• Asian Pacific Journal of Cancer Prevention
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• v.16 no.5
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• pp.2093-2098
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• 2015

In patients with multiple myeloma (MM), once-weekly intravenous injection or twice-weekly subcutaneous injection (SC) of bortezomib has been proven to offer non-inferior efficacy to standard twice-weekly intravenous administration, with an improved safety profile. However, whether once-weekly SC bortezomib can further reduce the incidence rate of peripheral neuropathy (PN) and not compromise the efficacy remains to be investigated. 25 patients of MM treated with once-weekly SC bortezomib were reviewed in this study. The median treatment cycles were 4 (range, 2-9 cycles). Complete response (CR) rate was 52%, ${\geq}$very good partial response (VGPR) rate was 72%, and ${\geq}$partial response (PR) rate was 84%. 1-year and 2-year PFS rate was 63.0% and 34.3%, respectively, and 2-year OS rate was 100%. Any grade of PN was reported in 9 patients (36.0%), with 7 patients (28.0%) had grade 1 PN, and 2 patients (8.0%) had grade 2 PN. No patients reported grade 3/4 PN in this cohort. In conclusion, once-weekly subcutaneous administration of bortezomib offers excellent efficacy with a further improved safety profile, especially with regard to PN. It needs to be validated in future prospective randomized trials.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.39 no.12
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• pp.1287-1295
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• 2015

Recently, fieldbus communication technologies have been widely deployed for industrial automation because they are profitable in providing easy system integration and management for multiple devices, as well as high-speed communication. It is essential for smart encoders to support fieldbus connectivity, where the device configuration and various types of information related to position are exchanged between an external controller and multiple encoders over the communication link. In this study, we implemented the CiA 406 device profile for smart encoders from the CANopen standards by extending an open-source CANopen standard-compliant framework, called CanFestival. The CiA 406 functionalities implemented in this study were validated on a test-bed consisting of a CANopen master and virtual CANopen encoders with our CiA 406 extension module.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.13 no.3
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• pp.48-55
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• 1999

Ths paper presents an optimization method which determines locations and size of capacitors simultaneously while minimizing power losses and improving voltage profile in radial distribution systems. Especially, the cost function associated with capacitor pla.cerrent is considered as step function due to banks of standard discrete capacities. Genetic algorithms(GA) are used to obtain efficiently the solution of the cost function associated with capacitors which is non-continuous and non-differentiable function. The strings in GA consist of the node nwnber index and size of capacitors to be installed. The length mutation operator, which is able to change the length of strings in each generation, is used. The proposed Jrethod which determines locations and size of capacitors simultaneously can reduce power losses and improve voltage proftle with capacitors of minimum size. Its efficiency is proved through the arolication in radial distribution systems.ystems.

• Asian-Australasian Journal of Animal Sciences
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• v.26 no.11
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• pp.1637-1643
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• 2013

The present work describes the effect of slaughtering age on horse carcass traits and on meat quality. Eighteen male Italian heavy draught horse (IHDH) breed foals were employed in the study. Soon after foaling they were randomly subdivided in 3 groups according to 3 age at slaughtering classes: 6 months old, 11 months old and 18 months old. Live weight, hot carcass weight and dressing percentage of each animal were recorded. After slaughtering, meat samples were collected from Longissimus Dorsi muscle between 13th and 18th thoracic vertebra of each animal and then analyzed. The right half carcass of each animal was then divided in cuts. Each one was subdivided into lean, fat and bones. Then, the classification of the lean meat in first and second quality cuts was performed according to the butchers' customs. Older animals were characterized by a lower incidence of first quality cuts (p<0.01) on carcass. Younger animals showed greater content in protein (p<0.01). Fatty acid profile showed an increasing trend of PUFA connected to the increasing of slaughtering age (p<0.05). The unsaturation index of intramuscular fatty acids was not affected by slaughtering age, confirming that horse meat, if compared to beef, is more suitable from a nutritional point of view. Season influenced reproduction, birth as well as production aspects of this species. The different slaughtering age could represent the way to produce meat of IHDH foals during the entire year without change in the qualitative standard expected by consumers.

