• Journal of Venture Innovation
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• v.5 no.3
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• pp.19-40
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• 2022

The purpose of this study is to analyze and evaluate the role and merits and demerits of insurance agencies, which are the main sales channels of the domestic insurance market, from a neutral standpoint, and to present a roadmap by finding ways and tasks for the sustainable development of the insurance agency industry. Recently, criticisms and regulations on independent distribution channels have been strengthened due to deterioration in growth potential and profitability, and increase in civil complaints of insurance companies. In the 2000s, as the center of insurance sales channels shifted to GA and bancassurance, the supervisory authorities regarded the irrationality of project costs and recruitment fees as the root causes and announced a regulatory improvement plan. In view of these circumstance, the operating status, problems of domestic insurance agencies and their contribution to the insurance industry were reviewed. In addition, we tried to find a mid-to-long term development plan by analyzing the case of insurance agency operation in Japan. This study identified the operating status and contribution of insurance agencies in South Korea, and focused on the major status of the Japanese insurance agency industry, ways to improve management efficiency, and the status and role of self-regulatory organizations for insurance agencies. Based on this, it was proposed to improve the professionalism of the sales organization, introduce a company specializing in insurance sales, and to strengthen the status of the association of the insurance agency as for the development plan of the insurance agency industry in South Korea.

• Journal of Korea Port Economic Association
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• v.24 no.4
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• pp.363-384
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• 2008

This study aims at improving Korea's competitiveness in port logistics through marketing strategy with integrating the conceptual approach into the empirical one and combining both the oldest military treatise and the newest evaluating model in social science that was applied by the HFP(hierarchical fuzzy process) model enhanced by the KJ method. The empirical results of this study show Busan in the middle among subject ports. At present, Korea plays a reciprocal role in the port market in East Asia, but in the medium- and long-term, Korea's ports will vie together with most major ports in the East Asian region. A descriptive investigation shows that Korea's developing tasks in port logistics must be considered in the context of the direction for developing port policies, the necessity of expanding port facilities in the capital region, securing the sufficient traffic volume through the establishment of the hinterland linking system and its positive utilization, and reforming the direction for developing the global logistics through increased port competitiveness. In the short- and medium-term, Korea must use the opportunity factor of 'Growth and open door policy of China' as a geoeconomic advantage and to utilize Korea's ports as a gate to Chinese foreign trade. With the rise of China's economy, China also plays a significant role in both port and airport markets. Hence, the linking system between the two must be established to meet the expanding traffic volume, especially in the capital area. Moreover, it is necessary for Korea to secure port logistics through the establishment of the hinterland linking system and its positive utilization. The great accomplishment of this paper is to present strategies to increase Korea's port competitiveness in the rapidly changing environments of world logistics with the focus on both the oldest military strategic treatise and the newest empirical method in social science. In order to reinforce this study, it needs further compensative research because the evaluation structure could be subdivided with more extensive and precise criteria.

• Journal of Korea Port Economic Association
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• v.23 no.3
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• pp.1-27
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• 2007

The used car export of Korea has rapid growth with the competitive price through economic situation of IMF, but the export volume would be decreased due to the import restriction of used car by Iraqi, Middle Asian countries since 2004. This research would be suggested the proposal of "the used car's innovative export logistics system" to solve the increased supplying of used car and decreasing of used car's export. This proposal of "the used car's innovative export logistics system" present the advanced used car's export logistics center for activation of export and construction of integrated export logistics system to be promoted the export process. As a result of analysis of the economic effectiveness through the activation of used car's export at the port of Incheon, it is forecasted that the concerned companies have the increasing of net profit 27,000 million Korean won; the value added effectiveness 340,000 million Korean won, acceleration of employment 2,200 persons. The policy should be consistent in order to process of "the used car's innovative export logistics system". For promotion of used car's export, not only near vision for solve the current matter, but also the strategic policy and master plan for promotion of used car's export to the international competitiveness strength continuously. The object of this research is directed to "the used car's export integrated logistics system" and "policy" for creation of export logistics complex".

