• Journal of the Korean Society of Propulsion Engineers
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• v.24 no.5
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• pp.56-64
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• 2020

A wind tunnel test of 29.7% scaled model of NASA Common Research Model was performed in small low speed wind tunnel. The wind tunnel model was fabricated in Aluminium in consultation with NASA Langley Research Center and AIAA Drag Prediction Workshop committee members. The static aerodynamic forces and moments were measured at a relatively low Reynolds number of 0.3 × 10⁶ due to tunnel capability limitations. Pitching moment of three types of model support(Fin sting, Blade sting and Belly sting) were compared. The pitching moment for corrected Belly sting and Fin sting were similar. The result of pitching moment for Blade sting was very small.

• Journal of Acupuncture Research
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• v.26 no.1
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• pp.135-151
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• 2009

Objectives : To survey concept, meaning, and problems of beekeeper's bee sting therapy by reviewing and summarizing outline, indications, and clinical cases of 'Research on Bee Sting Therapy' described in Monthly Yangbonggye. Methods : As a narrative review, literature researches were carried out based on 'Research on Bee Sting Therapy' in Monthly Yangbonggye in the aspects of outline, indications, and clinical cases. In the concrete, outline was just summarized and described, and indications were categorized by recent version of international statistical classification of diseases and related health problems(ICD) of WHO(World health organization), and clinical cases were collected and summarized from the viewpoint of acupoints and methods of therapy. Results : 1. Bee sting therapy is to inject venom into skin by stimulating affected lesions or acupoints on meridian with sting of bee alive for therapeutic purposes. It can be divided into two classes(direct stimulation(直針法) and indirect stimulation(拔針法)) by the differences of methods, and is different from bee venom acupuncture therapy in the aspects of the way of extraction and injection. 2. In this material, bee sting therapy has 83 indications classified into 17 of 22 chapters of ICD. Among clinical cases, cases on neoplasm, goitre, lump, and haemorrhoids by direct stimulation were especially outstanding. 3. The therapeutic acupoints selected in bee sting therapy are mainly Ashi points(阿是穴), and partly acupoints on meridian(經穴), Extra points(經外奇穴), and New points(新穴) with careful consideration of patients' condition. Conclusions : Although bee sting therapy has more or less controversial points of diagnosis, treatment, and management of side effects, it is thought that the accumulated and inherited experiences from old times can be used as meaningful material by further experimental and clinical researches.

• Fisheries and Aquatic Sciences
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• v.21 no.3
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• pp.5.1-5.8
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• 2018

Stimulator of interferon gene (STING) is induced by various inflammatory agents, such as lipopolysaccharide and microbial pathogens, including virus and bacteria. In this study, we obtained a full-length cDNA of a STING homolog from olive flounder using rapid amplification of cDNA ends PCR technique. The full-length cDNA of Paralichthys olivaceus STING (PoSTING) was 1442 bp in length and contained a 1209-bp open reading frame that translated into 402 amino acids. The theoretical molecular mass of the predicted protein sequence was 45.09 kDa. In the PoSTING protein, three transmembrane domains and the STING superfamily domain were identified as characteristic features. Quantitative real-time PCR revealed that PoSTING expressed in all the tissues analyzed, but showed the highest level in the spleen. Temporal expression analysis examined the significantly upregulated expression of PoSTING mRNA after viral hemorrhagic septicemia virus (VHSV) stimulation. In contrast, no significant changes in the PoSTING expression were detected in Edwardsiella tarda-challenged group compared to the un-injected control. The expression of P. olivaceus type I interferon (PoIFN-I) was also highly upregulated upon VHSV challenge. These results suggest that STING might be involved in the essential immune defense against viral infection together with the activation of IFN-I in olive flounder.

• BMB Reports
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• v.52 no.5
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• pp.336-341
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• 2019

The cGAS-STING pathway plays an important role in pathogen-induced activation of the innate immune response. The 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) found predominantly in the synovial fluid of osteoarthritis (OA) patients increases the expression of catabolic factors via the toll-like receptor-2 (TLR-2) signaling pathway. In this study, we investigated whether 29-kDa FN-f induces inflammatory responses via the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon gene (STING) pathway in human primary chondrocytes. The levels of cGAS and STING were elevated in OA cartilage compared with normal cartilage. Long-term treatment of chondrocytes with 29-kDa FN-f activated the cGAS/STING pathway together with the increased level of gamma-H2AX, a marker of DNA breaks. In addition, the expression of pro-inflammatory cytokines, including granulocyte-macrophage colony-stimulating factor (GM-CSF/CSF-2), granulocyte colony-stimulating factor (G-CSF/CSF-3), and type I interferon ($IFN-{\alpha}$), was increased more than 100-fold in 29-kDa FN-f-treated chondrocytes. However, knockdown of cGAS and STING suppressed 29-kDa FN-f-induced expression of GM-CSF, G-CSF, and $IFN-{\alpha}$ together with the decreased activation of TANK-binding kinase 1 (TBK1), interferon regulatory factor 3 (IRF3), and inhibitor protein ${\kappa}B{\alpha}$ ($I{\kappa}B{\alpha}$). Furthermore, NOD2 or TLR-2 knockdown suppressed the expression of GM-CSF, G-CSF, and $IFN-{\alpha}$ as well as decreased the activation of the cGAS/STING pathway in 29-kDa FN-f-treated chondrocytes. These data demonstrate that the cGAS/STING/TBK1/IRF3 pathway plays a critical role in 29-kDa FN-f-induced expression of pro-inflammatory cytokines.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.30 no.8
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• pp.30-36
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• 2002

