• Nuclear Engineering and Technology
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• v.54 no.3
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• pp.940-947
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• 2022

Meta-heuristic algorithms have found their place in optimization problems. Henry gas solubility optimization (HGSO) is one of the newest population-based algorithms. This algorithm is inspired by Henry's law of physics. To evaluate the performance of a new algorithm, it must be used in various problems. On the other hand, the optimization of the proportional-integral-derivative (PID) gains for load-following of a nuclear power plant (NPP) is a good challenge to assess the performance of HGSO. Accordingly, the power control of a pressurized water reactor (PWR) is targeted, based on the point kinetics model with six groups of delayed-neutron precursors. In any optimization problem based on meta-heuristic algorithms, an efficient objective function is required. Therefore, the integral of the time-weighted square error (ITSE) performance index is utilized as the objective (cost) function of HGSO, which is constrained by a stability criterion in steady-state operations. A Lyapunov approach guarantees this stability. The results show that this method provides superior results compared to an empirically tuned PID controller with the least error. It also achieves good accuracy compared to an established GA-tuned PID controller.

• Nuclear Engineering and Technology
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• v.54 no.8
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• pp.2898-2914
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• 2022

When evaluating energy balance and temperature in reduced-scale fire experiments, which are conducted as an alternative to full-scale fire experiments, it is important to consider the similarity in the scale among these experiments. In this paper, a method considering the similarity of energy balance is proposed for setting the conditions for reduced-scale experiments of mechanically ventilated compartment fires. A small-scale fire experiment consisting of various cases with different compartment geometries (aspect ratios between 0.2 and 4.7) and heights of vents and fire sources was conducted under mechanical ventilation, and the energy balance in the quasi-steady state was evaluated. The results indicate the following: (1) although the compartment geometry varies the energy balance in a mechanically ventilated compartment, the variation in the energy balance can be evaluated irrespective of the compartment size and geometry by considering scaling factor F (∝h_effA_wR_T, where h_eff is the effective heat transfer coefficient, A_w is the total wall area, and R_T is the ratio of the spatial mean gas temperature to the exhaust temperature); (2) the value of R_T, which is a part of F, reflects the effects of the compartment geometry and corresponds to the distributions of the gas temperature and wall heat loss.

• The Korean Journal of Physiology and Pharmacology
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• v.3 no.2
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• pp.183-189
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• 1999

This investigation is to determine whether the surface complexation of iron influence acute pulmonary responses induced by silica. For this study, three varieties of cation complexed silica were used: $silica-H^+,\;-Zn^{2+},\;and\;-Fe^{3+},$ since the first two are not active in the transport of electrons and generate little free radicals relative to the dust with the surface iron. Rats (270 to 280 g) were intratracheally (IT) instilled with saline, $silica-H^+,\;-Zn^{2+},\;or\;-Fe^{3+}$(5 mg in 0.5 ml saline). After 4 h, cell number, type, and differentiation were analysed in the bronchoalveolar lavage cells, and the levels of lactate dehydrogenase (LDH) and total protein were determined in the lavage fluid. In addition, bronchoalveolar lavage cells were cultured, and nitric oxide production was measured using nitrate assay. Inducible nitric oxide synthase (iNOS) mRNA in the bronchoalveolar lavage cells was also determined by northern blot analysis. Differential counts of the lavage cells showed that red blood cells were increased by 9-, 8-, and 13-fold and total leukocytes (lymphocytes plus polymorphonuclear neutrophils) by 48-, 36-, and 33-fold, following IT $silica-H^+,\;-Zn^{2+},\;and\;-Fe^{3+},$ respectively compared with the saline group. Meanwhile, there were no significant differences in red blood cells and total leukocytes among any of the cation complexed silica groups. The levels of LDH and total protein in the lavage fluid were significantly increased by 3- to 4-fold. However, compared among these silica groups, $Fe^{3+}$? complexation did not significantly change the LDH activity and total protein. NO production in cultured bronchoalveolar lavage cells was elevated by 2-fold, following IT any of the silica treatments compared with the saline group. Furthermore, the steady-state levels of iNOS mRNA in the lavage cells were greatly increased. There were any differences in iNOS mRNA expression among the silica-treated groups as with NO production. These findings suggest that surface complexed iron may not influence the acute pulmonary responses resulted from 4h exposure to silica.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.36 no.1
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• pp.60-65
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• 2000

