• Journal of Ginseng Research
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• v.48 no.4
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• pp.395-404
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• 2024

Background: Ginsenoside Rg₁ (Rg₁) is one of the main active components in Chinese medicines, Panax ginseng and Panax notoginseng. Research has shown that Rg₁ has a protective effect on the cardiovascular system, including anti-myocardial ischemia-reperfusion injury, anti-apoptosis, and promotion of myocardial angiogenesis, suggesting it a potential cardiovascular agent. However, the protective mechanism involved is still not fully understood. Methods: Based on network pharmacology, ligand-based protein docking, proteomics, Western blot, protein recombination and spectroscopic analysis (UV-Vis and fluorescence spectra) techniques, potential targets and pathways for Rg₁ against myocardial ischemia (MI) were screened and explored. Results: An important target set containing 19 proteins was constructed. Two target proteins with more favorable binding activity for Rg₁ against MI were further identified by molecular docking, including mitogen-activated protein kinase 1 (MAPK1) and adenosine kinase (ADK). Meanwhile, Rg₁ intervention on H9c2 cells injured by H₂O₂ showed an inhibitory oxidative phosphorylation (OXPHOS) pathway. The inhibition of Rg₁ on MAPK1 and OXPHOS pathway was confirmed by Western blot assay. By protein recombination and spectroscopic analysis, the binding reaction between ADK and Rg₁ was also evaluated. Conclusion: Rg₁ can effectively alleviate cardiomyocytes oxidative stress injury via targeting MAPK1 and ADK, and inhibiting oxidative phosphorylation (OXPHOS) pathway. The present study provides scientific basis for the clinical application of the natural active ingredient, Rg₁, and also gives rise to a methodological reference to the searching of action targets and pathways of other natural active ingredients.

• Ocean Systems Engineering
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• v.4 no.4
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• pp.327-342
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• 2014

The tension leg platform (TLP) is one of the compliant structures which are generally used for deep water oil exploration. With respect to the horizontal degrees of freedom, it behaves like a floating structure moored by vertical tethers which are pretension due to the excess buoyancy of the platform, whereas with respect to the vertical degrees of freedom, it is stiff and resembles a fixed structure and is not allowed to float freely. In the current study, a numerical study for square TLP using modified Morison equation was carried out in the time domain with water particle kinematics using Airy's linear wave theory to investigate the effect of changing the tether tension force on the stiffness matrix of TLP's, the dynamic behavior of TLP's; and on the fatigue stresses in the cables. The effect was investigated for different parameters of the hydrodynamic forces such as wave periods, and wave heights. The numerical study takes into consideration the effect of coupling between various degrees of freedom. The stiffness of the TLP was derived from a combination of hydrostatic restoring forces and restoring forces due to cables. Nonlinear equation was solved using Newmark's beta integration method. Only uni-directional waves in the surge direction was considered in the analysis. It was found that for short wave periods (i.e., 10 sec.), the surge response consisted of small amplitude oscillations about a displaced position that is significantly dependent on tether tension force, wave height; whereas for longer wave periods, the surge response showed high amplitude oscillations that is significantly dependent on wave height, and that special attention should be given to tethers fatigue because of their high tensile static and dynamic stress.

• JSTS:Journal of Semiconductor Technology and Science
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• v.17 no.3
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• pp.319-325
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• 2017

Through silicon via (TSV) technology is extensively used in 3D IC integrations. The special structure of the TSV is realized by CMP (Chemically Mechanical Polishing) process with a high Cu removal rate and, low dishing, yielding fine topography without defects. In this study, we investigated the electrochemical behavior of copper slurries with various inhibitors in the Cu CMP process for advanced TSV applications. One of the slurries was carried out for the most promising process with a high removal rate (${\sim}18000{\AA}/Min$ @ 3 psi) and low dishing (${\sim}800{\AA}$), providing good microstructure. The effects of pH value and $H_2O_2$ concentration on the slurry corrosion potential and Cu static etching rate (SER) were also examined. The slurry formula with a pH of 6 and 2% $H_2O_2$, hadthe lowest SER (${\sim}75{\AA}/Min$) and was the best for TSV CMP. A novel Cu TSV CMP process was developed with two CMPs and an additional annealing step after some of the bulk Cu had been removed, effectively improving the condition of the TSV Cu surface and preventing the formation of crack defects by variations in wafer stress during TSV process integration.

