• 제목/요약/키워드: Structure-activity relation

검색결과 74건 처리시간 0.026초

주거.사무공간의 조명환경 평가구조에 관한 연구 (A Study on Evaluation Structure of luminous Environment in o residential space and office work space)

  • 이선영
    • 조명전기설비학회논문지
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    • 제17권2호
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    • pp.1-9
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    • 2003
  • 본 연구는 공간 특성이 서로 다른 주거공간과 사무공간의 조명환경 평가구조에 어떠한 차이가 있는지를 파악하고, 분위기항목과 행위항목과의 관계를 정립하는데 목적을 두고 먼저 조명환경에 대한 평가항목으로써 20개의 분위기항목과 15개의 행위항목을 선정하였다. 그리고 SD법에 의한 주관평가실험을 실시하였다. 그 결과, 공간의 특성이 달라도 조명환경의 분위기평가는 <활동성>, <안정감>, <고급감>의 3인자로 설명이 가능한 것으로 나타났다. 행위 인자에 있어서는 주거공간의 경우 <작업행위>,<휴식행위>,<오락행위>의 3인자가 추출되었고, 사무공간의 경우 <작업행위>, <비작업행위>의 2인자가 추출되었다. 주거공간에서의 3가지 행위인자를 설명하는데 있어서 가장 커다란 영향을 미치는 분위기인자는 <활동성>인자로 나타났으며, 사무공간의 경우, <작업행위>는 <활동성>인자가, <비작업행위>는 <고급감>인자가 가장 큰 영향을 미치고 있는 것으로 나타났다.

학교시설 건설공사의 작업분류체계 구축 및 단위작업별 선후행 관계 분석 (Development of Work Breakdown Structure and Analysis of Precedence Relations by Activity in School Facilities Construction Work)

  • 방종대;손정락
    • 토지주택연구
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    • 제8권3호
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    • pp.189-200
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    • 2017
  • The work breakdown structure and the precedence relations by work activity are very important because they are the basic data for estimating the construction duration in the construction work. However, there is no standard to accurately estimate the construction duration since the size of the school facilities construction is smaller than the general construction work. Therefore, some schools are unable to open in March or September and the delay of the construction duration can cause damage to the students. To solve this problem, this study developed a work breakdown structure of school facilities construction work and analyzed the precedence relations by work activities. The work breakdown structure of the school facilities construction is composed of three steps. The operations corresponding to level 1 and level 2 are as follows. (1) 2 preparatory work categories; preparation period and temporary construction. (2) 17 architectural work categories; temporary construction, foundation & pile work, reinforced concrete work, steel roof work, brick work, plaster work, tile work, stone work, waterproof construction, wood work, interior construction, floor work, metal work, roof work, windows construction, glazing work and paint construction. (3) 7 mechanic and fire work categories; outside trunk line work, plumbing work, air-conditioning equipment work, machine room work, city gas plumbing work, sanitation facilities and inspection & test working. (4) 4 civil work categories; wastewater work, drainage work, pavement work and other work. (5) 1 landscaping work categories; planting work. The work breakdown structure was derived from interviews with experts based on the milestones and detailed statements of existing school facilities. The analysis of precedence relations by school facilities work activity utilized PDM(Precedence Diagramming Method)which does not need a dummy and the relations were applied using FS(Finish to Start), FF(Finish to Finish), SS(Start to Start), SF(Start to Finish). The analysis of this study shows that if one work activity is delayed, the entire construction duration may be delayed because the majority of the works are FS relations. Therefore, it is necessary to use the Lag at the appropriate time to estimate the standard construction duration of the school facility construction. Lag is a term used only in the PDM method and it is used to define the relationship between the predecessor and the successor in creating the network milestone. And it means the delay time applied to the two work activities. The results of this study can reasonably estimate the standard construction duration of school facilities and it will contribute to the quality of the school facilities construction.