• Journal of computational fluids engineering
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• v.20 no.3
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• pp.35-40
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• 2015

Centrifugal pumps consume considerable amounts of energy in various industrial applications. Therefore, improving the efficiency of pumps machine is a crucial challenge in industrial world. This paper presents numerical investigation of flow characteristics in volutes of centrifugal pumps in order to compare the energy consumption. A wide range of volumetric flow rate has been investigated for each case. The standard k-${\varepsilon}$ is adopted as the turbulence model. The impeller rotation is simulated employing the Multi Reference Frames(MRF) method. First, two different conventional design methods, i.e., the constant angular momentum(CAM) and the constant mean velocity (CMV) are studied and compared to a baseline volute model. The CAM volute profile is a logarithmic spiral. The CMV volute profile shape is an Archimedes spiral curve. The modified volute models show lower head value than baseline volute model, but in case of efficiency graph, CAM curve has higher values than others. Finally for this part, CAM curve is selected to be used in the simulation of different cross-section shape. Two different types of cross-section are generated. One is a simple rectangular shape, and the other one is fan shape. In terms of different cross-section shape, simple rectangular geometry generated higher head and efficiency. Overall, simulation results showed that the volute designed using constant angular momentum(CAM) method has higher characteristic performances than one by CMV volute.

• Journal of Korean Society for Atmospheric Environment
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• v.19 no.6
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• pp.789-803
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• 2003

The purpose of this study is to compare the usefulness between Gaussian dispersion model and receptor model with the experimental result of the dispersion tracing of the particulate pollutants from Taean coal-fired power plants. For this purpose, the component analysis of the collected PM 10 samples was performed. In order to trace the pollution sources, factor analysis was done with the result of the component analysis. As a result of the correlativity analysis of the fifteen power plants' profiles offered by US EPA, the correlativity of No.11202 source profile showed highest rate up to 84.5%. Thus it was adopted as proper one and the contribution rate by each pollution source was calculated by Chemical Mass Balance (CMB)-8 model. The contribution rate, which was the effect rate of the power plants on each measuring point, were calculated with a range of 24∼52％ and the standard error was below 0.9 $\mu\textrm{g}$/㎥. This indicates the selection of the source profile was appropriate. Also, the concentrations of each point were calculated by the ISCST3 which is suggested by US EPA as one of the regulatory Gaussian dispersion model. The calculation result showed that the predicted concentration was 50∼58 $\mu\textrm{g}$/㎥, comparing with the measured result of 9∼65 $\mu\textrm{g}$/㎥. It was found that the concentration calculated by ISCST3 was underpredicted. It was thought that the receptor model was more favorable than the Gaussian dispersion model in estimating the effect of the particulate matter on a certain receptive point.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.6
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• pp.1338-1342
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• 2011

In this paper, threshold voltage characteristics have been analyzed as one of short channel effects occurred in double gate(DG)MOSFET to be next-generation devices. The Gaussian function to be nearly experimental distribution has been used as carrier distribution to solve Poisson's equation, and threshold voltage has been investigated according to projected range and standard projected deviation, variables of Gaussian function. The analytical potential distribution model has been derived from Poisson's equation, and threshold voltage has been obtained from this model. Since threshold voltage has been defined as gate voltage when surface potential is twice of Fermi potential, threshold voltage has been derived from analytical model of surface potential. Those results of this potential model are compared with those of numerical simulation to verify this model. As a result, since potential model presented in this paper is good agreement with numerical model, the threshold voltage characteristics have been considered according to the doping profile of DGMOSFET.

