• Clinical and Experimental Pediatrics
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• 제63권12호
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• pp.491-498
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• 2020

Background: Renal size is an important indicator in the diagnosis of renal diseases and urinary tract infections in children. Purpose: The purpose of this study is twofold. First, it aimed to measure the renal length and calculate the renal volume of normal Thai children using 2-dimensional ultrasonography (2D-US) and study their correlations with somatic parameters. Second, it aimed to compare the age-specific renal size of normal Thai children with the published data of their Western and Chinese counterparts. Methods: A total of 321 children (150 boys, 171 girls; age, 6-15 years) with a normal renal profile were prospectively recruited. All subjects underwent 2D-US by an experienced pediatric radiologist and the renal length, width, and depth were measured. Renal volume was calculated using the ellipsoid formula as recommended. The data were compared between the left and right kidneys, the sexes, and various somatic parameters. The age-specific renal lengths were compared using a nomogram derived from a Western cohort that is currently referred by many Thailand hospitals, while the renal volumes were compared with the published data of a Chinese cohort. Results: No statistically significant difference (P<0.05) was found between sexes or the right and left kidneys. The renal sizes had strong correlations with height, weight, body surface area, and age but not with body mass index. The renal length of the Thai children was moderately correlated (r=0.59) with that of the Western cohort, while the age-specific renal volume was significantly smaller (P<0.05) than that of the Chinese children. Conclusion: Therefore, we concluded that the age-specific renal length and volume obtained by 2D-US would vary between children in different regions and may not be suitably used as an international standard for diagnosis, although further studies may be needed to confirm our findings.

• 한국미생물·생명공학회지
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• 제47권2호
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• pp.310-316
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• 2019

Distribution of Salmonella enterica serovars and their associated virulence determinants is wide-spread among food animals, which are continuously implicated in periodic salmonellosis outbreaks globally. The aim of this study was to determine and evaluate the diversity of five Salmonella serovar virulence genes (invA, pefA, cdtB, spvC and iroN) isolated from food animals and humans. Using standard microbiological techniques, Salmonella spp. were isolated from the feces of humans and three major food animals. Virulence determinants of the isolates were assayed using PCR. Clonal relatedness of the dominant serovar was determined via pulsed-field gel electrophoresis (PFGE) using the restriction enzyme, Xbal. Seventy one Salmonella spp. were isolated and serotyped into 44 serovars. Non-typhoidal Salmonella (NTS; 68) accounted for majority (95.8%) of the Salmonella serovars. Isolates from chicken (34) accounted for 47.9% of all isolates, out of which S. Budapest (14) was predominant (34.8%). However, the dominant S. Budapest serovars showed no genetic relatedness. The invA gene located on SPI-1 was detected in all isolates. Furthermore, 94% of the isolates from sheep harbored the spvC genes. The iroN gene was present in 50%, 100%, 88%, and 91% of isolates from human, chicken, sheep, and cattle, respectively. The pefA gene was detected in 18 isolates from chicken and a single isolate from sheep. Notably, having diverse Salmonella serovars containing plasmid encoded virulence genes circulating the food chain is of public health significance; hence, surveillance is required.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2014년도 추계학술대회
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• pp.829-832
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• 2014

최근 정부의 스마트워크 활성화 전략에 따라 공공기관 및 대기업을 중심으로 스마트워크의 핵심 서비스인 화상회의 도입의 활성화되고 있다. 그러나 국내 화상회의 도입은 외국 주요기업 제품과 국내 다양한 중소 제품이 설치되어, 기 구축된 시스템간은 물론 신규로 구축될 장비간의 상호운용성 확보는 매우 시급하고 중요한 사항이다. 또한, 동일 회사의 화상회의시스템 간에만 서비스가 제공되던 협소한 시장 환경에서 다양한 형태의 복수 회사 제품의 상호운용성 확보가 요구되는 시장 환경으로 변화함에 따라, 상호연동이 가능한 형태의 표준개발이 이루어져야 한다. 따라서 본 논문에서는 화상회의 시스템 및 서비스 간 상호연동 프로파일 표준 개발을 통하여 플랫폼 규격의 상호호환성을 확보할 표준화 추진방향을 제시하고자 한다.

