• Journal of Korean Academy of Oral Health
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• v.42 no.4
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• pp.145-151
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• 2018

Objectives: The purpose of this study was to interpret regional disparities in the number of teeth sealed with pit and fissure sealants, identify the factors that affect these disparities and find solutions for the same. Methods: Data were collected from the National Health Insurance Service and Korean statistical information service using metropolis-city-rural area dental health infrastructure variables, regional health behavior variables, and local finance-related variables. Results: In 2015, the number of teeth sealed with pit and fissure sealants per 100 people was higher in the metropolis or city than in the rural area. There was a positive correlation between the number of teeth sealed with pit and fissure sealants and the number of dentists, dental hygienists, dental institutions, standardization rate of subjective awareness of well-being, standardization rate of brushing after lunch, and the proportion of welfare budget in the general budget. There was a negative correlation with the annual standardization rate of health institution use, the standardization rate of unused medical services, and the local government's financial independence. According to the final model of the multiple regression analysis, while the impact of infrastructure on dentistry was not statistically significant, the statistical significance of standardization rate of brushing after lunch, the local government's financial independence, and the proportion of welfare budget in the general budget were maintained. Conclusions: To reduce regional disparities in the volume of use of pit and fissure sealants, it was concluded that it may be effective to select regions with a consideration of the level of regional economic power, implement separate and appropriate policies and projects, and improve the awareness in residents.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.2
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• pp.409-417
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• 2021

The standardization of weapon system parts is one of the elements of parts management and is an important factor for reducing the cost of acquiring and maintaining a weapon system, enhancing its reliability, improving interoperability, alleviating parts obsolescence problems, improving logistics efficiency, and strengthening the military's combat readiness. This study examined how to manage parts of domestic R&D weapon systems, overseas imports weapon system parts, and various commercial parts from a standardization perspective, and to study parts management methods for standardizing parts in the future. This system was used to achieve systematic part standardization in a military weapon system. To this end, this study investigated what elements are used to standardize weapon system parts. The importance and weight of each element were calculated using the AHP (Analytic Hierarchy Process), one of the decision-making techniques, and the design stage standards using the part selection method were studied. Through this, the selection process of standard parts, which has been made according to the experience and subjective judgment of designers and personnel, was improved to propose a systematic and objective method of standardizing weapons parts.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.10
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• pp.2500-2506
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• 2015

Proposal assessments for new weapon system development such as C4I system have been applying a qualitative assessment. The main problem of qualitative assessment is that the results vary depending on the evaluator's subjective preferences and priorities. Also, if there is no discrimination of technical skills degrade, the company will be selected by bid price regardless of technical power. In order to making a fairness, We need a method to compensate for the evaluator's subjectivity and to enhance discrimination. Previous standardization method is limited because targets of the proposal assessment are minority and have similar skill level. So, The new standardized evaluation methods applicable to the proposal was presented. This way is using the priority instead of the score and has better performance than existing methods as the target numbers are smaller.

• The Journal of Korean Medicine
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• v.31 no.1
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• pp.57-68
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• 2010

Objectives: Standard is a unified criterion for some repeated things or concepts in a certain scope. It is fundamental to implement standardization in English translation of traditional Korean medicine (TKM) formulae to promote progress in the evaluation of TKM and also to serve in enhancing the efficiency in studies of medical formulae. Methods: We undertook literature research on current Korean and Chinese medicinal formulae in English translation, analyzing 485 Korean formulae and 464 Chinese. We also undertook a comparative study of 102 common English translation of both Korean and Chinese, proposing a constant and effective methods for English translation of medical formulae. Results: To have a precise English translation we classified medical formulae nomenclature in advance. We found that formulae naming can be fundamentally classified into 6 forms which are (a) Materia Medica + Preparation Form, (b) Materia Medica + Indication + Preparation Form, (c) Materia Medica Numbers + Preparation Form, (d) Indication + Preparation Form, (e) Concept + Preparation Form, and (f) Miscellaneous. Based on these findings we could determine that these 6 types ((a)-(f)) can all be translated into English by (1) Materia Medica + Preparation Form and (2) Indication + Preparation Form + of (with) + Materia Medica schemes. In regard to translation of Indication it can follow Noun+~ing participle form. Conclusion: This research provides a common method of TKM medicinal formulae English translation for better understanding, education, training, practice and research in TKM. Consequently, English translation using these methods can serve as the initial study for standardization of TKM medicinal formulae.