• The Korean Journal of Applied Statistics
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• v.22 no.5
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• pp.911-921
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• 2009

Receiver Operating Characteristic(ROC) and Cumulative Accuracy Profile(CAP) curves are two methods used to assess the discriminatory power of different credit-rating approaches. The points of optimal classification accuracy on an ROC curve and of maximal profit on a CAP curve can be found by using iso-performance tangent lines, which are based on the standard notion of accuracy. In this paper, we offer an alternative accuracy measure called the true rate. Using this rate, one can obtain alternative optimal threshold points on both ROC and CAP curves. For most real populations of borrowers, the number of the defaults is much less than that of the non-defaults, and in such cases the true rate may be more efficient than the accuracy rate in terms of cost functions. Moreover, it is shown that both alternative scores of optimal classification accuracy and maximal profit are the identical, and this single score coincides with the score corresponding to Kolmogorov-Smirnov statistic used to test the homogeneous distribution functions of the defaults and non-defaults.

• Journal of the Korean Society for Nondestructive Testing
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• v.31 no.5
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• pp.543-551
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• 2011

Steam generator tubes for nuclear power plants contain the local shape transitions on their inner or outer surface such as dent, bulge, over-expansion, eccentricity, deflection, and so on by the application of physical force during the tube manufacturing and steam generator assembling and by the sludge (that is, corrosion products) produced during the plant operation. The structural integrity of tubes will be degraded by generating the corrosive crack at that location. The profilometry using the traditional bobbin probes which are currently applied for measuring the profile change of tubes gives us basic information such as axial locations and average magnitudes of deformations. However, the three-dimensional quantitative evaluation on circumferential locations, distributional angle, and size of deformations will have to be conducted to understand the effects of residual stresses increased by local deformations on corrosive cracking of tubes. Steam generator tubes of Korean standard nuclear power plants expanded within their tube-sheets by the explosive expansion method and suffered from corrosive cracks in the early stage of power operation. Thus, local deformations of steam generator tubes at the top of tube-sheet were measured with an advanced rotating probe and a laser profiling system for the two cases where the tubes expanded by the explosive expansion method and hydraulic expansion. Also, the trends of eccentricity, deflection, and over-expansion of tubes were evaluated. The advanced eddy current profilometry was confirmed to provide accurate information of local deformations compared with laser profilometry.

• Wind and Structures
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• v.5 no.2_3_4
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• pp.177-192
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• 2002

Computation solutions for the flow around a cube, which were generated as part of the Computational Wind Engineering 2000 Conference Competition, are compared with full-scale measurements. The three solutions shown all use the RANS approach to predict mean flow fields. The major differences appear to be related to the use of the standard $k-{\varepsilon}$, the MMK $k-{\varepsilon}$ and the RNG $k-{\varepsilon}$ turbulence models. The inlet conditions chosen by the three modellers illustrate one of the dilemmas faced in computational wind engineering. While all modeller matched the inlet velocity profile to the full-scale profile, only one of the modellers chose to match the full-scale turbulence data. This approach led to a boundary layer that was not in equilibrium. The approach taken by the other modeller was to specify lower inlet turbulent kinetic energy level, which are more consistent with the turbulence models chosen and lead to a homogeneous boundary layer. For the $0^{\circ}$ case, wind normal to one face of the cube, it is shown that the RNG solution is closest to the full-scale data. This result appears to be associated with the RNG solution showing the correct flow separation and reattachment on the roof. The other solutions show either excessive separation (MMK) or no separation at all (K-E). For the $45^{\circ}$ case the three solutions are fairly similar. None of them correctly predicting the high suctions along the windward edges of the roof. In general the velocity components are more accurately predicted than the pressures. However in all cases the turbulence levels are poorly matched, with all of the solutions failing to match the high turbulence levels measured around the edges of separated flows. Although all of the computational solutions have deficiencies, the variability of results is shown to be similar to that which has been obtained with a similar comparative wind tunnel study. This suggests that the computational solutions are only slightly less reliable than the wind tunnel.