• Journal of the Korean Institute of Intelligent Systems
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• v.25 no.6
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• pp.529-535
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• 2015

Biological networks have been handled with the static concept. However, life phenomena in cells occur depending on the cellular state and the external environment, and only a few proteins and their interactions are selectively activated. Therefore, we should adopt the dynamic network concept that the structure of a biological network varies along the flow of time. This concept is effective to analyze the progressive transition of the disease. In this paper, we applied the proposed method to Alzheimer's disease to analyze the structural and functional characteristics of the disease network. Using gene expression data and protein-protein interaction data, we constructed the sub-networks in accordance with the progress of disease (normal, early, middle and late). Based on this, we analyzed structural properties of the network. Furthermore, we found module structures in the network to analyze the functional properties of the sub-networks using the gene ontology analysis (GO). As a result, it was shown that the functional characteristics of the dynamics network is well compatible with the stage of the disease which shows that it can be used to describe important biological events of the disease. Via the proposed approach, it is possible to observe the molecular network change involved in the disease progression which is not generally investigated, and to understand the pathogenesis and progression mechanism of the disease at a molecular level.

• Korean Journal of Construction Engineering and Management
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• v.16 no.6
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• pp.3-11
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• 2015

The current real estate market is in a state that is considerably shrink due to the recession and long-term reduction of trading. In response, the government recently announced an innovative way for the middle-class residential housing and it is taking the lead to activate the real estate market. Meanwhile, the domestic housing market is entering a transition period, including structural changes of household structure, changes from joeonse to rent increasingly. Also single-member households will rise steeply, so that makes the high demand of small houses. In addition, the domestic construction industry is interested in new technology called Modular building. The Modular construction is an off-site construction system that shorten construction period, eco-friendly building technology and mobility etc, which can be used in various field. Overall, there are two major issues of the current market, one is the change of the real estate market, and the other is the modular construction. This study will propose modular business model in the rental market through the analysis the profitability of the modular business scenarios and IRR analysis.

• Journal of the Microelectronics and Packaging Society
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• v.24 no.2
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• pp.49-53
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• 2017

We study on the change of electrical properties of two-dimensional (2D) $SnSe_2$ materials with respect to Cl doping as $SnSe_{1.994}Cl_{0.006}$ under a high temperature condition. (300~450 K) By the simple solid-state reaction method, non-and Cl-doped 2D $SnSe_2$ materials are successfully synthesized with negligible impurities as confirmed by X-ray diffraction. From the temperature dependence of resistivity, it is observed that the conduction mechanism is changed from hopping to degenerate conduction with Cl doping. By Hall effect measurement, an increase on electron carrier concentration from ${\sim}7{\times}10^{16}$ to ${\sim}3{\times}10^{18}cm^{-3}$ with Cl doping verifies that Cl is an effective electron donor which results in the encouraged carrier concentration. Detailed analysis for temperature dependent Hall mobility reveals that the electrical transports in high temperature regime are governed by the grain boundary-controlled mechanism for non-doped $SnSe_2$, which is effectively suppressed by Cl-doping as entering metallic transport regime.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.12
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• pp.5797-5804
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• 2011

Recently, the medical education is undergoing system transition from a medical college to a medical graduate school and introduction of performance test in the doctor license state examination. Therefore, To deal with these challenges, it is needed that medical faculty prepare the education programs for considering student's personal characteristics and improving Clinical performance. So, The purpose of this study was to understand relation among Stress, ego-resilience, self-efficacy and Clinical performance in graduate medical student, and for this study, We conducted a survey of 97 medical graduate school students in D city during the period from August 19st to 20st. 2011. The study found a negative correlation between Stress and Ego-Resilience, a positive correlation of stress with confidence at low region in Self-Efficacy. Ego-Resilience correlates positively with CPX at low region in Clinical performance, Preference for difficulty level of the task at low region in Self-Efficacy correlates negatively with OSCE. OSCE and CPX at low region in Clinical performance are positively correlated. Therefore, Stress reduction of students can improve Self-Efficacy, Furthermore, improve ultimately Clinical performance. According to this study, To improve Clinical performance competence, student's personal characteristics should be considered and education programs for self-efficacy and ego-resilience advancement be reflected in curriculum.

