• Journal of Pharmacopuncture
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• v.20 no.1
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• pp.5-9
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• 2017

Objectives: Gan Mai Da Zao (GMDZ) decoction is widely used for the treatment of various diseases of the internal organ and of the central nervous system. The aim of this study is to investigate the effects of GMDZ decoction on neuropsychiatric disorders in an animal model. Methods: We searched seven databases for randomized animal studies published until April 2015: Pubmed, four Korean databases (DBpia, Oriental Medicine Advanced Searching Integrated System, Korean Studies Information Service System, and Research Information Sharing Service), and one Chinese database (China National Knowledge Infrastructure). The randomized animal studies were included if the effects of GMDZ decoction were tested on neuropsychiatric disorders. All articles were read in full and extracted predefined criteria by two independent reviewers. Results: From a total of 258 hits, six randomized controlled animal studies were included. Five studies used a Sprague Dawley rat model for acute psychological stress, post-traumatic stress disorders, and unpredictable mild stress depression whereas one study used a Kunming mouse model for prenatal depression. The results of the studies showed that GMDZ decoction improved the related outcomes. Conclusion: Regardless of the dose and concentration used, GMDZ decoction significantly improved neuropsychiatric disease-related outcomes in animal models. However, additional systematic and extensive studies should be conducted to establish a strong conclusion.

• Anxiety and mood
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• v.15 no.2
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• pp.122-126
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• 2019

Objective : Dynamic proteolysis, through the ubiquitin-proteasome system, is an important molecular mechanism for the constant regulation of synaptic plasticity and stress responses in humans. In this study, we examined whether genetic variants in the ubiquitin-specific peptidase (USP) genes were associated with psychological traits of resilience and susceptibility to neuropsychiatric disorders for each gender. Methods : A total of 344 Korean healthy youths (190 males, 154 females) were included in the study. A genotyping of rs2241646 of USP2 and rs346006 of USP46 was performed. The Connor-Davidson Resilience Scale and Brief Fear of Negative Evaluation Scale were administered for measuring trait resilience and social anxiety, respectively. The genetic associations of the USP variants were tested using multiple analyses of covariance with psychological traits as dependent variables after controlling for age in each gender. Results : For USP2 rs2241646, women with the TT genotype showed significantly higher resilience and lower social anxiety, as compared to those carrying the C allele. There were no associations between USP46 rs346005 and the psychological traits in both genders. Conclusions : The present study showed a possible genetic association between the USP2 rs2241646 and stress resilience and trait anxiety in women. The findings suggest that ubiquitin-proteasome system may be related to the resilience and susceptibility to stress-related neuropsychiatric disorders such as anxiety disorders, possibly through the regulation of dynamic proteolysis responses to stress.

• Journal of the Ergonomics Society of Korea
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• v.22 no.4
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• pp.15-25
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• 2003

Recent studies indicate potential links between various psychosocial factors and work-related musculoskeletal disorders (WMSDs). In this research, the effects of job stressors on the WMSDs symptoms were investigated using questionnaire in the largest automotive company in Korea. It was found that perception of workload, over time and shift work, and working using powered hand tools were significant factors for the symptoms of WMSDs, along with smoking habit, periodic exercise, and interpersonal relationship. Practical applications of this research include practitioners taking into account psychosocial work factors and job stress in their efforts to reduce and control WMSDs.

• IE interfaces
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• v.10 no.3
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• pp.197-208
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• 1997

In workplace design, an ergonomic solution should ensure low postural stress in the operator during his/her work. Stress caused by awkward working postures of the trunk, shoulders and legs can result in fatigue, discomfort, musculo-skeletal disorders and nerve entrapment syndromes. Since discomfort and musculo-skeletal disorders are both related to exposure to biomechanical load on the musculo-skeletal system, minimization of discomfort will contribute to reduction of the risk for musculo-skeletal disorders as well. Therefore, in this study, perceived discomfort on the human body joints was measured in the standing postures using the magnitude estimation in order to have a standardized numerical scale for joint discomfort. Nine healthy graduate students participated voluntarily in the laboratory study. The results revealed that perceived discomfort of all the joints increased as the joints deviated from neutral position. Especially, it showed drastic increment on perceived discomfort when deviation from neutral position in each human body joint increased from 75% to 100%. in terms of relative range of motion(R0M). On the basis of these experimental results, a preliminary ranking for assessment of stressfulness of non-neutral postures around the human body joints was suggested.

• Journal of Agricultural Extension & Community Development
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• v.18 no.4
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• pp.861-877
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• 2011

The purpose of this study is to survey job stress and Musculoskeletal Disorder(MSDs) of workers in small plants with agricultural products. The subjects were comprised of 69 workers participated in "Helping the rural women to get the small businesses" project. The questionnaire surveys were Korean Occupational Stress Scale(KOSS), and Legal Risk Assessment of Musculoskeletal Disorders(KOSHA CODE H-30-2003). As a result of the survey, scores of KOSS 8 sub-items except for job demand were similar to that of Korea workers. Prevalence of MSDs symptoms of small plants workers was high percent (44.9%). And the rate according to kinds of product was significant difference at neck (p<0.01), lumbar (p<0.01), and leg (p<0.01). There was no significant difference between view person sign of MSDs and non MSDs according to sex, year, the number of workers, working years, working time per one day, rest time per one day, and subjective working intensity, but there were significant difference between high stress group and low stress group about MSDs at interpersonal conflict(p<0.05). Job stress and MSDs were important factor to workers of small plants producted agricultural products. Therefore, starting a business with small plats, workers consider interpersonal conflict and body part showing MSDs.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.33 no.4
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• pp.447-454
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• 2023

