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Inhibitory Effects of Total Ginseng Saponin on Catecholamine Secretion from the Perfused Adrenal Medulla of SHRs

  • Jang, Seok-Jeong;Lim, Hyo-Jeong;Lim, Dong-Yoon
    • Journal of Ginseng Research
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    • v.35 no.2
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    • pp.176-190
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    • 2011
  • There seems to be some controversy about the effect of total ginseng saponin (TGS) on the secretion of catecholamines (CA) from the adrenal gland. Therefore, the present study aimed to determine whether TGS can affect the CA release in the perfused model of the adrenal medulla isolated from spontaneously hypertensive rats (SHRs). TGS (15-150 ${\mu}g/mL$), perfused into an adrenal vein for 90 min, inhibited the CA secretory responses evoked by acetylcholine (ACh, 5.32 mM) and high $K^+$ (56 mM, a direct membrane depolarizer) in a dose- and time-dependent fashion. TGS (50 ${\mu}g/mL$) also time-dependently inhibited the CA secretion evoked by 1.1-dimethyl-4 -phenyl piperazinium iodide (DMPP; 100 ${\mu}M$, a selective neuronal nicotinic receptor agonist) and McN-A-343 (100 ${\mu}M$, a selective muscarinic M1 receptor agonist). TGS itself did not affect basal CA secretion (data not shown). Also, in the presence of TGS (50 ${\mu}g/mL$), the secretory responses of CA evoked by veratridine (a selective $Na^+$ channel activator (50 ${\mu}M$), Bay-K-8644 (an L-type dihydropyridine $Ca^{2+}$ channel activator, 10 ${\mu}M$), and cyclopiazonic acid (a cytoplasmic $Ca^{2+}$-ATPase inhibitor, 10 ${\mu}M$) were significantly reduced, respectively. Interestingly, in the simultaneous presence of TGS (50 ${\mu}g/mL$) and N${\omega}$-nitro-L-arginine methyl ester hydrochloride [an inhibitor of nitric oxide (NO) synthase, 30 ${\mu}M$], the inhibitory responses of TGS on the CA secretion evoked by ACh, high $K^+$, DMPP, McN-A-343, Bay-K-8644, cyclopiazonic acid, and veratridine were considerably recovered to the extent of the corresponding control secretion compared with the inhibitory effect of TGS-treatment alone. Practically, the level of NO released from adrenal medulla after the treatment of TGS (150 ${\mu}g/mL$) was greatly elevated compared to the corresponding basal released level. Taken together, these results demonstrate that TGS inhibits the CA secretory responses evoked by stimulation of cholinergic (both muscarinic and nicotinic) receptors as well as by direct membrane-depolarization from the isolated perfused adrenal medulla of the SHRs. It seems that this inhibitory effect of TGS is mediated by inhibiting both the influx of $Ca^{2+}$ and Na+ into the adrenomedullary chromaffin cells and also by suppressing the release of $Ca^{2+}$ from the cytoplasmic calcium store, at least partly through the increased NO production due to the activation of nitric oxide synthase, which is relevant to neuronal nicotinic receptor blockade, without the enhancement effect on the CA release. Based on these effects, it is also thought that there are some species differences in the adrenomedullary CA secretion between the rabbit and SHR.

Accelerating GPU-based Volume Ray-casting Using Brick Vertex (브릭 정점을 이용한 GPU 기반 볼륨 광선투사법 가속화)

  • Chae, Su-Pyeong;Shin, Byeong-Seok
    • Journal of the Korea Computer Graphics Society
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    • v.17 no.3
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    • pp.1-7
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    • 2011
  • Recently, various researches have been proposed to accelerate GPU-based volume ray-casting. However, those researches may cause several problems such as bottleneck of data transmission between CPU and GPU, requirement of additional video memory for hierarchical structure and increase of processing time whenever opacity transfer function changes. In this paper, we propose an efficient GPU-based empty space skipping technique to solve these problems. We store maximum density in a brick of volume dataset on a vertex element. Then we delete vertices regarded as transparent one by opacity transfer function in geometry shader. Remaining vertices are used to generate bounding boxes of non-transparent area that helps the ray to traverse efficiently. Although these vertices are independent on viewing condition they need to be reproduced when opacity transfer function changes. Our technique provides fast generation of opaque vertices for interactive processing since the generation stage of the opaque vertices is running in GPU pipeline. The rendering results of our algorithm are identical to the that of general GPU ray-casting, but the performance can be up to more than 10 times faster.

