• 한국응용과학기술학회지
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• 제31권3호
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• pp.367-374
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• 2014

In this study, skin permeation enhancement was confirmed by designing it to have a structure and composition similarity to the intercellular lipids that improve miscibility with skin by cross-linked lipids poloxamer. The cross-linked lipids poloxamer was synthesized and analyzed by 1H NMR that structure dose had conjugated pluronic with ceramide3. Active component is released by modification of liquid crystal structure because PPO part, large-scale molecule block of pluronic, has hydrophobic nature at skin temperature of $35^{\circ}C$. Conjugated pluronic with ceramide3 was synthesized using Pluronic F127 and p-NPC (4-nitrophenyl chloroformate) at room temperature yielded 89%. Pluronic(Ceramide 3-conjugated Pluronic) was synthesized by reaction of p-NP-Pluronic with Ceramide3 and DMAP. The yield was 51%. This cross-linked lipids poloxamer was blended and dissolved at isotropic state with skin surface lipids, phospholipid, ceramide, cholesterol and anhydrous additive solvent. Next step was preceded by ${\alpha}$-Transition at low temperature for making the structure of Meso-Phase Lamella, and non-hydrous skin analogue liquid crystal using thermo-sensitivity smart sensor, lamellar liquid crystal structure through aging time. For confirmation of conjugation thermo-sensitivity smart sensor and non-hydrous skin analogue liquid crystal, structural observation and stability test were performed using XRD(Xray Diffraction), DSC(Differential Scanning Calorimetry), PM (Polarized Microscope) And C-SEM (Cryo-Scanning Electron Microscope). Thermo-sensitivity observation by Franz cell revealed that synthesized smart sensor shown skin permeation effect over 75% than normal liquid crystal. Furthermore, normal non-hydrous skin analogue liquid crystal that not applied smart sensor shown similar results below $35^{\circ}C$ of skin temperature, but its effects has increased more than 30% above $35^{\circ}C$.

• 한국실내디자인학회논문집
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• 제40호
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• pp.26-33
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• 2003

Contemporary architecture has two different movements that one is the utilization of digital technology and the other is the inclination to nature. After deconstructivism in architecture, the tendency of design shows the fusion between digitalism and organicism and as a consequence the phenomena of 'skin expression' has emerged which can be thought as 'organic digitalism' or 'digital organicism'. The definition of skin tendency in environmental design is the design of nature based on the technology. As a result, the surface becomes the design issue compared to structure and the momentum for new aesthetic value. There are post-structuralism, complex system theory and the organic architecture as theoretical background for the tendency of skin expression. Specially the ideas of post-structural philosophy has effected deeply to the formation of its movement and also offered the theoretical nutrition for digital architecture. The characteristics of the skin tendency can be analyzed as topological transformation, smooth continuum, deterritorialization, ecological response system, and tactility. These design characteristics has combined with conventional material and design vocabulary to transform and develope new spatial conception.

• Biomolecules & Therapeutics
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• 제21권5호
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• pp.343-348
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• 2013

We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Rab27A and melanophilin (MLPH). Hesperidin did not inhibit melanin production in B16F10 murine melanoma cells stimulated with ${\alpha}$-melanocyte stimulating hormone (${\alpha}$-MSH), and also did not affect the catalytic activity of tyrosinase. But, hesperidin inhibited melanosome transport in melanocyte and showed skin lightening effect in pigmented reconstructed epidermis model. Therefore, we suggest that hesperidin is a useful inhibitor of melanosome transport and it might be applied to whitening agent.

• Smart Structures and Systems
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• 제8권1호
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• pp.139-155
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• 2011

Polymeric thin-film assemblies whose bulk electrical conductivity and mechanical performance have been enhanced by single-walled carbon nanotubes are proposed for measuring strain and corrosion activity in metallic structural systems. Similar to the dermatological system found in animals, the proposed self-sensing thin-film assembly supports spatial strain and pH sensing via localized changes in electrical conductivity. Specifically, electrical impedance tomography (EIT) is used to create detailed mappings of film conductivity over its complete surface area using electrical measurements taken at the film boundary. While EIT is a powerful means of mapping the sensing skin's spatial response, it requires a data acquisition system capable of taking electrical impedance measurements on a large number of electrodes. A low-cost wireless impedance analyzer is proposed to fully automate EIT data acquisition. The key attribute of the device is a flexible sinusoidal waveform generator capable of generating regulated current signals with frequencies from near-DC to 20 MHz. Furthermore, a multiplexed sensing interface offers 32 addressable channels from which voltage measurements can be made. A wireless interface is included to eliminate the cumbersome wiring often required for data acquisition in a structure. The functionality of the wireless impedance analyzer is illustrated on an experimental setup with the system used for automated acquisition of electrical impedance measurements taken on the boundary of a bio-inspired sensing skin recently proposed for structural health monitoring.

