• 동서간호학연구지
• /
• 제27권2호
• /
• pp.104-113
• /
• 2021

Purpose: The purpose of this study was to investigate the status of emotional labor of nursing personnel working in comprehensive nursing service ward and to suggest the way service improvement can be achieved. Methods: A total of 28 nurses working in comprehensive nursing service ward were divided into four groups to conduct focus group interview. All interviews were recorded and transcribed after the interview to perform data analysis in the order of data classification, topic categorization, and keyword derivation. Results: The five categories of subjects and relating keywords drawn from the focus group interviews are as follows: 1) Emotional labor experience: suppressing emotions, expressing emotions or actions that are different from reality, 2) Situations of emotional labor: verbal abuse and assault, sexual harassment, personal needs and errands, 3) Responses to emotional labor: responding directly, responding directly, receiving senior's help, using the organizational system, persevering, 4) Problems caused by emotional labor: work exhaustion, job change intention, job stress, 5) Protection plan against emotional labor: manual or education for nurses, education for patients and carers, compensation, tough sanctions though system strengthening. Conclusion: This study shows that although nurses working in comprehensive nursing service ward generally experience high levels of emotional labor, the problem solving of them relies mainly on personal response. Therefore, it is necessary to develop various measures to protect nurses in an organizational level response, thus to improve the comprehensive nursing service system.

• Safety and Health at Work
• /
• 제12권3호
• /
• pp.390-395
• /
• 2021

Background: Health-care providers typically undergo shift work and are subjected to increased stress. Night shift work may induce disturbed sleep cycles and circadian rhythm. The objective of this study was to explore if night shift workers (NSWs) show an increased risk of abnormal thyroid-stimulating hormone (TSH). Methods: We conducted a retrospective cohort study of 574 employees without thyroid disease and abnormal TSH at baseline who underwent annual check-ups between 2007 and 2016 in a medical center. NSWs were defined as those with working time schedules other than daytime hours. We calculated the incidence rate and estimated the adjusted hazard ratio (HR) for incident abnormal TSH and subclinical hypothyroidism compared with non-NSWs using a Cox regression model. Results: A total of 56 incident abnormal TSH cases and 39 subclinical hypothyroidism cases in NSWs were identified during 3000 person-years of follow-up. In models adjusted for age, sex, obesity, and working departments, we found no increased relative risk for incident abnormal TSH (HR: 0.72, 95% confidence interval: 0.33-1.60) or subclinical hypothyroidism (HR: 0.52, 95% confidence interval: 0.19-1.45) when comparing NSWs to non-NSWs; nor were incidence rates significantly different among exclusively medical employees after excluding administrative staff. Conclusion: In this hospital-based nine-year follow-up retrospective cohort study, NSWs were not associated with increased relative risk of incident abnormal TSH and subclinical hypothyroidism, in contrast to previous cross-sectional studies.

• 한국융합학회논문지
• /
• 제10권6호
• /
• pp.287-297
• /
• 2019

본 연구는 여성 청소년의 주관적 체형인식과 치주질환의 관련성에 대하여 제6기 3차년도(2015년) 국민건강영양조사 자료를 활용하여 파악하고자 하였다. 연구대상은 만 12~18세 여성 청소년 211명이며, 분석 결과, 여성 청소년의 주관적 체형인식은 연령, 수면시간, BMI, 체중조절, 칫솔질 횟수와 관련이 있으며, 치주질환 여부에는 연령, 흡연, 수면시간, 스트레스, BMI, 칫솔질 횟수가 영향을 주는 것으로 나타났다. 여성 청소년의 주관적 체형인식과 치주질환의 관계에 대하여 교란변수를 통제하고 분석한 결과, 체형을 보통으로 인식하는 경우에 비하여 비만으로 인식하는 경우 치주질환이 3.18배(OR = 3.18, 95% CI: 1.21, 8.38) 높게 나타났다. 앞으로 여성 청소년의 정신건강을 고려한 구강건강관리를 통하여 치주질환을 예방하여야 할 것이다.

• Molecules and Cells
• /
• 제42권4호
• /
• pp.292-300
• /
• 2019

Immunometabolism, defined as the interaction of metabolic pathways with the immune system, influences the pathogenesis of metabolic diseases. Metformin and carbon monoxide (CO) are two pharmacological agents known to ameliorate metabolic disorders. There are notable similarities and differences in the reported effects of metformin and CO on immunometabolism. Metformin, an anti-diabetes drug, has positive effects on metabolism and can exert anti-inflammatory and anti-cancer effects via adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms. CO, an endogenous product of heme oxygenase-1 (HO-1), can exert anti-inflammatory and antioxidant effects at low concentration. CO can confer cytoprotection in metabolic disorders and cancer via selective activation of the protein kinase R-like endoplasmic reticulum (ER) kinase (PERK) pathway. Both metformin and CO can induce mitochondrial stress to produce a mild elevation of mitochondrial ROS (mtROS) by distinct mechanisms. Metformin inhibits complex I of the mitochondrial electron transport chain (ETC), while CO inhibits ETC complex IV. Both metformin and CO can differentially induce several protein factors, including fibroblast growth factor 21 (FGF21) and sestrin2 (SESN2), which maintain metabolic homeostasis; nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of the antioxidant response; and REDD1, which exhibits an anticancer effect. However, metformin and CO regulate these effects via different pathways. Metformin stimulates p53- and AMPK-dependent pathways whereas CO can selectively trigger the PERK-dependent signaling pathway. Although further studies are needed to identify the mechanistic differences between metformin and CO, pharmacological application of these agents may represent useful strategies to ameliorate metabolic diseases associated with altered immunometabolism.

