Toxicological Research
- 제14권2호
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- Pages.273-283
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- 1998
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
비글개에서 신원방우황청심원의 급성 및 아급성독성시험
Acute and Subacute Toxicity Studies of New Won-bangwoohwangchungsimwon in Beagle Dogs
초록
Single and 4 weeks oral administration of New wonbangwoohwangchungsimwon (NSCH) which was used l-muscone as substitutive material qf musk, to beagle dogs of both sexes were per-formed to investigate both acute and subacute toxicity. Beagle dogs (3 males and 3 females) in acute experiments were administered orally with single dose of 2,000 mg/kg and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NSCH, 160 mg/kg/day (low dosage group), 400 mg/kg/day (middle dosage group), 1,000 mg/kg/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Ad-ministration (l996. 4. 16).