• Applied Chemistry for Engineering
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• v.23 no.6
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• pp.534-538
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• 2012

$Na^+$-beta-alumina solid electrolyte was synthesized by solid state reaction using $Li_2O$ and MgO as a phase stabilizer, and the effect of stabilizers on the phase formation and sintering density was investigated. In order to determine the phase fraction according to the synthesizing temperature, the molar ratio of [$Na_2O$] : [$Al_2O_3$] was fixed at 1 : 5, and calcination was conducted at temperatures between $1200{\sim}1500^{\circ}C$ for 2 h. In the $Li_2O$-$Na_2O$-$Al_2O_3$ ternary system, ${\beta}^{{\prime}{\prime}}$-alumina phase fraction considerably increased by the secondary phase transition at $1500^{\circ}C$, whereas it maintained similarly in the MgO-$Na_2O$-$Al_2O_3$ system. Additionally, the disc-type specimens of $Na^+$-beta-alumina were sintered at the temperature between $1550{\sim}1650^{\circ}C$ for 30 min, and relative sintering densities, phase changes, and microstructures were analyzed. In case of $Li_2O$-stabilized $Na^+$-beta-alumina, ${\beta}^{{\prime}{\prime}}$-phase fraction and relative density of specimen sintered at $1600^{\circ}C$ were 94.7% and 98%, respectively. Relative density of MgO-stabilized $Na^+$-beta-alumina increased with a rise in sintering temperature.

• The Korean Journal of Urological Oncology
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• 제15권3호
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• pp.178-186
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• 2017

Purpose: Poloxamer 407 (P407) thermo-sensitive hydrogel formulations were developed to enhance the retention time in the urinary bladder after intravesical instillation. Materials and Methods: P407 hydrogels (P407Gels) containing 0.2 w/w% fluorescein isothiocyanate dextran (FD, MW 4 kDa) as a fluorescent probe were prepared by the cold method with different concentrations of the polymer (20, 25, and 30 w/w%). The gel-forming capacities were characterized in terms of gelation temperature (G-Temp), gelation time (G-Time), and gel duration (G-Dur). Homogenous dispersion of the probe throughout the hydrogel was observed by using fluorescence microscopy. The in vitro bladder simulation model was established to evaluate the retention and drug release properties. P407Gels in the solution state were administered to nude mice via urinary instillation, and the in vivo retention behavior of P407Gels was visualized by using an in vivo imaging system (IVIS). Results: P407Gels showed a thermo-reversible phase transition at $4^{\circ}C$ (refrigerated; sol) and $37^{\circ}C$ (body temperature; gel). The G-Temp, G-Time, and G-Dur of FD-free P407Gels were approximately $10^{\circ}C-20^{\circ}C$, 12-30 seconds, and 12-35 hours, respectively, and were not altered by the addition of FD. Fluorescence imaging showed that FD was spread homogenously in the gelled P407 solution. In a bladder simulation model, even after repeated periodic filling-emptying cycles, the hydrogel formulation displayed excellent retention with continuous release of the probe over 8 hours. The FD release from P407Gels and the erosion of the gel, both of which followed zero-order kinetics, had a linear relationship ($r^2=0.988$). IVIS demonstrated that the intravesical retention time of P407Gels was over 4 hours, which was longer than that of the FD solution (<1 hour), even though periodic urination occurred in the mice. Conclusions: FD release from P407Gels was erosion-controlled. P407Gels represent a promising system to enhance intravesical retention with extended drug delivery.

• Journal of Legislation Research
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• no.44
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• pp.7-31
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• 2013

Paradigm of Global economy is changing to creative economy. This study focuses on the role of creative economy to clarify (understand clearly) the impact (influence) which transition of economy system will bring about. The creative economy is basically came from New economy theory. According to the New economy theory, a state can achieve sustainable growth without an inflation, or higher growth rate under given inflation rate, through an investment on ICT. However, different from America, Korea had limited effect of New Economy. This is because Korean economy had factor-input driven growth model rather than New Economy mechanism. However, ICT is essential requirement to move toward New Economy(Digital Economy), it does not sufficiently explain the increase of productivity and economic growth. A crucial point to realize New economy is how to diffuse and spill over the technology development on ICT sector to other industry. ICT is not creative industry or creative economy per se, and it should play as an enabler to improve other industry's productivity. The creative economy can be understood as an extension of New Economy theory. It means the economy that creates values by cultural assets and human resource, as well as capital and labor factors. However, if we understand the meaning of creative economy as change of input factors, it is hard to bring real shape of creative economy.

