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Implementation of Proteomics for Cancer Research: Past, Present, and Future

  • Karimi, Parisa;Shahrokni, Armin;Nezami Ranjbar, Mohammad R.
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.6
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    • pp.2433-2438
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    • 2014
  • Cancer is the leading cause of the death, accounts for about 13% of all annual deaths worldwide. Many different fields of science are collaborating together studying cancer to improve our knowledge of this lethal disease, and find better solutions for diagnosis and treatment. Proteomics is one of the most recent and rapidly growing areas in molecular biology that helps understanding cancer from an omics data analysis point of view. The human proteome project was officially initiated in 2008. Proteomics enables the scientists to interrogate a variety of biospecimens for their protein contents and measure the concentrations of these proteins. Current necessary equipment and technologies for cancer proteomics are mass spectrometry, protein microarrays, nanotechnology and bioinformatics. In this paper, we provide a brief review on proteomics and its application in cancer research. After a brief introduction including its definition, we summarize the history of major previous work conducted by researchers, followed by an overview on the role of proteomics in cancer studies. We also provide a list of different utilities in cancer proteomics and investigate their advantages and shortcomings from theoretical and practical angles. Finally, we explore some of the main challenges and conclude the paper with future directions in this field.

Exploration of Fit Reviews and its Impact on Ratings of Rental Dresses

  • Shin, Eonyou;McKinney, Ellen
    • Fashion, Industry and Education
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    • v.15 no.2
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    • pp.1-10
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    • 2017
  • The purposes of this study were to explore (1) how fit reviews differ among height groups and (2) how overall numerical ratings differ depending on height groups and ifferent types of fit reviews. Content analysis was used to analyze systematically sampled online consumer reviews (OCRs) of formalwear dresses rented online. In part 1, 201 OCRs were analyzed to develop the coding scheme, which included three aspects of fit (physical, aesthetic, and functional), valence (negative, neutral, positive), and overall numerical rating. In part 2, 600 OCRs were coded and statistically analyzed. Differences in frequency were not found among height groups for any types of mentions (negative, neutral, and positive) in terms of the three aspects of fit in the OCRs. Differences in overall mean ratings were not found among height groups. Interestingly, valence of each aspect of fit reviews affected mean numeric ratings. This study is new in examining relationships among textual information (i.e., fit reviews), numerical information (i.e., numerical rating), and reviewer's characteristic (i.e., height). The results of this study offered practical implications for etailers and marketers that they should pay attention to the three aspects of fit reviews and monitor garments with negative fit evaluations for lower ratings. They may attempt to increase ratings by providing customers recommendations to get a better fit.

Light and Electron Microscopy Studies Elucidating Mechanisms of Tomato Leaf Infection by Pseudocercospora fuligena

  • Zelalem Mersha;Girma Birru;Bernhard Hau
    • The Plant Pathology Journal
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    • v.39 no.2
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    • pp.181-190
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    • 2023
  • The fungal pathogen Pseudocercospora fuligena, known to affect tomatoes in the tropics and subtropics, has been reported from temperate climates including the United States and Turkey in recent years. In this study, an isolate from fresh tomatoes and the disease it causes were characterized and infection mechanisms investigated. Macroscopically, both sides of tomato leaves show indistinct effuse patches but prolific production of fuliginous lesions is conspicuous on the abaxial side first but also on the adaxial side later on as infection progressed. Microscopically, fascicles of conidiophores (11-128 ㎛ × 3.5-9 ㎛) arising from stromata and conidia with up to 12 septations were observed. Molecular characterization of the isolate revealed high homology (99.8%) to other P. fuligena isolated from tomatoes in Turkey. Out of the 10 media tested, P. fuligena grew significantly well and sporulated better on unsealed tomato oatmeal agar and carrot leaf decoction agar, both supplemented with CaCO3. Direct transfer of conidia from profusely sporulating lesions was the easiest and quickest method of isolation for in-vitro studies. Light and scanning electron microscopy on cleared and intact tomato leaves further confirmed stomatal penetration and egress as well as prevalence of primary and secondary infection hyphae. In situ, blocked stomatal aperture areas of 154, 401, and 2,043 ㎛2 were recorded at 7, 12, and 17 days after inoculation, respectively. With the recent expanded horizon of the pathosystem and its consequential impact, such studies will be useful for a proper diagnosis, identification and management of the disease on tomato worldwide.