• 한국치위생학회지
• /
• 제19권5호
• /
• pp.699-713
• /
• 2019

Objectives: This study aimed to identify the relationships of oral and systemic health-related characteristics with health-related quality of life (EQ-5D) in the elderly, and factors related to quality of life were compared according to age subgroups classified as either younger (young-old) or older (old-old) than 75 years of age. Methods: Data acquired by the Sixth Korean National Health and Nutrition Examination Survey(KNHANES) from 2013 to 2015 were used, and the research target was 3,124 people aged 65 years or older. A complex samples general linear model was used to identify health-related quality of life factors. Results: Education, economic activity, depression, stress, regular walking, self-rated oral health, pronunciation problems, and unmet dental care had significant effects on quality of life in both young-old and old-old participants. Marriage, income, number of systemic diseases, sleeping, and chewing inconveniences were significant factors for the young-old but not in the old-old participants. Instead, obesity and drinking were identified as significant factors in the old-old participants. Conclusions: We reaffirmed that factors affecting health-related quality of life in older adults differed by age group. We also confirmed the impact of oral health-related characteristics on this quality. Therefore, to improve quality of life for older adults, it would be efficient to divide groups by age and develop and implement programs that take relevant factors into consideration.

• 한국방사선학회논문지
• /
• 제15권4호
• /
• pp.499-505
• /
• 2021

본 연구는 HRV 신호를 분석하여 비임산부와 임산부의 시기별 자율신경계 활성도를 비교하였다. W병원의 질병이 없는 임산부 99명과 비임산부 27명을 연구대상으로 하였다. 획득한 HRV 신호는 프로그램을 이용해 시간영역 분석, 주파수 영역 분석을 실시하였다. 측정된 값은 일원배치 분산 분석을 통해 임신 시기별 간의 차이를 통계 분석 하였다. 결과에서, 시간 영역 분석에서 SDNN과 RMSSD는 임신 초기와 비임신 여성의 결과값이 임신 중기, 말기와 비교했을 때 유의하게 높았다. 주파수 영역 분석에서 LF와 HF는 임신 초기와 비임신의 값이 중기, 말기에 비하여 유의하게 높았으나 VLF와 LF/HF에서는 유의한 차이가 없었다. 이는 임신이 진행될수록 비임신 상태와 임신 초기보다 중기 및 말기에 자율신경 조절 능력이 저하되고 신체적 피로도와 정신적 피로도가 증가하게 되는 것을 의미한다. 따라서 임신 기간이 길어질수록 임산부의 심신 안정을 유지하기 위해 각별한 관리가 필요할 것으로 사료된다.

• 한국콘텐츠학회논문지
• /
• 제21권3호
• /
• pp.282-300
• /
• 2021

본 연구의 목적은 코로나19 확산으로 가족생활에서 급격한 변화가 일어난 1차 확산기에 블로그와 온라인 카페에 게시된 소셜 빅데이터를 분석하여 키워드를 파악하고, 게시글에 잠재된 주요 토픽을 발견하는 것이다. 강화된 사회적 거리두기가 처음 시행되었던 2020년 2월 23일부터 4월 19일까지 네이버와 다음의 블로그 및 카페에 게시된 글 중 '코로나'와 '가족' 또는 '코로나'와 '가정'이 함께 언급된 문서 총 351,734건을 분석하였다. 수집된 데이터는 전처리를 거쳐 텍스트 마이닝 기법으로 분석하였다. TF-IDF 가중치 값을 바탕으로 상위 100개 단어를 살펴보았으며, 잠재디리클레할당 방식의 토픽모델 분석을 통해 총 22개 토픽을 도출하고 토픽명을 부여하였다. 연구결과, 코로나19가 가족의 일상생활에 미친 전방위적 영향이 나타났으며, 특히 식생활, 주거생활, 여가생활, 종교생활, 자녀돌봄, 자녀교육, 가족관계, 가족의례 등에서 변화가 두드러졌다. 더불어, 가족 관련 국내 문헌에서는 잘 논의되지 않던 건강공동체로서의 가족을 시사하는 토픽도 등장하였다.

