• Journal of Korea Trade
• /
• v.24 no.8
• /
• pp.171-188
• /
• 2020

Purpose - This is an exploratory study that aims to apply text mining techniques, which computationally extracts words from the large-scale text data, to legal documents to quantify trade claim contents and enables statistical analysis. Design/methodology - This is designed to verify the validity of the application of text mining techniques as a quantitative methodology for trade claim studies, that have relied mainly on a qualitative approach. The subjects are 81 cases of arbitration and court judgments from China published on the website of the UNCITRAL where the CISG was applied. Validation is performed by comparing the manually analyzed result with the automatically analyzed result. The manual analysis result is the cluster analysis wherein the researcher reads and codes the case. The automatic analysis result is an analysis applying text mining techniques to the result of the cluster analysis. Topic modeling and semantic network analysis are applied for the statistical approach. Findings - Results show that the results of cluster analysis and text mining results are consistent with each other and the internal validity is confirmed. And the degree centrality of words that play a key role in the topic is high as the between centrality of words that are useful for grasping the topic and the eigenvector centrality of the important words in the topic is high. This indicates that text mining techniques can be applied to research on content analysis of trade claims for statistical analysis. Originality/value - Firstly, the validity of the text mining technique in the study of trade claim cases is confirmed. Prior studies on trade claims have relied on traditional approach. Secondly, this study has an originality in that it is an attempt to quantitatively study the trade claim cases, whereas prior trade claim cases were mainly studied via qualitative methods. Lastly, this study shows that the use of the text mining can lower the barrier for acquiring information from a large amount of digitalized text.

• Journal of Korean Society for Quality Management
• /
• v.50 no.3
• /
• pp.373-386
• /
• 2022

Purpose: This study proposes the application of Six Sigma management innovation method for more systematically enhanced execution of Quality by Design (QbD) activities. QbD requires a deeper understanding of the product and process at the design and development stage of the drug, and it is very important to ensure that no fault is fundamentally generated through thorough process control. Methods: Analyzing the background and specific procedures of quality improvement based on the drug design basis, and analyzing the key contents of each step, we have differentated and common points from the 6 Sigma methodology. We propose a new model of Six Sigma management innovation method suitable for pharmaceutical industry. Results: Regulatory agencies are demanding results from statistical analysis as a scientific basis in developing medicines to treat human life through quality improvement activities based on drug design. By utilizing the education system to improve the statistical analysis capacity in the Six Sigma activities and operating the 6 Sigma Belt system in conjunction, it helped systematically strengthen the execution power of quality improvement activities based on pharmaceutical design based on the members of the pharmaceutical industry. Conclusion: By using QbD Six Sigma, which combines quality enhancement based on pharmaceutical design basis and Six Sigma methodology suitable for pharmaceutical industry, it is possible to obtain satisfactory results both by pharmaceutical companies and regulators by using appropriate statistical analysis methods for preparing scientific evidence data required by regulatory.

• Journal of Marine Bioscience and Biotechnology
• /
• v.6 no.1
• /
• pp.31-40
• /
• 2014

The production of astaxanthin in the microalga Haematococcus pluvialis has been investigated using a sequential methodology based on the application of two types of statistical designs. The employed preliminary experiment was a fractional factorial design $2^6$ in which the factors studied were: excessive irradiance and nitrate starvation, phosphate deficiency, acetate supplementation, salt stress, and elevated temperature. The experimental results indicate that the amount of astaxanthin accumulation in the cells can be enhanced by excessive irradiance and nitrate starvation whereas the other factors tested did not yield any enhancement. In the subsequent experiment, a central composite design was applied with four variables, light intensity, nitrate, phosphate, and acetate, at five levels each. The optimal conditions for the highest astaxanthin production were found to be $1040{\mu}E/(m^2{\cdot}s)$ light intensity, 0.04 g/L nitrate, 0.31 g/L phosphate, 0.05 g/L acetate concentration.

• Nuclear Engineering and Technology
• /
• v.18 no.1
• /
• pp.38-47
• /
• 1986

A statistical procedure, which uses response surface method and Monte Carlo simulation technique, is proposed for analyzing the thermal margin of light water reactor core. The statistical thermal margin analysis method performs the best.estimate thermal margin evaluation by the probabilistic treatment of uncertainties of input parameters. This methodology is applied to KNU-1 core thermal margin analysis under the steady state nominal operating condition. Also discussed are the comparisons with conventional deterministic method and Improved Thermal Design Procedure of Westinghouse. It is deduced from this study that the response surface method is useful for performing the statistical thermal margin analysis and that thermal margin improvement is assured through this procedure.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.22 no.3
• /
• pp.671-678
• /
• 2021

In a previous study, technology protection levels were set on a qualitative basis. That study lacked quantitative standards, so here, we conduct a study to complement the previous study and to present an objective standard. This paper provides a method of setting a technical protection level that applies statistical analysis. To set the technology protection level, statistical analysis of six technical survey items is performed first. Second, the technical survey items are analyzed by AHP to quantify the opinions of experts in order to derive weights for each technical survey item. Finally, by using the normal distribution scatter map and median calculation method, the technology protection level is selected in three stages using the final detailed factor technology score reflecting the weight. The technology protection level methodology developed through this study is the first methodology with objectivity that can evaluate defense technology by level. If this methodology is applied in practice, it is believed that it will provide a scientific and quantitative technology value judgment criterion when setting the technology protection level in the future.