• Information Systems Review
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• v.7 no.2
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• pp.1-21
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• 2005

Integrated Railroad Information System(IRIS) Construction Project is one of the super projects in Korea required to invest over 100 billion won and 10,000 engaged manpower until Dec 30, 2004. Composition of this paper is as follows; firstly, examined individual contents and aspects of IRIS, and studied formality and contents that have been based to project methodology for successful propulsion of project in overall situation of SI project progress until present. Secondly, presented for construction background of IRIS as well as Project Management and Project Development Methodologies. Thirdly, described each characteristic and development substance for individual systems after present whole contents and system image of the system. Finally, presented successful propulsion result of this project and development directions. We presented development example laying stress on IRIS's Project contents and propulsion circumstances. Evaluation about operation results should be analyzed and studied in detail operating system from now on.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.41 no.4
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• pp.275-283
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• 2013

In this paper, the structural optimum design method of composite rotor blade cross-section was investigated with the genetic algorithm. An auto-mesh generation program was developed for iterative calculations of optimum design, and stresses in the blade cross-section were analyzed by VABS (variational asymptotic beam sectional analysis) program. Minimum mass of rotor blade was defined as an object function, and stress failure index, center mass and blade minimum mass per unit length were chosen as constraints. Finally, design parameters such as the thickness and layup angles of a skin, and the thickness, position and width of a torsion box were determined through the structural optimum design method of composite rotor blade cross-section presented in this paper.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.14 no.1
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• pp.56-63
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• 2004

Exact solutions are presented for the free vibration and buckling of rectangular plates haying two opposite edges ( x=0 and a) simply supported and the other two ( y=0 and b) clamped, with the simply supported edges subjected to a linearly varying normal stress $\sigma$$_{x}$=- $N_{0}$[1-a(y/b)]/h, where h is the plate thickness. By assuming the transverse displacement ( w) to vary as sin(m$\pi$x/a), the governing partial differential equation of motion is reduced to an ordinary differential equation in y with variable coefficients. for which an exact solution is obtained as a power series (the method of Frobenius). Applying the clamped boundary conditions at y=0 and byields the frequency determinant. Buckling loads arise as the frequencies approach zero. A careful study of the convergence of the power series is made. Buckling loads are determined for loading parameters a= 0, 0.5, 1, 1.5. 2, for which a=2 is a pure in-plane bending moment. Comparisons are made with published buckling loads for a= 0, 1, 2 obtained by the method of integration of the differential equation (a=0) or the method of energy (a=1, 2). Novel results are presented for the free vibration frequencies of rectangular plates with aspect ratios a/b =0.5, 1, 2 when a=2, with load intensities $N_{0}$ / $N_{cr}$ =0, 0.5, 0.8, 0.95, 1. where $N_{cr}$ is the critical buckling load of the plate. Contour plots of buckling and free vibration mode shapes ate also shown.shown.

• Structural Engineering and Mechanics
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• v.68 no.4
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• pp.385-398
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• 2018

In the present paper, we offer a new flat shell finite element. It is the result of the combination of a membrane element and a bending element, both based on the strain-based formulation. It is known that $C^{\circ}$ plane membrane elements provide poor deflection and stress for problems where bending is dominant. In addition, they encounter continuity and compliance problems when they connect to C1 class plate elements. The reach of the present work is to surmount these problems when a membrane element is coupled with a thin plate element in order to construct a shell element. The membrane element used is a triangular element with four nodes, three nodes at the vertices of the triangle and the fourth one at its barycenter. Each node has three degrees of freedom, two translations and one rotation around the normal. The coefficients related to the degrees of freedom at the internal node are subsequently removed from the element stiffness matrix by using the static condensation technique. The interpolation functions of strain, displacements and stresses fields are developed from equilibrium conditions. The plate element used for the construction of the present shell element is a triangular four-node thin plate element based on Kirchhoff plate theory, the strain approach, the four fictitious node, the static condensation and the analytic integration. The shell element result of this combination is robust, competitive and efficient.

