• Asian-Australasian Journal of Animal Sciences
• /
• 제17권5호
• /
• pp.726-732
• /
• 2004

In this manuscript, a review of the diversity of Chinese indigenous goat breeds according to data from body stature and appearance, chromosome group, blood proteins, DNA molecular markers (mitochondria DNA, random amplified polymorphic DNA, microsatellite DNA, major histocompatibility complex) has been introduced. All of these provide efficient tools for the diversity analysis of Chinese indigenous goat breeds and are very important for biodiversity conservation, restoration of declining goat breeds, the priority defining in Chinese indigenous goat breeds' protection and the selection of nature preservation zones. Many Chinese indigenous goat breeds with small population size in the isolated mountains or reservoir areas are verging the potential threat of extinction, effectively lost with the rapid destroying of ecological environment. On the other hand, as a result of the introduction of modern commercial goat breeds and shortage of effective conservation, some populations, such as Small-xiang goat and Tibetan goat decrease rapidly in number of sires. In the interests of the long-term future of the goat breeds in China, conservation of goat breeds' genetic resources should be considered urgently and some conservation measures should be adopted. In addition, the continuing development of molecular biology will further enhance conservation of diversity of Chinese indigenous goat breeds.

• 종양간호연구
• /
• 제8권2호
• /
• pp.120-127
• /
• 2008

Purpose: The purpose of this study was secondary analysis to explore about risk factors with breast cancer on a basis of primary literature. Methods: This study was searched articles by using CINAHL, MEDLINE, Riss4u, Internet website regarding breast cancer. This study searched for the journal published in Korea and foreign countries from 2000 to 2008, about risk factors of breast cancer. This study was reviewed 42 articles (5 experimental study, 35 survey, 1 qualitative study, 1 report) suitable for the research objectives. Results: Magnitude of risk breast cancer (++) was age, geographic region, family history, mutations in BRCA1, BRCA2 genes and in other penetrance genes, radiation, history of benign breast disease, late age of menopause, early age of menarch, nulliparity and older age at first birth, high mammographic breast density, high insulin-like growth factor 1 level. Magnitude of risk factor (+) was hormone replacement therapy, oral contraceptives use, obesity, tall stature, alcohol consumption, high prolactin level, high saturated fat and well-done meat intake, polymorphisms in low penetrance gene, high socioeconomic status. Conclusion: A breast cancer screening protocol according to magnitude of risk factors is needed for disease prevention. The nurses need to educate and counsel women with risk factors of breast cancer.

• Clinical and Experimental Pediatrics
• /
• 제55권7호
• /
• pp.224-231
• /
• 2012

Prader-Willi syndrome (PWS) is a complex multisystem genetic disorder characterized by hypothalamic-pituitary dysfunction. The main clinical features include neonatal hypotonia, distinctive facial features, overall developmental delay, and poor growth in infancy, followed by overeating with severe obesity, short stature, and hypogonadism later in development. This paper reviews recent updates regarding the genetic aspects of this disorder. Three mechanisms (paternal deletion, maternal disomy, and deficient imprinting) are recognized. Maternal disomy can arise because of 4 possible mechanisms: trisomy rescue (TR), gamete complementation (GC), monosomy rescue (MR), and postfertilization mitotic nondisjunction (Mit). Recently, TR/GC caused by nondisjunction at maternal meiosis 1 has been identified increasingly, as a result of advanced maternal childbearing age in Korea. We verified that the d3 allele increases the responsiveness of the growth hormone (GH) receptor to endogenous GH. This paper also provides an overview of endocrine dysfunctions in children with PWS, including GH deficiency, obesity, sexual development, hypothyroidism, and adrenal insufficiency, as well as the effects of GH treatment. GH treatment coupled with a strictly controlled diet during early childhood may help to reduce obesity, improve neurodevelopment, and increase muscle mass. A more active approach to correct these hormone deficiencies would benefit patients with PWS.

• Asian-Australasian Journal of Animal Sciences
• /
• 제27권6호
• /
• pp.784-790
• /
• 2014

In this study we aimed to evaluate the reduction in dimensionality of 20 linear type traits and more final score in 14,943 Holstein cows in Brazil using factor analysis, and indicate their relationship with longevity and 305 d first lactation milk production. Low partial correlations (-0.19 to 0.38), the medium to high Kaiser sampling mean (0.79) and the significance of the Bartlett sphericity test (p<0.001), indicated correlations between type traits and the suitability of these data for a factor analysis, after the elimination of seven traits. Two factors had autovalues greater than one. The first included width and height of posterior udder, udder texture, udder cleft, loin strength, bone quality and final score. The second included stature, top line, chest width, body depth, fore udder attachment, angularity and final score. The linear regression of the factors on several measures of longevity and 305 d milk production showed that selection considering only the first factor should lead to improvements in longevity and 305 milk production.

• 복식문화연구
• /
• 제13권1호
• /
• pp.6-17
• /
• 2005

The purpose of this research is to define low body shapes of Plus-sized women at ages between 21 and 69 whose satisfied the Plus-sized judgment criteria took part in this study. This research also classifies different body types, and provides basic data for designing skirt's and slacks' prototypes according to each body type. Based on factor analysis of the measured data, seven key factors are grouped. And four different body types are classified based on the cluster analysis using factor marks. Type 1 refers to those who are tall in stature and balanced. This body type is characterized by trapezoid body shape when looked from the front, and slim the abdomen, bulge the belly and flat the buttocks when looked from the side. Type 2 refers to short and an obese body shapes, with trapezoid front and bulge abdomen and belly and flat the buttocks. Type 3 refers to those who are of medium height and long-legged body shapes, with rectangular front, protruding belly and buttocks. Type 4 refers to obese body shapes, with rectangular front, protruding abdomen and belly, flat the buttocks. 9 items are available to judge Plus-sized women's low body types and the hit ratio is 93.5%.

