• Title/Summary/Keyword: Statistical Analysis Approach

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Exploitation of the Dose/Time-Response Relationship for a New Measure of DNA Repari in the Single-Cell Gel Electrophoresis (Comet) Assay

  • Kim, Byung-Soo;Edler, Lutz;Park, Jin-Joo;Fournier, Dietrich Von;Haase, Wulf;Sautter-Bihl, Mare-Luise;Hagmuller, Egbert;Gotzes, Florian;Thielmann, Heinz Walter
    • Toxicological Research
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    • v.20 no.2
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    • pp.89-100
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    • 2004
  • The comet assay (also called the single-cell gel electrophoresis assay) has been widely used for detecting DNA damage and repair in individual cells. Since the conventional methods of evaluating comet assay data using frequency statistics are unsatisfactory we developed a new quantitative measure of DNA damage/repair that is based on all information residing in the dose/time-response curves of a comet experiment. Blood samples were taken from 25 breast cancer patients before undergoing radiotherapy. The comet assay was performed under alkaline conditions using isolated lymphocytes. Tail DNA, tail length, tail moment and tail inertia of the comet were measured for each patient at four doses of $\gamma$-rays (0, 2, 4 and 8 Gy) and at four time points after irradiation (0, 10, 20 and 30 min) using 100 cells each. The resulting three-dimensional dose-time response surface was modeled by multiple regression, and the second derivative, termed 2D, on dose and time was determined. A software module was programmed in SAS/AF to compute 2D values. We applied the new method successfully to data obtained from cancer patients to be assessed for their radiation sensitivity. We computed the 2D values for the four damage measures, i.e., tail moment, tail length, tail DNA and tail inertia, and examined the pairwise correlation coefficients of 2D both on the log scale and the unlogged scale. 2D values based on tail moment and tail DNA showed a high correlation and, therefore, these two damage measures can be used interchangeably as far as DNA repair is concerned. 2D values based on tail inertia have a correlation profile different from the other 2D values which may reflect different facets of DNA damage/repair. Using the dose-time response surface, other statistical models, e.g., the proportional hazards model, become applicable for data analysis. The 2D approach can be applied to all DNA repair measures, Le., tail moment, tail length, tail DNA and tail inertia, and appears to be superior to conventional evaluation methods as it integrates all data of the dose/time-response curves of a comet assay.

Application of Artificial Neural Networks for Prediction of the Unconfined Compressive Strength (UCS) of Sedimentary Rocks in Daegu (대구지역 퇴적암의 일축압축강도 예측을 위한 인공신경망 적용)

  • Yim Sung-Bin;Kim Gyo-Won;Seo Yong-Seok
    • The Journal of Engineering Geology
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    • v.15 no.1
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    • pp.67-76
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    • 2005
  • This paper presents the application of a neural network for prediction of the unconfined compressive strength from physical properties and schmidt hardness number on rock samples. To investigate the suitability of this approach, the results of analysis using a neural network are compared to predictions obtained by statistical relations. The data sets containing 55 rock sample records which are composed of sandstone and shale were assembled in Daegu area. They were used to learn the neural network model with the back-propagation teaming algorithm. The rock characteristics as the teaming input of the neural network are: schmidt hardness number, specific gravity, absorption, porosity, p-wave velocity and S-wave velocity, while the corresponding unconfined compressive strength value functions as the teaming output of the neural network. A data set containing 45 test results was used to train the networks with the back-propagation teaming algorithm. Another data set of 10 test results was used to validate the generalization and prediction capabilities of the neural network.

Drought Forecasting Using the Multi Layer Perceptron (MLP) Artificial Neural Network Model (다층 퍼셉트론 인공신경망 모형을 이용한 가뭄예측)

  • Lee, Joo-Heon;Kim, Jong-Suk;Jang, Ho-Won;Lee, Jang-Choon
    • Journal of Korea Water Resources Association
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    • v.46 no.12
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    • pp.1249-1263
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    • 2013
  • In order to minimize the damages caused by long-term drought, appropriate drought management plans of the basin should be established with the drought forecasting technology. Further, in order to build reasonable adaptive measurement for future drought, the duration and severity of drought must be predicted quantitatively in advance. Thus, this study, attempts to forecast drought in Korea by using an Artificial Neural Network Model, and drought index, which are the representative statistical approach most frequently used for hydrological time series forecasting. SPI (Standardized Precipitation Index) for major weather stations in Korea, estimated using observed historical precipitation, was used as input variables to the MLP (Multi Layer Perceptron) Neural Network model. Data set from 1976 to 2000 was selected as the training period for the parameter calibration and data from 2001 to 2010 was set as the validation period for the drought forecast. The optimal model for drought forecast determined by training process was applied to drought forecast using SPI (3), SPI (6) and SPI (12) over different forecasting lead time (1 to 6 months). Drought forecast with SPI (3) shows good result only in case of 1 month forecast lead time, SPI (6) shows good accordance with observed data for 1-3 months forecast lead time and SPI (12) shows relatively good results in case of up to 1~5 months forecast lead time. The analysis of this study shows that SPI (3) can be used for only 1-month short-term drought forecast. SPI (6) and SPI (12) have advantage over long-term drought forecast for 3~5 months lead time.

