• 한국실내디자인학회논문집
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• 제3호
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• pp.46-57
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• 1994

Today, it is a fact that interior design plays a very important role as much as architecture on contributing to our society as a rising new professional field. On the other hand, our interior design education is still in immagture stage unlike the graudal development of the mood of interior design line , If the interior design field has any educational value to invest to be noticed as an environmental design that creates the human environment. There are great deal of meanings to indicate the direction for better education after recognizing the manu different problems on presently offering interior design education. Therefore, the objectives of this study is , after establishing the innovative methods of education and course contents of the four year interior design program, to produce the interior designers of manifold abilities, who is able to fit well in the professional practice, in order to materialize the settlement of interior design education which will be the key point in our circumstances, which has ow social recognition toward interior design. There were four phases in this study. First was to gather and to analyze information from printed materials, such as curriculum and catalog from each institution. Secondly, we had collected existing previous studies in all interior design area in order to sude as references. Thirdly, we have managed to suggest ideal improvement for better basic design program in the area of interior design education after the arranging and analyzing . Finally, we were able to persuade the importance of improved basic design program to the interior design education parties and to suggest the direction for the future. Because interior design as a scholastic pursuit is combined practical application study by the art and technology, it emphasizes specialty . From that reason interior design education must be performed as professional specialist education instead of vocational education. In another words, the ultimate goal of the interior design objectives must be in producing professional specialist.

• Ocean and Polar Research
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• 제36권1호
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• pp.49-57
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• 2014

The seabird plays an important role as one of the indicator species for the status of and changes within marine ecosystems. Therefore, the conservation of seabirds and their habitats is important for maintaining the structure and function of marine ecosystems. Biological invasions affect most ecosystems on oceanic islands. In particular, Rattus spp. is the invasive species with the greatest impact on the seabird population. Introduced predators, like rats, severely affect seabirds and endanger them worldwide. The breeding population of Streaked Shearwaters Calonectris leucomelas in Sasu Island is one of biggest seabird colonies in Korea, and the Norway Rat Rattus norvegicus is known as an alien predator in this island. In this study we investigated rates of burrow occupancy and breeding success of Streaked Shearwaters for 7 years, and the impact of Norway Rats on the breeding success of Streaked Shearwaters breeding in Sasu Island for 4 years. Our results show that the percentage of breeding burrows decreased according to breeding stage during several years in the monitoring period, and that predation by the Norway Rat was the main cause in hatching failures. Consequently, although our results indicate that their breeding population is not likely to decline, Norway Rats have been affecting the breeding status of Streaked Shearwaters on Sasu Island during the last decade.

• 한국동물생명공학회지
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• 제35권2호
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• pp.163-170
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• 2020

Partheno Embryo's research is known to play a very important role in identifying the development of embryonic cells or analyzing the genetic mechanisms of embryonic development, but the information on apoptosis formed during the early stage of development on Partheno Embryo is very little. Therefore, this study analyzed whether the embryonic cell death of unit embryos can be inhibited by adding Scriptaid, one of HDACi, which plays a role in demethylation of histone proteins as a method of regulating the cell cycle in the early embryo development of Partheno Embryo. As a result, the differentiation rate was higher in the group that added Scriptaid and FBS, but the cellular development was higher in the group that added pregnant serum to Scriptaid. As a result of analyzing the expression of the gene through IF and PCR, the group with the addition of gestational serum increased the expression of BCL2 and PCNA, which affects the anti-Casp3 action in cell survival. In addition, it is interpreted that treatment of Scriptaid for 16 hours, rather than 24 h treatment lowers the expression of Casp-3, a representative factor of apoptosis, and also increases embryonic development, thus affecting early embryo development. Therefore, it is concluded that the 16-hour treatment of Scriptaid and the use of gestational serum will inhibit cell death in the early embryonic development and increase the development rate of the embryo.