• 대한한방소아과학회지
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• 제33권3호
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• pp.30-41
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• 2019

Objectives Development of objective clinical measure for analyzing pediatric weakness has been studied. However, there is no gold standard clinical measures with acceptable validity and reliability were not provided yet and these has been major issue for clinics. Methods Some Korean medicine hospital outpatients (n=324) were recruited as participants, and 55 preliminary questions were given. Pediatric Weakness Scale (PWS) with five subscales and thirty questions were developed using factor analysis and item analysis. The internal consistency of PWS subscales were examined with using Cronbach's alpha. The correlations between PWS subscales and physical characteristics of Body Mass Index (BMI) and Ponderal Index (PI) were attested using Pearson's correlation. The differences between PWS subscale scores and profiles among 3 to 13 years old children were examined using profile analysis and ANOVA by gender. Results PWS five subscales explained 49.1% of total variance, and the range of Cronbach's alpha was from 0.700 to 0.803. The range of correlation coefficient between PWS total score and five subscales was from 0.643 to 0.748, and the PWS total score was significantly (p<0.001) correlated positively with BMI (r=-0.237) and negatively with PI (r=-0.280). The scores and profiles of PWS five subscales, BMI and PI were found to be significantly different among the all age groups. Conclusions Objective and validated clinical measure for analyzing pediatric weakness with five subscales was developed in current study, and foundations for screening, managing and treating pediatric weakness during the development were established as well. This study would contribute to the integrative education and clinical practice of the Eastern and Western medicine.

• Journal of Applied Biological Chemistry
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• 제62권1호
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• pp.31-38
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• 2019

Scutellaria baicalensis Georgi (Scutellariae Radix)는 이뇨제, 고지혈증, 항박테리아, 항알레르기, 항염증제 및 항암제와 같은 건강보조식 및 전통 생약으로도 널리 사용되어 왔다. 본 연구에서 복잡한 S. baicalensis 추출물에서 지표 물질 또는 유효화합물들을 분리하는 것은 신원 확인 및 생리활성 평가를 위한 필수적인 단계다. 8개의 성분들로 구성된 타겟 분획물을 두개의 gradient elution를 사용하여 고성능 액체 크로마토 그래피에서 분석하였다. 중압 액체크로마토그래피 및 개방형칼럼으로 분취를 시뮬레이션함으로 예비실험에서 충분히 분리가 되도록 용리 조건을 결정할 수 있었다. 최적 분취방법으로 확보된 표준유효분획물로부터 8개의 지표성분들이 포함된 것을 확인하였다. 또한, 분획물은 UPLC-QTof-MS 비교 분석으로 MS, UV, HRESIMS 결과를 확인할 수 있었다. 따라서, 스케일 업 실험법은 S. baicalensis 추출물에 성공적으로 적용될 수 있었다.

• International Journal of Computer Science & Network Security
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• 제21권6호
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• pp.312-318
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• 2021

Lack of knowledge and digital skills is a threat to the information security of the state and society, so the formation and development of organizational culture of information security is extremely important to manage this threat. The purpose of the article is to assess the state of information security of the state and society. The research methodology is based on a quantitative statistical analysis of the information security culture according to the EU-27 2019. The theoretical basis of the study is the theory of defense motivation (PMT), which involves predicting the individual negative consequences of certain events and the desire to minimize them, which determines the motive for protection. The results show the passive behavior of EU citizens in ensuring information security, which is confirmed by the low level of participation in trainings for the development of digital skills and mastery of basic or above basic overall digital skills 56% of the EU population with a deviation of 16%. High risks to information security in the context of damage to information assets, including software and databases, have been identified. Passive behavior of the population also involves the use of standard identification procedures when using the Internet (login, password, SMS). At the same time, 69% of EU citizens are aware of methods of tracking Internet activity and access control capabilities (denial of permission to use personal data, access to geographical location, profile or content on social networking sites or shared online storage, site security checks). Phishing and illegal acquisition of personal data are the biggest threats to EU citizens. It have been identified problems related to information security: restrictions on the purchase of products, Internet banking, provision of personal information, communication, etc. The practical value of this research is the possibility of applying the results in the development of programs of education, training and public awareness of security issues.

• Nutrition Research and Practice
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• 제13권6호
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• pp.529-534
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• 2019