Active shape change of an SMA hybrid composite plate

  • Daghia, Federica;Inman, Daniel J.;Ubertini, Francesco;Viola, Erasmo
    • Smart Structures and Systems
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    • v.6 no.2
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    • pp.91-100
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    • 2010
  • An experimental study was carried out to investigate the shape control of plates via embedded shape memory alloy (SMA) wires. An extensive body of literature proposes the use of SMA wires to actively modify the shape or stiffness of a structure; in most cases, however, the study focuses on modeling and little experimental data is available. In this work, a simple proof of concept specimen was built by attaching four prestrained SMA wires to one side of a carbon fiber laminate plate strip. The specimen was clamped at one end and tested in an environmental chamber, measuring the tip displacement and the SMA temperature. At heating, actuation of the SMA wires bends the plate; at cooling deformation is partially recovered. The specimen was actuated a few times between two fixed temperatures $T_c$ and $T_h$, whereas in the last actuation a temperature $T_f$ > $T_h$ was reached. Contrary to most model predictions, in the first actuation the transformation temperatures are significantly higher than in the following cycles, which are stable. Moreover, if the temperature $T_h$ is exceeded, two separate actuations occur during heating: the first follows the path of the stable cycles; the second, starting at $T_h$, is similar to the first cycle. An interpretation of the phenomenon is given using some differential scanning calorimeter (DSC) measurements. The observed behavior emphasizes the need to build a more comprehensive constitutive model able to include these effects.

Asymmetries in Chickens from Lines Selected and Relaxed for High or Low Antibody Titers to Sheep Red Blood Cells

  • Tu, Yunjie;Siegel, P.B.
    • Asian-Australasian Journal of Animal Sciences
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    • v.28 no.3
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    • pp.323-327
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    • 2015
  • Wattle length, width, and area were measured to classify bilateral asymmetries in four lines of chickens. The lines were the S26 generation of White Leghorns selected for high (HAS) or low (LAS) response to sheep red blood cells and sublines in which selection had been relaxed for three generations (high antibody relaxed [HAR] and low antibody relaxed [LAR]). Antibody titers (AB) were greater for HAS than for HAR with both greater than for LAS and LAR which while different for males did not differ for females. The low antibody lines were heavier and reached sexual maturity at younger age than the high antibody lines. In general, wattle length, width, and area were greater in the low than high antibody lines. In 24 comparisons for bilaterality 18 exhibited fluctuating asymmetry and 6 exhibited directional asymmetry with 5 of the 6 being for wattle length. There was not a clear pattern for changes in degree of asymmetry when selection was relaxed for 3 generations. For females, the relative asymmetry (RA) of wattle area was larger ($p{\leq}0.05$) for HAR than for LAR and not different from the selected lines and relaxed lines. There were no differences among lines for RA of wattle length and width of females and wattle length, width, and area of males.

Special Function Inverse Series Pairs

  • Alsardary, Salar Yaseen;Gould, Henry Wadsworth
    • Kyungpook Mathematical Journal
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    • v.50 no.2
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    • pp.177-193
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    • 2010
  • Working with the various special functions of mathematical physics and applied mathematics we often encounter inverse relations of the type $F_n(x)=\sum\limits_{k=0}^{n}A^n_kG_k(x)$ and $ G_n(x)=\sum\limits_{k=0}^{n}B_k^nF_k(x)$, where 0, 1, 2,$\cdots$. Here $F_n(x)$, $G_n(x)$ denote special polynomial functions, and $A_k^n$, $B_k^n$ denote coefficients found by use of the orthogonal properties of $F_n(x)$ and $G_n(x)$, or by skillful series manipulations. Typically $G_n(x)=x^n$ and $F_n(x)=P_n(x)$, the n-th Legendre polynomial. We give a collection of inverse series pairs of the type $f(n)=\sum\limits_{k=0}^{n}A_k^ng(k)$ if and only if $g(n)=\sum\limits_{k=0}^{n}B_k^nf(k)$, each pair being based on some reasonably well-known special function. We also state and prove an interesting generalization of a theorem of Rainville in this form.

