• BMB Reports
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• v.47 no.2
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• pp.51-59
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• 2014

Cellular senescence is a physiological process of irreversible cell-cycle arrest that contributes to various physiological and pathological processes of aging. Whereas replicative senescence is associated with telomere attrition after repeated cell division, stress-induced premature senescence occurs in response to aberrant oncogenic signaling, oxidative stress, and DNA damage which is independent of telomere dysfunction. Recent evidence indicates that cellular senescence provides a barrier to tumorigenesis and is a determinant of the outcome of cancer treatment. However, the senescence-associated secretory phenotype, which contributes to multiple facets of senescent cancer cells, may influence both cancer-inhibitory and cancer-promoting mechanisms of neighboring cells. Conventional treatments, such as chemo- and radiotherapies, preferentially induce premature senescence instead of apoptosis in the appropriate cellular context. In addition, treatment-induced premature senescence could compensate for resistance to apoptosis via alternative signaling pathways. Therefore, we believe that an intensive effort to understand cancer cell senescence could facilitate the development of novel therapeutic strategies for improving the efficacy of anticancer therapies. This review summarizes the current understanding of molecular mechanisms, functions, and clinical applications of cellular senescence for anticancer therapy.

• Journal of the Korean Wood Science and Technology
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• v.39 no.2
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• pp.125-131
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• 2011

The characteristics of radio-frequency/vacuum drying Japanese larch boxed heart round logs with 150 mm and 210 mm in diameter and 2,500 mm in length, subjected to compressive loading, after the pretreatment of kerf were investigated. The results of this study were as the follows: The drying time of about 120 hours~130 hours was needed from green to about 15 percent of moisture content. The gradient of final moisture content for all specimens was very gentle in both longitudinal and transverse directions owing to dielectric heating. The surface checks seriously occurred although the occurrence extent of surface check for the kerfed specimens was slight compared with that for the control specimens because drying stress was relieved by kerf. The occurrence of surface checks for the L-specimen was more serious than that for the S-specimen.

• Toxicological Research
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• v.20 no.1
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• pp.21-29
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• 2004

We used cDNA microarray to assess gene expression profiles in hematopoetic cell line, U-937, exposed to low doses of ionizing irradiation. The 1,000 DNA elements on this array were PCR-amplified cDNAs selected from named human cancer related genes. According to the strength of irradiation, the levels of some gene expression were increased or decreased as dose-dependent manner. The gene expressions of Tubulin alpha, protein kinase, interferon-alpha, -beta, -omega receptor and ras homolog gene family H were significantly increased. Especially, Tubulin gene was shown 2.5 fold up-regulated manner under stress of 500 rad irradiation than 200 rad. On the other hand, fibroblast growth factor 12 and four and a half LIM domains, etc. were significantly down-regu-lated. Also, tumor protein 53(TP53) related genes that p53 inducible protein, tumor protein 53-binding protein looks of little significance as radiation sensitive manner. The radio-sensitivity of tubulin gene etc. that we proposed could be useful to rapid and correct survey for the bio-damage by exposure to low dose irradiation.

• Journal of the Korea Furniture Society
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• v.17 no.1
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• pp.33-46
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• 2006

This study was carried out to investigate a radio-frequency/vacuum (RF/V) drying ability and physical properties of the green boards and the pre-kiln dried boards with 40 mm thickness, and the 70 mm-thick green board of Iroko (Milicia excelsa). The major results were summarized as follows; The drying time from initial moisture content (MC) of 110% to approximate 6% MC for a 40mm-thick green board was 192 hours, and about 200 hours for the 70 mm-thick green board, respectively and so the RF/V drying times were dramatically shortened compared to conventional kiln drying time. The case hardenings at the RF/V drying completion stage test were very negligible, thus represented almost no existence of the residual stress. The checks were very slightly formed on all of the boards during the RF/V drying test, but crook appeared quite severely. During the accelerating test, the water-resistant treated specimens had not experienced any signs of checking occurred, whereas the control boards had encountered very frequent occurrences of end checking and slight surface checking. There were no observations of warping and discoloring regardless of the treatment.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.08a
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• pp.271-271
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• 2011