• Korean Journal of Radiology
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• v.24 no.4
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• pp.294-304
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• 2023

Objective: We aimed to investigate whether image standardization using deep learning-based computed tomography (CT) image conversion would improve the performance of deep learning-based automated hepatic segmentation across various reconstruction methods. Materials and Methods: We collected contrast-enhanced dual-energy CT of the abdomen that was obtained using various reconstruction methods, including filtered back projection, iterative reconstruction, optimum contrast, and monoenergetic images with 40, 60, and 80 keV. A deep learning based image conversion algorithm was developed to standardize the CT images using 142 CT examinations (128 for training and 14 for tuning). A separate set of 43 CT examinations from 42 patients (mean age, 10.1 years) was used as the test data. A commercial software program (MEDIP PRO v2.0.0.0, MEDICALIP Co. Ltd.) based on 2D U-NET was used to create liver segmentation masks with liver volume. The original 80 keV images were used as the ground truth. We used the paired t-test to compare the segmentation performance in the Dice similarity coefficient (DSC) and difference ratio of the liver volume relative to the ground truth volume before and after image standardization. The concordance correlation coefficient (CCC) was used to assess the agreement between the segmented liver volume and ground-truth volume. Results: The original CT images showed variable and poor segmentation performances. The standardized images achieved significantly higher DSCs for liver segmentation than the original images (DSC [original, 5.40%-91.27%] vs. [standardized, 93.16%-96.74%], all P < 0.001). The difference ratio of liver volume also decreased significantly after image conversion (original, 9.84%-91.37% vs. standardized, 1.99%-4.41%). In all protocols, CCCs improved after image conversion (original, -0.006-0.964 vs. standardized, 0.990-0.998). Conclusion: Deep learning-based CT image standardization can improve the performance of automated hepatic segmentation using CT images reconstructed using various methods. Deep learning-based CT image conversion may have the potential to improve the generalizability of the segmentation network.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.17 no.32
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• pp.255-266
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• 1994

This study does present things to suggest to foreign multinational corporation or domestic corporation through the empirical study on the standardization level. If we summary this study, it is as follows. In chapter I, we did institute the problems and explain the objects and methods and system of the study. In chapter II, we did explain the universality of the culture and international advertisement. Next, we did explain the background of doing specialization strategy and standardization strategy. Also we did study the previous study about the arguements for and against these. Lsat we did institute the hypothesises as follows. - Hypothesis 1 $H_0$ : The use of westerner appeal means has been increased than 11 years before and is able to increase continuously. - Hypothesis 2 $H_0$ : The use of westerner model and knowned has been increased than 11 years before and is able to increase continuously. - Hypothesis 3 $H_0$ : The use of the English language has been increased than 11 years before and is able to increase continuously. - Hypothesis 4 $H_0$ : The use of the west short piece and background has been increased than 11 years before and is able to increase continuously. In chapter III, we did refer to the method of this study. First, we did adjust the measure of standardization index, and we did work coding it, such after the two coder did check the freguency of the appeal meanstype about the advertisement of four daily report. Then we did select eight production as high involvement production and seven production as low involvement. We did test the coder's trust degree on the such sample to be selected through the 't-test' of the SAS statistic program and regression analysis through the spss/$pc^+$ statistic program to approve the this study's hypothesises. In chapter IV, we did analysis the results of the empirical study on the high or low involvement productions. First, the results of t-test to approve the coder's trust degree is that it is same statistically attentionly the distribution of the sample between coder at 10% attention level. Next, the results of the regression analysis on eight hypothesises are as fellows. In case of high involvement production we are able to speak that the use of the English language appeal among the eight appeals is only standardized. And incase of low involvement production, we are able to speak that the use of the hard-sell appeal among the eight appeds is only standardized. Therefore we did conclude that the standardization level of Korea newspaper advertisement is low. Also this suggests that it will do plan and do the specialzation strategy or localization strategy foreign multinational corporation or domestic corporation in Korea newspaper advertisement. In chapter V, we do present the boundary of this study and new study methods.

• Journal of Ginseng Research
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• v.43 no.3
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• pp.377-384
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• 2019

