• Anxiety and mood
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• v.4 no.1
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• pp.42-48
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• 2008

Objective : Due to a better understanding of the pathophysiology of posttraumatic stress disorder (PTSD) and the relative limitations in the treatment of patients with PTSD, a variety of medications and treatment algorithms for PTSD have been investigated. This study was conducted to investigate the trends in the pharmacotherapy used in the treatment of inpatients with PTSD at a single university hospital in Korea. Methods : Data from 75 patients diagnosed with PTSD according to the DSM-IV criteria from January 1998 to December 2007 were collected. Demographic data and clinical data, including medications prescribed, were investigated. Results : Thirty-three of the 75 subjects included in this study were male, and 42 were female. Considering psychiatric comorbidity, depressive disorder, cognitive disorder, psychotic disorder and anxiety disorder were reported in order. Approximately 97% of the subjects were treated with antidepressants, including paroxetine in 54.7%, and 24% of the subjects were treated with two different kinds of antidepressants. In addition, atypical antipsychotics were prescribed in 33.3% of patients, mood stabilizers in 17.3%, and anxiolytics in 94.7% of the subjects. Conclusion : In our study, various kinds of antidepressants were prescribed for most patients with PTSD. Antipsychotics and mood stabilizers were added to the treatment regimens of some subjects, and anxiolytics were added to the treatment regimens of most subjects. Despite its many limitations, this study shows the prescription pattern and trends in PTSD treatment in Korea. We hope that these preliminary data would be helpful for the development and integration of a practical guideline for the treatment of PTSD in Korea.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.11
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• pp.205-212
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• 2018

In order to overcome shortcomings of commercial analysis program for solving certain geotechnical problems, finite element method adopting isoparametric quadrilateral element was selected as a tool for analyzing soil behavior and calculating process was programmed. Two examples were considered in order to verify reliability of the developed program. One of the two examples is the case of acting isotropic confining pressure on finite element and the other is the case of acting shear stress on the sides of the finite element. Isoparametric quadrilateral element was considered as the finite element and displacements in the element can be expressed by node displacements and shape functions in the considered element. Calculating process for determining strain which is defined by derivatives using global coordinates was coded using the Jacobian and the natural coordinates. Four point Gauss rule was adopted to convert double integral which defines stiffness of the element into numerical integration. As a result of executing analysis of the finite element under isotropic confining pressure, calculated stress corresponding to four Gauss points and center of the element were equal to the confining pressure. In addition, according to the analyzed results for the element under shear stress, horizontal stresses and vertical stresses were varied with positions in the element and the magnitudes and distribution pattern of the stresses were thought to be rational.

• Journal of Animal Science and Technology
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• v.64 no.4
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• pp.800-811
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• 2022

The integration of metabolomics and transcriptomics may elucidate the correlation between the genotypic and phenotypic patterns in organisms. In equine physiology, various metabolite levels vary during exercise, which may be correlated with a modified gene expression pattern of related genes. Integrated metabolomic and transcriptomic studies in horses have not been conducted to date. The objective of this study was to detect the effect of moderate exercise on the metabolomic and transcriptomic levels in horses. In this study, using nuclear magnetic resonance (NMR) spectroscopy, we analyzed the concentrations of metabolites in muscle and plasma; we also determined the gene expression patterns of branched chain (alpha) keto acid dehydrogenase kinase complex (BCKDK), which encodes the key regulatory enzymes in branched-chain amino acid (BCAA) catabolism, in two breeds of horses, Thoroughbred and Jeju, at different time intervals. The concentrations of metabolites in muscle and plasma were measured by ¹H NMR (nuclear magnetic resonance) spectroscopy, and the relative metabolite levels before and after exercise in the two samples were compared. Subsequently, multivariate data analysis based on the metabolic profiles was performed using orthogonal partial least square discriminant analysis (OPLS-DA), and variable important plots and t-test were used for basic statistical analysis. The stress-induced expression patterns of BCKDK genes in horse muscle-derived cells were examined using quantitative reverse transcription polymerase chain reaction (qPCR) to gain insight into the role of transcript in response to exercise stress. In this study, we found higher concentrations of aspartate, leucine, isoleucine, and lysine in the skeletal muscle of Jeju horses than in Thoroughbred horses. In plasma, compared with Jeju horses, Thoroughbred horses had higher levels of alanine and methionine before exercise; whereas post-exercise, lysine levels were increased. Gene expression analysis revealed a decreased expression level of BCKDK in the post-exercise period in Thoroughbred horses.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.12
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• pp.205-217
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• 2016

