• Translational and Clinical Pharmacology
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• v.25 no.3
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• pp.147-152
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• 2017

This study focused on the role of cytochrome P450 2D6 (CYP2D6) genotypes to predict phenotypes in the metabolism of dextromethorphan. CYP2D6 genotypes and metabolic ratios (MRs) of dextromethorphan were determined in 201 Koreans. Unsupervised clustering algorithms, hierarchical and k-means clustering analysis, and color visualizations of CYP2D6 activity were performed on a subset of 130 subjects. A total of 23 different genotypes were identified, five of which were observed in one subject. Phenotype classifications were based on the means, medians, and standard deviations of the log MR values for each genotype. Color visualization was used to display the mean and median of each genotype as different color intensities. Cutoff values were determined using receiver operating characteristic curves from the k-means analysis, and the data were validated in the remaining subset of 71 subjects. Using the two highest silhouette values, the selected numbers of clusters were three (the best) and four. The findings from the two clustering algorithms were similar to those of other studies, classifying $^*5/^*5$ as a lowest activity group and genotypes containing duplicated alleles (i.e., $CYP2D6^*1/^*2N$) as a highest activity group. The validation of the k-means clustering results with data from the 71 subjects revealed relatively high concordance rates: 92.8% and 73.9% in three and four clusters, respectively. Additionally, color visualization allowed for rapid interpretation of results. Although the clustering approach to predict CYP2D6 phenotype from CYP2D6 genotype is not fully complete, it provides general information about the genotype to phenotype relationship, including rare genotypes with only one subject.

• Journal of The Korean Society of Agricultural Engineers
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• v.61 no.3
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• pp.101-112
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• 2019

This study developed selection criteria of small-scales reservoirs, having under $300,000m^3$ storage capacity, for the Emergency Action Plan(EAP) establishment in order to reduce the disaster risks of the reservoir's failures. Those reservoirs are out of ranges of Korean EAP establishment standard, but have potential risk of disasters as they have often failed by the recent extreme rainfall events and earthquakes, causing economical and life losses. The problem of reservoir aging is also one of the reasons of them. In this study, the developed selection criteria of small reservoirs for EAP establishment are storage capacity, embankment height, reservoir age, heavy rain factor and earthquake factor. These criteria were selected based on the review of the existing EAP establishment guidelines, analysis of the past dam failure cases, and the previous related studies. The quantification of these criteria were conducted for the practical applications in the fields, and applied to 67 previous failures in order to investigate the relation of each criteria with these failures. The earthquake factor found to be the highest relations followed by heavy rain factors, combination of earthquake and heavy rain factors, and reservoir age. The classification was made as observation and review groups for EAP establishments based on overlapping numbers of each criteria. This classifications applied to 354 reservoirs designated as having the potential disaster risk by MOIS, and showed 38.4% of observation and 11.9% of review groups. Anticipatory monitoring and regular inspection should be made by professional facility managers for the observation group, and necessity of EAP establishment should be assessed for the review group based on the downstream status and financial budget.

• Imaging Science in Dentistry
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• v.49 no.2
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• pp.97-102
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• 2019

Purpose: This study was conducted to evaluate the effect of different spatial resolutions of a photostimulable phosphor plate (PSP) radiography system on the detection of proximal caries lesions. Materials and Methods: Forty-five extracted human permanent teeth were radiographed using a PSP system (VistaScan Perio Plus) and scanned at the 4 resolutions (10 lp/mm, 20 lp/mm, 25 lp/mm, and 40 lp/mm) available in the system. Three independent examiners scored the images for the presence and absence of proximal caries lesions using a 5-point scale. The presence or absence of caries was confirmed by histological sections of the examined teeth (defined as the gold standard). Intra- and inter-observer reproducibility was calculated by the weighted kappa test. One-way analysis of variance with the post hoc Tukey test was used to compare the area under the receiver operating characteristic curve for the classifications made with each resolution. Results: For the detection of enamel lesions, the spatial resolution of 10 lp/mm was significantly superior to the other resolutions. However, the spatial resolution did not affect the detection of caries lesions in dentin (P>0.05). Conclusion: Spatial resolution may influence the accuracy of the detection of incipient caries lesions in radiographs with PSP plates. Images with low spatial resolution seem to be more appropriate for this purpose.