The virtual mass of net is an important parameter in the analysis and control of net movement in the water. This experiment was performed with the purpose of getting a relation on the quantity of netting and virtual mass of trawl nets using the circulating water channel that can control flow speed. Twelve types of conical nets were examined. Resistance of the conical net at the steady and acceleration state was recorded as text on the personal computer through the tension meter and current meter. The results were obtained as follows ;1. Resistance(R) of the conical net is proportional to the degree of attack angle in the sam e amount of twine material.2. Coefficient of the resistance(Cd)could be defined by the following regression model as a function of Reynolds Number(Re). Cd=0.039Re-0.14743. Resistance(R) is proportional to TSA(Twine surface area) and defined as follows; R=21.398TSA-0.12194. Coefficient of virtual mass(CM) could be calculated by the following first order regression model. CM=37.557U-8.96845. Virtual mass is directly proportional to Volume of net(V) or d/l.

• YAKHAK HOEJI
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• v.39 no.6
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• pp.636-644
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• 1995

Comparison of bioavailabflity (BA) of three brands of ranitidine (RT) tablets has been studied m rats. The purpose of this study was to characterize the pharniacolunetics of RT tablets in the rat and to coinpare phannacolunetic parameters of three brands of RT tablets. In addition, it was investigated whether plasma RT concentrations m humans can be predicted from pharmacokinetic parameters obtained in rats. RT was administered intravenously in dose of RT.HCI 10mg/kg and orally in dose of RT.HCI 50mg/kg as solution or crushed sample of thablets. Plasma RT concentrations were determned by HPLC. Plasma RT concentrations as a function of time were fitted to two compartment model. Plasma RT concentrations declined with a terminal half life ($t_{{1}/2{\betha}}$) of 40.9 min. The plasma RT concentration-time curve showed two peak plasma concentrations following an oral administration of solution or crushed sample in rats like humans. No significant difference among pharmacokinetic parameters was observed except $T_{max2}$ (p<0.05). The BA for crushed sample A, B and C were found to be 54.6 40.7 and 40.0%, respectively. Equivalence of $C_{max1}$ and $T_{max2}$ were guaranteed in this study. However, it was concluded that three brands of RT tablets are bioequivalent, taking the following characteristics of RT into consideration;(1) rapid onset of the effect is not required, (2) $C_{max1}$ and $T_{max2}$ do not seem to influence the effectiveness of the drug during a long-term treatment by the usual administration of twice a day. Results from this study were combined with plarmacokinetic data for RT in dogs and humans to develop a basis for interspecies scale-up of the disposition characteristics of the drug. there were similarities in the general disposition of the drug. Allometric relationships were sought between pharmacokinetic parameters nd species body weight. Significant interspecies correlations were found for total body clearance($Cl_{t}$) and steady state volume of distribution ($Bd_{ss}$). Thus, plasma RT concentrations in humans can be predicted from pharmacokinetic parameters obtained in rats.

• Current Research on Agriculture and Life Sciences
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• v.10
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• pp.41-47
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• 1992

