• IMMUNE NETWORK
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• v.22 no.6
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• pp.49.1-49.15
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• 2022

Exosomes derived from mesenchymal stem cells (MSCs) could protect against myocardial infarction (MI). TLR4 is reported to play an important role in MI, while microRNA-182-5p (miR-182-5p) negatively regulates TLR4 expression. Therefore, we hypothesize that MSCs-derived exosomes overexpressing miR-182-5p may have beneficial effects on MI. We generated bone marrow mesenchymal stem cells (BM-MSCs) and overexpressed miR-182-5p in these cells for exosome isolation. H₂O₂-stimulated neonatal mouse ventricle myocytes (NMVMs) and MI mouse model were employed, which were subjected to exosome treatment. The expression of inflammatory factors, heart function, and TLR4 signaling pathway activation were monitored. It was found that miR-182-5p decreased TLR4 expression in BM-MSCs and NMVMs. Administration of exosomes overexpressing miR-182-5p to H₂O₂-stimulated NMVMs enhanced cell viability and suppressed the expression of inflammatory cytokines. In addition, they promoted heart function, suppressed inflammatory responses, and de-activated TLR4/NF-κB signaling pathway in MI mice. In conclusion, miR-182-5p transferred by the exosomes derived from BM-MSCs protected against MI-induced impairments by targeting TLR4.

• Journal of The Korean Society of Integrative Medicine
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• v.11 no.2
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• pp.221-230
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• 2023

Purpose : This study was performed to evaluate the effects of virtual reality combined robot assist gait training (VRG) on improvement of balance and respiratory function in chronic stroke patients. Methods : A single-blind, randomized controlled trial (RCT) was conducted with 35 chronic stroke patients. They were randomly allocated 2 groups; VRG group (n=18) and conservative treatment group (CG; n=17). The VRG group received 30 minutes robot assisted gait training combined virtual reality training, robot assisted gait training was conducted in parallel using a virtual reality device (2 sessions of 15 minutes in a 3D-recorded walking environment and 15 minutes in a downtown walking environment). In the conservative treatment group, neurodevelopmental therapy and exercise therapy were performed according to the function of stroke patients. Each group performed 30 minutes a day 3 times a week for 8 weeks. The primary outcome balance and respiratory function were measured by a balance measurement system (BioRescue, Marseille, France), Berg balance scale, functional reach test for balance, Spirometry (Cosmed Micro Quark, Cosmed, Italy) for respiratory function Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV₁), and maximum expiratory volume (PEF) were measured according to the protocol. The measurement were performed before and after the 8 weeks intervention period. Results : Both groups demonstrated significant improvement of outcome in balance and respiratory function during intervention period. VRG revealed significant differences in balance and respiratory function as compared to the CG groups (p<.05). Our results showed that VRG was more effective on balance and respiratory function in patients with chronic stroke. Conclusion : Our findings indicate that VRG can improve balance and respiratory function, highlight the benefits of VRG. This study will be able to be used as an intervention data for recovering balance and respiratory function in chronic stroke patients.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.19 no.1
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• pp.35-39
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• 2006

In this study, in order to develop the multilayer piezoelectric actuator and ultrasonic resonator, PMN-PNN-PZT ceramics were fabricated by sintering with $Li_2CO_3-Na_2CO_3$ as sintering aids at $950^{\circ}C$ and their piezoelectric and dielectric characteristics were investigated as a function of PNN substitution. With increasing PNN substitution, dielectric constant(${\epsilon}_r$), electromechanical coupling factor(kp), and piezoelectric d constant($d_{33}$) were increased to $12 mol\%$ PNN substitution and then showed a tendency to decrease rapidly With increasing PNN substitution, crystal structure changed from tetragonal to rhombohedral at $12 mol\%$ PNN substitution and then secondary phase was appeared and its intensity was increased. At the $12 mol\%$ PNN substituted PMN-PZT composition ceramic sintered at $950^{\circ}C$, density, kp, $d_{33}$ and Qm showed the optimum value of $7.79 g/cm^3$, 0.599, 419 pC/N, and 894, respectively for multilayer piezoelectric actuator application.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.24 no.9
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• pp.728-732
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• 2011

In this study, piezoelectric and dielectric properties of Lead-free $0.97[(K_{0.5}Na_{0.5})(Nb_{0.97}Sb_{0.03})O_3]+0.03[(Bi_{0.5}K_{0.5})TiO_3]$ (abbreviated as 0.97NKNS-0.03BKT)ceramics synthesized by conventional solid-state reaction process were investigated as a function of $K_{5.4}Cu_{1.3}Ta_{10}O_{29}$ addition. The results indicated that the $K_{5.4}Cu_{1.3}Ta_{10}O_{29}$ addition significantly improved the sinterability, grain growth and piezoelctric properties of 0.97NKNS-0.03BKT ceramics. The optimum values as planar piezoelectric coupling coefficient ($k_p$= 0.355), piezoelectric constant ($d_{33}$= 207 pC/N) and mechanical quality factor ($Q_m$= 128) were obtained when 0.009KCT was added. The electromechanical coupling factor($k_p$) was slightly decreased according to the increasing temperature.