Investigation of Consumers' Knowledge and Preference towards Functional Cosmetics (기능성 화장품에 대한 소비자 인지도와 선호도 조사)

  • Choi, Sun-Hye;Hong, Ran-Hee
    • Journal of the Korean Society of Fashion and Beauty
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    • v.3 no.2 s.2
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    • pp.55-64
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    • 2005
  • The purpose of this study is to investigate consumers' knowledge and preference towards functional cosmetics. Through the beauty advisors' surveys, their own selling styles and consumer behaviors recognized by beauty advisors were analyzed. It was intended to help extend and strengthen the functional cosmetic market which has continued to grow rapidly since the approved goods under cosmetic law in 2001. For this study, the data was collected through questionnaires the professional consumer counselors confirmed from Korean women over the age. of twenty old living in the Seoul and Kyoungki areas. After pre-research was implemented on 45 women, 328 samples were analyzed as final samples. In addition,46 samples, which were collected through the questionnaires from beauty advisors were analyzed. Samples were analyzed by frequency, percentage, T-test, ANOVA using the SPSS program. The results of study were as follows: First consumers recognized whether functional cosmetics or not. According to the beauty advisor's surveys, consumers regard the functional cosmetic boundary as being wider than real functional cosmetic boundary according to cosmetic law. So, there is a gap between consumers' opinions and real law. Second, regarding the purchasing channels, the largest channel is the cosmetic store. As far as consumers are concerned the most important factor when buying cosmetics, is the suitability of their own skin types. The second factor is product quality and the third factor is price. Functional cosmetics non-experienced group are more concerned with price compared to experienced group. Related to purchasing products, functional cosmetics experienced group buy set products compared to non-experienced group buy one product. Third, the ultraviolet filter cosmetics portion is the largest in the functional cosmetics market the second largest portion is bleaching cosmetics and the third largest portion is the anti-senility cosmetics. However, Most preferred by consumers is the anti-senility cosmetics. Moreover, preference for ultraviolet filter cosmetics is the least. Finally, the level of satisfaction for functional cosmetics is high and dissatisfaction is low. Consumers feel that beauty advisors are simply pushing high priced products without recognizing the consumers' real needs. In conclusion, to develop the functional cosmetic market continually in the future, it needs to extend various products and advertise them until consumers are more aware.

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An Efficient Page-Level Mapping Algorithm for Handling Write Requests in the Flash Translation Layer by Exploiting Temporal Locality (플래시 변환 계층에서 시간적 지역성을 이용하여 쓰기 요청을 처리하는 효율적인 페이지 레벨 매핑 알고리듬)

  • Li, Hai-Long;Hwang, Sun-Young
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.41 no.10
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    • pp.1167-1175
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    • 2016
  • This paper proposes an efficient page-level mapping algorithm that reduces the erase count in the FTL for flash memory systems. By maintaining the weight for each write request in the request buffer, the proposed algorithm estimates the degree of temporal locality for each incoming write request. To exploit temporal locality deliberately for determination of hot request, the degree of temporal locality should be much higher than the reference point determined experimentally. While previous LRU algorithm treats a new write request to have high temporal locality, the proposed algorithm allows write requests that are estimated to have high temporal locality to access hot blocks to store hot data intensively. The pages are more frequently updated in hot blocks than warm blocks. A hot block that has most of invalid pages is always selected as victim block at Garbage Collection, which results in delayed erase operation and in reduced erase count. Experimental results show that erase count is reduced by 9.3% for real I/O workloads, when compared to the previous LRU algorithm.