The objective of this study was to understand the fundamental aspects of the laughter therapy using the Van Manen's hermeneutic phenomenological method. Participants of this study included twelve elderly people-four men and eight women-who agreed to participate in this study underwent laughter therapy at a senior citizen's center. Data were collected through focus interviews, a literary work, and a work of art. The essential themes of this study are a healthy life (restoration of health, refreshed feeling), a happy life (stress relief, put idle thoughts out of one's mind, vitality in daily routine, double pleasure through laughter, re-juvenescence with reminiscence), and a wishful life (became optimistic while leaving behind suffering, look forward to things). Healthy life was defined as experiencing the basic motive power of life, happy life was defined as experiencing delightfulness through relationships with others and empathy, and wishful life was defined as experiencing an affirmative life integration through overcoming suffering from losses. In conclusion, laughter therapy showed to improve health, personal relations and life integration for elderly people. Therefore, utilization of laughter therapy will help to improve independence and self-esteem in elderly people.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.22 no.5
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• pp.463-474
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• 2009

Double symmetric patch repair of existing structures always causes membrane action only, however, in many cases this technique is not practical. On the other hand, the bending stiffness of the patch and the skin increases as tensile loading is increased and affects the bending deformation significantly in the case of single-sided patch repair. In this study, the p-convergent full layerwise model has been proposed to determine the stress concentration factor in the vicinity of a circular hole as well as across the thickness of plates with single-sided patch repair. In assumed displacement field, the strain-displacement relations and 3-D constitutive equations of a layer are obtained by the combination of 2-D and 3-D hierarchical shape functions. The transfinite mapping technique has been used to represent a circular boundary and Gauss-Lobatto numerical integration is implemented in order to directly obtain stresses occurred at the nodal points of each layer without other extrapolation techniques. The accuracy and simplicity of the present model are verified with comparison of the previous results in literatures using experiment and conventional 3-D finite element. Also, the bending effect has been investigated with various patch types like square, circular and annular shape.

• Molecules and Cells
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• v.41 no.5
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• pp.413-422
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• 2018

Soybean transgenic plants with ectopically expressed AtABF3 were produced by Agrobacterium-mediated transformation and investigated the effects of AtABF3 expression on drought and salt tolerance. Stable Agrobacterium-mediated soybean transformation was carried based on the half-seed method (Paz et al. 2006). The integration of the transgene was confirmed from the genomic DNA of transformed soybean plants using PCR and the copy number of transgene was determined by Southern blotting using leaf samples from $T_2$ seedlings. In addition to genomic integration, the expression of the transgenes was analyzed by RT-PCR and most of the transgenic lines expressed the transgenes introduced. The chosen two transgenic lines (line #2 and #9) for further experiment showed the substantial drought stress tolerance by surviving even at the end of the 20-day of drought treatment. And the positive relationship between the levels of AtABF3 gene expression and drought-tolerance was confirmed by qRT-PCR and drought tolerance test. The stronger drought tolerance of transgenic lines seemed to be resulted from physiological changes. Transgenic lines #2 and #9 showed ion leakage at a significantly lower level (P < 0.01) than ${\underline{n}}on-{\underline{t}}ransgenic$ (NT) control. In addition, the chlorophyll contents of the leaves of transgenic lines were significantly higher (P < 0.01). The results indicated that their enhanced drought tolerance was due to the prevention of cell membrane damage and maintenance of chlorophyll content. Water loss by transpiration also slowly proceeded in transgenic plants. In microscopic observation, higher stomata closure was confirmed in transgenic lines. Especially, line #9 had 56% of completely closed stomata whereas only 16% were completely open. In subsequent salt tolerance test, the apparently enhanced salt tolerance of transgenic lines was measured in ion leakage rate and chlorophyll contents. Finally, the agronomic characteristics of ectopically expressed AtABF3 transgenic plants ($T_2$) compared to NT plants under regular watering (every 4 days) or low rate of watering condition (every 10 days) was investigated. When watered regularly, the plant height of drought-tolerant line (#9) was shorter than NT plants. However, under the drought condition, total seed weight of line #9 was significantly higher than in NT plants (P < 0.01). Moreover, the pods of NT plants showed severe withering, and most of the pods failed to set normal seeds. All the evidences in the study clearly suggested that overexpression of the AtABF3 gene conferred drought and salt tolerance in major crop soybean, especially under the growth condition of low watering.