• Computational Structural Engineering
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• v.10 no.3
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• pp.241-250
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• 1997

The strain localization of concrete is a phenomenon such that the deformation of concrete is localized in finite region along with softening behavior. The objective of this paper is to develop a plasticity and damage algorithm for the finite element analysis of the strain-localization in concrete. In this paper, concrete member under strain localization is modeled with localized zone and non-localized zone. For modeling of the localized zone in concrete under strain localization, a general Drucker-Prager failure criterion by which the nonlinear strain softening behavior of concrete after peak-stress can be considered is introduced in a thermodynamic formulation of the classical plasticity model. The return-mapping algorithm is used for the integration of the elasto-plastic rate equation and the consistent tangent modulus is also derived. For the modeling of non-localized zone in concrete under strain localization, a consistent nonlinear elastic-damage algorithm is developed by modifying the free energy in thermodynamics. Using finite element program implemented with the developed algorithm, strain localization behaviors for concrete specimens under compression are simulated.

• Journal of the Ergonomics Society of Korea
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• v.33 no.5
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• pp.323-335
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• 2014

Objective: The aim of this study is to identify the relationship between personality and psychological responses induced by emotional stimuli (happiness, sadness, anger, boring and stress) for children. Background: Many researches are interested in assertion that there is close correlation between personality and emotion. The relationship between personality and emotion needs to be studied in view of the extended integration, not in view of respective property, because personality is deeply ingrained, and the relatively enduring patterns of thought, feeling and behavior and emotion can take advantage of individual differences in sensitivities to situational cues and predispositions to emotional state. In particular, studies on the personality and emotion for children are necessary in that childhood is an important period for formation of their personality and emotion expression and regulation. Method: Prior to the experiment, we made parents of 94 children rate personalities of their children, based on Korean Personality Inventory for Children (K-PIC). Results of 64 children without missing answers to all questions were analyzed. 64 children were exposed to five emotional stimuli and were asked to report the classification and intensity of their experienced emotion. Results: Children were classified into two groups of the lower 25% and higher 25% scores in twenty sub-scales of K-PIC, and psychological responses to five emotional stimuli between two groups were compared. Accuracy of emotion experienced by emotional stimuli showed a significant difference between the two groups, the lower and higher scores in Hyperactivity and Adjustment. Also, there was a significant difference in the intensity of experienced emotions between the two groups in Intellectual Screening and Psychosis. Conclusion: Our result has shown that hyperactivity, adjustment, intellectual screening and psychosis influence the accuracy and intensity of emotional responses. Application: This study can offer a guideline to overcome methodological limitation of emotion studies for children and help researcher basically understand and recognize human emotion in HCI.

• Korean Journal of Social Welfare
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• v.63 no.4
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• pp.131-154
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• 2011

This study aimed to find out how to support school adaptation among multicultural family youth from accompanied entry, specifically the children who came to Incheon, Korea to live with new stepfather because of their mother's international marriage. The objective of the study is to seek for counter-measurements against the problems of their high probability of leaving and quitting school. Based on grounded theory in qualitative studies, the study was to analyze various categories and dimensions in school adaptation process among the elementary students. Individual, family, and school related factors were involved in the school adaptation process, positively or negatively. Probing and speculating multi-dimensional aspects of the adapting process, the study paid attention to the followings. First, to extent to which the experiences of school adjustment among the multicultural youths were differentiated from those of other students. Second, how the youths responded to society and other people, directly or indirectly, and modified their actions and attitudes. Third, how we can help the youths out of school maladjustment and toward social integration. In conclusion, policy suggestions are given to assist the struggles of the disadvantaged youth, who are under acculturative stress and adapting problems at the new country.