• 한국전산구조공학회논문집
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• 제14권3호
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• pp.267-276
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• 2001

이 논문은 회전식 수문(radial gate)의 구조해석에 근거하여 지지점 위치에 따른 모멘트 분배를 최적화하는 것에 관심을 두고 있다. 회전식 수문(radial gate)의 경제적인 관점에서의 중요성에도 불구하고 이의 지지점 위치에 따른 최적설계에 관한 자료를 찾기 어려운 실정이다. 그래서 본 연구에서는 주판(skin plate)의 곡률 반경, 수심, 동압 등의 주어진 자료를 이요약하여 지지점(gate arm)의 수가 2개인 경우와 3개인 경우에 대하여 곡선형태의 주판(skin plate)에서 지지점 (arm)의 최적 위치를 얻어서 설계자료에 의한 것들과 비교한다. 그 결과 최적 설계에 의한 회전식 수문 (radial gate)의 치수가 설계자료에 의한 것에 비해 현저히 감소되는 것을 알 수 있다.

• Journal of the Korean Wood Science and Technology
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• 제38권4호
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• pp.282-291
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• 2010

기존의 중공재에 비해 다량의 목질부를 제거하여 천공한 스킨 팀버는 짧은 건조시간과 건조 결함 발생이 적은 점, 상당히 낮은 수준(MC 8~9%)까지 함수율을 떨어트릴 수 있다는 이점, 약제 주입처리의 용이함, 한옥을 포함한 중목구조의 대단면 경량 구조부재로서의 사용 가능성, 다양한 가구나 생활용품으로의 가능성 등 많은 장점을 가지고 있는 재료이다. 하지만 고부가가치 재료로 사용되기 위해서, 그리고 일반 소비자들에게 구조적 신뢰감을 제공하기 위해서는 스킨 팀버를 하이브리드 구조부재로 만들 필요가 있다. 따라서 본 연구에서는 가능한 얇은 철판을 사용하여 소나무와 낙엽송 개량 스킨 팀버를 제작하고 압축 성능을 분석하였다. 이에 따른 본 연구의 결론은 다음과 같다: 1. 소나무와 낙엽송 개량 스킨 팀버의 경우 무처리 스킨 팀버에 비해 재료 성능의 균일성을 가져올 수 있었다. 2. 소나무나 낙엽송 개량 스킨 팀버 모두 철판두께별 압축 성능의 유의차가 존재하지 않아 두꺼운 철판을 사용 할 필요성이 없다고 판단되었다. 소나무 개량 스킨 팀버와 낙엽송 개량 스킨 팀버간의 압축 성능 역시 유의차가 존재하지 않아 사용자의 기호에 따라 사용할 수 있을 것으로 판단되었다. 4. 소나무 개량 스킨 팀버의 경우 다양한 파괴 형태를 보였지만 낙엽송 스킨 팀버의 경우 전체적으로 splitting의 파괴 모드를 보이는 것이 특징이었다.

• Archives of Plastic Surgery
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• 제43권5호
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• pp.418-423
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• 2016

Background Skin grafting is a relatively simple and thus widely used procedure. However, the elastic and structural quality of grafted skin is poor. Recently, various dermal substitutes have been developed to overcome this disadvantage of split-thickness skin grafts. The present study aims to determine the feasibility of RapiGraft as a new dermal substitute. Methods This prospective study included 20 patients with partial- or full-thickness skin defects; the patients were enrolled between January 2013 and March 2014. After skin defect debridement, the wound was divided into two parts by an imaginary line. Split-thickness skin grafting alone was performed on one side (group A), and RapiGraft and split-thickness skin grafting were used on the other side (group B). All patients were evaluated using photographs and self-questionnaires. The Manchester scar scale (MSS), a chromameter, and a durometer were used for the scar evaluation. The average follow-up period was 6 months. Results The skin graft take rates were 93% in group A and 89% in group B, a non-significant difference (P=0.082). Statistically, group B had significantly lower MSS, vascularity, and pigmentation results than group A (P<0.05 for all). However, the groups did not differ significantly in pliability (P=0.155). Conclusions The present study indicates that a simultaneous application of RapiGraft and a split-thickness skin graft is safe and yields improved results. Therefore, we conclude that the use of RapiGraft along with skin grafting will be beneficial for patients requiring reconstructive surgery.