• Journal of the Korean Magnetics Society
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• v.8 no.6
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• pp.335-340
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• 1998

Colossal magnetoresistance $La_{0.67}Ca_{0.33}Mn_{0.99}^{57}Fe_{0.01}O_3$ material has been produced by a metal-salt routed sol-gel process method. Magnetic properties of $La_{0.67}Ca_{0.33}Mn_{0.99}^{57}Fe_{0.01}O_3$ have been studied with x-ray diffraction, Rutherford back-scattering spectroscopy(RBS), vibrating sample magnetometer, and Mossbauer spectroscopy. Crystalline $La_{0.67}Ca_{0.33}Mn_{0.99}^{57}Fe_{0.01}O_3$ was perovskite cubic structure with a lattice parameter $a_0=3.868$\AA$$. And there was no appreciable change in the value of the lattice parameter when a small amount (x=0.01) of iron was added. However, Mossbauer and VSM data indicate the Curie temperature of the $La_{0.67}Ca_{0.33}Mn_{0.99}^{57}Fe_{0.01}O_3$ decreased from 282 to 270 k and also the saturation magnetization from 84 to 81 emu/g at 77 K. Mossbauer spectra of $La_{0.67}Ca_{0.33}Mn_{0.99}^{57}Fe_{0.01}O_3$ have been taken at various temperatures ranging form 4.2 K to room temperature. Analysis of $^{57}Fe$ Mossbauer data in terms of the local configurations of Mn atoms has permitted the influence of the magnetic hyperfine interactions to be monitored. The isomer shifts show that the charge state of all Fe ions are ferric. The magnetoresistance of $La_{0.67}Ca_{0.33}Mn_{0.99}^{57}Fe_{0.01}O_3$ was about 33 % at semiconductor-metal transition temperature $T_{SC-M}=250K$.

• Journal of Technology Innovation
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• v.28 no.4
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• pp.151-163
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• 2020

The routinized tasks in the post-COVID era are to be replaced by digital technologies, while there is a high possibility that digital transformation technologies and non-routinized tasks have strong complementarity. In particular, looking at the job composition within Korea's industries, the intensities of routinized works appear to be continuously rising. It suggests that the potential side effects on the labor market caused by the acceleration of digital transformation in the post-COVID era will be greater within Korean innovation system. With this background, this study aims to provide a conceptual framework for dealing with potential crises such as, job polarization and widening gaps between workers in terms of economic earnings, based on an in-depth understanding of the inherent properties of digital transformation that will lead to structural changes in our economic and social system. In particular, focusing on the interaction between digital transformation technology and learning in the post-COVID era, this study attempts to redefine the role of the innovation policy for making a successful transition to a new equilibrium state. In addition, this study examines the institutional conditions of the Korean innovation system which affect the creative learning activities of economic actors to draw policy implications for establishing future-oriented innovation policy. Based on these approaches, this study highlights the importance of coevolution between the skills demand and skills supply to spur inclusiveness of Korean innovation system in the post-COVID era.

• Journal of Korean Philosophical Society
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• no.114
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• pp.241-263
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• 2016

History is not only Hegel's philosophical subject, but it corresponds to his entire system of philosophy. Because his system of philosophy is a description of the self-movement of spirit and 'world history' reveals the overall movement of spirit. Hegel's 'historical and philosophical standpoint' goes through the description of his entire system, and this tendency is more and more reinforced towards the later Hegel. If it is reasonable to find the corresponding relationship between Hegel's system of philosophy and 'world history', the relationship between 'objective spirit' and 'absolute spirit' must be systematically unraveled in the horizon of world history. The world-historical perspective in 'objective spirit' has the limit to consider 'modern European nations' as a final destination. On the contrary, world history that acts as a mediator in the transition from 'objective spirit' to 'absolute spirit' makes it possible to jump in absolute horizon by recognizing limitations of nation states and avoiding specific and limited conditions dialectically. So what is revealed through the study of 'world history' in Hegel's system of philosophy is that in the view of 'absolute spirit' of art, religion, philosophy 'political state' is not the end that all mankind should aim at. Therefore, it is undesirable only to criticize Hegel's philosophy of history as 'Eurocentrism'.