Streamflow Modeling in Data-scarce Estuary Reservoir Watershed Using HSPF (HSPF 모형과 호소 물수지를 이용한 미계측 간척 담수화호 수문모델링)

  • Seong, Choung Hyun
    • Journal of The Korean Society of Agricultural Engineers
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    • v.56 no.6
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    • pp.129-137
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    • 2014
  • This research presents an streamflow modeling approach in a data-scarce estuary reservoir watershed which has been suffered from high salinity irrigation water problem after completion of land reclamation project in South Korea. Since limited hydrology data was available on the Iwon estuary reservoir watershed, water balance relation of the reservoir was used to estimate runoff from upstream of the reservoir. Water balance components in the reservoir consists precipitation, inflow from upstream, discharge through sluice, and evaporation. Estimated daily inflow data, which is stream discharge from upstream, shows a good consistency with the observed water level data in the reservoir in terms of EI (0.93) and $R^2$ (0.94), and were used as observed flow data for the streamflow modeling. HSPF (Hydrological Simulation Program - Fortran) was used to simulate hydrologic response of upstream of the reservoir. The model was calibrated and validated for the periods of 2006 to 2007 and 2008 to 2009, respectively, showing that values of EI and $R^2$ were 0.89 and 0.91 for calibration period, 0.71 and 0.84 for validation period.

Design of Innovative SMA PR Connections Between Steel Beams and Composite Columns (강재보와 합성기둥에 사용된 새로운 반강접 접합부의 설계)

  • Son, Hong Min;Leon, Roberto T.;Hu, Jong Wan
    • Journal of the Korean Society for Advanced Composite Structures
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    • v.5 no.1
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    • pp.28-36
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    • 2014
  • This study describes the development of innovative connections between steel beams and concrete-filled tube columns that utilize a combination of low-carbon steel and super-elastic shape memory alloy components. The intent is to combine the recentering behavior provided by the shape memory alloys to reduce building damage and residual drift after a major earthquake with the excellent energy dissipation of the low-carbon steel. The analysis and design of structures requires that simple yet accurate models for the connection behavior be developed. The development of a simplified 2D spring connection model for cyclic loads from advanced 3D FE monotonic studies is described. The implementation of those models into non-linear frame analyses indicates hat the recentering systems will provide substantial benefits for smaller earthquakes and superior performance to all-welded moment frames for large earthquakes.

Development of Recycling Technique of Mill Reject Produce using Ttiboelectrostatic Separation (마찰하전형정전선별법을 이용한 Mill Reject 산물 재활용 기술개발)

  • 전호석;한오형;신선명;윤로한
    • Resources Recycling
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    • v.11 no.2
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    • pp.20-27
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    • 2002
  • This study was to develop the triboelectrostatic separation technique to recycle the coal from about 20% of mill reject products remained by grinding process in the coal thermoelectric power plant. In this study, we get a test results that can product the cleaned coal of 15% ash content and 66.23% recovery from mill reject of 47% ash content. And then, from the result of the releases analysis, we proved the excellence of treatment method, after showing the treament processing which is able to get 80% of recovery of coal from 20% of ash content demanded in the power plant.

Assessing Temporal and Spatial Salinity Variations in Estuary Reservoir Using EFDC (염분수지 및 EFDC 모형을 이용한 간척 담수화호 염도변화모의)

  • Seong, Choung Hyun
    • Journal of The Korean Society of Agricultural Engineers
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    • v.56 no.6
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    • pp.139-147
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    • 2014
  • Forecasting salinity in an estuary reservoir is essential to promise irrigation water for the reclaimed land. The objective of the research was to assess salinity balance and its temporal and spatial variations in the Iwon estuary reservoir which has been issued by its high contents of salinity in spite of desalination process for four years. Seepage flows through the see dikes which could be one of possible reason of high salinity level of the reservoir was calculated based on the salinity balance in the reservoir, and used as input data for salinity modeling. A three-dimensional hydrodynamic model, Environmental Fluid Dynamics Code (EFDC), was used to simulate salinity level in the reservoir. The model was calibrated and validated based on weekly or biweekly observed salinity data from 2006 to 2010 in four different locations in the reservoir. The values of $R^2$, RMSE and RMAE between simulated and observed salinity were calculated as 0.70, 2.16 dS/m, and 1.72 dS/m for calibration period, and 0.89, 1.15 dS/m, and 0.89 dS/m for validation period, respectively, showing that simulation results was generally consistent with the observation data.