Design And Implementation Real-Time Load Balancing Using TMO Replica Of LTMOS In Distributed Environment (분산 환경에서 LTMOS의 TMO 리플리카를 이용한 실시간 로드 밸런싱의 설계 및 구현)

  • Joo Koonho;Lim Bosub;Heu Shin;Kim Jungguk
    • Proceedings of the Korean Information Science Society Conference
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    • 2005.07a
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    • pp.829-831
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    • 2005
  • 실시간 시스템이란 시간적인 제한을 가지고 작업 수행 결과의 정확도가 보장되는 시스템으로 경성 실시간 시스템과 연성 실시간 시스템으로 분류된다. 최근 분산 실시간 분야에서 새로운 패러다임으로써 폭넓게 활용되기 시작한 실시간 객체 모델인 TMO는 Kane Kim과 Kopetz에 의해 처음 제안되었다. TMO 모델은 경성 또는 연성 실시간 응용과 병렬 컴퓨팅 응용 프로그램에서 사용 될 수 있으며, 시스템의 기능적인 면과 시간 조건 수행 모두를 명확히 정의할 수 있다. TMO의 네트워크로 구성되는 실시간 분산 환경에서의 실행을 위해 몇 개의 TMO 실행 엔진이 개발 되었는데, 그 중에서 LTMOS라는 리눅스 기반의 연성 실시간 미들웨어 엔진이 한국외대 RTDCS lab.에서 개발되었다. 하지만 LTMOS의 실시간 시스템 수행 중 작업량의 과부하로 인한 deadline 위반이나, 시스템간의 분산 IPC 통신에 있어서 Channel Traffic이 빈번한 경우 실시간 시스템을 유지할 수 없다는 문제점들을 갖고 있다. 이러한 문제점들을 해결하고 조금 더 효율적인 실시간 시스템을 유지하기 위해서, TMO 프로그램의 resource 정보를 담고 있는 ODS(Object Data Store)만을 다른 노드에 있는 자신의 TMO 프로그램 Replica로 이주해서 실시간 로드 밸런싱을 구현하는 기법을 사용하였다. 이에 본 논문에서는 TMO 프로그램들의 deadline 위반 및 Channel Traffic 부하를 감지할 수 있는 Node Monitor와 최적의 노드를 선별할 수 있는 Migration Manager를 새롭게 추가하였고, 쓰레드들의 스케줄러인 WRMT에 이주 작업을 하기 위한 부가적인 기능을 구현하였다. 2D 이미지의 관측점을 줄여 계산량을 대폭 감소시키는 장점을 갖는다.것으로 조사되었으며 40대 이상의 연령층은 점심비용으로 더 많은 지출을 하고 있는 것으로 나타났다. 4) 끼니별 한식에 대한 선호도는 아침식사의 경우가 가장 높았으며, 이는 40대와 50대에서 높게 나타났다. 점심 식사로 가장 선호되는 음식은 중식, 일식이었으며 저녁 식사에서 가장 선호되는 메뉴는 전 연령층에서 일식, 분식류 이었으며, 한식에 대한 선택 정도는 전 연령층에서 매우 낮게 나타났다. 5) 각 연령층에서 선호하는 한식에 대한 조사에서는 된장찌개가 전 연령층에서 가장 높은 선호도를 나타내었고, 김치는 40대 이상의 선호도가 30대보다 높게 나타났으며, 흥미롭게도 30세 이하의 선호도는 30대보다 높게 나타났다. 그 외에도 떡과 죽에 대한 선호도는 전 연령층에서 낮게 조사되었다. 장아찌류의 선호도는 전 연령대에서 낮았으며 특히 30세 이하에서 매우 낮게 조사되었다. 한식의 맛에 대한 만족도 조사에서는 연령이 올라갈수록 한식의 맛에 대한 만족도는 낮아지고 있었으나, 한식의 맛에 대한 만족도가 높을수록 양과 가격에 대한 만족도는 높은 경향을 나타내었다. 전반적으로 한식에 대한 선호도는 식사 때와 식사 목적에 따라 연령대 별로 다르게 나타나고 있으나, 선호도는 성별이나 세대에 관계없이 폭 넓은 선호도를 반영하고 있으며, 이는 대학생들을 대상으로 하는 연구 등에서도 나타난바 같다. 주 5일 근무제의 확산과 초 중 고생들의 토요일 휴무와 더불어 여행과 엔터테인먼트산업은 더욱 더 발전을 거듭하고 있으며, 외식은 여행과 여가 활동의 필수적인 요소로써 그 역할을 일조하고 있다. 이와 같은 여가시간의 증가는 독신자들에게는 좀더 많은 여유시간을 가족을

