• 약학회지
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• 제49권4호
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• pp.268-274
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• 2005

Paclitaxel is an effective antineoplastic agent against ovarian, colon and breast tumors. But there have been many difficulties to formulate this drug due to the extremely low aqueous solubility. Paclitaxel is currently formulated in a vehicle composed of Cremophor EL and absolute ethanol mixture which is $5\~20$ fold diluted in normal saline or $5\%$ dextrose solution before I.V. injection. However, this formulation has many problems such as allergic reactions and drug precipitation on aqueous dilution. To overcome these problems, we prepared the micelle and microemulsion systems for parenteral administration of paclitaxel by using glycofurol, $Soluto^{(R)}lHS$ 15 and oleic acid. Phase diagram, pH-rate stability, particle size distributions and pharmacokinetics of the systems were studied. Micelles and microemulsions formulated as nano-particle delivery system were physically and chemically stable. Therefore, these formulations might be the promising alternative candidate for the parenteral delivery of paclitaxel.

• The Korean Journal of Ecology
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• 제25권1호
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• pp.45-49
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• 2002

Pollen analyses and $^{14}$ C dating of the sediments of the Akindonuma moor, which is situated in a closed depression of an old landslide, were peformed in order to study the vegetation history of the montane zone of the Miyagi Prefecture, Northeast Japan. The main results are as follows: Two forest zones have been distinguished: 1) the A-I zone, or the Fagus-Quercus-Betula forest (R I stage, before about 11,700 yrs B.P.), and 2) the A-II zone, or the Fagus-Quercus forest (R II stage, after about 11,700 yrs B.P.). By comparing the geological section with the pollen diagram of the moor, it is assumed that the deposit environment of the Middle Part, which mostly consists of peat layers, is very stable. During the period, the Ulmus/Zelfkova pollen ratio was very low and small peak was not recognized. According to the preceding research, theme is a close relationship between the fluctuation of the Ulmus/Zelkova pollen ratio and the general trend of hillslope instability in the changing balance of temporature and precipitation Actually, Zelkova serrata tends to cover the footslope and the lower sideslope. Ulmus davidiana covers the footslope and the alluvial cone. Therefore, the fact that the Ulmus/Zeikova pollen ratio was very low and small peak was not recognized, is believed to reflect the stability of the earth's surface environment, which was estimated from the geological section.

• 연구논문집
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• 통권27호
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• pp.183-200
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• 1997

We have calculated the energy of three distinct grain configurations, namely completely connected, partially connected and unconnected configurations, evolving during a spheroidization of polycrystalline thin film by extending a geometrical model due to Miller et al. to the case of spheroidization at both the surface and film-substrate interface. "Stabilitl" diagram defining a stable region of each grain configuration has been established in terms of the ratio of grain size to film thickness vs. equilibrium wetting or dihedral angles at various interface energy conditions. The occurrence of spheroidization at the film-substrate interface significantly enlarges the stable region of unconnected grain configuration thereby greatly facilitating the occurrence of agglomeration. Complete separation of grain boundary is increasingly difficult with a reduction of equilibrium wetting angle. The condition for the occurrence of agglomeration differs depending on the equilibrium wetting or dihedral angles. The agglomeration occurs, at low equilibrium angles, via partially connected configuration containing stable holes centered at grain boundary vertices, whereas it occurs directly via completely connected configuration at large equilibrium angles except for the case having small surface and/or film-substrate interface energy. The initiation condition of agglomeration is defined by the equilibrium boundary condition between the partially connected and unconnected configurations for the former case, whereas it can, for the latter case, largely deviate from the equilibrium boundary condition between the completely connected and unconnected configurations because of the presence of a finite energy barrier to overcome to reach the unconnected grain configuration.

• 한국전산유체공학회지
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• 제17권1호
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• pp.86-93
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• 2012

A numerical investigation is conducted to search for the optimal flow rate for a rotating-disk chemical vapor decomposition reactor operating at a high temperature and a low pressure. The flow of a gas mixture supplied into the reactor is modeled by a laminar flow of an ideal gas obeying the kinetic theory. The axisymmetric two-dimensional flow in the reactor is simulated by employing a CFD package FLUENT. With operating pressure and temperature fixed, numerical computations are performed by varying rotation rate and flow rate. Examination of the structures of flow and thermal fields leads to a flow regime diagram illustrating that there are a stable plug-like flow regime and a few unfavorable flow regimes induced by mass unbalance or buoyancy. The criterion for sustaining a plug-like flow regime is discussed based on a theoretical scaling argument. Interpretation of the flow regime map suggests that a favorable flow is attainable with a minimum flow rate at the smallest rotation rate guaranteeing the dominance of rotation effects over buoyancy.