Objective: This study aims to investigate the impact of changes in working conditions on job-related stress and musculoskeletal disorders using the results of seven surveys conducted at a single workplace from 2004 to 2022 regarding factors hazardous to the musculoskeletal system. Additionally, the study aims to propose alternative methods of investigating factors hazardous to the musculoskeletal system. Methods: A car parts manufacturing plant where the same survey was taken seven times from 2004 to 2022 was selected and the survey data was analyzed. The main contents of the survey were weekly working hours, Borg's scale, work intensity, job-related stress, and the prevalence of musculoskeletal symptoms. The statistical analysis was performed using SAS (version 9.4). Results: The results of this study are as follows. Firstly, changes in working conditions have an impact on job-related stress. Secondly, changes in working conditions have an impact on work intensity indicators. Thirdly, changes in working conditions have an impact on the prevalence of musculoskeletal symptoms. Fourthly, even with an increase in age and length of service, job-related stress and musculoskeletal symptoms were alleviated when working conditions were improved. Conclusions: In order for measures to reduce musculoskeletal disorders to be successful, working conditions must not deteriorate, and it is necessary to demand revisions to regulations, etc. to reflect these points in the investigation of hazardous factors to the musculoskeletal system.

• Korean Journal of Psychosomatic Medicine
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• v.16 no.1
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• pp.5-16
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• 2008

Several treatment programs putting mindfulness to practical use are being utilized in the various clinical settings as well as educational fields since 1980's. In this article, I studied several books and journals related with mindfulness and tried to show that mindfulness may have its neural circuits in the brain and can be utilized in the form of MBSR, MBCT, ACT, DBT not only to reduce stress and the symptoms of various psychosomatic conditions but to be applied to psychiatric illness such as, anxiety disorders, depressive disorders, and eating disorders, predicting its usefulness as a new psycho-social treatment.

• CELLMED
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• v.9 no.3
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• pp.4.1-4.8
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• 2019

Now researchers have focused attention on exploring the mechanism of acute responses of heat stress given in heat therapy that ultimately promotes the long term health benefits. Heat therapy is not a new idea rather it was practiced since thousands years back in the form of hot bath, sauna bath, steam room. Similarly in Ayurveda there is very comprehensive description of heat therapy in the form of Svedan karma (Sudation therapy). Svedan is a process to induce sweating artificially in a patient who had already undergone Snehan. Svedan is applied for purification of body, as well as in management of various disorders originated due to vitiation of Vata, Kapha Dosha, Meda Dhatu and musculoskeletal disorders. It produces various beneficial effects by augmenting the Agni like clears the channels, liquefies the deposited Dosha, regulates Vata Dosha, helps in removal and pacification of Dosha, augments metabolism (Agni Deepan), increases appetite, flexibility in body parts, softness and shining of skin, removes coldness, stiffness, drowsiness, improves joint motility. However, Svedana karma is vastly used by Ayurveda Physicians in treatment of various disorders but the mechanisms of beneficial effects produced by Svedan Karma are yet not completely explored on scientific basis. In this article, we will discuss and try to establish a possible mechanism of action of Svedana karma in relation to heat stress, mitochondrial adaptation, heat shock protein (HSP) and glucocorticoids as these are secreted under stressful conditions.

• Journal of Oral Medicine and Pain
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• v.47 no.4
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• pp.183-188
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• 2022

Purpose: The goal of this study was to investigate the causative factors related to the stress of temporomandibular disorders (TMDs) by evaluating salivary cortisol concentration in young adult TMD patients and control groups. Methods: Saliva was obtained from 32 young adult TMDs patients and 34 control patients without a history of TMDs who visited Chosun University Dental Hospital between June 1 and August 31, 2021. Enzyme-linked immunosorbent assay was conducted to measure the salivary cortisol concentration. Results: The salivary cortisol concentration in the TMD patient group and the control group differed significant significantly (p<0.05). The salivary cortisol concentration according to the duration of the clinical symptom of TMD differed significantly difference between the two groups in the male. The salivary cortisol concentration according to perceived stress level differed significantly in the mild and moderate groups (p<0.05). There was no significant difference in salivary cortisol concentration between the two groups related to bruxism or clenching (p>0.05). Conclusions: The salivary cortisol concentration in the TMD patient group and the control group showed statistical relevance, indicating that stress was a causative factor.

• Korean Journal of Psychosomatic Medicine
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• v.15 no.1
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• pp.3-6
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• 2007

Anxiety disorders are common illness to general physician. The comorbidity between anxiety disorders and medical illness is not only a diagnostic issue, but also has implications of the course of the disease and its outcome. The comorbid condition requires consideration of each individual illness, their psychological and physiological condition. This article aims to review the literature on the prevalence of anxiety disorders in patients prescribing to psychiatrists and to discuss pharmacological treatment options for patients with a comorbid anxiety disorder and medical illness.