• Asian-Australasian Journal of Animal Sciences
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• 제21권2호
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• pp.225-231
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• 2008

Oxidative stress plays a crucial role in the laying stage which is a critical period for chick survival. We investigated the relationship of neonatal chick performance, brain antioxidant status and vitamin E supplementation level in hens. Starting at 17 weeks, hens were randomly divided into five groups. The control group received a basal diet without supplemental vitamin E (VE, dl-${\alpha}$-tocopherol acetate). Other groups received the same basal diet supplemented with vitamin E (40, 80, 120 and 160 mg/kg) through growth to egg production. Hens were artificially inseminated at 28 weeks of age and egg yolks were collected at day two. All remaining eggs were hatched. Yolk vitamin E content, hatchability and fertility of eggs were evaluated. Brains of the newly hatched chicks were further evaluated for their oxidative stress status, antioxidative status and vitamin E levels. Increased reproductive performance was observed in fertility and hatchability in the group supplemented at 40 mg/kg. Egg yolk and neonatal brain ${\alpha}$-tocopherol was highest in eggs from hens fed 120 mg/kg and 80 mg/kg supplemental vitamin E, respectively. Brain MDA, ROS and iron levels were significantly higher in unsupplemented hens (p<0.01). SOD activity was significantly higher in the group supplemented at 160 mg/kg than in all other groups. We concluded that maternal supplementation of vitamin E had beneficial effects on fertility, hatchability of eggs, neonatal brain oxidative status and SOD activity.

• Asian Pacific Journal of Cancer Prevention
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• 제15권1호
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• pp.29-32
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• 2014

Background and Objective: Lung cancer is one of the malignant diseases which most seriously threat humansurvival and development. This study aimed to assess osteopontin (OPN) expression in non-small cell lung cancer (NSCLC) and any relationship with clinicopathological features. Methods: Immunohistochemistry was used to determine OPN expression and microvascular density (MVD) in 120 cases of NSCLC also undergoing clinical assessment. Results: Moderately positive expression of OPN was found in 34.6% (41/120) and strong expression in 47.5% (57/120) of the NSCLCs; OPN expression in carcinomas was higher than in pericarcinoma tissues (P<0.05). While no obvious association was observed with NSCLC patient age, gender, maximum diameter of the tumor and pathological type, OPN expression was more commonly detected in poorly differentiated carcinoma tissue and lymph node metastasis as well as at advanced clinical stage (P<0.05); OPN expression in cancer tissue was positively correlated with MVD (r = 0.839, P = 0.000). Conclusion: OPN plays an important role in promoting tumor angiogenesis and progress of NSCLCs and has the possibility to become the new target for therapy.

• 한국콘텐츠학회논문지
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• 제13권8호
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• pp.371-385
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• 2013

대학 도서관의 지식문헌정보서비스는 대학 교육 및 교수의 연구를 지원하는 중요한 역할을 수행하고 있다. 이에 따라, 서비스 품질요소를 계층적 관점에서 정의하고 이들의 중요성을 분석함으로써 대학 도서관의 서비스를 개선하기 위한 연구들이 선행되어 왔다. 그러나 기존 연구들은 서비스 품질을 구성하는 하위요소들 간의 상호 영향관계, 그리고 서비스 이용자와 제공자 두 집단간의 서비스 품질요인에 대한 인식차를 파악하여 서비스를 개선하는 측면에서는 연구가 미흡한 실정이다. 따라서 본 연구는 SERVQUAL의 관점을 바탕으로 도서관 서비스를 구성하는 서비스 품질요소 간 상관관계를 네트워크 모델로 도출하고, Analytic Network Process를 활용하여 서비스 이용자와 제공자 집단간의 서비스 품질요소에 대한 인식차이를 도출, 분석하였다. 그 결과 제공자는 요소들을 비교적 균일하게 중요하게 인식하지만 이용자는 특정 몇 가지 요소들을 중요하게 인식하는 것을 확인하였다. 도서관 서비스 품질요소들간의 상관관계와 집단간의 인식차이를 파악하는 본 연구의 접근방법은 추후 대학 도서관의 지식문헌서비스 경쟁력 확보에 기여할 것으로 기대된다.

• 한국콘텐츠학회논문지
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• 제10권10호
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• pp.161-171
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• 2010

