 100 and 1,000 mg/kg). There were neither dead animals nor significant changes of body weights during the experimental period. In addition, no differences were found between control and treated groups in clinical signs, urinalysis, hematology, serum biochemical analysist and other findings. Above data suggest that no observed adverse effect level of l-muscone in rats might be over 1,000 mg/kg/day in this study.

• 한국건설순환자원학회논문집
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• 제6권1호
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• pp.120-127
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• 2011

최근 천연골재는 점차 고갈되고 그 채취에 대한 엄격한 환경적인 규제 때문에 골재의 부족이 건설분야의 큰 문제로 대두되고 있어 이를 대체할 수 있는 대체재의 개발이 시급한 실정이다. 따라서 본 연구에서는 페로니켈 생산 과정에서 부산물로 발생되는 수쇄 페로니켈슬래그를 잔골재의 대체재로 활용하기 위하여 콘크리트의 역학적 특성 및 내구특성 시험결과를 비교 고찰하여 그 활용 가능성과 적정 대체율 및 페로니켈슬래그 콘크리트의 내구특성을 검토하였다. 실험결과, 수쇄 페로니켈슬래그의 품질특성과 내구성능 및 경제성을 고려할 경우 최적 혼합률은 40% 정도가 적당할 것으로 판단된다. 또한 수쇄 페로니켈슬래그 잔골재 혼합률 40% 콘크리트의 내구특성 중 동결융해 저항성은 일반 잔골재 콘크리트와 동등하며, 탄산화 저항성은 일반 잔골재 콘크리트와 동등하거나 떨어지는 것으로 나타났다.

• 농촌지도와개발
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• 제18권4호
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• pp.825-860
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• 2011

For the first time basic settlement area development plan was established in 2010, in order to promote cooperative coexisting development among regions, as time that regional competitiveness determines national competitiveness started. Basic settlement area development plan is composed of 7 sectors and 24 general subsidy projects. It was judged that experience and tourism business as the center is required to be analyzed, which may have effect on activation of farm village, fishing village and mountain village, and inflow of city people, in agriculture, forestry and fishery sector in order that added value of agriculture and fishery is increased, and tangible and intangible resources are applied, and pure agriculture, forestry and fishery is developed. And currently farm village, mountain village and fishing village of our country faces desperate crisis situation that they cannot help groping for substitutive to create new revenue model, and agriculture and fishery of primary industry has limit of increasing income of farmer and fisherman. Agriculture, forestry and fishery experience and tourism business was classified by types, and then standard of 12 categories and 48 sections was prepared, for searching method to supplement and develop it. Trend of experience and tourism business was understood, and problem was found, and then it may be used as indicator material to carry out creative and differentiated business plan establishment and business operation, and may be opportunity to reject overlapped business among regions, and to promote balanced regional development.

• 한국콘텐츠학회논문지
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• 제21권10호
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• pp.163-171
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• 2021

한국의 조리서와 한의서, 역사서 등 고문헌에는 건강과 음식, 치료에 관한 다양한 기록들이 있으며, 이러한 기록을 통해 '식치(食治)'의 원리를 발견할 수 있다. 식치(食治)는 '의료와 식품이 같은 원리로 작용한다' 라는 식약동원(食藥同源)의 뜻을 포함하는 의미로 전통지식으로만 그치지 않고 현대의 식문화까지 영향을 미치고 있다. 본 연구는 이러한 식치(食治)의 원리를 바탕으로 고문헌의 기록된 식품에 대한 과학적 검증을 통해 현대의 건강식품 소재로서 활용할 수 있는 토대를 마련하고자 하였다. 이를 위해 현대인의 대표적인 대사질환 중 하나인 혈당 조절과 관련이 있는 오미자, 콩, 꿀을 주원료로 하는 전통음료인 '오미갈수(五味渴水)'를 본 연구의 대상으로 선정하였다. 고문헌의 기록을 토대로 전통 오미갈수를 재현하였을 때 꿀에 의해 발생하는 음료의 엉김현상이나 섭취 후 혈당 상승 작용을 보완하기 위해 꿀을 대체할 수 있는 식품 소재를 발굴하였다. 이 소재를 활용하여 새롭게 제조한 오미갈수를 전통 오미갈수와 비교 시험을 통해 새롭게 제조한 오미갈수의 건강증진 및 품질개선 효과를 확인하였다. 본 연구를 바탕으로 전통지식의 하나인 식치의 원리를 활용한 과학적 연구를 통해 현대사회의 식품바이오, 헬스케어 등 의료 및 식품 분야의 다양한 콘텐츠로서 활용될 수 있는 기반을 마련하고자 한다.

• Clinical and Experimental Reproductive Medicine
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• 제23권1호
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• pp.95-102
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• 1996

This study was performed to investigate the effect of human follicular fluid (HFF) on development of mouse embryos, for evaluating the suitability of HFF as a substitutive material of human fetal cord serum in ART program. The various concentrations of HFF were added into the culture medium and the effects of HFF concentrations were examined to identify the optimal concentration of HFF for embryo development. The potency of HFF in improving embryo development was compared to that of other protein supplement. Collected HFFs were classified with the maturity of the containing oocytes; mature, immature, atretic, and then the effects of the classified HFFs on embryo development were examined. Also, HFF was separated into the low (<30,000 Da) and high (>30,000 Da) molecular weight fractions and the effects of the fractions on embryo development were investigated. The highest development rate was found in culture medium supplemented with 20% HFF, bnt this rate was reversely reduced at the concentrations of HFF higher than 20%. The development rates to the blastocyst, hatching blastocyst, attachment and outgrowth cultured in mature HFF was significantly higher than those in immature and atretic HFF, and mean cell number in blastocyst was higher in mature HFF than in immature and atretic HFF. The development rates of mouse embryos according to protein sources were significantly higher in HFF than in fetal cord serum (FCS), maternal serum (MS) and bovine serum albumin (BSA), and mean cell number in blastocyst cultured in HFF was higher than that in FCS, MS and BSA. The development rates of embryo and mean cell number in blastocyst cultured in high molecular weight fraction of HFF were higher than those in low molecular weight fraction, but the results of high molecular weight fraction were lower than those of whole HFF. Therefore, these results indicated that human mature follicular fluid was useful for improving the development of mouse embryos, which suggests a possibility that HFF also may be used efficiently for improving the culture condition in human ART program as a protein supplement.