Antineoplastic Natural Products and the Analogues(IX). A Review of the Series

  • Ahn, Byung-Zun;Kim, Shin-Il;Ryu, Sung-Ho;Kang, Kyu-Sang;Lee, You-Hui
    • 생약학회지
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    • 제17권2호
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    • pp.168-177
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    • 1986
  • Bioassay-directed isolation has yielded some cytotoxic substances against L1210 cell from the Korean traditional medicine. These include 5,2'-dihydroxy-6,7,8,6'-teramethoxyflavone $(IV,\;scutellaria\;root,\;ED_{50}\;=\;1.7\;{mu}g/ml)$, 7-geranyloxycoumarin $(XXXII,\;poncirus\;fruit,\;10.2\;{mu}g/ml) $and panaxydol $(I,\;white\;ginseng,\;0.03\;{mu}g/ml)$. IV, XXXII and their derivatives were synthesized in the purpose of in vivo tests and for observation of structure-activity relations. Among the flavone derivatives, 5,2',6'-trihydroxy-6,7,8-trimethoxy flavone (XVIII), 5-hydroxy-6,7,8-trimethoxy-6'-benzyloxyflavone (XVII) and 5,8-dihydroxy-6,7-dimethoxyflavone (X) showed the cytotoxicity which has no correlation to the flavone structures. Of the coumarins synthesized, 7,8-dihydroxycoumarin (XXVI), 6-7-dihydroxycoumarin (XXIX) and 6-hydroxy-5,7-dimethoxycoumarin (XXXI) showed considerable activities. Acetylated XXXI has moderate activity $(ED_{50}=17.2\;{mu}g/ml)$. Monobydroxycoumarins or their methyl and allyl ether were inactive. IV inhibits the growth of the solid form of S-180 by 70% at 40 mg/kg and shows T/C of 166% on the ascitic S-180 at 40 mg/kg. It strongly inhibits the activity of the membrane bounded ATPase from L1210 cell. The most cytotoxic fraction of the antitumor materials studied is the one from the trichosanthes root showing $ED_{50}=0. 0003\;{mu}g/ml$ against L1210 cell. This fraction, obtained from ethyl acetate extract, showed T/C of 130 and 135%, on ICR mice bearing S-180 and $BDF_1$ mice bearing L1210 at 10 mg/kg and 7.5 mg/kg, respectively.

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PCB 이성질체가 설치류 신경세포에 미치는 영향: 키토산의 효과 (Effects of PCB Congeners in Rodent Neuronal Cells in Culture : Effects of Chitosan)

  • 김선영;이현교
    • Environmental Analysis Health and Toxicology
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    • 제22권3호
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    • pp.279-285
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    • 2007
  • The present study attempted to analyze the mechanism of PCB-induced neurotoxicity with respect to the PKC signaling. Since the developing neuron is particularly sensitive to PCB-induced neurotoxicity, we isolated cerebellar granule cells derived from 7-day old SD rats and grew cells in culture for additional 7 days to mimic PND-14 conditions. Only non-coplanar PCBs at a high dose showed a significant increase of total PKC activity at $[^3H]PDBu$ binding assay, indicating that non-coplanar PCBs are more neuroactive than coplanar PCBs in neuronal cells. PKC isoforms were immunoblotted with respective monoclonal antibodies. PKC-alpha and-epsilon were activated with non-coplanar PCB exposure. The result suggests that coplanar PCBs have a PKC pathway different from non-coplanar PCBs. Activation of PKC with exposure was dampened with treatment of high molecular weight of chitosan. Chilean (M.W. > 1,000 kDa) inhibited the total activity of PKC induced by the non-coplanar PCBs. Translocation of PKC isoforms was also inhibited by the high molecular weight of chitosan. The study demonstrated that non-coplanar PCBs are more potent neurotoxic congeners than coplanar PCBs and the alteration of PKC activities by PCB exposure can be blocked with the treatment of chitosan. The results suggest a potential use of chitosan as a means of nutritional intervention to prevent the harmful effects of pollutant-derived diseases.

AgI/AgCl/H2WO4 Double Heterojunctions Composites: Preparation and Visible-Light Photocatalytic Performance

  • Liu, Chunping;Lin, Haili;Gao, Shanmin;Yin, Ping;Guo, Lei;Huang, Baibiao;Dai, Ying
    • Bulletin of the Korean Chemical Society
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    • 제35권2호
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    • pp.441-447
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    • 2014
  • $AgI/AgCl/H_2WO_4$ double heterojunctions photocatalyst was prepared via deposition-precipitation followed by ion exchange method. The structure, crystallinity, morphology, chemical content and other physical-chemical properties of the samples are characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive x-ray spectra (EDX), UV-vis diffuse reflectance spectroscopy (DRS), and photoluminescence (PL). The photocatalytic activity of the $AgI/AgCl/H_2WO_4$ was evaluated by degrading methyl orange (MO) under visible light irradiation (${\lambda}$ > 400 nm). The double heterojunctions photocatalyst displayed more efficient photocatalytic activity than pure AgI, AgCl, $H_2WO_4$ and AgCl/$H_2WO_4$. Based on the reactive species and energy band structure, the enhanced photocatalytic activity mechanism of $AgI/AgCl/H_2WO_4$ was discussed in detail. The improved photocatalytic performance of $AgI/AgCl/H_2WO_4$ double heterojunctions could be ascribed to the enhanced interfacial charge transfer and the inhibited recombination of electron-hole pairs, which was in close relation with the $AgI/AgCl/H_2WO_4$ heterojunctions formed between AgI, AgCl and $H_2WO_4$.