In general, the behavior of moisture transmission is estimated by vapor permeability or vapor transmission resistance, but its values obtained by experiments do not have great adaptability for practical situations because of changes in the experimental conditions. This fact is why only theoretical discussions have advanced. Thus, the fundamental study of the moisture transmission phenomenon has been treated lightly. Here, as the first step toward the basic research of moisture transmission, the amount of moisture transmission and the moisture distribution in specimens were investigated. The experiment was conducted in a steady state, and the moisture distribution was measured by slicing and weighing the specimens. From the examination of the vapor transmission resistance, the phenomenon of moisture transmission was dealt with devide the moisture transfer on the wood surface and moisture diffusion in wood. The following results were obtained. 1) The phenomenon of moisture transmission should be approached by its division into moisture transfer on the wood surface and moisture diffusion in the wood because the positive values of vapor transmission resistance exist in the extrapolation of thickness 0mm. 2) The distribution of moisture in wood can be illustrated by two straight lines intersecting at the point of nine percent moisture content : namely, diffusion coefficients have two constant values at moisture contents below and above nine percent. The shape of the distribution curve of moisture content is similar irrespective of the wood thickness. On the other hand, when the moisture contents on both sides was more than nine percent, the distribution of the moisture content could be illustrated by one straight lines. 3) The amount of moisture movement is determined by the moisture gradient in wood. 4) Coefficients of the moisture transfer depend on the thickness of the specimens.

• Korean Journal of Veterinary Research
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• v.35 no.4
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• pp.815-822
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• 1995

The toxicokinetics of rifapentine was studied after an oral administration to beagle dogs. High-performance liquid chromatography(HPLC) using column-switching technique was performed to determine the serum concentrations of rifapentine. The pharmacokinetic profiles of rifapentine were analysed using one-compartment open model. Following a single oral administration of 10mg/kg, pharmacokinetic parameters were determined as follows: maximum serum concentration($C_{max}$), $28.90{\mu}g/ml$; maximum concentration time($T_{max}$), 3.7hr; elimination half-life($t_{1/2}$, 4.7hr; area under the curve(AUC), $339.0{\mu}g{\cdot}hr/ml$; volume of disiribution/bioavailability (Vd/F), 0.21 l/kg; lag time, 24min; absorption rate constant($k_a$), $0.445hr^{-1}$; elimination rate constant($k_{el}$), $0.148hr^{-1}$. After 6 month multiple oral doses of 10mg/kg/day, parameters were as follows: $C_{max}$, $34.40{\mu}g/ml$; $T_{max}$, 2.6hr; $t_{1/2}$, 6.7hr; AUC, $391.3{\mu}g{\cdot}hr/ml$; Vd/F, 0.291/kg; $k_a$, $0.976hr^{-1}$; $k_{el}$, $0.104hr^{-1}$. The consistant kinetic parameters after a single and multiple oral administration show that there was no accumulation of rifapentine after 6 month oral administration. We also simulated the concentration of rifapentine after oral multiple administration of 10 and 50mg/kg/ day, based on the parameters obtained form the single administration. The measured serum concentrations of rifapentine were well fitted to the simulated results. The simulated results show that rifapentine readily reaches to steady-state after about 3 doses and the steady-state serum concentrations($C_{ss}$) are fluctuated in between $2.2{\sim}25.2{\mu}g/ml$, and $10.6{\sim}125.2{\mu}g/ml$ at the doses of 10 and 50mg/kg/day, respectively.

• Korean Journal of Applied Biomechanics
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• v.27 no.2
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• pp.117-124
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• 2017

Objective: The purpose of this study was to examine the effect of changes in degrees of freedom of the fingers (i.e., the number of the fingers involved in tasks) on the task performance during force production and releasing task. Method: Eight right-handed young men (age: $29.63{\pm}3.02yr$, height: $1.73{\pm}0.04m$, weight: $70.25{\pm}9.05kg$) participated in this study. The subjects were required to press the transducers with three combinations of fingers, including the index-middle (IM), index-middle-ring (IMR), and index-middle-ring-little (IMRL). During the trials, they were instructed to maintain a steady-state level of both normal and tangential forces within the first 5 sec. After the first 5 sec, the subjects were instructed to release the fingers on the transducers as quickly as possible at a self-selected manner within the next 5 sec, resulting in zero force at the end. Customized MATLAB codes (MathWorks Inc., Natick, MA, USA) were written for data analysis. The following variables were quantified: 1) finger force sharing pattern, 2) root mean square error (RMSE) of force to the target force in three axes at the aiming phase, 3) the time duration of the release phase (release time), and 4) the accuracy and precision indexes of the virtual firing position. Results: The RMSE was decreased with the number of fingers increased in both normal and tangential forces at the steady-state phase. The precision index was smaller (more precise) in the IMR condition than in the IM condition, while no significant difference in the accuracy index was observed between the conditions. In addition, no significant difference in release time was found between the conditions. Conclusion: The study provides evidence that the increased number of fingers resulted in better error compensation at the aiming phase and performed a more constant shooting (i.e., smaller precision index). However, the increased number of fingers did not affect the release time, which may influence the consistency of terminal performance. Thus, the number of fingers led to positive results for the current task.