• Nuclear Engineering and Technology
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• v.53 no.11
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• pp.3808-3815
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• 2021

In this paper, the EPICS2017 photoatomic database was used to evaluate the photon mass attenuation coefficients and buildup factors of soils collected at different depths in the Philippine islands. The extraction and interpolation of the library was accomplished at the recommended linear-linear scales to obtain the incoherent and total cross section and mass attenuation coefficient. The buildup factors were evaluated using the G-P fitting method in ANSI/ANS-6.4.3. An agreement was achieved between XCOM, MCNP5, and EPICS2017 for the calculated mass attenuation coefficient values. The buildup factors were reported at several penetration depths within the standard energy grid. The highest values of both buildup factor classifications were found in the energy range between 100 and 400 keV where incoherent scattering interaction probabilities are predominant, and least at the region of predominant photoionization events. The buildup factors were examined as a function of different soil silica contents. The soil samples with larger silica concentrations were found to have higher buildup factor values and hence lower shielding characteristics, while conversely, those with the least silica contents have increased shielding characteristics brought by the increased proportions of the abundant heavier oxides.

• Information Systems Review
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• v.18 no.4
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• pp.173-187
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• 2016

This study on the social effects of Internet of Things (IoTs) provides an overview of future job prospects through the scenario planning approach, highlighting the challenges and opportunities that IoTs will bring in the future. IoTs and the related field of technological innovations have become increasingly important in both academic and business communities in the past few years because of computing power breakthrough and its price drop. IoTs enables people to deal with routine works efficiently and challenges them even in non-routine and/or cognitive tasks, which are considered a unique area for individuals. The scenario planning analysis helps us to define the uncertain boundary and to estimate the potential opportunities and inherent threats to provide decision makers with a mind map on how the development of IoTs can influence employment. To assess the potential effects on jobs described in our scenarios, we briefly examine the local structure of employment and discuss which careers are expected to decline or grow in particular among the 52 standard occupational classifications in Korea.

• Journal of Korean Society of Forest Science
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• v.110 no.4
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• pp.630-647
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• 2021

We determined the current problem of the restoration deposit-estimation system, stipulated by the Mountainous Districts Management Act, using the Delphi technique. Consequently, we proposed a standard model for forest land restoration to derive a reasonable deposit-estimation system. With the result of the Delphi survey, the inappropriateness of land-use type and slope gradient classifications was shown; the insufficiency of standard works was a significant problem in the current system. A way to solve these problems was devised, to reorganize the current land-use type into the subject of the site. The specific subjects included the following: (i) to permit or report forest land-use change and temporary use of forest land, (ii) to report temporary use of forest land, (iii) to permit stone collection or sale for mineral mining, and (iv) to allow sediment collection. The current slope gradient subdivision into (a) θ<10°, (b) 10°≦θ<15°, (c) 15°≦θ<20°, (d) 20°≦θ<25°, (e) 25°≦θ<30°, and (f) θ≧30° and the reorganization of 17 standard works into 22 standard works were deemed as solutions, along with seven additional works. We developed 24 standard models for the forest land restoration project based on the aforementioned results. The deposits estimated by these models ranged from 34,185,000 (Korean) won to 607,403,000 won. If additional works, premiums, discounts, and supervision fees are added to the models, the deposit increases to an estimated 668,143,000 won subject to permission for stone collection or sale and mineral mining. Experts agree on the distribution of the restoration deposits estimated by these models at a high level in the Delphi survey. Our findings are expected to contribute to securing the appropriateness of the restoration cost deposited for the smooth performance of the vicariously executed restoration project.

• Journal of the Korean Association of Geographic Information Studies
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• v.21 no.2
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• pp.44-55
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• 2018

The importance of establishing a greenhouse gas inventory is emerging for policymaking and its implementation to cope with climate change. Thus, it is needed to establish Approach 3 level Land Use, Land-Use Change and Forestry (LULUCF) matrix that is spatially explicit regarding land use classifications and changes. In this study, four types of spatial information suitable for establishing the LULUCF matrix were analyzed - Cadastral Map, Land Cover Map, Forest Map, and Biotope Map. This research analyzed the classification properties of each type of spatial information and compared the quantitative and qualitative characteristics of the maps in Boryeong city. Drawn from the conclusions of the quantitative comparison, the forest area showed the maximum difference of 50.42% ($303.79km^2$) in the forest map and 46.09%($276.65km^2$) in the cadastral map. The qualitative comparison drew five qualitative characteristics: data construction scope difference, data construction purpose difference, classification standard difference, and classification item difference. As a result of the study, it was evident that the biotope map was the most appropriate spatial information for the establishment of the LULUCF matrix. In addition, if the LULUCF matrix is made by integrating the biotope, the forest map, and the land cover map, the limitations of each spatial information would be improved. The accuracy of the LULUCF matrix is expected to be improved when the map of the level-3 land cover map and the biotope map of 1:5,000 covering the whole country are completed.