• Geomechanics and Engineering
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• 제5권3호
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• pp.195-221
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• 2013

A centrifuge model study is carried out to investigate the behavior of pile subject to negative skin friction induced by pile installation, ground water drawdown and surcharge loading. A single end-bearing pile is examined as the induced negative skin friction would induce the most severe stress on the pile structural material as compared to friction piles. In addition, the behavior of the pile under simultaneous negative skin friction and dead/live loads is examined. To facilitate detailed interpretations of the test results, the model setup is extensively instrumented and involves elaborate test control schemes. To further examine the phenomenon of negative skin friction on an end-bearing pile, finite element analyses were conducted. The numerical analysis is first validated against the centrifuge test data and subsequently extended to examine the effects of pile slenderness ratio, surcharge intensity and pile-soil stiffness ratio on the degree of mobilization of negative skin friction induced on the pile. Finally experimental and numerical studies are conducted to examine the effect of applied transient live load on pile subject to negative skin friction.

• 한국수산과학회지
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• 제36권2호
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• pp.107-112
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• 2003

Effect of PCBs on the skin and gill development of olive flounder, Paralichthys olivaceus were investigated by histological methodology and morphometric data. The olive flounder were exposed to limit concentration of effulent of PCBs (3.0 ${\mu}g/L$) for 60 days. Skin development can be classified into four stages: SSEL (simple squamous epithelial layer), MCA (mucous cell appearance) & CCA (club cell appearance) DLA (dermal layer appearance), and SEL (startification of epidermal layer) stages. Gill development had five stages: GFA (gill filament appearance), IGFE (identification of early gill filament epithelial cell) MCA (mucous cell appearance), PCA (pillar cell appearance), and FGL (formation of gill lamella) stages. The periods of structural completion of skin and gill were 22-30 days and 23-30 days after hatching in the exposure group respectively. The process of development of skin and gill of the exposure group was very similar to that of the control group. Therefore, PCBs (3 ${\mu}g/L$) have no influence on the development of skin and gill in the larval stage of olive flounder.

• Archives of Pharmacal Research
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• 제27권11호
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• pp.1177-1182
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• 2004

The effect of poly[2-methacryloyloxyethyl phosphorylcholine] (pMPC) on the skin permeation property was investigated by performing in vitro skin permeation study of a model drug, nicotinic acid (NA). Effect of pMPC polymer in donor solution on skin permeation rates was evaluated using side-by-side diffusion cells. Also, the structural alterations in the stratum corneum (SC), inter-lamellar bilayer (ILB) and dermis layers in pMPC-treated and -untreated skin sections were investigated with transmission electron microscopy (TEM). The permeation profile of NA without pMPC in donor solution showed biphasic mode: initial $1^{st} phase and 2^{nd}$ hydration phase. The sudden, more than 10-fold increase in flux from the initial steady state (43.5 $\mu g/cm^2$/hr) to the $2^{nd}$ hydration phase (457.3 $\mu g/cm^2$/hr) suggests the disruption of skin barrier function due to extensive hydration. The permeation profile of NA with 3% pMPC in the donor solution showed monophasic pattern: the steady state flux (10.9 $\mu g/cm^2$/hr) without abrupt increase of the flux. The degree of NA permeation rate decreased in a concentration-dependent manner of pMPC. TEM of skin equilibrated with water or 2% pMPC for 12 h showed that corneocytes are still cohesive and epidermis is tightly bound to dermis in 2% pMPC-treated skin, while wider separation between corneocytes and focal dilations in inter-cellular spaces were observed in water-treated skin. This result suggests that pMPC could protect the barrier property of the stratum corneum by preventing the disruption of ILB structure caused by extensive skin hydration during skin permeation study.