• Journal of Plant Biology
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• v.36 no.2
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• pp.127-132
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• 1993

Self-incompatibility in Brassica campestris is controlled by multi-allele system in a single genetic locus, the S locus, and it is elucidated that S-glycoproteins are S gene products. In this experiments, we examined the genetic mode(pollen tube behavior and segregation of S-glycoprotein), characteristic of S-glycoproteins and DNA constitution within nuclear genome on S gene family that unexplained by single locus model, and investigated the segregation pattern of S-glycoproteins in bred F1 generation. By diallel cross among the 15 plants within one family the existence of three types of homozygotes and three types of heterozygotes were observed, and segregation of S-allele could not explained by single locus model. From the results of IEF-immunoblot analysis for non-segregated individual plant, the segregation pattern of S specific bands was corresponded with results of diallel cross except with one case(SaSa genotype). The molecular weight of 6 different S-genotype varied in near by 50 kD, and each genotype expressed with 2 or 3 bands. Specific bands in SaSa, SbSb, ScSc has almost similar molecular weight between them. Southern analysis of genomic DNA probed with S-glycoprotein cDNA for 6 different genotypes revealed that there are clear difference in polymorphism, multiple bands of hybridization, when restriction enzymes of EcoR I were used. It could be assumed that there are several sequences related to the S-glycoprotein structural genes within their nuclear genome. Therefore, we suggested the possibilities that S-allele system could be controlled by multi-locus, that dominance-recessive interactions could be explained by modifier gene or supressor gene based on the results of abnormal segregation of S-glycoprotein in bred F1. The F2 analyses are progressing in now.

• Journal of IKEEE
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• v.21 no.3
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• pp.252-255
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• 2017

$Mo_xW_{1-x}Si_2$ heaters were fabricated by self-propagating high-temperature synthesis (SHS) process and post sintering process. To validate the reliability of the $Mo_xW_{1-x}Si_2$ heaters, the accelerated life test (ALT) was conducted, and then lifetime to $Mo_xW_{1-x}Si_2$ heaters was estimated by using Minitab programs. Also, the failure analysis of $Mo_xW_{1-x}Si_2$ heaters after ALT was performed through electrical and structural properties. As the results, it was confirmed that the dominant failure mode of $Mo_xW_{1-x}Si_2$ heaters is the crack formation in heaters and the delamination of protective $SiO_2$ layers.

• Earthquakes and Structures
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• v.8 no.3
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• pp.555-572
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• 2015

This paper presents an experimental study of three two-dimensional (2D/planar) steel reinforced concrete (SRC) T-shaped column-RC beam hybrid joints and six 3D SRC T-shaped column-steel beam hybrid joints under low cyclic reversed loads. Considering different categories of steel configuration types in column cross section and horizontal loading angles for the specimens were selected, and a reliable structural testing system for the spatial loading was employed in the tests. The load-displacement curves, carrying capacity, energy dissipation capacity, ductility and deformation characteristics of the test subassemblies were analyzed. Especially, the seismic performance discrepancies between planar hybrid joints and 3D hybrid joints were intensively compared. The failure modes for planar loading and spatial loading observed in the tests showed that the shear-diagonal compressive failure was the dominating failure mode for all the specimens. In addition, the 3D hybrid joints illustrated plumper hysteretic loops for the columns configured with solid-web steel, but a little more pinched hysteretic loops for the columns configured with T-shaped steel or channel-shaped steel, better energy dissipation capacity & ductility, and larger interlayer deformation capacity than those of the planar hybrid joints. Furthermore, it was revealed that the hysteretic loops for the specimens under $45^{\circ}$ loading angle are generally plumper than those for the specimens under $30^{\circ}$ loading angle. Finally, the effects of steel configuration type and loading angle on the seismic damage for the specimens were analyzed by means of the Park-Ang model.

• Structural Engineering and Mechanics
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• v.31 no.4
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• pp.453-475
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• 2009

The literature regarding the free vibration analysis of Bernoulli-Euler and Timoshenko beams on elastic soil is plenty, but the free vibration analysis of Reddy-Bickford beams on elastic soil with/without axial force effect using the Differential Transform Method (DTM) has not been investigated by any of the studies in open literature so far. In this study, the free vibration analysis of axially loaded Reddy-Bickford beam on elastic soil is carried out by using DTM. The model has six degrees of freedom at the two ends, one transverse displacement and two rotations, and the end forces are a shear force and two end moments in this study. The governing differential equations of motion of the rectangular beam in free vibration are derived using Hamilton's principle and considering rotatory inertia. Parameters for the relative stiffness, stiffness ratio and nondimensionalized multiplication factor for the axial compressive force are incorporated into the equations of motion in order to investigate their effects on the natural frequencies. At first, the terms are found directly from the analytical solutions of the differential equations that describe the deformations of the cross-section according to the high-order theory. After the analytical solution, an efficient and easy mathematical technique called DTM is used to solve the governing differential equations of the motion. The calculated natural frequencies of one end fixed and the other end simply supported Reddy-Bickford beam on elastic soil using DTM are tabulated in several tables and figures and are compared with the results of the analytical solution where a very good agreement is observed and the mode shapes are presented in graphs.