• Journal of Korean Society of Steel Construction
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• v.16 no.4 s.71
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• pp.407-414
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• 2004

Bridges in common use are expected to have more varieties of load in their connected members and bolts than in construction. Faults in connection members or bolts occur so often according to the time flow. One of the purposes of this study is to find out the behavior and structural features of high-tension bolted joints with faults that are very difficult and cost much to find out through experimentation with finite element analysis. Another purpose of this study is to provide sufficient data, estimated experimental results, and the scheme of the test plate for an economical experimental study in the future. Surveys of bridges with a variety of faults and statistical classifications of their faults were performed, as was a finite element analysis of the internal stress and the sliding behavior of standard and defective bridge models. The finite element analysis of the internal stress was performed according to the interval of the bolt, the thickness of the plate, the distance of the edge, the diameter of the bolt, and the expansion of the construction. Furthermore, the analysis explained the sliding behavior of high-tension bolt joints and showed the geometric non-linear against the large deformation, and the boundary non-linear against the non-linear in the contact surface, including the material non-linear, to best explain the exceeding of the yield stress by sliding. A normally bolted high-tension bolt joint and deduction of bolt tension were also analyzed with the finite element analysis of bridge-sliding behavior.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.3
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• pp.185-198
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• 2017

Since the year 2000, the growth rate of domestic manufacturing has declined and the sales and employment have decreased. Major developed countries have established a variety of strategies to strengthen their manufacturing competitiveness, and promote manufacturing innovation through the convergence of technology and ICT. The key to manufacturing innovation is to reduce the time and cost for developing new products using modeling and simulation (M&S) technology in the product design stage. M&S industries, which belong to the top sector of the industry value chain, have a huge ripple effect across other industries. On the other hand, the competitiveness of the domestic M&S industry is weak compared to developed countries and even the definition and classification of domestic M&S companies have not been made. In this paper, by analyzing the Korea Standard Industry Classification (KSIC), five fine industry classifications included in M&S service companies were derived. In addition, the 307 M&S service companies were derived in accordance with the selection procedure of 3 steps from the 11,822 related companies. To analyze the capabilities of domestic M&S service companies, the current status of the selected M&S service companies was investigated. Considering the Korean economy's high dependence on the manufacturing industry, strengthening the competitiveness of manufacturing industry is required by enhancing the capacities and building an ecosystem in domestic M&S services for future sustainable economic growth.

• The Research Journal of the Costume Culture
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• v.8 no.5
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• pp.681-706
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• 2000

This study is intended to understand an implication system and significance in the current community which a body image symbolizes by correlating it with fashion that is on the rise as a principal issue in various fields. For this study, the symbolism of the body image was contemplated in terms of philosophy and art, and then on the basis of it, the symbolism of the body image shown in modern fashion design was analyzed through fashion works. The research results are as follows, 1. The manifestation of sex can be taken as the symbolism of the body image which is expressed in modern fashion design. Recently sexual chaos and vagueness such as homosexuality and bisexuality are expressed through a dress and its ornaments. Though displaying sexual characteristics of male and female as they are exposing a sign or a diagram, decorating a part of body or representing sex in garments, uncertain sex identity in modern society is manifested in dress and its ornaments. It is to deny absoluteness regarding sex and emphasize diversity indwelt in human beings, and after all it shows to pursue the human essence. 2. Another symbolism of the body image is body expression as the human race and an ethnic group. The discriminating situations and the restoration of their status appeared in modern fashion too. Moreover, their cultures and issues came to alter the aesthetic standard of body made from a view of the Western white supremacist. Hereupon, fashion trends like ethnic fashion, Orientalism and African look etc. appear according to this tendency, which represents race and national identity and in addition, which signifies to present transcendental human conception embracing alienated human conception. 3. The symbolism of the body image expressed in a body, and a dress and its ornaments as nature can be considered in terms of the concern on environmental contamination and the respect of echo system. Getting away from reigning over, developing and stamping down nature at their will, the human beings pursue unity with nature, which is described in fashion. They are stressing that natural materials and objects such as animal, plant and soil etc. should activily be introduced into fashion and humans are a communal fate group and should reframe their status in nature at last. 4. The body image shown in a body, a dress and its ornaments as technology is transformed and recreated by modern scientific techniques and medical science to show post human conception namely, forthcoming future human conception as a cyborg which loses individual identity. This presents a perfect future human conception with high level of preternatural power but after all, leaves us a task to seek the meaning of human existence in alienation caused by the loss of human identity and existence. In this manner, the moderns crave for perceiving the identity of a natural human being in the current thoughts tendency of the modern times such as postmodernism, post structuralism, deconstructionism, feminism and so on, which build discussions affecting the art and fashion worlds. The categories, like sexual characteristics indwelt in a human body, racial classifications, the natural environment surrounding human beings and development of science, bring out the importance of the internal and external meaning in today's fashion which a human body contains, and present sew human conception in the coming future society.