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Effect of Vitamin C Supplementation on Iron Status of Adolescent Girls with Low Hemoglobin Levels

  • Lee, Joung-Won;Park, Chun-Keun
    • Korean Journal of Community Nutrition
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    • v.2 no.5
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    • pp.687-694
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    • 1997
  • This study investigated the effects of vitamin C supplementation on the nutritional iron status of 31 adolescent girls, aged 12-15 years, with low hemoglobin levels. They were randomly divided into four groups, and for two groups daily150mg or 900mg of L-ascorbic acid(AsA) was given in three equal doses at three meals during 9 weeks. To another group daily 60mg iron as ferrous sulfate was given in the same way as AsA. The control group was given sugar placebo. Body iron status was monitored through the determination of Hb, Hct, MCHC, and serum ferritin concentrations. Dietary AsA and iron intakes were measured from food consumption surveys performed by 3-day 24-hour recalls. The amount of absorbed iron was estimated from the model of Monsen et al. The average amounts of food iron for four groups were 12.3- 15.0mg and 11.1 - 18.9mg at initial and at final period of the supplementation trial, respectively. The tentatively estimated amount of absorbed iron was significantly increased in the 900mg AsA and iron supplementing groups, but not in the 150mg AsA and placebo groups. Both Hb and MCHC were improved to above normal levels in all groups except the placebo group. Hct was elevated only in the AsA 900mg group whose Hct was relatively lower than the other groups. Serum ferritin concentrations of the four groups, which were as low as 8.50 - 14.39ng/mL on average at the intial periods, augmented significantly to 20.18ng/mL and 26.63ng/mL in the 900mg AsA and iron groups, respectively. Serum ferritin was not elevated in either the AsA 300mg group or the placebo group. The above data indicated that the daily supplementaion of 150mg AsA to the meals containing 12-15mg iron per day promoted Hb levels of adolescent girls with low Hb, and the 900mg AsA supplementing improved not only Hb level but also body iron store. A supplementation of 60mg iron per day appeared to be slightly more effective in improving the iron status in comparison to the 900mg AsA supplement. (Korean J Community Nutrition 2(5) : 687-694, 1997)

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A Study on Establishing Online Document Communication System by Means of Intranet Web Site (ODCS(Online Document Communication System)인트라넷 웹사이트 구축과정 및 사용자 효과 연구)

  • 양초산
    • Archives of design research
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    • v.17 no.3
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    • pp.167-178
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    • 2004
  • The purpose of this treatise is to show merits and method of establishing Lotte department store design division Online Documents Communication System through illustration of examples of intranet in which internet environment convenient to use for its openness is applied for establishing Design Online Documents Communication System for fundamentals of organization. In this connection merits and effect attainable from establishing Design Outline Documents Communication System of the enterprise as found were as follows: Firstly, it brought about reduction in workload of staffs through sharing various existing resources. It reduced redundant works and enables speedy handling of works. Secondly, it was possible to exchange viewpoints and share information by pertinent parties. Thirdly, by expediting information exchange and communication among persons in charge it was possible to improve work efficiency. Fourthly, it was possible to build and operate such system at relatively low cost on the basis of web browser. Without using any other significant instrument or equipment but by linking it to business network and using existing computer system operation was possible. Fifthly, by common sharing of work exclusive to design room through on-line it was possible to improve professionalism and convenience in data preservation. Through this treatise and survey and study on process for establishing intranet it was possible to find that there were sharing work, improving work efficiency, reducing workload, saving cost and expediting communication to a significant degree.