• Journal of Navigation and Port Research
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• v.33 no.10
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• pp.723-734
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• 2009

Container Vessel is becoming larger and faster thanks to the rapid growth of global trade and development of technology. Therefore, 15,000TEU vessel is expected to be ordered in near future. Every nations in north-east Asia are facing strong competition to be logistics hub to get the initiatives of logistics in response to the rapid change of logistics environment. According to the globalization of economy and major ports in this region also are trying to catch big shipping line for their survival. Considering above circumstances of the advent of ultra-large container vessel and spoke-and-hub strategy, it is inevitably necessary to make a fast and accurate vessel job in the terminal in order to be a leading port To meet this objective, current vessel planning system has to be improved innovatively. Therefore, this thesis propose multi distributed vessel planning system which enables multi loading/discharging planning with several planner simultaneously for faster and more accurate than existing planning and enhances quality of planning through information sharing among planners. Also this thesis uses simulation through Arena to verify the efficiency of this multi-distributed vessel planning system.

• BMB Reports
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• v.56 no.3
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• pp.196-201
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• 2023

Renal fibrosis is the final manifestation of chronic kidney disease (CKD) regardless of etiology. Hypoxia-inducible factor-2 alpha (HIF-2α) is an important regulator of chronic hypoxia, and the late-stage renal tubular HIF-2α activation exerts protective effects against renal fibrosis. However, its specific role in progressive renal fibrosis remains unclear. Here, we investigated the effects of the long-term tubular activation of HIF-2α on renal function and fibrosis, using in vivo and in vitro models of renal fibrosis. Progressive renal fibrosis was induced in renal tubular epithelial cells (TECs) of tetracycline-controlled HIF-2α transgenic (Tg) mice and wild-type (WT) controls through a 6-week adenine diet. Tg mice were maintained on doxycycline (DOX) for the diet period to induce Tg HIF-2α expression. Primary TECs isolated from Tg mice were treated with DOX (5 ㎍/ml), transforming growth factor-β1 (TGF-β1) (10 ng/ml), and a combination of both for 24, 48, and 72 hr. Blood was collected to analyze creatinine (Cr) and blood urea nitrogen (BUN) levels. Pathological changes in the kidney tissues were observed using hematoxylin and eosin, Masson's trichrome, and Sirius Red staining. Meanwhile, the expression of fibronectin, E-cadherin and α-smooth muscle actin (α-SMA) and the phosphorylation of p38 mitogen-activated protein kinase (MAPK) was observed using western blotting. Our data showed that serum Cr and BUN levels were significantly lower in Tg mice than in WT mice following the adenine diet. Moreover, the protein levels of fibronectin and E-cadherin and the phosphorylation of p38 MAPK were markedly reduced in the kidneys of adenine-fed Tg mice. These results were accompanied by attenuated fibrosis in Tg mice following adenine administration. Consistent with these findings, HIF-2α overexpression significantly decreased the expression of fibronectin in TECs, whereas an increase in α-SMA protein levels was observed after TGF-β1 stimulation for 72 hr. Taken together, these results indicate that long-term HIF-2α activation in CKD may inhibit the progression of renal fibrosis and improve renal function, suggesting that long-term renal HIF-2α activation may be used as a novel therapeutic strategy for the treatment of CKD.

• Journal of Information Technology Applications and Management
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• v.13 no.3
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• pp.29-57
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• 2006

Small and medium-sized companies (SMEs) face a number of different kinds of barriers to adopt information technology, including the lack of information, limited financial and technical resources, and absence of the well-trained work force in the realm of information technology. But application service provider (ASP)enables these SMEs to informatize. This paper is focused on studying the cases of the adoption and use of the ASP-based ERP systems that 7 SME shad adopted. The factors that influence the adoption and use of SMEs' ASP-based ERP systems are divided into the user companies that adopted the systems, the systems vendors, and environment. From the viewpoint of the user company, the successful adoption and use of the systems is significantly influenced by the clear motive of adopting the systems, the financial readiness, and the strong intention of CEO for pushing ahead with e-Business. From the systems vendor, it is influenced by the technical expertise of the vendor, the knowledge of the user company, and the experience of the systems development. From the perspective of environment, it is influenced by the push from the players in the value chains. The companies that had adopted the ASP-based ERP systems and that had extended the level of systems use had the benefits through reducing the cost, improving the internal business process, and achieving the learning and growth of the organization.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.8
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• pp.433-440
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• 2018

As government research and development projects become more important, such as the creation of future-oriented growth engines and expansion of budgets, the future vision of R&D is presented through paradigm shifts such as efficiency, investment direction and strategy. On the other hand, research and interest in sanctions are poor, and this paper examines legal grounds, comparative analysis of laws, and cases outside the country, draws implications for domestic applications, have. In addition, we will contribute to the prevention of damages caused by neglect, or the transparency of the execution of research funds. This study was conducted by comparing the characteristics of government R&D and sanctions with the sanctions for the top three R&D investment related SMEs. In Korea, starting with the introduction of sanctions in 2001, the moral hazard of research and development has been prevented through the cumulative violation of aggravation, expansion of the period of restriction of participation, and the introduction of a strikeout system. Nevertheless, fraudulent use of business expenses is constantly being detected. In order to ensure maximum autonomy and stronger responsibility than strong institutions, the willingness of the researchers to execute transparent business expenses, the moral approach to public resources, Precedence of recognition conversion is important.