Bundled SW Design with Application Method of Diary Study (번들소프트웨어 디자인을 위한 다이어리 스터디 적용 연구)

  • Ha, Kwang Soo
    • The Journal of the Korea Contents Association
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    • v.12 no.11
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    • pp.49-57
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    • 2012
  • Recently as the user experience's importance has been emphasized, there has been many tries of various research methodology in order to understand the user. Specially, as the political investigation method's user understanding method based on the statistical analysis so far has encountered a limit, there has been a continuous tendency to try to introduce a humanitarian or cultural anthropological methodology. As part of this effort, there has been many tries of various approach methods of the Ethnography which is the cultural anthropological typical research methodology, but among those the Diary Study Method is mentioned as one of the effective methodologies. Therefore this thesis applies the Diary Study Method to the notebook PC bundle SW's attitude research and tries a deep rooted research about the user attitude. Also centered to the project of understanding the notebook PC bundle SW's user receptivity. it shows a specific example of the Diary Study applied to the user understanding. Through this process, we will examine the summary about the Ethnography research method, and will discuss an effective research methodology by through the process of analyzing and deducting the user inclination by applying and designing the Diary Study to the project. That is to say, it was progressed by actually applying the research methodology through a specific case, with the purpose of breaking away from the textbook discussion and progress with an application aspect discussion. Through the current research, we will verify an active user-inclined process about the user's notebook PC SW, and it is expected to be useful in establishing a SW UX strategy and distribution related to the bundle software.

Status of Development of Pyroprocessing Safeguards at KAERI (한국원자력연구원 파이로 안전조치 기술개발 현황)

  • Park, Se-Hwan;Ahn, Seong-Kyu;Chang, Hong Lae;Han, Bo Young;Kim, Bong Young;Kim, Dongseon;Kim, Ho-Dong;Lee, Chaehun;Oh, Jong-Myeong;Seo, Hee;Shin, Hee-Sung;Won, Byung-Hee;Ku, Jeong-Hoe
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.15 no.3
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    • pp.191-197
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    • 2017
  • The Korea Atomic Energy Research Institute (KAERI) has developed a safeguards technology for pyroprocessing based on the Safeguards-By-Design (SBD) concept. KAERI took part in a Member-State Support Program (MSSP) to establish a pyroprocessing safeguards approach. A Reference Engineering-scale Pyroprocessing Facility (REPF) concept was designed on which KAERI developed its safeguards system. Recently the REPF is being upgraded to the REPF+, a scaled-up facility. For assessment of the nuclear-material accountancy (NMA) system, KAERI has developed a simulation program named Pyroprocessing Material Flow and MUF Uncertainty Simulation (PYMUS). The PYMUS is currently being upgraded to include a Near-Real-Time Accountancy (NRTA) statistical analysis function. The Advanced Spent Fuel Conditioning Process Safeguards Neutron Counter (ASNC) has been updated as Non-Destructive Assay (NDA) equipment for input-material accountancy, and a Hybrid Induced-fission-based Pu-Accounting Instrument (HIPAI) has been developed for the NMA of uranium/transuranic (U/TRU) ingots. Currently, performance testing of Compton-suppressed Gamma-ray measurement, Laser-Induced Breakdown Spectroscopy (LIBS), and homogenization sampling are underway. These efforts will provide an essential basis for the realization of an advanced nuclear-fuel cycle in the ROK.

Visit Push Motivation for a Trading Area and Flow, Satisfaction, and Revisit Intention (상권방문 추진동기와 몰입, 만족, 재방문 의도)