액체혼합물의 활동도계수의 이론적 계산 (Theoretical Calculation of Activity Coefficients of Liquid Mixtures)

  • 문대원;전무식;이태규
    • 대한화학회지
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    • 제21권6호
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    • pp.395-403
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    • 1977
  • 액체이론(Significant Structure Theory)를 단원자 분자로부터 다원자 분자에 이르는 여러 액체혼합물에 적용하여 전 농도 범위에서 액체 혼합물의 활동도 계수를 계산했다. 단원자 분자계(Ar-Kr, Kr-Xe)와 이원자 분자계$(Ar-O_2,\;N_2-CO)$와 메탄-크립톤계의 액체혼합물의 활동도 계수는 ${\delta}E_s$ 수정 변수에 의해 좋은 결과를 얻었다. 아르곤-질소, 산소-질소, 그리고 메탄-프로판계에 대해서는 이 외에 ${\delta}$V, ${\delta}$n 수정 변수가 더 필요했다.

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Synthesis of CdS with Graphene by CBD(Chemical Bath Deposition) Method and Its Photocatalytic Activity

  • Pawar, R.C.;Lee, Jin-Yong;Kim, Eun-Jeong;Kim, Hyungsub;Lee, Caroline Sunyong
    • 한국재료학회지
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    • 제22권10호
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    • pp.504-507
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    • 2012
  • Synthesis of RGO (reduced graphene oxide)-CdS composite material was performed through CBD (chemical bath deposition) method in which graphene oxide served as the support and Cadmium Sulfate Hydrate as the starting material. Graphene-based semiconductor photocatalysts have attracted extensive attention due to their usefulness for environmental and energy applications. The band gap (2.4 eV) of CdS corresponds well with the spectrum of sunlight because the crystalline phase, size, morphology, specic surface area and defects, etc., of CdS can affect its photocatalytic activity. The specific surface structure (morphology) of the photocatalyst can be effective for the suppression of recombination between photogenerated electrons and holes. Graphene (GN) has unique properties such as a high value of Young's modulus, large theoretical specific surface area, excellent thermal conductivity, high mobility of charge carriers, and good optical transmittance. These excellent properties make GN an ideal building block in nanocomposites. It can act as an excellent electron-acceptor/transport material. Therefore, the morphology, structural characterization and crystal structure were observed using various analytical tools, such as X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and Raman spectroscopy. From this analysis, it is shown that CdS particles were well dispersed uniformly in the RGO sheet. Furthermore, the photocatalytic property of the resulting RGO-CdS composite is also discussed in relation to environmental applications such as the photocatalytic degradation of pollutants. It was found that the prepared RGO-CdS nanocomposites exhibited enhanced photocatalytic activity as compared with that of CdS nanoparticles. Therefore, better efficiency of photodegradation was found for water purification applications using RGO-CdS composite.

균형훈련이 뇌졸중환자의 발목 근육 활성도와 정적균형에 미치는 영향 (Effect of Balance Training on Ankle Muscle Activity and Static Balance in Stroke Patients)

  • 이영민;김상철;윤성경
    • PNF and Movement
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    • 제12권4호
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    • pp.209-215
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    • 2014
  • Purpose: This study aims to understand the effect of balance training on ankle muscle activity and static balance in stroke patients. Methods: The subjects were composed of 12 patients who were admitted with chronic stroke in H, K, and R hospitals located in Gangwon-do from August to October 2014. This study conducted balance training on the subjects for 20 min a session, twice a day, five times a week for six weeks. This study measured the surface electromyogram (EMG) of the paretic side's tibialis anterior and medial gastrocnemius for muscle activity. Static balance was measured as a TETRAX stability index. The measurements were conducted before the experiment and six weeks after. The result was statistically analyzed using paired t-test at the significance level of 0.05. Result: Muscle activity of the paretic side's tibialis anterior and medial gastrocnemius did not show a significant difference in the comparison between pre- and post-balancing training. However, the stability index showed a significant difference (p<0.05) between standing with eyes open (NO) and standing on a sponge with eyes open (PO). Conclusion: Although balance training did not affect the muscle activity of chronic stroke patients, it had an effective influence on the stability index. That is, balance training was effective at the functional level, but it did not change the structure level in terms of the ICF evaluation standard. Balance training becomes more effective when it is applied in relation to task.