• The Journal of Korean Academy of Sensory Integration
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• v.16 no.2
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• pp.36-49
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• 2018

Objective : The purpose of this study was to examine the validity and reliability of the Korean version of Life Balance Inventory (K-LBI) and to present the relationship between life balance and sensory processing. Methods : K-LBI was constructed through forward and backward translation. Convergent validity, internal consistency, and test-retest reliability were tested for college students. To verify convergent validity, correlation analyses between K-LBI and Korean version of Perceived Stress Scale, Korean version of Satisfaction With Life Scale, and Adult Self Report-Achenbach system of empirically based assessment were performed. Split-half reliability and test-retest reliability were also obtained for reliability verification. We performed the correlation analysis between K-LBI and Korean version of Adolescent/Adult Sensory Profile. Results : A significant correlation was found between K-LBI and the scales for convergent validity. A favorable split-half reliability and test-retest reliability were calculated. The positive correlations were found between relationship life balance and sensory sensitivity/sensation avoiding quadrants. The negative correlation was found between challenges life balance and low registration. Conclusion : This study shows that K-LBI is a valid and reliable tool in Korea. It also provides an in-depth understanding of the relationship between life balance and sensory processing.

• The Journal of Korean Academy of Sensory Integration
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• v.21 no.3
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• pp.79-102
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• 2023

Objective : Autistic Spectrum Disorders(ASD) is a developmental disorder characterized by atypical sensory adaptation, communication problem, stereotyped behavior, and feeding disorders. The reasons for ASD feeding disorders are oral sensory motor, cognitive, behavioral, and social problems. Major symptoms include picky eating, selective eating, food refusal, food neophobia, limited food variety, and food aversion. ASD feeding disorders could be accompanied by various problems such as health and nutrition intake problems, feeding development, eating-related sociability, and family and caregiver stress. Feeding problems and disorders in ASD can present from birth. However, ASD is diagnosed by the age of 3, and there might be an appropriate treatment gap. Usually, symptoms of feeding disorders tend to decrease with age. However, the symptoms often remain, so early evaluation, intervention, and periodic checking are necessary. In this study, the general information about the feeding disorder characteristics of ASD, influencing factors, and intervention were described through a literature review. Conclusion : Sensory-based therapy and behavior-based therapies are generally used for feeding disorders in ASD. Sensory-based therapy is effective for food sensitivity and behavior-based therapy for food selection. As the symptoms of feeding disorders in ASD are diverse, a comprehensive approach includes play and participation, oral motor exercise, diet, and daily life. However, appropriate evaluation, intervention protocol, and guidelines for the treatment of feeding disorders in ASD are limited. Therefore, a complex approach based on a more systematic understanding is needed. Feeding rehabilitation specialists, such as occupational therapists, should provide appropriate evaluation and intervention.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.11 no.1
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• pp.45-53
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• 1991

The underground structure, which has infinite or semi-infinite boundary conditions, is subjected by body forces and in-situ stresses. It also has stress concentration, which causes material nonlinear behavior, in the vicinity of the excavated surface. In this paper, some methods which can be used to transform domain integrals into boundary integrals are reviewed in order to analyze the effect of the body forces and the in-situ stresses. First, the domain integral of the body force is transformed into boundary integral by using the Galerkin tensor and divergence theorem. Second, it is transformed by writing the domain integral in cylindrical coordinates and using direct integration. The domain integral of the in-situ stress is transformed into boundary integral applying the direct integral method in cylindrical coordinates. The methodology is verified by comparing the results from the boundary element analysis with those of the finite element analysis. Coupling the above boundary elements with finite elements, the nonlinear behavior that occurs locally in the vicinity of the excavation is analyzed and the results are verified. Thus, it is concluded that the domain integrals of body forces and in-situ stresses could be performed effectively by transforming them into the boundary integrals, and the nonlinear behavior can be reasonably analyzed by coupled nonlinear finite element and boundary element method. The result of this research is expected to he used for the analysis of the underground structures in the effective manner.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.13 no.3
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• pp.25-34
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• 1993

The long-term behavior, such as in excavation problems of weak medium, can be dealt with by the elasto-viscoplasticity models. In this paper, a combined formulation of elasto-viscoplasticity using boundary elements and finite elements without using internal cells is presented. The domain integral introduced due to the viscoplastic stresses is transformed into a boundary integral applying direct integration in cylindrical coordinates. The results of the developed boundary element analysis are compared with those from the explicit solution and from the finite element analysis. It is observed that the boundary element analysis without internal cells results in some error because of its deficiency in handling the nonlinearity in local stress concentration. Therefore, a coupled analysis of boundary elements and finite elements, in which finite elements are used in the area of stress concentration, is developed. The coupled method is applied to a time dependent inelastic problem with semi-infinite boundaries. It results in reasonable solution compared with other methods where relatively higher degree of freedoms are employed. Thus, it is concluded that the combined analysis may be used for such problems in the effective manner.