  • Lee, Soo-Duck;Lee, Yong-Ki
    • Journal of Distribution Science
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    • v.16 no.9
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    • pp.65-77
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    • 2018
  • Purpose - A trading area is very closely related to consumer life. A trading area is a cultural and social space that consumes culture and promotes human relationships as well as an economic space where consumers live their daily lives. In this context, a trading area research should be conducted objectively and empirically because it deals with the activities of consumer's life. The purpose of this study is to identify the intrinsic psychological motivation(push motivation) caused when consumers visit a trading area and to demonstrate how the push motivation for a trading area influence on consumer's flow, satisfaction, revisit intention. Research design, data, and methodology - In order to develop research hypotheses for this study, the development procedures for push motivation scale are as follows; (1) generating initial pool of items based on previous studies, (2) expert judgement to evaluate content and face validity, and (3) assessing convergent and discriminant validity using confirmatory factor analysis. In order to achieve these purposes, online surveys were conducted on frequent or familiar visitors to the trading areas around the Gangnam, Kunkuk University and Hongik University Station. Among the 1,343 questionnaires collected, 1,157 cases were analyzed by using SPSS 22.0 and SmartPLS 3.0 statistical package program, except for 186 responses in which responses were judged to be unfaithful. Results - The push motivation was classified into five sub-dimensions of excitement/stimulus, rest/relaxation, exit/refreshing, knowledge/learning and human relationship promotion as multidimensional and complex factors composed of individual and social-related dimensions. The excitement/stimulus and human relationship promotion of push motivation have positive effects on satisfaction. However, all dimensions of the push motivation have positive effects on flow. And flow has a positive effect on satisfaction and revisit intention. Meanwhile, the mediation test using boostrapping shows that flow plays a full mediating role in the relationship between rest/relaxation, exit/refreshing, knowledge/learning and satisfaction, but a partial mediating rol e between excitement/stimulus, human relationship promotion and satisfaction. Finally, satisfaction plays a partial mediating role between flow and revisit intention. Conclusions - This study shows that the push motivation is multidimensional and compositive depending on the situation of a consumer. In addition, it is found that the human relationship promotion(a social-related motivation) has a much more important effect on flow and satisfaction than other push motivations of individual dimensions. It also shows that satisfaction increases when consumers are being flowed at their visit and degree of revisit intention also grows as satisfaction increases. As implications of this study, a marketer should try to understand consumer's visit motivation at first and then develop factors that increase their flow, satisfaction, revisit intention. It also requires a marketer to approach subjects on a trading area more objectively and empirically based on the psychology and behavior of consumers, in order to establish a proper and efficient strategy on development of a trading area.

The Effects and Development of a Hospital Based Community Reintegration Support Program for Patients with Spinal Cord Injury (척수손상 환자를 위한 병원기반 사회복귀지원 프로그램의 개발 및 효과)

  • Ho, S.H.;Yu, S.Y.;Kim, Y.S.;Bang, M.S.;Lee, B.S.;Kim, D.A.;Kim, E.J.;Kim, H.K.
    • Journal of rehabilitation welfare engineering & assistive technology
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    • v.9 no.2
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    • pp.89-103
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    • 2015
  • The purpose of this research attempted to developed the Community Reintegration support Program(H-CRsP) on patients with Spinal Cord Injury(SCI) and identity the effect. To assess the effectiveness of a Hospital based H-CRsP with a comprehensive team approach for treating inpatients with Spinal Cord Injury(SCI), offered by the Korea National Rehabilitation Hospital. Participants with SCI were recruited from the Korean National Rehabilitation Hospital. Twenty-five participants who met inclusion criteria were provided with a H-CRsP. A H-CRsP with modules related to the training of daily living skills, driving, vocations and school support activities, leisure or recreational activities, peer counseling, sexual rehabilitation, and others support activities. The 25 enrolled patients had been treated with average of 6.1 programs 2 times a week for over 2 or 3months. COPM, HADS, WHOQOL-BREF, AD-R were administered before the treatment(pre-test) and also at the time of discharge(post-test) to compare the treatment outcomes in the 25 program participants. Measured level of community integration by CIQ at discharge. The data were analyzed by such statistical methods as frequency and paired t-test analysis. Significant improvements were found on the Occupational Performance and Satisfaction, Acceptance of Disability, Quality of Life score in the COPM, AD-R, WHOQOL-BREF (p<0.05). In addition, 10 of the 25 patients returned to home, work or school. These results demonstrated the effectiveness of the H-CRsP in helping patients with SCI return their communities to which they belong. It considered development of the variety of programs and prepare systematically related system.