Benzotriazole계 유도체의 제초활성과 분자 설계 (Herbicidal activity and molecular design of benzotriazole derivatives)

  • 성낙도;박현주;박승희;변종영
    • Applied Biological Chemistry
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    • 제34권3호
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    • pp.287-294
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    • 1991
  • Benzotriazole 유도체들의 정량적인 구조와 발아후 벼(Oryzae sativa L) 및 피(Echinochloa crus-galli)에 대한 생장저해 활성값$(pI_{50})$사이의 관계들이 QSAR 방법으로 연구되었다. QSAR 분석에 의하면, 자유 라디칼 파라미터$(E_R)$가 매우 중요한 요소이었으며 $pI_{50}$ 값은 파라치환기(X)의 $E_R$ 파라미터에 대하여 포물선형의 관계를 나타내었다. (3)의 생장저해 활성은 (4)보다 우세하였으며 생장저해 활성이 가장 큰 화합물은 (3b)이었고 피의 생장저해 활성에 대한 $E_R$ 파라미터의 적정값은 각각 $E_R(3)=0.52$$E_R(4)=0.15$이었다. 분자설계 결과, 치환기(X)가 전자 끌게이고 적정값 (0.52)의 $E_R$ 파라미터를 가지는 분자가 가장 활성이 클 것으로 기대되었으며 Benzotriazole 유도체들의 생장저해 활성은 광합성반응(PS-II)에서 전자전달을 효과적으로 차단하는 결과로 믿어진다.

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수, 해운 승선계열 대학생의 의식 구조 (The structure of consciousness of board system collegian who attended in fisheries and maritime college)

  • 이길래;배석제;홍성근
    • 수산해양교육연구
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    • 제6권2호
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    • pp.143-160
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    • 1994
  • I have investigated questionaire concerning to the view of worth and construction of consciousness as to boarding system collegian who will employed in fisheries and maritime industries. The results were as follows; It appeared 38.9% that most collegian had a firm subjectivity about enrolled motive, selection of department, they had selected department according to the neighborhood recommendation, own squired score rather than the adaption and prospection, also it was appeared 55% that they had not satisfied with attending to their college, accordingly, the effectiveness of education were demolished in such aspects. It was appeared 74.3% that the education of fisheries and maritime college were divided into theory and practice pertinently also, 77.1% that modulate both technical education and human like education but as a general rule, the education of ocean going liscensed officer was appeared 7.1% only so that, the reformation of the curriculum and contents of education would be needed. As to the relation between professors and collegian, it was appeared 38.4% that well understanding professor, 18.1% that well teaching professor, 13.3% that they having humanlish relation with professor, 30.6% that they will benefit to vocational selection. consequently, the professor have to brings up the harmony on dint of education and industries. The things which collegian think to be worth were 43.6%, intercourse of friend 30.3%, circle activity. 6.6% listening lecture, also, the leisure activity after school were 74.7% with friends. 16.4% alone. consequently, the professor has to guide of leisure activity after lesson. most collegian has a good relationship with their parent(91.6%) but the respond with bad relationship was 8.4%. The most serious agony which collegian think about is vocational problems (48.9%), the other sex problem(22.5%). The objects consult with agony was aquaintance(54.9%). The parent(5.1%), professors(2.3%), the collegian who did not consult with agony was 20.9%. The parents and the professor is not object consult with their agony. so that, the professors has to strengthen the education according to the human nature. As to job after graduation of such college, collegian who wish to be taken job on the fisheries and maritime industry were 50.5%, on the contrary, the collegian who wish to be taken a job no relation with his major subjects was 29.1% especially, the collegian who want to be embarked was 26.3% (fisheries 23.3%, maritime 30.5%). so that, we must adopt the counter plan for the globalization and effective investment on the fisheries and maritime college.

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