Background: Inflammation is widespread in the clinical pathology and closely associated to the progress of many diseases. Triterpenoid saponins as a key group of active ingredients in Panax notoginseng (Burk.) F.H. Chen were demonstrated to show antiinflammatory effects. However, the chemical structures of saponins in the leaves and stems of Panax notoginseng (PNLS) are still not fully clear. Herein, the isolation, purification and further evaluation of the antiinflammatory activity of dammarane-type triterpenoid saponins from PNLS were conducted. Methods: Silica gel and reversed-phase C8 column chromatography were used. Furthermore, preparative HPLC was used as a final purification technique to obtain minor saponins with high purities. MS, NMR experiments, and chemical methods were used in the structural identifications. The antiinflammatory activities of the isolated saponins were assessed by measuring the nitric oxide production in RAW 264.7 cells stimulated by lipopolysaccharides. Real-time reverse transcription polymerase chain reaction was used to measure the gene expressions of inflammation-related gene. Results: Eight new minor dammarane-type triterpene oligoglycosides, namely notoginsenosides LK1-LK8 (1-8) were obtained from PNLS, along with seven known ones. Among the isolated saponins, gypenoside IX significantly suppressed the nitric oxide production and inflammatory cytokines including tumor necrosis $factor-{\alpha}$, interleukin 10, interferon-inducible protein 10 and $interleukin-1{\beta}$. Conclusion: The eight saponins may enrich and expand the chemical library of saponins in Panax genus. Moreover, it is reported for the first time that gypenoside IX showed moderate antiinflammatory activity.

• Journal of Ginseng Research
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• v.44 no.3
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• pp.442-452
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• 2020

Backgroud: Sleep deprivation (SD) impairs learning and memory by inhibiting hippocampal functioning at molecular and cellular levels. Abnormal autophagy and apoptosis are closely associated with neurodegeneration in the central nervous system. This study is aimed to explore the alleviative effect and the underlying molecular mechanism of stem-leaf saponins of Panax notoginseng (SLSP) on the abnormal neuronal autophagy and apoptosis in hippocampus of mice with impaired learning and memory induced by SD. Methods: Mouse spatial learning and memory were assessed by Morris water maze test. Neuronal morphological changes were observed by Nissl staining. Autophagosome formation was examined by transmission electron microscopy, immunofluorescent staining, acridine orange staining, and transient transfection of the tf-LC3 plasmid. Apoptotic event was analyzed by flow cytometry after PI/annexin V staining. The expression or activation of autophagy and apoptosis-related proteins were detected by Western blotting assay. Results: SLSP was shown to improve the spatial learning and memory of mice after SD for 48 h, accomanied with restrained excessive autophage and apoptosis, whereas enhanced activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway in hippocampal neurons. Meanwhile, it improved the aberrant autophagy and apoptosis induced by rapamycin and re-activated phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signaling transduction in HT-22 cells, a hippocampal neuronal cell line. Conclusion: SLSP could alleviate cognitive impairment induced by SD, which was achieved probably through suppressing the abnormal autophagy and apoptosis of hippocampal neurons. The findings may contribute to the clinical application of SLSP in the prevention or therapy of neurological disorders associated with SD.

• The Korea Journal of Herbology
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• v.26 no.1
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• pp.103-110
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• 2011

Objective : For the standardization and quality control of eleutheroside E in Eleutherococcus species, HPLC analysis was performed and eleutherosdie E content was compared in 23 kinds of Eleutherococcus species collected from Korea and China. Methods : The content of eleutheroside E in stem bark of Eleutherococcus species collected from Korea and China were analyzed by HPLC. 0.5% phosphoric acid and acetonitrile was used as mobile solvent. Validation of HPLC analysis method was confirmed by analyzing specificity, linearity, precision and accuracy following ICH guideline. Results : Content of eleutheroside E was determined to be 1.0-1.6% and 0.5-0.8% in Korean and Chinese E. senticosus, respectively. Content of eleutheroside E in E. sessiliflorus was 0.7-1.1% and 0.2-0.4% respectively in Korean and Chinese origin. All calibration curves showed good linear regression. The method showed good precision and accuracy with intra-day and inter-day variations of 0.880-3.442% (RSD) and 0.606-3.328% (RSD), respectively, and average recovery was of 0.141-1.363% (RSD), for the eleutheroside E analyzed. Conclusion : These results might be used to establish a criterion of eleutheroside E in Eleutherococcus species.

• Fisheries and Aquatic Sciences
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• v.19 no.1
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• pp.3.1-3.6
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• 2016

Phlorotannins are reported to have diverse biological properties. However, no analytical methods for the standardization of phlorotannin preparations have been reported. Herein, we developed and validated an analytical method for the determination of dieckol in phlorotannin extracts (PRT) using high-performance liquid chromatography (HPLC). The optimum HPLC conditions consisted of a Supelco Discovery C18 column stationary phase, a mobile phase (A: 15 % HPLC grade methanol in deionized water, B: methanol), UV detection at 230 nm, and a flow rate of 0.7 mL/min. The optimized chromatographic conditions were validated and exhibited good specificity and linearity ($R^2$ > 0.9994-1.0000). The recoveries were in the range of 100.9-102.3 %. The method had good intermediate (%RSD 1.2) and intra-day (%RSD 0.4-1.7) assay precisions. This HPLC method had good accuracy and quality in the determination of dieckol in PRT.