• Journal of Pharmaceutical Investigation
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• v.34 no.1
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• pp.1-14
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• 2004

A promising approach to the development of a new single-step vaccine, which would eliminate the requirement for multiple injections, involves the encapsulation of antigens into microspheres. Biodegradable poly(lactide-co-glycolide) (PLGA) microspheres gave us a bright insight for controling antigen release in a pulsatile fashion, thereby mimicking two or tree boosting injections. However, in spite of the above merits, the level of immunization induced by a single-shot vaccination is often lower tan two doses of alum-adsorbed antigen. Therefore, optima modification of the microsphere is essential for the development of single-step vaccines. In the review, we discuss the stability of antigen in microsphere, safety and non-toxic in human and encapsulation technology. Also, we attempted to outline relevant physicochemical properties on the immunogenicity of microsphere vaccine and attainment of pulsatile release pater by combination of different microsphere, as well as to analyze immunological data associated with antigen delivery by microsphere. Although a lot of variables are related to the optimized microsphere formulation, we could conclude that judicious choice of proper polymer type, adjustment of particles size, and appropriate immunization protocol along with a suitable adjuvant might be a crucial factor for the generation of long-lasting immune response from a single-step vaccine formulation employing PLGA microsphere.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.14 no.6
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• pp.1357-1363
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• 1994

A Monte-Carlo simulation model is developed to predict size distribution produced by the coalescence of air bubbles in turbulent shear f1ow. The simulation consists of generating a population of air bubbles into the initial positions at each time step and tracking them by simulating motions and checking collisions. The radial displacement of air bubbles in the simulation model is produced by numerically solving an advective diffusion equation. Longitudinal displacements are generated from the logarithmic flow velovity distribution and the bubble rise velocity. Collision of air bubbles for each time step is detected by a geometric test using their relative positions at the beginning of the time step and relative displacements during the time step. At the end of the time step, the total number of bubbles, their positions, and sizes are updated. The computer program is coded such that minimum storages for sizes and positions of bubbles are required.

• Journal of Industrial Technology
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• v.35
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• pp.3-8
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• 2015

A study has been made on defects which are formed in manufacturing processes of engine bearing and also on fatigue crack growth behavior in each step of bearing metal manufacturing. After the first step(sinter brass powder on steel plate ; Series A) many voids are made on brass surface and its size is decreased by the second step(rolling process of sintered plate ; Series B). After the third step(re-sintering step of brass powder and rolling ; Series C) the number of voids is decreased and its type shows line. The time of fatigue crack initiation and the growth rate of fatigue crack are in order of Series A, Series B, Series C. These reasons are that void fosters the crack initiation and growth, and residual stress made by rolling process effects on the crack growth rate in Series B, C. In forming and machining processes by use of final bearing metal, crack was observed at internal corner of flange and peeling off was observed at junction between steel and brass. Owing to the above crack and peeling off, it is considered that there is a possibility of fatigue fracture during the application time.

• Proceedings of the KIEE Conference
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• 2005.11a
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• pp.6-8
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• 2005

The optical and electrical properties of indium tin oxide (ITO) thin films deposited at room temperature can be substantially enhanced by adopting a two-step process. In the first step, the films (50 nm thick) were grown by pulsed laser deposition (PLD) on glass substrate at room temperature and quickly annealed at $400^{\circ}C$ in nitrogen ambient for 1 minute by using rapid thermal annealing method. The process was completed by additional deposition (150 nm thick) on annealed film at room temperature. High quality ITO films grown by two-step process at room temperature could be obtained with the resistivity of $3.02{\times}10^{-4}{\Omega}cm$, the carrier mobility of 32.07 $cm^2/Vs$, and the transparency above 90 % in visible region mainly due to the enhancement of the film crystallinity and the increase of grain size.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.26 no.12
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• pp.1674-1680
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• 2002

An experimental study was made of a large-scale vortical structure over a backward-facing step. The Reynolds number based on the step height was R $e_{H}$ =33,000. To recognize the large-scale vortex, three components of velocity were measured. The measurements were performed in the recirculation zone (x/H=4.0) and the reattachment zone(x/H=7.5). To measure the wall pressure fluctuations in a turbulent flow over a backward-facing step, a 32-channel microphone array was installed beneath the wall in the streamwise and spanwise directions. From the measured pressure field, the size of large-scale vortex was obtained. As a detailed study, a conditionally-averaging technique was employed to characterize the coherent structure of the large-scale vortex. To see the relationship between the flow field and the relevant spatial mode of the pressure field, the spatial box filtering (SBF) was examined. A cross-correlation between velocity and pressure fluctuations was performed to identify the structure and the length scale of the large-scale vortex.x.

