• Journal of Radiopharmaceuticals and Molecular Probes
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• v.7 no.2
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• pp.105-111
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• 2021

⁸⁹Zr is a positron-emitting radioisotope, which has known as well-suited radioisotope for use in a monoclonal antibody-based imaging agent for immuno-PET. The purpose of this study was to quantitatively evaluate the diagnostic ability of general trastuzumab and thio-trastuzumab as HER2 positive receptors based on Df hexadentate iron chelator. Desferrioxamine-p-SCN (Df-Bz-NCS) and desferroixamine-maleimide (Df-Mal) were purchased from Macrocyclics (Dallas, TX, USA). The trastuzumab was purchased from Roche (Schweiz), and thio-trastuzumab was obtained from professor Hyo-Jeong Hong group (Kangwon National University). The radioisotope ⁸⁹Zr was produced by domestic purification system and KIRAMS using medical cyclotron (50 MeV, Scantronix). The conjugates of Df-trastuzumab and Df-thio-trastuzumab were prepared with Df-Bz-NCS and Df-Mal under basic aqueous solution (pH 8-9) at room temperature, respectively. The conjugates purified by PD-10 column were mixed with dried ⁸⁹Zr chloride. ⁸⁹Zr-labeled conjugates were purified and concentrated by Amicon ultra centrifugal filter. The preparation step and time of ⁸⁹Zr-labeled conjugates was shorted as 4 steps within 2 hours. ⁸⁹Zr-labeled conjugates showed the highly radiochemical purity of over 98%, and were very stable until 7 days by the analysis of radio-ITLC method. Each radio-labeled conjugates were also exhibited the highly stability in both PBS buffer and mouse serum. Immuno-PET imaging of ⁸⁹Zr-labeled conjugates in mice bearing gastric cancer xenograft tumors with HER2 expression showed high tumor uptake in the NCI-N87 HER2-expressing. However, ⁸⁹Zr-Df-Mal-thio-trastuzumab showed a relatively lower tumor-to-background ratio than ⁸⁹Zr-Df-Bz-trastuzumab, as well as whole-body distribution. In the results, ⁸⁹Zr-Df-Bz-trastuzumab was evaluated to have a relatively higher HER2 diagnostic ability than ⁸⁹Zr-Df-Mal-thio-trastuzumab.

• Journal of Korea Entertainment Industry Association
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• v.13 no.8
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• pp.231-242
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• 2019

(2014) directed by British-born second generation Iranian-American Ana Lily Amirpour, set in 'the Iranian ghost-town Bad City' attempts to make how the hybridization of multi-cultures makes interesting interpretations culture-politically, presenting a female vampire skateboarding in a striped t-shirt and a black chador. In traditional horror films, mainly male-Dracula was the center of the vampire narrative as other, but since the post-modernism era, vampire films try to shift women from the passive and dependent victim to the subjective and independent main agent. And the main character of the film, 'The Girl' who is a female Muslim vampire takes a step forward to punish men who commit gender violence. Shot in black and white, the film puts images ahead of narrative, while featuring Iranian actors, speaking Farsi. Furthermore, the film crosses over Iranian politics into American-European pop cultures with this eclectic mix of Iran's rock, British electro-pop and Ennio-Morricone-like western stylings. This study focuses on the style featured in which has successfully transformed and transplanted a vampire story into a critical contemporary discourse, mixing multiple genres and citing cultural trends while not following the traditional conventions of vampire films.

• Genomics & Informatics
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• v.20 no.4
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• pp.44.1-44.13
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• 2022

Brugada syndrome (BS) is an autosomal dominant inheritance cardiac arrhythmia disorder associated with sudden death in young adults. Thailand has the highest prevalence of BS worldwide, and over 60% of patients with BS still have unclear disease etiology. Here, we performed a new viral metagenome analysis pipeline called VIRIN and validated it with whole genome sequencing (WGS) data of HeLa cell lines and hepatocellular carcinoma. Then the VIRIN pipeline was applied to identify viral integration positions from unmapped WGS data of Thai males, including 100 BS patients (case) and 100 controls. Even though the sample preparation had no viral enrichment step, we can identify several virus genes from our analysis pipeline. The predominance of human endogenous retrovirus K (HERV-K) viruses was found in both cases and controls by blastn and blastx analysis. This study is the first report on the full-length HERV-K assembled genomes in the Thai population. Furthermore, the HERV-K integration breakpoint positions were validated and compared between the case and control datasets. Interestingly, Brugada cases contained HERV-K integration breakpoints at promoters five times more often than controls. Overall, the highlight of this study is the BS-specific HERV-K breakpoint positions that were found at the gene coding region "NBPF11" (n = 9), "NBPF12" (n = 8) and long non-coding RNA (lncRNA) "PCAT14" (n = 4) region. The genes and the lncRNA have been reported to be associated with congenital heart and arterial diseases. These findings provide another aspect of the BS etiology associated with viral genome integrations within the human genome.