본 논문에서는 W-N 확산 방지막을 각각 다른 질소 유입 조건 (0 sccm, 0.5 sccm, 1 sccm) 하에 Si (Silicon) (100) 기판 위에 rf (radio-frequency) magnetron sputter를 이용하여 증착하였다. 증착된 박막은 800$^{\circ}C$에서 열처리하였고, 이때 각각의 W-N 확산 방지 막의 열적 안정성을 분석하였다. 기존 W-N박막의 분석은 X-ray diffraction (XRD)와 같은 분광학적 방법을 사용하여 분석하였으나, 이는 점점 미세화 되어가는 반도체 산업의 최근 동향에는 적합하지 않다. 따라서 이번 실험에서는 박막 국부적인 영역에서 nano scale의 분석이 가능한 nano indentation을 이용하여 분석하였다. 본 연구에서는 열적 안정성을 분석하기 위하여 각각 열처리 온도가 다른 박막의 stress 분포를 XRD와 AFM를 이용하여 구한 격자상수로 먼저 박막 전체적인 영역을 분석하였다. 박막의 국부적인 영역은 앞서 언급하였던 nano indentation을 이용하여 stress 분포를 분석하였다. 실험 결과, 표면의 RMS roughness는 3.6에서 1.4 nm으로 변하였으며, 박막은 미열처리에서 열처리 온도의 증가 시 보다 tensile stress를 많이 받는 것으로 분석하였다.

• Journal of the Korean Vacuum Society
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• v.13 no.4
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• pp.157-163
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• 2004

Dependence of residual compressive stress of diamond-like carbon (DLC) films on relative humidity was investigated. Polymeric, graphitic and diamond-like carbon films were prepared by r.f.-PACVD using methane or benzene with the negative self bias voltage of the substrate ranging from -100 to -800 V. In-situ measurements of the residual stress were carried out in an environment chamber where the relative humidity was varied from 10％ to 90％. In dense DLC film of high residual compressive stress and hardness, we could not observe any change in the residual compressive stress with relative humidity. However, in the cases of graphitic and polymeric DLC films, abrupt change in the residual stress occurred by changing the relative humidity. The quantity of the stress change was inversely proportional to the film thickness, which means that the stress change with humidity is not due to the penetration of the water molecule into the film structure, but due to surface interaction between water molecules and film surface.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.17 no.5 s.108
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• pp.451-460
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• 2006

We have designed local exposure systems for long-time mice experiments in PCS and cellular frequency band(PCS: 1,762.5 MHz, cellular: 848.5 MHz). The fabricated systems are local exposure systems of carousel type, and 40 mice can be exposed at a time. In order not to give extra stress to the mice ender experiment, the systems were fabricated to meet the environmental conditions such as illumination, ventilation, noise etc. SAR measurement was performed using a temperature probe. Measurements at 3 points in the head of mouse cadaver and solid phantom were made, and it has been confirmed that the measurement results are in good agreement with the simulation results in the real exposure environment. The exposure systems are currently used for long-term mice experiments.

• The Transactions of the Korean Institute of Power Electronics
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• v.24 no.3
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• pp.161-168
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• 2019

This study introduces a new topology to decrease the voltage stress experienced by a 13.56 MHz electrical variable capacitor (EVC) circuit with an asymmetrical switch structure applied to the impedance matching circuit of a radio frequency (RF) plasma system. The method adopts a symmetrical switch structure instead of an asymmetrical one in each of the capacitor's leg in the EVC circuit. The proposed topology successfully reduces voltage stress in the EVC circuit due to the symmetrical charging and discharging mode. This topology can also be applied to the impedance matching circuit of a high-power and high-frequency RF etching system. The target features of the proposed circuit topology are investigated via simulation and experiment. Voltage stress on the switch of the EVC circuit is successfully reduced by more than 40%.

• Proceedings of the Korean Nuclear Society Conference
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• 1998.05b
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• pp.935-940
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• 1998

The Korea Superconducting Tokamak Research (KSTAR) tokamak will have 6 MW of radio-frequency (rf) heating in the ion cyclotron range of frequencies (ICRF). The response of the antenna to the heat loads is analyzed and the resulting stresses in the Faraday shield during the normal operation is calculated. Various heat loading conditions including in the analyzes are the heat loads from the plasma, the ripple-trapped beam particles and the rf loss.

• Journal of Applied Reliability
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• v.14 no.2
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• pp.93-96
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• 2014

RFID (Radio Frequency IDentification) system is recognition technology which can maintain various object's information. Reliability of RFID tags is the most important factor in RFID system. In this paper, we proposed ALT (Accelerated Life Test) method for UHF RFID tags. Temperature and humidity were adopted as stress factors and the accelerated life tests were conducted in three different conditions. We performed failure analysis for identifying failure mechanism and statistical analysis of test data. In the statistical analysis, we employed Inverse Power law for relationship between tag's life and stress. Through the statistical analysis, we proposed acceleration factor for several levels of temperature-humidity. The reliability qualification test plans were also designed for the tag's target reliability.