• Journal of the Korean institute of surface engineering
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• v.46 no.1
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• pp.16-21
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• 2013

CIGS (Cu-In-Ga-Se) films were deposited on the Mo coated soda lime glass (Mo/SLG) by RF magnetron sputtering using a single sintered target with different chemical compositions. Heat treatment of the CIGS films were carried out under three different conditions, 1step ($350^{\circ}C$ for 2 hour and $550^{\circ}C$ for 2 hour) and 2step ($350^{\circ}C$ for 1 hour and $550^{\circ}C$ for 1 hour). In the case of CIGS films post-annealed on 2step method, grain size remarkably increased compared to other methods, indicating that chemical composition [Cu/(Ga+In) = 1] of CIGS films was same as CIGS target. After heat treatment by 2step method, band gap energy of the CIGS film deposited at RF 80 W showed 1.4 eV which is broadly similar to identical band gap energy (1.2 eV) of CIGS film prepared by evaporation method. Therefore, 2step heat treatment method could be expected to low temperature process.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.11 no.10
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• pp.796-803
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• 1998

Intrinsic and proximity gettering are popular processes to get higher cumulative production yield and usually adopt multi-step annealing and high energy ion implantation, respectively. In order to test the combined processed of these, high energy \ulcornerAs\ulcorner ion implantation and 2-step annealing process were adopted. After the ion implantation followed by 2-step annealing, the wafers were cleaved and etched with Wright etchant. The morphology of cross section on samples was inspected by FESEM. The concentration profile of As was measured by SRP. The location and type of secondary defects inspected by HRTEM were dependent on the 1st annealing temperatures. That is, a line of dislocation located at $1.5mutextrm{m}$ apart from the surface at $600^{\circ}C$ lst annealing was changed to some dislocation lines or loops nearby the surface at 100$0^{\circ}C$. The density of dislocation line was reduced but the size of the defects was enlarged as the temperature increased.

• Journal of Industrial Technology
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• v.31 no.A
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• pp.45-51
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• 2011

A study has been made on defects which are formed in manufacturing processes of engine bearing and also on fatigue crack growth behavior in each step of bearing metal manufacturing. After the first step (sinter brass powder on steel plate ; Series A) many voids are made on brass surface and its size is decreased at the second step (rolling process of sintered plate ; Series B). After the third step (re-sintering step of brass powder and rolling ; Series C) the number of voids is decreased and its type shows line. The time of fatigue crack initiation and the growth rate of fatigue crack are in order of Series A, Series B, Series C. These reasons are that void fosters the crack initiation and growth, and residual stress made by rolling process affects on the crack growth rate in Series B, C. In forming and machining processes by use of final bearing metal, crack was observed at internal corner of flange and peeling off was observed at interface between steel and brass. Owing to the above crack and peeling off, it is considered that there is a possibility of fatigue fracture during the application time.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.20 no.2
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• pp.97-102
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• 2020

This paper relates with the Hybrid-SE-MMA (Signed-Error MMA) that is possible to improving the equalization performance by using the adaptive modulus and adaptive step size in SE-MMA adaptive equalizer for the minimizing the intersymbol interference. The equalizer tap coefficient is updatted use the error signal in MMA algorithm for adaptive equalizer. But the sign of error signal is used for the simplification of arithmetic operation in SE-MMA algorithm in order to updating the coefficient. By this simplification, we get the fast convergence speed and the reduce the algorithm processing speed, but not in the equalization performance. In this paper, it is possible to improve the equalization performance by computer simulation applying the adaptive modulus to the SE-MMA which is proposional to the power of equalizer output signal. In order to compare the improved equalization performance compared to the present SE-MMA, the recovered signal constellation that is the output of the equalizer, residual isi, MD(maximum distortion), MSE and the SER perfomance that means the robustness to the external noise were used. As a result of computer simulation, the Hybrid-SE-MMA improve equalization performance in the residual isi and MD, MSE, SER than the SE-MMA.

• Korean Journal of Materials Research
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• v.12 no.11
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• pp.840-844
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• 2002

A spherical $BaMgAl_{10}$ $O_{17}$ :Eu phosphor has been synthesized by a multi-step precipitation route. In order to successfully synthesize the phosphor with spherical shape, the hydrated-alumina particles should be controlled for spherical shape. In this process, the hydroxypropyl cellulose (HPC) was used as a dispersing reagent. This reagent plays an important role in that the particles were controlled to have the uniform size of sub-micron. The final product prepared by the multi-step precipitation method maintained spherical shape with uniform size of 0.4$\mu\textrm{m}$. It can be seen in X-ray diffraction patterns, formation of the single phase of $BaMgAl_{10}$ $O_{17}$ :Eu phosphor prepared by the multi-step precipitation method at $1350^{\circ}C$. Also, the emission spectra of spherical $BaMgAl_{O}$ $10_{17}$ :Eu phosphor in the present case was compared with those of commercially-available blue phosphor under VUV (Vacuum Ultra Violet) excitation. The luminescence process of the $BaMgAl_{10}$ $O_{17}$ :Eu phosphor is characterized by the $4f^{6}$$5d^1$longrightarrow4f$^{7}$ transition (blue) of the $Eu^{2+}$ ion acting as an activating center and the maximum luminescence intensity was obtained by reduction treatment at 145$0^{\circ}C$.