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(Buffer Management for the Router-based Reliable Multicast) (라우터 기반의 신뢰적 멀티캐스트를 위한 버퍼 관리)

  • 박선옥;안상현
    • Journal of KIISE:Information Networking
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    • v.30 no.3
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    • pp.407-415
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    • 2003
  • As services requesting data transfer from a sender to a multiple number of receivers become popular, efficient group communication mechanisms like multicast get much attention. Since multicast is more efficient than unicast in terms of bandwidth usage and group management for group communication, many multicast protocols providing scalability and reliability have been proposed. Recently, router-supported reliable multicast protocols have been proposed because routers have the knowledge of the physical multicast tree structure and, in this scheme, repliers which retransmit lost packets are selected by routers. Repliers are selected dynamically based on the network situation, therefore, any receiver within a multicast group can become a replier Hence, all receivers within a group maintains a buffer for loss recovery within which received packets are stored. It is an overhead for all group receivers to store unnecessary packets. Therefore, in this paper, we propose a new scheme which reduces resource usage by discarding packets unnecessary for loss recovery from the receiver buffer. Our scheme performs the replier selection and the loss recovery of lost packets based on the LSM [1] model, and discards unnecessary packets determined by ACKs from erasers which represent local groups.

Implementation of XML Query Processing System Using the Materialized View Cache-Answerability (실체뷰 캐쉬 기법을 이용한 XML 질의 처리 시스템의 구현)

  • Moon, Chan-Ho;Park, Jung-Kee;Kang, Hyun-Chul
    • The KIPS Transactions:PartD
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    • v.11D no.2
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    • pp.293-304
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    • 2004
  • Recently, caching for the database-backed web applications has received much attention. The results of frequent queries could be cached for repeated reuse or for efficient processing of the relevant queries. Since the emergence of XML as a standard for data exchange on the web, today's web applications are to retrieve information from the remote XML sources across the network, and thus it is desirable to maintain the XML query results in the cache for the web applications. In this paper, we describe implementation of an XML query processing system that supports cache-answerability of XML queries, and evaluate its performance. XML path expression, which is one of the core features of XML query languages including XQuery, XPath, and XQL was considered as the XML query. Their result is maintained as an XML materialized view in the XML cache. The algorithms to rewrite the given XML path expression using its relevant materialized view proposed in [13] were implemented with RDBMS as XML store. The major issues of implementation are described in detail. The results of performance experiments conducted with the implemented system showed effectiveness of cache-answerability of XML queries. Comparison with previous research in terms of performance is also Provided.

An Online Review Mining Approach to a Recommendation System (고객 온라인 구매후기를 활용한 추천시스템 개발 및 적용)

  • Cho, Seung-Yean;Choi, Jee-Eun;Lee, Kyu-Hyun;Kim, Hee-Woong
    • Information Systems Review
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    • v.17 no.3
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    • pp.95-111
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    • 2015
  • The recommendation system automatically provides the predicted items which are expected to be purchased by analyzing the previous customer behaviors. This recommendation system has been applied to many e-commerce businesses, and it is generating positive effects on user convenience as well as the company's revenue. However, there are several limitations of the existing recommendation systems. They do not reflect specific criteria for evaluating products or the factors that affect customer buying decisions. Thus, our research proposes a collaborative recommendation model algorithm that utilizes each customer's online product reviews. This study deploys topic modeling method for customer opinion mining. Also, it adopts a kernel-based machine learning concept by selecting kernels explaining individual similarities in accordance with customers' purchase history and online reviews. Our study further applies a multiple kernel learning algorithm to integrate the kernelsinto a combined model for predicting the product ratings, and it verifies its validity with a data set (including purchased item, product rating, and online review) of BestBuy, an online consumer electronics store. This study theoretically implicates by suggesting a new method for the online recommendation system, i.e., a collaborative recommendation method using topic modeling and kernel-based learning.