• Korean Journal of Agricultural and Forest Meteorology
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• v.1 no.1
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• pp.29-35
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• 1999

Soil structure and organic matter have been known to strongly affect water flow and solute transport, yet little information is available concerning soil hydraulic properties related to soil physical and chemical properties in the forest site. The purpose of this study was to quantify the spatial variability and spatial correlation of the measured parameter values from the plots established with the rainfall simulator on Japanese larch(Larix leptolepis) dominated site in Kwangju. Kyunggi-Do. Measurement of soil water flux and retention were made with the inherent soil texture, soil structure, and organic matter. The method was based on the observation that when water was applied at a constant rate to the soil surface on each plot. The method was simple to apply and consists of following steps: (i) Wet the soil from a rainfall simulator with several known discharge rates on a relatively leveled soil surface with and without organic matter. (ii) Once the borders of the ponded zone were steady, saturated hydraulic conductivity( $K_{s}$) and the matric flux function(F) was evaluated from a regression of flux vs. the reciprocal of the ponded area. A conductivity of the form $K_{i+}$$_1$ $_{c}$= $K_{i}$( $_{c}$) [1-d /dz] where flux continuity implies. For this, continuity of matric potential at the interface at all times are as follows: $_1$( $Z_{c}$) = $_2$( $Z_{c}$) = $_{c}$ for steady state intake from water ponded on the soil surface. Results of this investigation showed the importance of understanding spatial variability in wide differences of water retention and saturated hydraulic conductivity with respect to pore geometry and organic matter contents which influenced the water flux throughout the soil profile.l profile.ile.

• Wind and Structures
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• v.16 no.1
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• pp.1-23
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• 2013

The wind-induced transient response of internal pressure following the creation of a sudden dominant opening during the occurrence of high external pressure, in low-rise residential and industrial buildings was numerically investigated. The values of the ill-defined parameters namely the flow contraction coefficient, loss coefficient and the effective slug length were calibrated by matching the analytical response with the computational fluid dynamics predictions. The effect of a sudden i.e., "instantaneously created" windward opening in the Texas Technical University (TTU) test building envelope was studied for two different envelope flexibility-leakage combinations namely: (1) a quasi-statically flexible and non-porous envelope and (2) a quasi-statically flexible and porous envelope. The responses forced by creating the openings at different time leads/lags with respect to the occurrence of the peak external pressure showed that for cases where the openings are created in close temporal proximity to the peak pressure, the transient overshoot values of internal pressure could be higher than the peak values of internal pressure in the pre-sequent or subsequent resonant response. In addition, the influence of time taken for opening creation on the level of overshoot was also investigated for the TTU building for the two different envelope characteristics. Non-dimensional overshoot factors are presented for a variety of cavity volume-opening area combinations for (1) buildings with rigid/quasi-statically flexible non-porous envelope, and (2) buildings with rigid/quasi-statically flexible and porous envelope (representing most low rise residential and industrial buildings). While the factors appear slightly on the high side due to conservative assumptions made in the analysis, a careful consideration regarding the implication of the timing and magnitude of such overshoots during strong gusts, in relation to the steady state internal pressure response in cyclonic regions, is warranted.