• Journal of Preventive Medicine and Public Health
• /
• v.46 no.2
• /
• pp.96-104
• /
• 2013

Objectives: The inherent nature of the Korean National Health and Nutrition Examination Survey (KNHANES) design requires special analysis by incorporating sample weights, stratification, and clustering not used in ordinary statistical procedures. Methods: This study investigated the proportion of research papers that have used an appropriate statistical methodology out of the research papers analyzing the KNHANES cited in the PubMed online system from 2007 to 2012. We also compared differences in mean and regression estimates between the ordinary statistical data analyses without sampling weight and design-based data analyses using the KNHANES 2008 to 2010. Results: Of the 247 research articles cited in PubMed, only 19.8% of all articles used survey design analysis, compared with 80.2% of articles that used ordinary statistical analysis, treating KNHANES data as if it were collected using a simple random sampling method. Means and standard errors differed between the ordinary statistical data analyses and design-based analyses, and the standard errors in the design-based analyses tended to be larger than those in the ordinary statistical data analyses. Conclusions: Ignoring complex survey design can result in biased estimates and overstated significance levels. Sample weights, stratification, and clustering of the design must be incorporated into analyses to ensure the development of appropriate estimates and standard errors of these estimates.

• Membrane and Water Treatment
• /
• v.1 no.1
• /
• pp.49-60
• /
• 2010

In this study, response surface methodology (RSM) was performed in NF membrane process to evaluate the separation efficiency of membrane in the removal of salt and reactive dye by varying different variables such as pressure, temperature, pH, dye concentration and salt concentration. The significant level of both the main effects and the interaction were observed by analysis of variance (ANOVA) approach. Based on the statistical analysis, the results have provided valuable information on the relationship between these variables and the performances of membrane. The rejection of salt was found to be greatly influenced by pressure, pH and salt concentration whereas the dye rejection was relatively constant in between 96.22 and 99.43% regardless of the changes in the variables. The water flux on the other hand was found to be affected by the pressure and salt concentration. It is also found that the model predictions were in good agreement with the experimental data, indicating the validity of these models in predicting membrane performances prior to the real filtration process.

• Preventive Nutrition and Food Science
• /
• v.22 no.3
• /
• pp.241-245
• /
• 2017

Aged garlic has been reported to possess beneficial pharmacological activities, including anti-stress and anti-fatigue properties, and to exert protective effects on the cardiovascular system and liver. Pine needles are widely used in folk medicine and as food additives owing to their pharmacological properties such as anti-aging and anti-inflammatory effects. It has long been known that combining certain phytochemicals with other phenols or organic acids can produce synergistic effects. Therefore, the purpose of this study was to develop an optimal formula of aged garlic with added pine needle powder for improved antioxidant activity using the statistical technique of response surface methodology. The antioxidant activities of aged garlic mixed with pine needle powder were confirmed by measuring oxygen radical absorbance capacity and total polyphenol content. An optimized antioxidant formula was identified that contained 5.08 g aged garlic and 1.97 g pine needle powder. The antioxidant activities of the mixture prepared using this optimal formula were significantly higher than the predicted values according to an additive model. Hence, this study confirms that the addition of pine needle powder to aged garlic can improve its antioxidant activity. This study demonstrated an optimal mixing ratio to produce an aged garlic product with improved functionality through the addition of pine needle powder that could be successfully employed by the food industry to prepare functional foods.

• Journal of Nutrition and Health
• /
• v.35 no.2
• /
• pp.263-271
• /
• 2002

The purpose of this study was to determine the standard work time of dietetic staff through work sampling methodology in school flood service systems. Work measurement through work sampling methodology was conducted in five conventional, five commissary and five joint management flood service systems over two consecutive weeks in October 1999. Statistical analysis was performed on the SAS/Win 6.12 package program for Kruskal-Wallis test and multiple comparison. Observed data were satisfied with a confidence level of 95% and a confidence interval of $\pm$ 0.05. The results of this study can be summarized as follows. The actual time spent by dietetic staff members in conventional, commissary, joint-management flood servile systems was 2,394, 2,521 and 2,110 minutes per week, respectively. Transportation time of each flood service systeml and ILO allowance rate (11%) was applied. Thus, the standard work time per week of dietetic staff members in conventional, commissary, joint-management flood service systems was 2,746.14, 2,861.58 and 2,520.81 minutes, respectively. The standardized index was 1.04, 1.08 and 0.95 men in conventional, commissary, and joint-management flood service systems, respectively. Regardless of the school flood service system, those with "the duty of cooking and distribution management" had the longest labor time, while those with "duty of nutritional education" had the shortest labor time.

• Food Science and Biotechnology
• /
• v.18 no.4
• /
• pp.959-964
• /
• 2009

Production of the antioxidant substances by Bacillus polyfermenticus SCD was investigated using shake-flask fermentation. The one-factor-at-a-time method was first employed to determine the key ingredients for optimal medium composition, then further investigation of the medium composition was performed using response surface methodology (RSM). The antioxidant activity was measured using 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) assays. After screening various elements, fructose, tryptone, and $MgSO_4\;7H_2O$ were chosen as the main factors for study in the statistical experimental design. Central composite design (CCD) was then used to determine the optimal concentrations of these 3 components. Under the proposed optimized medium containing 2.8% fructose, 1.34% tryptone, 0.015% $MgSO_4\;7H_2O$), 0.5% NaCl, and 0.25% $K_2HPO_4$, the model predicted an antioxidant activity of 80.5% ($R^2=0.9421$. The actual experimental results were in agreement with the prediction.