• Journal of the Korea Convergence Society
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• v.8 no.3
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• pp.245-252
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• 2017

The purpose of this study is to analyze the effects of mergers and acquisitions of domestic IT companies on strategic aspects of internal capacity enhancement. Empirical analysis applied to this study analyzed the business performance in the market through the merger of Daum Communications and Kakao Group. After Daum pursued the merger with Kakao, it showed that the platform business of kakao is expanding to the domain of the existing portal site. The merger was completed, and the total value of the stocks went up to the highest level, but soon its value declined. The merger shows that the growth potential of the enterprise is temporarily declining, which seems to be the internal cost of the merger. Even in the case of profitability, the merger did not show positive results. In the case of stability, the expectation due to the merger was reflected and slightly increased. The following two companies were interested in the kakao when they viewed the merger through a chronological analysis. However, after the merger, the interest of the next kakao was similar. This is seen as a result of the expansion of kakao's diverse platform business rather than the following search sites. From the results of this study, it is suggested that domestic IT companies should approach by analyzing the strategic factors that generate synergy when pursuing M & A to strengthen their resources or capabilities.

• Tuberculosis and Respiratory Diseases
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• v.58 no.2
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• pp.142-152
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• 2005

Background : Priming and boosting vaccination strategy has been widely explored for new vaccine development against tuberculosis. As an effort to identify other vaccine candidates, this study was initiated to evaluate protective efficacy of adenylate kinase (AK), nucleoside diphosphate kinase (NdK), and heat shock protein 70 (Hsp70) of Mycobacterium tuberculosis. Method : M. tuberculosis genes encoding AK, NdK, and Hsp70 proteins were amplified by PCR and cloned into E. coli expression vector, pQE30. Recombinant AK, NdK, and Hsp70 was purified through Ni-NTA resin. To evaluate immune responses, we performed enzyme-linked immunosorbent assay (ELISA) for IgG isotype and $IFN-{\gamma}$ after mice were immunized subcutaneously with recombinant proteins delivered in dimethyl dioctadecylammonium bromide (DDA). Immunized- and control groups were challenged by aerosol with M. tuberculosis. The spleens and lungs of mice were removed aseptically and cultured for CFU of M. tuberculosis. Result : Vaccination with recombinant proteins AK, NdK, and Hsp70 delivered in DDA elicited significant level of antibody and $IFN-{\gamma}$ responses to corresponding antigens but no protective immunity comparable to that achieved with Mycobacterium bovis BCG. Conclusion : Recombinant proteins AK, NdK, and Hsp70 do not effectively control growth of M. tuberculosis in mice when immunized with DDA as an adjuvant.

• The Korean Journal of Pesticide Science
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• v.15 no.2
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• pp.188-193
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• 2011

Resistance monitoring for tolyfluanid was conducted over 2 years from 2005 to 2006 with 218 isolates of Botrytis cinerea obtained from infected plants of ginseng. All isolates of B. cinerea were divided into 3 groups such as highly sensitive (HS) group, sensitive (S) group and less sensitive (LS) group to tolyfluanid. HS group was defined as one showing $EC_{50}$ value less than $2.0\;{\mu}g\;mL^{-1}$. $EC_{50}$ value of S group ranged between $2.0\;{\mu}g\;mL^{-1}$ and $18.0\;{\mu}g\;mL^{-1}$, while that of LS group was more than $18.0\;{\mu}g\;mL^{-1}$ Among B. cinerea isolates tested in this study, 174 isolates were included into S group, while 22 isolates were done into HS group. The other isolates belonged to LS group. Botrytis cinerea isolates showed the high correlation of $EC_{50}$ value of mycelial growth with that of spore germination to tolyfluanid. This results could be used for the determination of fungicide resistance and the establishment of strategy for fungicide resistance management.