• 한국해양바이오학회지
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• 제1권3호
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• pp.144-155
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• 2006

This report reviews the literatures on chemical constituents of marine sponges of the genus Spongosorites and also highlights our own research. Specific biological activities of the metabolites from these sponges include: cytotoxic, antitumor, antibacterial, antifungal, antiviral, anti-inflammatory, and other pharmacological activities.

• 생약학회지
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• 제44권3호
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• pp.224-229
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• 2013

Bromotopsentin (BSM) is a bisindole alkaloid compound, which is recognized as a metabolite of the marine sponge Spongosorites sp. In this study, the antioxidant activity of BSM was investigated. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay, the trolox equivalent antioxidant capacity (TEAC) assay, the superoxide radical scavenging (NBT) assay, the lipid peroxidation and hydroxyl radical-induced DNA damage assays were carried out to evaluate the antioxidant activity of BSM. It was found that BSM had stronger scavenging activity on the stable free radical DPPH and superoxide radical than L-ascorbic acid with an $IC_{50}$ value of 62 and 64 ${\mu}M$, respectively. The TEAC value which indicated the total antioxidant capacity of BSM was about 0.8, which was also stronger than L-ascorbic acid. About 1.3 ${\mu}M$ of BSM induced 50% inhibition of lipid peroxidation. 60 nM of BSM exhibited a significant protective activity against DNA strand scission by hydroxyl radical on pBR322 DNA. Taken together, we suggest that BSM possesses strong antioxidant activity, and could be a valuable new addition to the list of anti-aging chemotherapeutic agents.

• Animal Systematics, Evolution and Diversity
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• 제8권2호
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• pp.301-324
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• 1992

제주도 연안과 부근 섬을 1991년 3월 부터 10월까지 5회에 걸쳐 채집한 재료와 그동안 한남대학교 생물학과와 이화여자대학교 생물학과에 보관되어 있던 제주도 표본들을 동정. 분류한 결과 30 과 40 속 67 종이 분류 되었고, 이 중 11 종은 한국미기록종이었다. 특기를 요하는 기록종에는 간단한 기재를 하였고, 미기록종에 대하여는 기재와 도판을 첨가 하였다.