피터 브룩은 흔히 현대 서구의 가장 중요한 연극 연출가로 일컬어진다. 그는 단일한 방법론에 구속되지 않고 여러 기법을 이용한 다양한 연극을 연출해왔다. 이러한 점은 그가 절충적인 모방자로 평가받게 만드는 요인이 된다. 하지만 그의 작업과 정신을 자세히 살펴보면 그의 열려있는 정신은 연극이 지니는 소통의 힘의 추구이며, 그 가능성의 타진임을 엿볼 수 있다. 이러한 그의 모색은 브리콜라주 발상을 노정한다. 브리콜라주는 "야생의 사고"에서 소개된 후 학술적으로 관심을 끌게 된 개념이다. 레비-스트로스는 현대 과학이 놓치고 있는 브리콜라주의 신화적 사고를 우리가 복원해야할 것으로 본다. 연출가 피터 브룩은 연극과 삶에 대한 넓은 시야를 바탕으로 그의 '빈공간'을 효율적으로 채워가는 열린 작업 방식을 추구해오고 있다. 브룩의 이러한 지속적인 시도는 브리콜라주의 신화적 사고가 지니는 긍정적인 가능성을 드러내며, 연극의 발전적 방향을 제시하는 고무적인 암시인 것이다.

• 한국산학기술학회논문지
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• 제11권6호
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• pp.2124-2128
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• 2010

본 연구에서는 MAPK 저해제인 U0126이 난자성숙과정에서 특히 감수분열, 미세소관 형성 그리고 액틴 필 라먼트 형성에 미치는 영향을 조사하였다. 그 결과 MAPK 단백질은 12시간째에 인산화되기 시작하여, 24시간째에 대부분 인산화 되었고 metaphase II에 이르기 까지 유지되었다. 배포단계(GV)에 있는 난자를 U0126의 $20{\mu}M$ 농도로 처리하였을 때 MAPK의 인산화가 완전히 억제되었으나 배포의 파열 단계(GVBD)로의 성숙에는 진행하였으나, metaphase I까지는 발달하지 못하였다. 또한 MAPK 저해제로 인해 비정상적인 방추사의 형성을 초래하였다. 난자를 배포의 파열단계(GVBD) 이후에 U0126을 처리하였을 때 극체의 방출은 정상 이였으나 중기 판의 배열과 염색체의 분열은 비정상적 이였다. 결론적으로, 유사분열 활성화 효소단백질인 MAPK의 활성은 돼지 난자의 체외성숙과정에서 배포단계(GV)의 염색체의 배열과 감수분열의 완성에 중요한 조절 인자임을 이번 연구를 통해 알 수 있었다.

• Journal of Microbiology and Biotechnology
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• 제26권7호
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• pp.1252-1258
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• 2016

1,3-Propanediol (1,3-PD) is a valuable platform compound. Many studies have shown that the supplement of NADH plays a key role in the bioproduction of 1,3-PD from Klebsiella pneumoniae. In this study, the xylA and xylB genes from Escherichia coli were overexpressed individually or simultaneously in K. pneumoniae to improve the production of 1,3-PD by cofermentation of glycerol and xylose. Compared with the parent strain, the xylose consumption was significantly increased by the introduction of these two genes. The 1,3-PD titers were raised from 17.9 g/l to 23.5, 23.9, and 24.4 g/l, respectively, by the overexpression of xylA and xylB as well as their coexpression. The glycerol conversion rate (mol/mol) was enhanced from 54.1% to 73.8%. The concentration of 2,3-butanediol was increased by 50% at the middle stage but drastically decreased after that. The NADH and NADH/NAD⁺ ratio were improved. This report suggests that overexpression of xylA or xylB is an effective strategy to improve the xylose assimilation rate to provide abundant reducing power for the biosynthesis of 1,3-PD in K. pneumoniae.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 춘계학술대회
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• pp.406-409
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• 1997

In this paper, the power spectral analysis and fractral dimension analysis of heart rate variability(HRV) were performed to evaluate effects of orthostatic stress with head-up tilt on autonomic nervous system(ANS) for 24 young and healthy subjects(age: $24{\pm}5yr$.). The ECG and respiration signals were recorded at the tilt angle of $0^{\circ},\;15^{\circ},\;30^{\circ},\;45^{\circ},\;70^{\circ}$ and $90^{\circ}$ successively for 5 minutes per each stage under the condition of frequency controlled respiration (0.25Hz). Heart rate(HR) gradually increased as the angle increased. Similarly, according to the increment of angle, normalized low frequency(LF) component(0.05-0.15Hz) gradually increased, whereas normalized high frequency(HF) component (0.20-0.30Hz) was reduced. From these results it is speculated that orthostatic stress, head-up tilt, results in the prevalence of sympathetic tone in autonomic balance with the increment of sympathetic tone and the decrement of parasympathetic tone, which seems to mean that autonomic nervous system plays a major role in compensating for disturbances of cardiovascular system due to it.