• Journal of Ceramic Processing Research
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• v.13 no.spc1
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• pp.37-41
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• 2012

A lithium ion conducting borosilicate glass was fabricated by a conventional melt quenching technique from a mixture of Li2CO3, B2O3 and SiO2 powders. The Li ion conductivity of the lithium borosilicate glasses was evaluated in terms of the SiO2/B2O3 ratio. In the Li2O-B2O3-SiO2 ternary glass, the glass forming region decreases with an increasing Li2O content. At the same Li2O, the crystallization tendency of the glass samples increases with the SiO2/B2O3 ratio, resulting in a reduced glass forming region in the Li2O-B2O3-SiO2 ternary glass. The electrical conductivity moderately depends on the SiO2/B2O3 ratio in the Li2O-B2O3-SiO2 ternary glass. The conductivity of the glasses slightly increases with the SiO2/B2O3 ratio. The observed phenomenon can be explained by the modification of the glass structure as a function of the SiO2 content.

• Bulletin of the Korean Mathematical Society
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• v.60 no.4
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• pp.1003-1016
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• 2023

In this paper, we introduce the idea of twisted product lightlike submanifolds of semi-Riemannian manifolds and provide non-trivial examples of such lightlike submanifolds. Then, we prove the non-existence of proper isotropic or totally lightlike twisted product submanifolds of a semi-Riemannian manifold. We also show that for a twisted product lightlike submanifold of a semi-Riemannian manifold, the induced connection ∇ is not a metric connection. Further, we prove that a totally umbilical SCR-lightlike submanifold of an indefinite Kaehler manifold ${\tilde{M}}$ does not admit any twisted product SCR-lightlike submanifold of the type M_⊥×_ϕM_T, where M_⊥ is a totally real submanifold and MT is a holomorphic submanifold of ${\tilde{M}}$. Consequently, we obtain a geometric inequality for the second fundamental form of twisted product SCR-lightlike submanifolds of the type M_T×_ϕM_⊥ of an indefinite Kaehler manifold ${\tilde{M}}$, in terms of the gradient of ln ϕ, where ϕ stands for the twisting function. Subsequently, the equality case of this inequality is discussed. Finally, we construct a non-trivial example of a twisted product SCR-lightlike submanifold in an indefinite Kaehler manifold.

• Advances in Computational Design
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• v.8 no.4
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• pp.295-307
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• 2023

This paper presents an optimization of the reinforced concrete ribbed slab in terms of minimum CO₂ emissions and an economic justification of the final optimal design. The design variables are six geometry variables including the slab thickness, the ribs spacing, the rib width at the lower and toper end, the depth of the rib and the bar diameter of the reinforcement, and the seventh variable defines the concrete strength. The objective function is considered to be the minimum amount of carbon dioxide gas (CO₂) emission and at the same time, the optimal design is economical. Seven significant design constraints of American Concrete Institute's Standard were considered. A robust metaheuristic optimization method called improved dolphin echolocation and ant colony optimization (IDEACO) has been used to obtain the best possible answer. At optimal design, the three most important sources of CO₂ emissions include concrete, steel reinforcement, and formwork that the contribution of them are 63.72, 32.17, and 4.11 percent respectively. Formwork, concrete, steel reinforcement, and CO₂ are the four most important sources of cost with contributions of 67.56, 19.49, 12.44, and 0.51 percent respectively. Results obtained by IDEACO show that cost and CO₂ emissions are closely related, so the presented method is a practical solution that was able to reduce the cost and CO₂ emissions simultaneously.

• Journal of the Korea Institute of Military Science and Technology
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• v.23 no.5
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• pp.452-458
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• 2020

In this paper, the contents of the development of RESS(Radar Environmental Signals Simulator) for the test of active phased array multi-function radar are described. The developed RESS can simulate multiple target environments, such as target/jamming/missile response/cluster signals, by using received radar operational information and simulated scenario. It can also modulate frequency, phase, gain, timing on all waveforms operated by multi-function radar and simulated two targets and one jamming in the beam. The RESS can be used to perform functional and performance verification of the active phased array multi-function radar with sub-array receiving structures.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39C no.7
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• pp.559-565
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• 2014

In this paper, we propose an unambiguous correlation function for time-multiplexed binary offset carrier (TMBOC) signal tracking. Specifically, considering that the TMBOC modulation transmits two kinds of sine-phased BOC signals in time domain alternatively, we generate sub-correlation functions for each of the BOC signals by using split sine-phased BOC signals, and then, obtain a correlation function with no side-peak by recombining the sub-correlation functions. From numerical results, we confirm that the proposed correlation function offers an improved tracking error standard deviation performance than the TMBOC autocorrelation function.

• Journal of the Korean Institute of Telematics and Electronics C
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• v.35C no.7
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• pp.78-91
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• 1998

This paper presents modular design techniques of multiple-valued logic functions about the function decomposition method and input variable management method. The function decomposition method takes avantage of the property of the column multiplicity in a single-column variable partitioning. Due to the increased number of identical modules, we can achieve a simpler circuit design by using a single T-gate, which can eliminate some of the control functions in the module libraty types. The input variable management method is to reduce the complexity of the input variables by proposing the look up table which assign input variables to a code. In this case as the number of sub-functions increase the code-length and the size of the code-assignment table grow. We identify some situations where shard input variables among sub-functions can be further reduced by a simplicication technique. According to the result of adapting this method to a function, we have demonstrated the superiority of the proposed methods which is bing decreased to about 12% of interconnection and about 16% of T-gate numbers compare with th eexisting for th enon-symmetric and irregular function realization.