• Journal of the Daesoon Academy of Sciences
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• v.24_1
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• pp.315-349
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• 2014

This paper was carried out to bring the researches on Cultivation Practice of Daesoonjinrihoe which have been at a standstill after analyzing the directions of studies on Cultivation Practice and diagnosing its problems, in addition to that, the paper was also conducted in a way of discussing the research directions in the future. This work enables scholars who have interests in Daesoon Thoughts to easily comprehend over the length and breadth of Cultivation Practice of Daesoonjinrihoe as well as help them understand what level of researches regarding Cultivation Practice has been demanded. Furthermore, this paper will be a step-stone for scholars to ponder how and on what perspective they approach a wide variety of studies on Daesoon Thoughts. The problems reflected on the previous researches on Cultivation Practice are summarized as follows: first, except a few researches in general, problem recognition, research target, style, method, and content are not diverged from the frame defined by Jang Byeong-Gil, who set it up in Daesoon Religion and Thought (Daesoon Jonggyo Sasang) in 1989. Proliferating overlapped researches without developing problem awareness is of great concern. And such researching climate has gradually set in. Secondly, there are numerous researches intending to reveal the researcher's forceful attitude implying faith. Thirdly, most of the previous researches neglect to focus on defining the range of researches. Fourthly, when defining concepts, more thorough insight is needed. Lastly, the researches on analysing symbols and attempting signification analysis are relatively few, only to find many errors. To solve these problems, this paper suggests to develop theories which back up Cultivation Practice by researching on the fields of theory of mind-nature(心性), theory of mind-qi(心氣), theory of pain, Religious Ethics, viewpoint of God/gods, and psychology. Secondly, all the symbols and meanings of elements shown in Cultivation Practice need analyzing more elaborately sophisticatedly and more in-depth. In order to fulfil this goal, by adapting the recent trends of historical studies, it is essential to attempt to engraft Cultivation Practice of Daesoonjinrihoe on cultural phenomena, to analyze thick layers of meanings beneath its surface, to interpret differently, utilizing various perspectives such as focusing on the gender problems, and to extract true meanings out of Cultivation Practice by analyzing everyday events which can occur in real cultivation practices. Thirdly, the terms and concepts regarding Cultivation Practice base the principle themselves. Fourthly, by utilizing methodology of comparative studies on religions, the comparative researches on cultivation practice of different religious traditions are also needed. Lastly, the history of aspects on Cultivation Practice such as transition of mantras, processes which have been conducted through proprieties of prayer and training should be collected and classified. In this context, this work is very important since it helps understand the aspects of transition of originality and characteristics in Cultivation Practice of Daesoonjinrihoe according to passage of time.

• Membrane Journal
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• v.33 no.6
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• pp.362-368
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• 2023

This research article explores the application of Polymer of Intrinsic Microporosity (PIM-1) as a cutting-edge material for CO₂ gas separation membranes in response to the escalating global concern over climate change and the imperative to reduce greenhouse gas emissions. The study delves into the synthesis, molecular weight control, and fabrication of PIM-1 membranes, providing comprehensive insights through various characterization techniques. The intrinsic microporosity of PIM-1, arising from its unique crosslinked and rigid structure, is harnessed for selective gas permeation, particularly of carbon dioxide. The article emphasizes the tunable chemical properties of PIM-1, allowing for customization and optimization of gas separation membranes. By controlling the molecular weight, higher molecular weight (H-PIM-1) membranes are demonstrated to exhibit superior CO₂ permeability and selectivity compared to lower molecular weight counterparts (L-PIM-1). The study's findings highlight the critical role of molecular weight in tailoring PIM-1 membrane properties, contributing to the advancement of next-generation membrane technologies for efficient and selective CO₂ capture-an essential step in addressing the pressing global challenge of climate change.

• Korea Trade Review
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• v.48 no.1
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• pp.215-241
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• 2023

As competition between ports intensifies, port efficiency has always been a hot topic in the port and shipping economy. Boosting regional and national economies by improving port efficiency and promoting sustainable development of ports is also a concern for port operators and local and national governments. In this situation, this study has the following objectives. First, using panel data from 2010 to 2017, the efficiency of 14 major inland ports along the Yangtze River was analyzed, and changes in port efficiency over time were examined. Second, 14 inland ports are divided into the middle, upper, and lower Yangtze River port groups to compare and review differences in efficiency levels of ports by basin. For the study, we applied a three-step DEA analysis method, which evaluated the pure relative efficiency of the port itself by removing the effects of environmental factors and statistical noise that could affect the efficiency evaluation and presented the results. As a result, it was confirmed that there was a clear difference in the efficiency value of the port between the first-stage and the third-stage efficiency evaluation result. In addition, the downstream ports showed relatively high efficiency compared to the middle and upstream ports.