• Current Optics and Photonics
• /
• 제6권3호
• /
• pp.227-235
• /
• 2022

To investigate the aging-related physiological functions of organic light-emitting diodes (OLEDs), we examined mRNA expression changes in aging-related genes due to oxidative stress inhibition by 630-nm red light OLEDs. As a result of irradiating 630-nm OLED with an intensity of 5 mW/cm² for 15 min, the viability of dermal fibroblasts significantly increased by 1.3-fold. In addition, reactive oxygen species generated by H₂O₂ were significantly reduced about 4.9-fold by irradiation with 630-nm OLED. Quantitative reverse-transcription polymerase chain reaction results showed that 630-nm OLEDs altered aging-related gene mRNA expression levels through antioxidant activity. The mRNA expression levels of matrix metalloproteinase1 (MMP1) and MMP9 decreased significantly, by about 2.2- and 2.5-fold, compared to the control group, whereas those of collagen, type I, and alpha 1 increased significantly, by 4.9-fold. The mRNA expression levels of cancer suppression genes p16 and p53 in dermal fibroblasts were also significantly reduced by 630-nm OLED irradiation, by about 1.4- and three-fold, respectively, compared to the control. Overall, it was confirmed that 630-nm OLED irradiation lowered the level of ROS formation induced by H₂O₂ in dermal fibroblasts, and that this antioxidant effect could regulate the mRNA expression levels of aging- and tumor suppression-related genes. This study shows a link between 630-nm OLED irradiation and anti-aging physiological functions such as antioxidant function, and suggests the potential of OLEDs as a useful light source for skin care.

• Tuberculosis and Respiratory Diseases
• /
• 제85권2호
• /
• pp.137-146
• /
• 2022

Background: Farinelli breathing (FB) exercise is a typical breathing exercise used by singers. This study aimed to compare effects of FB exercise and diaphragmatic breathing (DB) exercise on respiratory function and symptoms in patients with chronic obstructive pulmonary disease (COPD). Methods: Sixteen patients aged 51-80 years with mild or moderate COPD were recruited for this study. They were divided into two groups: DB group (n=8) and FB group (n=8). Both groups received complete breathing exercise training five times per week for 8 weeks. Their respiratory functions, COPD symptoms, cytokine levels, and oxidative stress variables were analyzed during pre- and post-tests. Dependent variables were compared between pre- and post-tests using paired t-tests. An independent t-test was used to compare variables between the groups. Differences were considered significant at p<0.05. Results: The maximal expiratory pressure (MEP), maximum oxygen consumption (VO₂max), and COPD Assessment Test (CAT) scores changed significantly in the DB group after the 8-week intervention compared to those at pre-test, whereas force vital capacity, forced expiratory volume in the first second, maximum voluntary ventilation, maximal inspiratory pressure (MIP), MEP, VO₂max, CAT score, tumor necrosis factor-α, and malondialdehyde level changed significantly in the FB group at post-test compared to those at pre-test. Moreover, both MIP and MEP in the FB group were significantly higher than those in the DB group. Conclusion: FB exercise improved respiratory functions and COPD symptoms of patients with COPD. It might be an alternative breathing exercise in pulmonary rehabilitation programs for patients with COPD.

• 인간식물환경학회지
• /
• 제23권2호
• /
• pp.191-199
• /
• 2020

Noni has been used for medicinal purposes for more than 2,000 years in South Pacific Polynesia, China and India, and has been heavily ingested as an extract for its excellent antioxidant and anti-inflammatory effects. However, a recent study found that the noni extract causes digestive disorders, kidney problems, and liver diseases, which made it necessary to use it for other purposes than as an extract. In this study, we want to evaluate the potential of noni as an anti-oxidant, anti-inflammatory and anti-wrinkling agent. Methods: Noni was freeze-dried, extracted in water, and concentrated. Skin cells were treated with the noni extract for 24 hrs and then were exposed to UVB (55 mJ/cm²). After 48 hrs of incubation, pro-inflammatory cytokine, elastase, MMP-1 and type-1 procollagen levels were measured by ELISA. Results: To find out the antioxidant effect of the noni extract, the DPPH and ABTS radical scavenging activity experiments were conducted and the noni extract showed 97.0 % and 92.0 % antioxidant efficacy at 200 ㎍/mL respectively. The noni extract (50 and 100 ㎍/mL) decreased IL-6 and TNF-α in RAW 264.7 cells induced by LPS in a concentration-dependent manner. In the RT-PCR experiment involving NO production, the noni extract (50 and 100 ㎍/mL) inhibited NO production by strongly inhibiting iNOS mRNA expression, and also inhibited the elevation of MMP-1 and elastases caused by UVB irradiation by 25.0 % and 7.0 % respectively. In addition, type-1 procollagen was elevated by 20.0 % by the noni extract treatment in HaCaT cells. Conclusion: The noni extract has photoprotective ability by reducing proinflammatory mediators, elastase and MMP-1 production, and elevation of collagen synthesis. Our findings suggest that the noni extract might be a good natural substance to protect against UVB-induced premature skin aging.