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Women and Poverty in Korea: the Feminization of Poverty? (한국의 빈곤의 여성화에 대한 실증 분석)

  • Seok, Jae-Eun
    • Korean Journal of Social Welfare
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    • v.56 no.2
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    • pp.167-194
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    • 2004
  • This paper examine the gender-poverty gap and the feminization of poverty in Korea with using data from the National Survey Household Income & Expenditure(1996, 2000) and the Urban Survey Household Income & Expenditure(1996-2002) by Korea National Statistical Office. The poverty rate in 2000 was 16.9 percent for female-head families and 7.9 percent for male-head families, which means that female-head families were 2.6 times more likely to be poor than male-head families. With examining impact of economic crisis in 1998 on gender-poverty gap, it show that both the poverty rate of female-head and male-head increase radically in peak of economic crisis, while, in the stage of recovering economy, the poverty rate of male-head families recovered mostly the level before economic crisis, but that of female-head families recover only the 2/3 level before and the 1/3 remain still under poverty. Thus gender-poverty gap appeared bigger during passing through economic crisis. With analyzing on influence factors of poverty, it appear that poverty is influenced by gender itself as well as education level, working condition which is reflected substantially characteristics of gender. Such an analysis results mean that the considering gender dimension is necessary to resolve poverty fundamentally because gender is a point intersection among family, labour market, and social security. Therefore it appears certain that to develop and adopt of women-friendly social policy is effective approach, which could resolve poverty and social problems related to social rights.

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The study on the maternal burden of caretaking, the support and educational need for the caretaking activities of the infants′ mother (영아어머니의 자녀돌봄의 부담감과 지지, 교육 및 상담요구에 관한 조사연구)

  • Han Kyung Ja
    • Child Health Nursing Research
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    • v.3 no.2
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    • pp.228-240
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    • 1997
  • It is important to asess the risk factors of parenting and provide early intervention for promotion of the maternal caretaking ability. The purpose of the study was to identify the maternal burden of caretaking, the supporting and the educational need for the caretaking activities of the mother of infant. Sixty three mothers of infants who visited the wellbaby clinic of S university hospital and one health center during the period of November 1st, to 30th in 1996 comprised the subjects of this study, Data were gathered through the instruments that were developed by researcher. Statistical analysis of this study was used ANOVA and Pearson correlation. The results were as follows : 1) The mean score of the maternal burden of caretaking was 22.06. The maternal burden of caretaking was significantly high in the mothers who had vaginal delivery compare with the mothers who had caeserean section and in the muthers who gave artificial feeding compare with the group of breast or mixed feeding. 2) The mean score of the support need for the caretaking activities was 30.69. The support need for the caretaking activities was significantly high in the mothers who had the second child, compare with the mothers who had first or third child. And the support need for the caretaking activities was significantly high in the mothers who had caretaking help compare with the mothers who had no caretaking help. The specific subjects of 'mother-infant interaction', 'immunization' and 'prevention of accident' on the support need for the caretaking activities were relatively high. 3) The mean score of the educational need of caretaking activities was 29.3. The educational need of caretaking activities was significantly high in the mother who had the second child compare with the mothers who had first or third child. And the educational need of caretaking activities was significantly high in the mothers who had caretaking help compare with the mothers who had no caretaking help. The specific subjects of 'mother-infant interaction', 'emergency care' and 'prevention of accident' on educational need of caretaking were relatively high. 4) The maternal burden of caretaking was not correlated with the support need or the educational need of caretaking activities. But the support need of caretaking activities was significantly correlated with the educational need of caretaking activities. 5) The support and educational need of caretaking activities were significantly high in the mothers who wanted home care for caretaking their infants. Through the study, it was found that there is considerable maternal burden of caretaking as well as the support and educational need on the caretaking activities in the mothers whose child is young. Therefore developing the systematic and effective program is needed to meet the mother's need. The results of this study will be useful resources to develop the program. On the other hand, it can be recommanded that home health care will be one of the approach to support the mothers caretaking activities.

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A Study on the Improvement of Public Library Workflow Using Process Innovation (프로세스 이노베이션을 활용한 공공도서관 업무 프로세스 개선에 관한 연구)

  • Noh, Dong-Jo;Kim, Young-Mi;Oh, Dong-Geun
    • Journal of the Korean BIBLIA Society for library and Information Science
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    • v.28 no.4
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    • pp.393-413
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    • 2017
  • This study will explore the possibility of applying process innovation as a public library for business innovation. In order to do this, the study defines the concept of process innovation through the literature review. According to survey and focus group interviews with librarians working for public libraries, this study will organize work done at libraries into the following categories: acquisition, resource management, user management, user services, programs, volunteer management, marketing, library computerization system, facility management, general affairs and statistical management. In addition, through face-to-face surveys with librarians working for public libraries it is confirmed that there are issues within acquisition, user management, and applied process innovation. In response to these issues a new process has been developed. Using this new approach, book contract procedure and requests for book related work could be improved and optimized. In the user management section, the study analyzes the requirements and subscription procedures for members through a website survey of 30 public libraries in the United States and then provides an improved system through process analysis of the membership process of Korean public libraries. It is expected that the new system will contribute to improvements in user satisfaction as well as improvements in library workflow.