• 한국소음진동공학회논문집
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• 제25권11호
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• pp.771-778
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• 2015

In this work, vibration characteristics of high speed rotary bell cup for paint atomizer are numerically investigated. New type of bell cup model is proposed and additional corresponding models with design parameter variations for length and diameter are constructed. Dynamic characteristics, such as natural frequencies and corresponding mode shapes, are studied for each model as a first step. To investigate operation stability, critical speed of rotary bell cup is numerically analyzed based on Campbell diagram and separation margin between operating speed and critical speed is identified. Unbalance vibration responses are also investigated with respect to design parameter variation, operating speed and balancing quality grade of G. Then the proper design guideline for stable operation of high speed rotary bell cup for paint atomizer is suggested.

• 한국환경과학회지
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• 제9권3호
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• pp.229-239
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• 2000

Spring, ground and thermal waters in the vicinity of Mt. Geumjeong and Mt. Baekyang area have been sampled and analyzed for major and minor elements. According to the Piper diagram, spring water belongs to $Ca-HCO_3$ and $Na-HCO_3$ types, groundwater to $Ca-HCO_3$ type, and thermal water to Na-Cl type. Based on the phase stability diagrams of $[Ca^{2+}]/{[H^+]}^2, [Mg^{2+}]/{[H^+]}^2, [K^+]/[H^+]$, and $[Na^+]/[H^+] vs. [H_4SiO_4]$, spring water, groundwater and thermal water are mostly in equilibrium with kaolinite. The result of factor analysis shows three factors (factor 1, 2 and factor 3) for the spring water, the groundwater and the thermal water which are represented by the influence of the dissolution of feldspar, calcite, anthropogenic sources (domestic and industrial wastes) and salt water.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 제39회 하계학술대회
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• pp.924-925
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• 2008

There are many types of grid-connected inverter controllers, PI controller based is the most popular methods. But, a common PI control is produced zero-steady state error and phase delay in sinusoidal reference. Synchronous reference frame or DQ transform based controller is capable for reducing both of zero-steady state error and phase delay is. But DQ transform based controller has cross-coupling component which difficult to analyze the system in single phase model. In this paper, to obtained single phase model of the system, DQ transform based controller is analyzed in two techniques. The first is by neglecting cross-coupling. The second is eliminated cross-coupling component by decoupling method. By these two techniques, single phase model is obtained. Then, the single phase model is analyzed to evaluate its performance in stability and frequency response, through Root Locus and Bode diagram, respectively. MATLAB and PSIM simulation is used to verify the analysis. Simulation result is shown; cross-coupling component has no significant influent to the controller.

• 대한기계학회논문집B
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• 제21권4호
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• pp.518-524
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• 1997

Experimental studies on combustion phenomena within a porous ceramic burner are reported. Main interest of the present work is to investigate fundamental flame behaviors and their effects on the burner operation. Due to high thermal capacity of the porous ceramic materials, the response of flame to burning condition changes is slow and thus to have a stabilized flame is quite difficult and takes much time. It is found that the temperature profile obtained at downstream of the flame zone is not much sensitive to the movement of flame and the speed of flame movement is less than 0.1 mm/sec for the conditions tested. With the premixed LPG/air flame imbedded within the porous ceramic burner, stable combustion regions and unstable combustion regions leading to blowoff or flashback phenomena are observed and mapped on flow velocity versus equivalence ratio diagram. For the development of burner operation technique which is more practical and safe, intermittent burning technique, where the fuel or/and air is supplied to the burner intermittently, is proposed as one of the flame control methods for the porous ceramic burner and tested in this study. Through the experiment, it is realized that the proposed method is acceptable in respect to burner performance and give much flexibility in the operation of porous ceramic burner.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2011년도 추계학술대회 논문집
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• pp.264-270
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• 2011

The goal of this study is a stability evaluation through eigenvalue and rotor dynamics analysis of the vacuum pump. The vacuum pump used is a roots type pump, one of the dry middle vacuum pumps, is necessary at the procedure to produce semiconductor and display. The eigenvalue evaluation is solved by numerical analysis through using Modal test and 2D 3D models. Both the experiment and the analysis result are similar, the analysis result using 2D is more oculate the 3D model comparing with test result. So rotor dynamic evaluation is performed through using 2D model. Rotor dynamic evaluation used the campbell diagram and root locus map which were acquired by complex eigenvalue analysis. And we checked minimum clearance of vacuum pump composition between two rotors through unbalance response analysis. Thus, vacuum pump, the target object of this study, was evaluated to be operated stably.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2013년도 춘계학술대회 논문집
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• pp.60-64
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• 2013

Water injection pump produced the 1st oil well through the high pressure after the Deep water oil well drilling. After finish the work it is hard to produce only using itself pressure due to low pressure. Therefore it can be increased recovery factor through the injection seawater of high pressure. Is the key equipment used in the marine plant and it is developing at many industries. In this paper, Analyze changes in the natural frequency due to the stiffness of the bearing. Analyze the critical speed of the natural frequency due to the change of operation speed. And evaluate the Stability. And then analyze the displacement and clearance through the unbalance response this way has contributed to the reliability of the developing product. Through a mathematical analysis.