• Journal of the Institute of Convergence Signal Processing
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• v.24 no.3
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• pp.166-171
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• 2023

Efficient energy management is a very important factor in sensor networks with limited resources, and cluster techniques have been studied a lot in this respect. However, a problem may occur in which energy use of the cluster header is concentrated, and when the cluster header is not evenly distributed over the entire area but concentrated in a specific area, the transmission distance of the cluster members may be large or very uneven. The transmission distance can be directly related to the problem of energy consumption. Since the energy of a specific node is quickly exhausted, the lifetime of the sensor network is shortened, and the efficiency of the entire sensor network is reduced. Thus, balanced energy consumption of sensor nodes is a very important research task. In this study, factors for balanced energy consumption by cluster headers and sensor nodes are analyzed, and a balancing distribution clustering method in which cluster headers are balanced distributed throughout the sensor network is proposed. The proposed cluster method uses multi-hop routing to reduce energy consumption of sensor nodes due to long-distance transmission. Existing multi-hop cluster studies sets up a multi-hop cluster path through a two-step process of cluster setup and routing path setup, whereas the proposed method establishes a hierarchical cluster routing path in the process of selecting cluster headers to minimize the overhead of control messages.

• Land and Housing Review
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• v.15 no.1
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• pp.167-177
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• 2024

This study aimed to assess the efficacy of an adsorption process in removing organic matter and micropollutant residuals. After a full-scale water circulation system, the adsorption process was considered a post-treatment step. The system, treating anthropogenically impacted surface waters, comprises a hydro-cyclone, coagulation, flocculation, and dissolved air flotation unit. While the system generally maintained stable and satisfactory effluent quality standards over months, it did not meet the highest standard for organic matter (as determined by chemical oxygen demands). Adsorption experiments utilized two granular activated carbon types, GAC 830 and GCN 830, derived from coal and coconut-shell feedstocks, respectively. The assessment encompassed organic materials along with two notable micropollutants: acetaminophen (APAP) and acid orange 7 (AO7). Adsorption kinetics and isotherm experiments were conducted to determine adsorption rates and maximum adsorption amounts. The quantitative findings derived from pseudo-second-order kinetics and Langmuir isotherm models suggest the effectiveness of the adsorption process. The findings of this study propose the potential of employing the adsorption process as a post-treatment to enhance the treatment of contaminants that are not satisfactorily treated by conventional water circulation systems. This enhancement is crucial for ensuring the sustainability of urban water cycles.

• Journal of The Korean Association For Science Education
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• v.26 no.6
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• pp.675-690
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• 2006

This study investigated students' views in relation to a career in science as a first step towards developing science career education programs and materials. The instrument was developed through preliminary surveys. The questionnaire was sent to, administered and returned by 3608 students including 1036 primary, 1137 middle, and 1435 high school students, who were selected through stratified cluster sampling from all over the country. The results were analyzed using statistical package program. The students' image view of science, preference for science and science learning, perception of science achievement, career hope for oneself, degree of hope in getting science-related job, perception about science-related career, important factors of science career choice, and their hope for science/non-science career and the reason for their choice in the past and present were investigated. The results show that "science as an experimentation activity" was the most frequent image view of science. The preference for science and science learning was more positive than the perception of science achievement. The percentage of total students who want to have science career was 21%, and this percentage of middle school students was especially low. The most frequent answers for advantages of science career were 'useful for national development', 'possible to get new knowledge', and those for disadvantages were 'dangerous', and 'too much to study'. The most frequent reason for students' choice of a science career was 'interest in science and science learning'. Judging from these results, the basic direction for science career education should be in raising the students' preference for and interest in science learning. The positive awareness for a career in science and vision for a science job in the future should be given through a science career education and science career education proper to the students' developmental stage and characteristics is more important.

• Journal of The Korean Association For Science Education
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• v.26 no.4
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• pp.502-509
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• 2006

The purpose of this study was to analyze physics problem solving processes according to students' cognitive style in the area of 'Force and Motion' at high school level. Students who have already learned t e area of 'Force and Motion' during the first semester of the 10th grade have taken physics test and cognitive style test to choose students who have basic knowledge of physics and reflective or impulsive style. Four students who got over 19 points in the cognitive style test were selected as reflective students, and another four students who got below 12 points were selected as impulsive students. After explaining the purpose and procedure of this study, think-aloud method was introduced to the students, and the students practiced it. After that, the students solved three quantitative and qualitative problems each. Then, the questionnaire on the belief system on physics and physics problem solving and prerequisite knowledge test were also administered. By recording the students' problem solving processes, protocol was made and analyzed. After solving the problems, the students expressed their confidence, intimacy, and preference on each problem by the five point Likert scale. Impulsive students tended to succeed in solving more problems, less intimate, and more spontaneous and positive in seeking alternative solution when confronted with unacquainted problems. On the other hand, reflective students used more time in executing the problems even without planning, and used more time in solving problems and verification. Whether making effective plan or not was important rather than how much time they used in the planning step. In addition, repeating steps were more likely shown to impulsive students; they tended to be attached to their first idea.