• 한국의류학회지
• /
• 제29권6호
• /
• pp.764-771
• /
• 2005

This study is to increase the efficiency for the suitability of clothing measurement and the production utility factors by setting up the measurement system with middle-aged men's physical characteristics. For this purpose this study measured the body sizes of middle-aged men and analyzed basic sizing items such as drop, height, and bust according to the ISO and KS systems and classified these sizes based on body shapes and heights. As a result, an internationally-compatible measuring system is presented in this study. The most common body shapes are portly (Drop 6) and regular (Drop 12) types and these two types form $74.7\%$. The height of 164cm$(31.2\%)$ and 170cm$(38.2\%)$ cover $69.4\%$; and the most general sizes of busts are 92, 96 and 100 and these sizes occupy $74.7\%$. In consideration of the ranges of height and bust, the general sizes (7 regular types and 9 portly types) are selected to present the standardized measurements; the mark for the top is height-bust-waist and the mark for the bottom is stature-waist-hip.

• Clinical and Experimental Pediatrics
• /
• 제58권7호
• /
• pp.270-273
• /
• 2015

Legg-Calve-Perthes (LCP) disease is characterized by idiopathic avascular osteonecrosis of the epiphysis of the femur head. The main factor that plays a role in the etiology of the disease is decreased blood flow to the epiphysis. Many predisposing factors have been suggested in the etiology of LCP disease, and most have varying degrees of effects. Here we present the case of a boy aged 4 years and 10 months with complaints of short stature and a diagnosis of multiple hypophyseal hormone deficiency, in whom LCP disease and difficult birth-related pituitary stalk interruption syndrome were identified by anamnesis. The present case revealed that LCP disease and hypophyseal hormone deficiency could be secondary to difficult birth and that LCP disease could be secondary to insulin-like growth factor 1 deficiency. Additionally, to the best of our knowledge there is no published case on the relation between LCP disease and insulin-like growth factor 1 deficiency. Therefore, we believe that this case is worthy of presentation.

• Clinical and Experimental Pediatrics
• /
• 제58권9호
• /
• pp.317-324
• /
• 2015

Kabuki syndrome (KS) is a rare syndrome characterized by multiple congenital anomalies and mental retardation. Other characteristics include a peculiar facial gestalt, short stature, skeletal and visceral abnormalities, cardiac anomalies, and immunological defects. Whole exome sequencing has uncovered the genetic basis of KS. Prior to 2013, there was no molecular genetic information about KS in Korean patients. More recently, direct Sanger sequencing and exome sequencing revealed KMT2D variants in 11 Korean patients and a KDM6A variant in one Korean patient. The high detection rate of KMT2D and KDM6A mutations (92.3%) is expected owing to the strict criteria used to establish a clinical diagnosis. Increased awareness and understanding of KS among clinicians is important for diagnosis and management of KS and for primary care of KS patients. Because mutation detection rates rely on the accuracy of the clinical diagnosis and the inclusion or exclusion of atypical cases, recognition of KS will facilitate the identification of novel mutations. A brief review of KS is provided, highlighting the clinical and genetic characteristics of patients with KS.

• 대한임상검사과학회지
• /
• 제49권4호
• /
• pp.495-497
• /
• 2017

Thalassemia major is a genetic disorder with a defective synthesis of either the alpha or the beta chain of hemoglobin A. Blood transfusion is crucial for the survival in these patients. Unfortunately, endocrine dysfunction is a very common complication in these patients and is principally due to excessive iron overload as a result of frequent blood transfusions. Although regular blood transfusion may increase life expectancy, disturbances in growth and pubertal development, abnormal gonadal functions, impaired thyroid, parathyroid and adrenal functions, diabetes, and disorderly bone growth are common side effects. We hereby present a case of a 23-year-old, unmarried woman with beta thalassemia major presenting with primary amenorrhea, poor development of secondary sexual character, and short stature. Thorough history, clinical examination, and laboratory investigation, including dynamic function test (insulin tolerance test) were conducted. These tests confirmed that she had multiple endocrinopathies, including hypogonadotropic hypogonadism, growth hormone deficiency, and subclinical adrenal insufficiency, which were caused by iron overload. She required hormone replacement therapy. Early recognition of possible deficiencies in hypothalamo-pituitary-end organ hormones caused by iron overload in thalassemia patients that undergo frequent blood transfusion procedures is essential. Appropriate treatments, including transfusion regimen and chelation therapy, as well as specific treatment of each complication are the crucial for the successful management and improvement of quality of life these patients.

• 한국의류산업학회지
• /
• 제5권4호
• /
• pp.379-388
• /
• 2003

The purpose of this study was to compare the somatometric characteristics obtained from the factor scores of both upper and lower body by regional differences. The sample group was drawn from boys at the ages 7 to 12 living in Pusan and Kyungsangnam-do. Data from each boy comprised 57 anthropometric measurements and 11 photographic measurements. The study reached following conclusions. 1. According to the result of factor analysis, five indicative factor's were obtained from the upper body measurements and four indicative factors were obtained from the lower body measurements. 2. According to the comparision of factor scores on measurements of the upper body between Pusan and Kyungsangnam-do, there were differences in all five factors. Boys in Pusan had higher stature, bigger frame, more protruded chest and shoulder blades, more sloping curve along with the backbone, more protruded belly, narrower and sloping shoulders than boys in Kyungsangnam-do. 4. According to the comparision of factor scores on measurements of the lower body between Pusan and Kyungsangnam-do, there were differences in factor 1 and factor 4. Boys in Pusan had bigger frame and flatter hip than boys in Kyungsangnam-do.