BACKGROUND/OBJECTIVES: The leaves of Moringa oleifera (MO) and Moringa stenopetala (MS) commonly grown in Ethiopia possess potential nutritional and medicinal value. The aim of this study was to evaluate the nutritional and functional characteristics of the dried leaf powder from two Moringa species to develop sustainable nutritional supplements for Ethiopians from locally grown plant sources. MATERIALS/METHODS: Freshly harvested and air-dried MO and MS leaves were authenticated and the nutritional contents, such as protein, ash, lipids, and selected vitamins and minerals, were analyzed using standard analytical procedures. Amino acid compositions were also determined by an amino acid analyzer. Nine-week-old mice were randomly divided into four groups to investigate the anti-obesity effects of Moringa. The first group was fed a basal diet, the second group a high-fat diet, and the others were fed a high-fat diet containing 0.1% Moringa leaf powder from each species. After seven weeks, serum indices related to lipid profiles from each mouse were analyzed. RESULTS: The present study revealed high protein (28-29%) and ash (7-11%) contents. Glutamic acid, aspartic acid, proline, and leucine were the most abundantly found amino acids in both species. The predominant minerals in the leaf powder were calcium (826-1,530 mg/100 g), potassium (794-904 mg/100 g), and magnesium (286-431 mg/100 g). Pyridoxine (475.06 mg/100 g) and vitamin E (34.2 mg/100 g) were found only in MS. Niacin was found only in MO at 32.21 mg/100 g, whereas ascorbic acid was found in both species (3.89 and 6.19 mg/100 g dry weight for MO and MS, respectively). The results of the animal study showed that mice on a high-fat diet containing 0.1% MO leaf powder alleviated the elevation of cholesterol, triglycerides, and low-density lipoprotein cholesterol induced by the high fat diet. MO was more effective than MS in preventing hypercholesterolemia and fat deposition. CONCLUSION: The findings in this work confirmed that Moringa leaves of both MO and MS possessed high nutritional value but MO was better at preventing the harmful effects of the high-fat diet than MS.

• 정보보호학회논문지
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• 제20권6호
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• pp.261-270
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• 2010

최근 SNS 이용이 활성화됨에 따라 SNS 제공환경에서의 정보보호에 대한 관심이 증가하고 있다. 하지만 SNS 산업 환경의 급격한 성장으로 인한 가입자 유치 위주의 투자 선행과 서비스 제공자 측면에서의 SNS 정보보호 투자 효과에 대한 확신 부족, 그리고 SNS에서의 정보보호 중요위협요인에 대한 분석체계 부재로 인해 아직까지 SNS 제공환경에서의 정보보호에 대한 투자가 미흡한 실정이다. 본 논문에서는 AHP를 이용한 SNS 제공환경에서 정보보호 중요위협요인 분석을 통해 정보보호 투자 결정 기준 도출에 대한 연구를 수행하였다. 본 연구를 통해, '서비스 이미지'가 정보보호 평가기준에서 가장 중요한 항목으로 도출되었으며, '개인 프로파일 위조 및 명예훼손'과 '산업 스파이'가 중요한 SNS 정보보호 위협요인인 것으로 나타났다.

• 대기
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• 제31권1호
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• pp.101-112
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• 2021

The long-term trend of surface wind speed in Korea is examined for 31 KMA weather stations from 1985 to 2019. Most stations, except Daegwallyeong, have several times of anemometer height changes from tens of centimeters to several meters. To minimize such height change effect on long-term wind trend, the present study adjusts anemometer height in each station to the standard height of 10 m using the power-law wind profile. This adjustment results in non-negligible trend change. For instance, the increasing surface wind speed at Suwon station, which has six times of anemometer height changes in a range of 0.8 m to 20 m, is weakened up to 67% and becomes statistically insignificant. Likewise, the decreasing trend at Andong station, with three times of anemometer height changes in a range of 10 m to 15.5 m, is weakened up to 66%. A similar weakening in long-term trend is observed in most stations regardless of positive and negative trends. However, due to the cancellation between weakened negative trends and weakened positive trends, the station-averaged wind speed trend in Korea does not change much. This result suggests that anemometer height adjustment is crucial for evaluating local wind speed trend but its impact on nation-wide wind speed trend is rather minor.

• 한국동물생명공학회지
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• 제36권1호
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• pp.35-44
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• 2021

A pregnancy diagnosis is an important standard for control of livestock's reproduction in paricular dairy cattle. High reproductive performance in dairy animals is a essential condition to realize of high life-time production. Pregnancy diagnosis is crucial to shortening the calving interval by enabling the farmer to identify open animals so as to treat or re-breed them at the earliest opportunity. MicroRNAs are short RNA molecules which are critically involved in regulating gene expression during both health and disease. This study is sought to establish the feasible of circulating miRNAs as biomarkers of early pregnancy in cattle. We applied Illumina small-RNA sequencing to profile miRNAs in plasma samples collected from 12 non-pregnant cows ("open" cows: samples were collected before insemination (non-pregnant state) and after pregnancy check at the indicated time points) on weeks 0, 4, 8, 12 and 16. Using small RNA sequencing we identified a total of 115 miRNAs that were differentially expressed weeks 16 relative to non-pregnancy ("open" cows). Weeks 8, 12 and 16 of pregnancy commonly showed a distinct increase in circulating levels of miR-221 and miR-320a. Through genome-wide analyses we have successfully profiled plasma miRNA populations associated with pregnancy in cattle. Their application in the field of reproductive biology has opened up opportunities for research communities to look for pregnancy biomarker molecules in dairy cattle.