• Molecules and Cells
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• v.41 no.6
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• pp.545-552
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• 2018

Spleen tyrosine kinase (SYK) is a cytosolic non-receptor protein tyrosine kinase. Because SYK mediates key receptor signaling pathways involving the B cell receptor and Fc receptors, SYK is an attractive target for autoimmune disease and cancer treatments. To date, representative oral SYK inhibitors, including fostamatinib (R406 or R788), entospletinib (GS-9973), cerdulatinib (PRT062070), and TAK-659, have been assessed in clinical trials. Here, we report the crystal structures of SYK in complex with two newly developed inhibitors possessing 4-aminopyrido[4,3-D]pyrimidine moieties (SKI-G-618 and SKI-O-85). One SYK inhibitor (SKI-G-618) exhibited moderate inhibitory activity against SYK, whereas the other inhibitor (SKI-O-85) exhibited a low inhibitory profile against SYK. Binding mode analysis indicates that a highly potent SYK inhibitor might be developed by modifying and optimizing the functional groups that interact with Leu377, Gly378, and Val385 in the G-loop and the nearby region in SYK. In agreement with our structural analysis, one of our SYK inhibitor (SKI-G-618) shows strong inhibitory activities on the ${\beta}$-hexosaminidase release and phosphorylation of SYK/Vav in RBL-2H3 cells. Taken together, our findings have important implications for the design of high affinity SYK inhibitors.

• Journal of the Korea Concrete Institute
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• v.20 no.2
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• pp.257-267
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• 2008

Results of seventy-seven specimens tested by this study and previous research were collected and evaluated to propose the flexural strength and shear strength for flexural members with steel fiber concrete. For strength evaluation, structural parameters such as compressive strength, steel fiber content, tensile reinforcement ratio, and shear span to effective depth ratio are involved. The proposed equations for flexural and shear strength are regarded to give a good prediction for the strength of steel fiber reinforced composite and/or RC beams to compare with equations by previous researchers. Especially, the proposed shear strength equation in this study shows the lowest the mean value, the coefficient of variation and the error ratio among predictions by several equations. Therefore, equations for shear strength and flexure strength, which are proposed in this study are to be useful measure to predict the actual behavior and failure mode of steel fiber reinforced composite beams.

• Journal of Ocean Engineering and Technology
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• v.31 no.4
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• pp.288-298
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• 2017

A study of the damage evolution laws for ductile materials was carried out to predict the ductile fracture behavior of a marine structural steel (EH36). We conducted proportional and non-proportional stress tests in the experiments. The existing 3-D fracture strain surface was newly calibrated using two fracture parameters: the average stress triaxiality and average normalized load angle taken from the proportional tests. Linear and non-linear damage evolution models were taken into account in this study. A damage exponent of 3.0 for the non-linear damage model was determined based on a simple optimization technique, for which proportional and non-proportional stress tests were simultaneously used. We verified the validity of the three fracture models: the newly calibrated fracture strain model, linear damage evolution model, and non-linear damage evolution model for the tensile tests of the asymmetric notch specimens. Because the stress evolution pattern for the verification tests remained at mode I in terms of the linear elastic fracture mechanics, the three models did not show significant differences in their fracture initiation predictions.

• The Transactions of the Korea Information Processing Society
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• v.5 no.8
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• pp.2061-2074
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• 1998

In pattern recognition and image analysis upplications, a graph is a useful tool for complex obect representation and recognition. However it takes much time to pair proper nodes between the prototype graph and an input data graph. Futhermore it is difficult to decide whether the two graphs in a class are the same hecause real images are degradd in general by noise and other distortions. In this paper we propose a matching algorithm using a matrix. The matrix is suiable for simple and easily understood representation and enables the ordering and matching process to be convenient due to its predefined matrix manipulation. The nodes which constitute a gaph are ordered in the matrix by their geometrical positions and this makes it possible to save much comparison time for finding proper node pairs. for the classification, we defined a distance measure thatreflects the symbo's structural aspect that is the sum of the mode distance and the relation distance; the fornet is from the parameters describing the node shapes, the latter from the relations with othes node in the matrix. We also introduced a subdivision operation to compensate node merging which is mainly due t the prepreocessing error. The proposed method is applied to the recognition of musteal symbols and the result is given. The result shows that almost all, except heavily degraded symbols are recognized, and the recognition rate is approximately 95 percent.

• Journal of the Korean Institute of Gas
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• v.12 no.2
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• pp.57-62
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• 2008

Difference of failure modes was studied by finite element analysis for elbows with local wall thinning area particularly at inner surface of intrados of the elbow. Longitudinal wall thinning length, minimum thickness were kept constant but circumferential wall thinning width was varied to get $90^{\circ}$, $180^{\circ}$ and $360^{\circ}$ thinning width. Elastic-plastic analysis were carried out under the combined loading conditions of internal pressure and in-plane bending moment closing the elbow. Von Mises stress were obtained from the outer surface central surface location in intrados, extrados and crown parts in elbow. The results showed that the plastic deformation and failure started from the crown location when the thinning width small ($90{\sim}180^{\circ}$). However, plastic collapse started from the intrados location when the thinning width is approaching $360^{\circ}C$. This should be reflected to assess structural integrity of elbows after wall thinning measurement is made.

• Journal of Korean Society of Steel Construction
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• v.20 no.4
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• pp.493-504
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• 2008

This paper deals with the experimental analysis of the flexural behaviour of encased composite beams with hollow core slabs and channels. The shear force between steel beams and hollow core slabs are transferred by channels. Three full-scale specimens were constructed and tested with different steel beam heights, which were compared with those of previous studies. Based on observation of the experiments, the encased composite beams exhibited full shear connection behaviour without any other shear connectors due to their inherent mechanical and chemical bond stress. Experimental results show a behaviour similar to steel-concrete composite beams with classical connectors: elastic and yield domains, great ductility, flexural failure mode (plastic hinge), low relative movement at steel-concrete interface and all specimens failed in a very ductile manner. Consequently, this study enables the validation of the proposed connection device under static loading and shows that it meets modern structural requirements.