Wind tunnel model has some difference in shape compared to the real flight vehicle because of model support system for testing. The support system can make some differences in the measured forces and moments to the flight test data. There are several correction methods involved such as cavity pressure correction and model support interference. Internal balance and belly sting support were used for this wind tunnel test and three types of model support correction methods, variable sting thickness method, dummy sting method, and wire support method, were compared. Variable sting thickness method is well matched with wire support method, which is known for almost interference free.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.49 no.3
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• pp.167-174
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• 2021

Computational Fluid Dynamics (CFD) was performed under low-speed wind tunnel test conditions using a 29.7% scale model of the NASA common research model. A wind tunnel test was conducted to measure the aerodynamic coefficient of the CRM with Belly sting model support configuration at a low Reynolds number of 0.3×106 and it was compared with the aerodynamic coefficient of CFD analysis. In order to verify the validation of the analysis, a computational analysis under the conditions of the advance research was performed and compared. The interference effect of the Belly sting model support affected not only the fuselage but also the main and tail wings.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.48 no.10
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• pp.753-763
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• 2020

A wind tunnel test of 29.7% scaled model of NASA Common Research Model with belly model support was performed in small low speed wind tunnel. The static aerodynamic forces and moments of CRM were measured with belly sting support configuration. Pitching moments of belly sting with various fairings were compared and small interference fairing shape was found. The belly sting model support interference and reducing effect of fairing shapes with CFD analysis.

• Molecules and Cells
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• v.38 no.5
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• pp.441-451
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• 2015

Recognition of cytosolic DNA initiates a series of innate immune responses by inducing IFN-I production and subsequent triggering JAK1-STAT1 signaling which plays critical roles in the pathogenesis of infection, inflammation and autoimmune diseases through promoting B cell activation and antibody responses. The stimulator of interferon genes protein (STING) has been demonstrated to be a critical hub of type I IFN induction in cytosolic DNA-sensing pathways. However, it still remains unknown whether cytosolic DNA can directly activate the JAK1-STAT1 signaling or not. And the role of STING is also unclear in this response. In the present study, we found that dsDNA directly triggered the JAK1-STAT1 signaling by inducing phosphorylation of the Lyn kinase. Moreover, this response is not dependent on type I IFN receptors. Interestingly, STING could inhibit dsDNA-triggered activation of JAK1-STAT1 signaling by inducing SHP-1 and SHP-2 phosphorylation. In addition, compared with normal B cells, the expression of STING was significantly lower and the phosphorylation level of JAK1 was significantly higher in B cells from MRL/lpr lupus-prone mice, highlighting the close association between STING low-expression and JAK1-STAT1 signaling activation in B cells in autoimmune diseases. Our data provide a molecular insight into the novel role of STING in dsDNA-mediated inflammatory disorders.

• Defense and Technology
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• no.3 s.145
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• pp.17-25
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• 1991

Sting Ray는 현대의 첨단기술로 제작된 경어뢰로서, 완전히 디지털 컴퓨터 제어에 의해 작동한다. 항공기에 장착된 유도미사일과 그 기능을 견줄수 있는 최첨단 수중유도무기이며, 수중에서의 음파탐지 및 식별에 수반되는 각종 난관을 극복하였다. 수중에서의 음의 반사 및 굴절효과로 인해 복잡성이 가중된 잡음의 근원과 바닷물의 특성이 수시로 변화되는 상황에서 음향장치 사용을 결정하는 것은 매우 어려운 과제이나, Sting Ray는 이러한 어려운 환경을 극복할수 있도록 설계되었다. 또한 선박, 항공기 또는 헬기등 어디에서 발사되더라도 자율적으로 자체의 전술을 창조하는 Shaped Charge형 탄두는 어떠한 표적에도 치명적 피해를 줄수 있다

• Parasites, Hosts and Diseases
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• v.52 no.6
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• pp.681-684
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• 2014

Hymenoptera stings can cause serious injury to humans. We report the clinical findings of 6 cases of Hymenoptera stings. All patients developed painful erythematous papules at the sting sites and had a past history of parasitoid wasp sting. This is the first clinical report of the parasitoid wasp, Cephalonomia gallicola, causing human stings in Korea.